hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02465
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | UniProt NCBI |
| PCGF3 | Polycomb group RING finger protein 3 (RING finger protein 3A) | UniProt NCBI |
| PCGF1 | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | UniProt NCBI |
| RYBP | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | UniProt NCBI |
| MORC4 | MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) | UniProt NCBI |
| BCOR | BCL-6 corepressor (BCoR) | UniProt NCBI |
| YAF2 | YY1-associated factor 2 | UniProt NCBI |
| ACTL8 | Actin-like protein 8 (Cancer/testis antigen 57) (CT57) | UniProt NCBI |
| BCORL1 | BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1178 | 1.77634479162e-10 | 0.444444444444 | RYBP KDM2B PCGF1 BCOR | BCOR complex |
| GO:0035518 | 6.37000481812e-09 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | histone H2A monoubiquitination |
| GO:0033522 | 5.45947312008e-08 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | histone H2A ubiquitination |
| GO:0010390 | 1.21919572366e-07 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | histone monoubiquitination |
| GO:0016574 | 9.851514256e-07 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | histone ubiquitination |
| GO:0006513 | 5.10531909805e-06 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | protein monoubiquitination |
| WP:WP4553 | 5.41611549437e-05 | 0.333333333333 | KDM2B PCGF1 BCOR | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| GO:0031519 | 0.000495971138644 | 0.444444444444 | RYBP PCGF3 PCGF1 KDM2B | PcG protein complex |
| GO:0016570 | 0.0281315666674 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | histone modification |
| GO:0016569 | 0.0351789800532 | 0.555555555556 | KDM2B PCGF3 RYBP PCGF1 BCOR | covalent chromatin modification |
| REAC:R-HSA-8953750 | 0.0359121718017 | 0.222222222222 | RYBP YAF2 | Transcriptional Regulation by E2F6 |
| WP:WP3651 | 0.0384300578645 | 0.222222222222 | BCOR BCORL1 | Pathways Affected in Adenoid Cystic Carcinoma |
| REAC:R-HSA-8939243 | 0.0403038960626 | 0.222222222222 | RYBP YAF2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PCGF1 | RYBP | 0.999 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (PCGF1) |
| RYBP | PCGF3 | 0.923 | 0.844 | bioplex (RYBP) bioplex_WMM |
| BCOR | RYBP | 0.863 | 0.799 | hein_WMM bioplex (RYBP) bioplex_WMM |
| KDM2B | RYBP | 0.772 | 0.751 | hein_WMM bioplex (RYBP) bioplex_WMM |
| PCGF1 | YAF2 | 0.726 | 0.736 | hein_WMM bioplex (YAF2) bioplex_WMM hein (PCGF1) |
| PCGF1 | KDM2B | 0.264 | 0.482 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1) gupta_WMM |
| YAF2 | BCOR | 0.196 | 0.45 | hein_WMM bioplex (YAF2) bioplex_WMM hein (BCOR) |
| RYBP | MORC4 | 0.191 | 0.444 | bioplex (RYBP) bioplex_WMM |
| PCGF1 | BCOR | 0.144 | 0.407 | hein_WMM bioplex_WMM youn_WMM hein (BCOR,PCGF1) gupta_WMM |
| YAF2 | KDM2B | 0.141 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | RYBP | 0.133 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | PCGF3 | 0.119 | 0.392 | bioplex (YAF2) bioplex_WMM |
| RYBP | BCORL1 | 0.118 | 0.392 | hein_WMM bioplex (RYBP) bioplex_WMM |
| BCOR | KDM2B | 0.04 | 0.267 | hein_WMM bioplex_WMM youn_WMM hein (BCOR) gupta_WMM |
| ACTL8 | PCGF1 | 0.031 | 0.237 | hein_WMM hein (PCGF1) |
| PCGF1 | BCORL1 | 0.027 | 0.228 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1) |
| YAF2 | BCORL1 | 0.025 | 0.218 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | MORC4 | 0.024 | 0.211 | bioplex (YAF2) bioplex_WMM |
| PCGF1 | PCGF3 | 0.012 | 0.145 | bioplex_WMM WMM_only |
| KDM2B | MORC4 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
| KDM2B | BCORL1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PCGF1 | MORC4 | 0.01 | 0.139 | bioplex_WMM youn_WMM WMM_only |
| KDM2B | PCGF3 | 0.01 | 0.133 | bioplex_WMM WMM_only |
| BCORL1 | MORC4 | 0.01 | 0.129 | bioplex_WMM youn_WMM WMM_only |
| PCGF3 | MORC4 | 0.01 | 0.101 | bioplex_WMM WMM_only |
| BCORL1 | PCGF3 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| BCOR | PCGF3 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| BCOR | BCORL1 | 0.009 | 0.09 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BCOR | MORC4 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| ACTL8 | KDM2B | 0.007 | 0.012 | hein_WMM WMM_only |
| ACTL8 | BCOR | 0.007 | 0.004 | hein_WMM hein (BCOR) |
| ACTL8 | RYBP | 0.007 | 0.002 | hein_WMM WMM_only |
| ACTL8 | BCORL1 | 0.007 | 0.005 | hein_WMM WMM_only |
| ACTL8 | YAF2 | 0.006 | 0.005 | hein_WMM WMM_only |
Images
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Complex HuMAP2_02465 has an average edge precision of 0.293 which is ranked 4698 out of all 6965 complexes.
Related Complexes