hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02471
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SNX33 | Sorting nexin-33 (SH3 and PX domain-containing protein 3) | UniProt NCBI |
| BBOX1 | Gamma-butyrobetaine dioxygenase (EC 1.14.11.1) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) (Gamma-butyrobetaine,2-oxoglutarate dioxygenase) | UniProt NCBI |
| AZI2 | 5-azacytidine-induced protein 2 (NF-kappa-B-activating kinase-associated protein 1) (Nak-associated protein 1) (TILP) | UniProt NCBI |
| FNBP1L | Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1) | UniProt NCBI |
| CASP2 | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] | UniProt NCBI |
| GBA | Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | UniProt NCBI |
| RNASET2 | Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6) | UniProt NCBI |
| HNRNPK | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformation up-regulated nuclear protein) (TUNP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5212 | 0.000374856382464 | 0.222222222222 | AZI2 TANK | Kinase maturation complex 2 |
| WP:WP3865 | 0.0273641612091 | 0.222222222222 | AZI2 TANK | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:04622 | 0.0328445223304 | 0.222222222222 | AZI2 TANK | RIG-I-like receptor signaling pathway |
| HPA:001040_23 | 0.0360400270153 | 0.555555555556 | AZI2 RNASET2 TANK SNX33 CASP2 | adrenal gland; glandular cells[Approved,High] |
| HPA:031010_22 | 0.041797512771 | 0.555555555556 | CASP2 TANK SNX33 FNBP1L RNASET2 | ovary; follicle cells[Approved,Medium] |
| CORUM:129 | 0.0499262710315 | 0.111111111111 | CASP2 | PIDDsome complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BBOX1 | CASP2 | 0.983 | 0.899 | bioplex (BBOX1) bioplex_WMM |
| BBOX1 | AZI2 | 0.598 | 0.668 | bioplex (BBOX1) bioplex_WMM |
| CASP2 | HNRNPK | 0.176 | 0.435 | bioplex (HNRNPK) bioplex_WMM |
| SNX33 | HNRNPK | 0.062 | 0.34 | bioplex (HNRNPK) bioplex_WMM |
| FNBP1L | HNRNPK | 0.043 | 0.27 | bioplex (HNRNPK) bioplex_WMM fraction boldt_WMM |
| RNASET2 | HNRNPK | 0.025 | 0.211 | bioplex (RNASET2) bioplex_WMM fraction |
| BBOX1 | TANK | 0.024 | 0.214 | bioplex (BBOX1) bioplex_WMM |
| GBA | RNASET2 | 0.021 | 0.188 | bioplex (RNASET2) bioplex_WMM fraction |
| TANK | AZI2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| CASP2 | AZI2 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| CASP2 | TANK | 0.008 | 0.089 | bioplex_WMM WMM_only |
| FNBP1L | CASP2 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| FNBP1L | SNX33 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| CASP2 | SNX33 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| BBOX1 | HNRNPK | 0.007 | 0.01 | bioplex (BBOX1) |
| TANK | HNRNPK | 0.007 | 0.002 | WMM_only |
| AZI2 | HNRNPK | 0.007 | 0.0 | WMM_only |
| GBA | HNRNPK | 0.0 | 0.001 | bioplex_WMM fraction |
Images
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Complex HuMAP2_02471 has an average edge precision of 0.2 which is ranked 6174 out of all 6965 complexes.
Related Complexes