hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02463
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| P4HB | Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55) | UniProt NCBI |
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | UniProt NCBI |
| LMNB1 | Lamin-B1 | UniProt NCBI |
| CCAR1 | Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain) | UniProt NCBI |
| P4HA2 | Prolyl 4-hydroxylase subunit alpha-2 (4-PH alpha-2) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2) | UniProt NCBI |
| YWHAZ | 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1) | UniProt NCBI |
| YWHAB | 14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5613 | 0.00120480805051 | 0.285714285714 | YWHAB LMNB1 | Emerin complex 25 |
| CORUM:5199 | 0.00120480805051 | 0.285714285714 | YWHAB YWHAZ | Kinase maturation complex 1 |
| REAC:R-HSA-9614399 | 0.00173796966748 | 0.285714285714 | YWHAB YWHAZ | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-392517 | 0.00208509668734 | 0.285714285714 | YWHAB YWHAZ | Rap1 signalling |
| REAC:R-HSA-75035 | 0.00246365348013 | 0.285714285714 | YWHAB YWHAZ | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| REAC:R-HSA-111447 | 0.00331497172198 | 0.285714285714 | YWHAB YWHAZ | Activation of BAD and translocation to mitochondria |
| REAC:R-HSA-449147 | 0.00732463375585 | 0.571428571429 | YWHAZ YWHAB LMNB1 P4HB | Signaling by Interleukins |
| REAC:R-HSA-109581 | 0.00812379143266 | 0.428571428571 | YWHAB LMNB1 YWHAZ | Apoptosis |
| REAC:R-HSA-5357801 | 0.00856161121757 | 0.428571428571 | YWHAB LMNB1 YWHAZ | Programmed Cell Death |
| MIRNA:hsa-miR-513c-3p | 0.0110368546879 | 0.428571428571 | YWHAB LMNB1 YWHAZ | hsa-miR-513c-3p |
| MIRNA:hsa-miR-3606-3p | 0.0114678324138 | 0.428571428571 | YWHAB LMNB1 YWHAZ | hsa-miR-3606-3p |
| MIRNA:hsa-miR-513a-3p | 0.0114678324138 | 0.428571428571 | YWHAB LMNB1 YWHAZ | hsa-miR-513a-3p |
| REAC:R-HSA-114452 | 0.0136873957341 | 0.285714285714 | YWHAB YWHAZ | Activation of BH3-only proteins |
| REAC:R-HSA-8953854 | 0.0191594284188 | 0.571428571429 | YWHAB NUDT21 CCAR1 YWHAZ | Metabolism of RNA |
| REAC:R-HSA-1280215 | 0.0238923711979 | 0.571428571429 | YWHAZ YWHAB LMNB1 P4HB | Cytokine Signaling in Immune system |
| REAC:R-HSA-9020591 | 0.0310461185517 | 0.285714285714 | LMNB1 P4HB | Interleukin-12 signaling |
| REAC:R-HSA-109606 | 0.038372634236 | 0.285714285714 | YWHAB YWHAZ | Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-447115 | 0.0431362871916 | 0.285714285714 | LMNB1 P4HB | Interleukin-12 family signaling |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | CCAR1 NUDT21 YWHAZ LMNB1 YWHAB P4HB | CORUM root |
| CORUM:472 | 0.0499886427319 | 0.142857142857 | P4HB | Prolyl 4-hydroxylase (alpha(I)-type) |
| CORUM:474 | 0.0499886427319 | 0.142857142857 | P4HB | Prolyl 4-hydroxylase (alpha(III)-type) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| YWHAZ | YWHAB | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (YWHAZ) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAZ | LMNB1 | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAB | LMNB1 | 0.988 | 0.901 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | YWHAZ | 0.983 | 0.899 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| P4HA2 | P4HB | 0.98 | 0.896 | hein_WMM bioplex (P4HA2,P4HB) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| YWHAZ | CCAR1 | 0.89 | 0.818 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| P4HA2 | YWHAB | 0.863 | 0.8 | bioplex (P4HA2) bioplex_WMM fraction |
| P4HB | YWHAZ | 0.849 | 0.79 | bioplex (P4HB) boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | YWHAB | 0.832 | 0.779 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| P4HA2 | YWHAZ | 0.804 | 0.768 | bioplex (P4HA2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| YWHAB | CCAR1 | 0.789 | 0.758 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| P4HB | YWHAB | 0.74 | 0.739 | boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| P4HB | LMNB1 | 0.164 | 0.42 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| P4HA2 | LMNB1 | 0.127 | 0.399 | bioplex (P4HA2) bioplex_WMM gupta_WMM fraction treiber_WMM |
| CCAR1 | LMNB1 | 0.103 | 0.366 | youn_WMM gupta_WMM fraction treiber_WMM |
| NUDT21 | LMNB1 | 0.014 | 0.143 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| P4HA2 | NUDT21 | 0.005 | 0.011 | bioplex (P4HA2) bioplex_WMM fraction |
| NUDT21 | CCAR1 | 0.003 | 0.019 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| P4HB | CCAR1 | 0.0 | 0.009 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| P4HB | NUDT21 | 0.0 | 0.002 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| P4HA2 | CCAR1 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_02463 has an average edge precision of 0.541 which is ranked 2260 out of all 6965 complexes.
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