hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02474
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MRE11 | Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) | UniProt NCBI |
| RAD50 | DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:263 | 1.67592346237e-06 | 1.0 | MRE11 RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:72 | 1.67592346237e-06 | 1.0 | MRE11 RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:264 | 1.67592346237e-06 | 1.0 | MRE11 RAD50 | R/M complex (RAD50-MRE11 complex) |
| CORUM:618 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:173 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:73 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:71 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:972 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:1081 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| CORUM:2767 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | RAD50-MRE11-NBN-p200-p350 complex |
| CORUM:331 | 5.02777038712e-06 | 1.0 | MRE11 RAD50 | MRN complex (MRE11-RAD50-NBN complex) |
| WP:WP2942 | 7.82420796608e-06 | 1.0 | MRE11 RAD50 | DDX1 as a regulatory component of the Drosha microprocessor |
| WP:WP438 | 7.82420796608e-06 | 1.0 | MRE11 RAD50 | Non-homologous end joining |
| CORUM:627 | 1.00555407742e-05 | 1.0 | MRE11 RAD50 | MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) |
| CORUM:202 | 1.00555407742e-05 | 1.0 | MRE11 RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| CORUM:2218 | 1.00555407742e-05 | 1.0 | MRE11 RAD50 | MDC1-MRE11-RAD50-NBS1 complex |
| CORUM:619 | 1.00555407742e-05 | 1.0 | MRE11 RAD50 | MRE11A-RAD50-NBN-TRF2 complex |
| CORUM:964 | 1.00555407742e-05 | 1.0 | MRE11 RAD50 | BRCA1-RAD50-MRE11-NBS1 complex |
| KEGG:03450 | 1.13800084426e-05 | 1.0 | MRE11 RAD50 | Non-homologous end-joining |
| WP:WP186 | 2.45903678934e-05 | 1.0 | MRE11 RAD50 | Homologous recombination |
| REAC:R-HSA-5693548 | 2.51388519356e-05 | 1.0 | MRE11 RAD50 | Sensing of DNA Double Strand Breaks |
| CORUM:2217 | 2.51388519356e-05 | 1.0 | MRE11 RAD50 | MDC1-MRN-ATM-FANCD2 complex |
| CORUM:5197 | 2.51388519356e-05 | 1.0 | MRE11 RAD50 | PTIP-DNA damage response complex |
| CORUM:1193 | 3.51943927099e-05 | 1.0 | MRE11 RAD50 | Rap1 complex |
| CORUM:1189 | 3.51943927099e-05 | 1.0 | MRE11 RAD50 | DNA double-strand break end-joining complex |
| CORUM:2766 | 3.51943927099e-05 | 1.0 | MRE11 RAD50 | TERF2-RAP1 complex |
| CORUM:2815 | 4.69258569465e-05 | 1.0 | MRE11 RAD50 | BRCA1-BARD1-BACH1-DNA damage complex II |
| REAC:R-HSA-5685939 | 7.54165558069e-05 | 1.0 | MRE11 RAD50 | HDR through MMEJ (alt-NHEJ) |
| CORUM:433 | 0.000110610948517 | 1.0 | MRE11 RAD50 | BASC complex (BRCA1-associated genome surveillance complex) |
| KEGG:03440 | 0.000113800084426 | 1.0 | MRE11 RAD50 | Homologous recombination |
| WP:WP2516 | 0.000276082766803 | 1.0 | MRE11 RAD50 | ATM Signaling Pathway |
| HP:0030406 | 0.000303888373596 | 1.0 | MRE11 RAD50 | Primary peritoneal carcinoma |
| WP:WP1971 | 0.000336440942541 | 1.0 | MRE11 RAD50 | Integrated Cancer Pathway |
| WP:WP3878 | 0.000352461939805 | 1.0 | MRE11 RAD50 | ATM Signaling Network in Development and Disease |
| REAC:R-HSA-5693554 | 0.000544675125272 | 1.0 | MRE11 RAD50 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| WP:WP3959 | 0.000553283277601 | 1.0 | MRE11 RAD50 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| WP:WP707 | 0.000823777324428 | 1.0 | MRE11 RAD50 | DNA Damage Response |
| REAC:R-HSA-5693568 | 0.000831258037338 | 1.0 | MRE11 RAD50 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.000884887588134 | 1.0 | MRE11 RAD50 | Resolution of D-Loop Structures |
| WP:WP1530 | 0.000899783916099 | 1.0 | MRE11 RAD50 | miRNA Regulation of DNA Damage Response |
| WP:WP4656 | 0.000979143739755 | 1.0 | MRE11 RAD50 | Joubert Syndrome |
| REAC:R-HSA-5685938 | 0.0010558317813 | 1.0 | MRE11 RAD50 | HDR through Single Strand Annealing (SSA) |
| HP:0011027 | 0.00108531561999 | 1.0 | MRE11 RAD50 | Abnormality of the fallopian tube |
| WP:WP4016 | 0.00111886173915 | 1.0 | MRE11 RAD50 | DNA IR-damage and cellular response via ATR |
| HP:0012125 | 0.00117214086958 | 1.0 | MRE11 RAD50 | Prostate cancer |
| HP:0100787 | 0.00117214086958 | 1.0 | MRE11 RAD50 | Prostate neoplasm |
| REAC:R-HSA-5693616 | 0.00117817419405 | 1.0 | MRE11 RAD50 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 0.00137425723915 | 1.0 | MRE11 RAD50 | Homologous DNA Pairing and Strand Exchange |
| KEGG:04218 | 0.00152317036077 | 1.0 | MRE11 RAD50 | Cellular senescence |
| HP:0008775 | 0.00176322045339 | 1.0 | MRE11 RAD50 | Abnormal prostate morphology |
| GO:0000019 | 0.00270494046827 | 1.0 | MRE11 RAD50 | regulation of mitotic recombination |
| GO:0031860 | 0.00270494046827 | 1.0 | MRE11 RAD50 | telomeric 3' overhang formation |
| HP:0000022 | 0.00345631282057 | 1.0 | MRE11 RAD50 | Abnormality of male internal genitalia |
| REAC:R-HSA-5685942 | 0.00348592080174 | 1.0 | MRE11 RAD50 | HDR through Homologous Recombination (HRR) |
| WP:WP4262 | 0.00357342755251 | 1.0 | MRE11 RAD50 | Breast cancer pathway |
| WP:WP1984 | 0.00383609739137 | 1.0 | MRE11 RAD50 | Integrated Breast Cancer Pathway |
| REAC:R-HSA-5693571 | 0.00393171644273 | 1.0 | MRE11 RAD50 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 0.00477638186777 | 1.0 | MRE11 RAD50 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.00490375205091 | 1.0 | MRE11 RAD50 | DNA Double Strand Break Response |
| HP:0003002 | 0.00495905752517 | 1.0 | MRE11 RAD50 | Breast carcinoma |
| REAC:R-HSA-2559586 | 0.00516352018758 | 1.0 | MRE11 RAD50 | DNA Damage/Telomere Stress Induced Senescence |
| HP:0100615 | 0.0053297345523 | 1.0 | MRE11 RAD50 | Ovarian neoplasm |
| HP:0002861 | 0.00552008221488 | 1.0 | MRE11 RAD50 | Melanoma |
| REAC:R-HSA-912446 | 0.00598304676068 | 1.0 | MRE11 RAD50 | Meiotic recombination |
| REAC:R-HSA-6804756 | 0.00686290657842 | 1.0 | MRE11 RAD50 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.00732546145404 | 1.0 | MRE11 RAD50 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.00780309964082 | 1.0 | MRE11 RAD50 | Processing of DNA double-strand break ends |
| HP:0002894 | 0.0085355899221 | 1.0 | MRE11 RAD50 | Neoplasm of the pancreas |
| HP:0100013 | 0.00877602907484 | 1.0 | MRE11 RAD50 | Neoplasm of the breast |
| GO:0030870 | 0.00946729163895 | 1.0 | MRE11 RAD50 | Mre11 complex |
| REAC:R-HSA-1500620 | 0.0107946230212 | 1.0 | MRE11 RAD50 | Meiosis |
| HP:0010785 | 0.0113640893994 | 1.0 | MRE11 RAD50 | Gonadal neoplasm |
| REAC:R-HSA-1474165 | 0.0134090636225 | 1.0 | MRE11 RAD50 | Reproduction |
| REAC:R-HSA-5693567 | 0.014052618232 | 1.0 | MRE11 RAD50 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.0153849773846 | 1.0 | MRE11 RAD50 | Homology Directed Repair |
| GO:0000014 | 0.0162296428096 | 1.0 | MRE11 RAD50 | single-stranded DNA endodeoxyribonuclease activity |
| HP:0010787 | 0.0200198988979 | 1.0 | MRE11 RAD50 | Genital neoplasm |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | MRE11 RAD50 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.0224003929981 | 1.0 | MRE11 RAD50 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.023229975112 | 1.0 | MRE11 RAD50 | G2/M Checkpoints |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | MRE11 RAD50 | Cellular Senescence |
| HP:0007379 | 0.0378190750657 | 1.0 | MRE11 RAD50 | Neoplasm of the genitourinary tract |
| HP:0100953 | 0.0497341708567 | 0.5 | MRE11 | Enlarged interhemispheric fissure |
| CORUM:2776 | 0.0499173803268 | 0.5 | RAD50 | RAD50-BRCA1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAD50 | MRE11 | 0.991 | 0.911 | bioplex_WMM boldt Malo fraction boldt_WMM |
Images
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Complex HuMAP2_02474 has an average edge precision of 0.911 which is ranked 506 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MRE11 | HuMAP2_01080 HuMAP2_02474 |
| RAD50 | HuMAP2_01080 HuMAP2_02474 HuMAP2_03572 HuMAP2_05113 |