hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02464
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ADGRA3 | Adhesion G protein-coupled receptor A3 (G-protein coupled receptor 125) | UniProt NCBI |
| RASA1 | Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP) | UniProt NCBI |
| HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | UniProt NCBI |
| STAM | Signal transducing adapter molecule 1 (STAM-1) | UniProt NCBI |
| DDI2 | Protein DDI1 homolog 2 (EC 3.4.23.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7287 | 2.0123342217e-05 | 0.4 | HGS STAM | SIMPLE-HRS-STAM1 complex |
| WP:WP437 | 0.000443577883382 | 0.6 | RASA1 HGS STAM | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-8875360 | 0.00122631290825 | 0.4 | HGS STAM | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 0.00230284247734 | 0.4 | HGS STAM | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 0.00255837003151 | 0.4 | HGS STAM | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 0.0040368179849 | 0.4 | HGS STAM | EGFR downregulation |
| REAC:R-HSA-917729 | 0.00625202329777 | 0.4 | HGS STAM | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-177929 | 0.012121451174 | 0.4 | HGS STAM | Signaling by EGFR |
| GO:0033565 | 0.0135228859698 | 0.4 | HGS STAM | ESCRT-0 complex |
| REAC:R-HSA-9006934 | 0.0291077226575 | 0.6 | RASA1 HGS STAM | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-6806834 | 0.0351349281697 | 0.4 | HGS STAM | Signaling by MET |
| CORUM:2578 | 0.0499494897235 | 0.2 | RASA1 | Sam68-p120GAP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STAM | HGS | 1.0 | 0.949 | bioplex (STAM) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| STAM | ADGRA3 | 0.133 | 0.406 | bioplex (STAM) bioplex_WMM |
| HGS | DDI2 | 0.075 | 0.356 | fraction |
| STAM | DDI2 | 0.051 | 0.296 | fraction |
| STAM | RASA1 | 0.028 | 0.233 | fraction |
| HGS | ADGRA3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02464 has an average edge precision of 0.389 which is ranked 3441 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ADGRA3 | HuMAP2_02464 HuMAP2_05413 HuMAP2_06440 |
| RASA1 | HuMAP2_02464 HuMAP2_03987 |
| HGS | HuMAP2_00820 HuMAP2_00893 HuMAP2_02464 HuMAP2_04329 HuMAP2_04638 HuMAP2_05413 HuMAP2_06440 |
| STAM | HuMAP2_00820 HuMAP2_02464 HuMAP2_04638 HuMAP2_05413 HuMAP2_06440 |
| DDI2 | HuMAP2_00893 HuMAP2_01853 HuMAP2_02464 HuMAP2_05413 |