hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02476
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | UniProt NCBI |
| UNG | Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) | UniProt NCBI |
| CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17) | UniProt NCBI |
| CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta (CaM kinase II subunit delta) (CaMK-II subunit delta) (EC 2.7.11.17) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111932 | 4.60032183236e-11 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | CaMK IV-mediated phosphorylation of CREB |
| GO:0005954 | 1.2197780676e-10 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | calcium- and calmodulin-dependent protein kinase complex |
| REAC:R-HSA-442982 | 1.11668064351e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-9617324 | 1.41438609596e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-438066 | 1.41438609596e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9620244 | 1.76788755434e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Long-term potentiation |
| REAC:R-HSA-3371571 | 3.2305714914e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | HSF1-dependent transactivation |
| REAC:R-HSA-442742 | 5.45333158978e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-399719 | 5.45333158978e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Trafficking of AMPA receptors |
| REAC:R-HSA-399721 | 5.45333158978e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Glutamate binding, activation of AMPA receptors and synaptic plasticity |
| REAC:R-HSA-5673000 | 8.66228610405e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | RAF activation |
| REAC:R-HSA-9022692 | 8.66228610405e-09 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Regulation of MECP2 expression and activity |
| WP:WP4008 | 1.1127214073e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | NO/cGMP/PKG mediated Neuroprotection |
| REAC:R-HSA-111933 | 1.49208230389e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Calmodulin induced events |
| REAC:R-HSA-111997 | 1.49208230389e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | CaM pathway |
| REAC:R-HSA-111996 | 1.90901811802e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Ca-dependent events |
| REAC:R-HSA-5576892 | 2.40770685636e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Phase 0 - rapid depolarisation |
| REAC:R-HSA-9609736 | 2.69082165127e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-1489509 | 2.99818273785e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | DAG and IP3 signaling |
| REAC:R-HSA-6802955 | 4.94701294863e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 4.94701294863e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Signaling by moderate kinase activity BRAF mutants |
| WP:WP4341 | 5.36500674309e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| REAC:R-HSA-5578775 | 5.42935600944e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Ion homeostasis |
| KEGG:04971 | 6.04378937267e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Gastric acid secretion |
| KEGG:04720 | 6.46025425563e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Long-term potentiation |
| KEGG:05031 | 6.46025425563e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Amphetamine addiction |
| REAC:R-HSA-936837 | 6.49889456043e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Ion transport by P-type ATPases |
| REAC:R-HSA-112043 | 9.1033774217e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | PLC beta mediated events |
| KEGG:05214 | 9.42812584165e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Glioma |
| REAC:R-HSA-112040 | 9.86146100692e-08 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | G-protein mediated events |
| REAC:R-HSA-8986944 | 1.06659036688e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Transcriptional Regulation by MECP2 |
| KEGG:04911 | 1.1907721613e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Insulin secretion |
| REAC:R-HSA-6802949 | 1.33760664717e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Signaling by RAS mutants |
| KEGG:04012 | 1.73841213182e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | ErbB signaling pathway |
| WP:WP673 | 1.82151113191e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | ErbB Signaling Pathway |
| KEGG:04750 | 1.92475995379e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Inflammatory mediator regulation of TRP channels |
| KEGG:04912 | 1.92475995379e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | GnRH signaling pathway |
| REAC:R-HSA-6802952 | 2.16849074945e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Signaling by BRAF and RAF fusions |
| KEGG:04925 | 2.69671550532e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Aldosterone synthesis and secretion |
| KEGG:04713 | 2.69671550532e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Circadian entrainment |
| KEGG:04916 | 2.82346737107e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Melanogenesis |
| KEGG:04922 | 3.84002380227e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Glucagon signaling pathway |
| KEGG:04725 | 3.84002380227e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cholinergic synapse |
| REAC:R-HSA-438064 | 3.96024318077e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Post NMDA receptor activation events |
| REAC:R-HSA-877300 | 4.42192738057e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Interferon gamma signaling |
| KEGG:04066 | 4.53176595774e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | HIF-1 signaling pathway |
| WP:WP428 | 4.63701037706e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Wnt Signaling |
| REAC:R-HSA-6802957 | 5.1886356556e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Oncogenic MAPK signaling |
| KEGG:04114 | 5.96187048479e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Oocyte meiosis |
| KEGG:04722 | 5.96187048479e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Neurotrophin signaling pathway |
| REAC:R-HSA-442755 | 7.01630822759e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-3371556 | 7.36239529367e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cellular response to heat stress |
| WP:WP536 | 7.37592908394e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-111885 | 7.72111985662e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Opioid Signalling |
| KEGG:04728 | 9.80702381829e-07 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Dopaminergic synapse |
| WP:WP289 | 1.05142095686e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Myometrial Relaxation and Contraction Pathways |
| KEGG:04740 | 1.08278740054e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Olfactory transduction |
| KEGG:04261 | 1.27036260649e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Adrenergic signaling in cardiomyocytes |
| KEGG:04921 | 1.52643011028e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Oxytocin signaling pathway |
| GO:0004683 | 1.54127830699e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | calmodulin-dependent protein kinase activity |
| KEGG:04934 | 1.81933554316e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cushing syndrome |
| REAC:R-HSA-5576891 | 2.02025437226e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cardiac conduction |
| KEGG:04310 | 2.15244167448e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Wnt signaling pathway |
| KEGG:05152 | 2.33516050441e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Tuberculosis |
| KEGG:04217 | 2.46326526745e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Necroptosis |
| KEGG:04020 | 2.95343153553e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Calcium signaling pathway |
| KEGG:04360 | 3.42876450157e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Axon guidance |
| KEGG:04024 | 3.86679299989e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | cAMP signaling pathway |
| KEGG:05205 | 5.79761916632e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Proteoglycans in cancer |
| REAC:R-HSA-983712 | 9.52229417821e-06 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Ion channel transport |
| REAC:R-HSA-397014 | 1.27422309093e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Muscle contraction |
| REAC:R-HSA-913531 | 1.33492879706e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Interferon Signaling |
| REAC:R-HSA-112314 | 1.3660811252e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-5673001 | 2.06804793503e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 2.29081302441e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 2.89852727833e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | FLT3 Signaling |
| REAC:R-HSA-112315 | 3.8873456186e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Transmission across Chemical Synapses |
| REAC:R-HSA-449836 | 3.8873456186e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Other interleukin signaling |
| REAC:R-HSA-5683057 | 4.54388535997e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | MAPK family signaling cascades |
| REAC:R-HSA-418594 | 6.804840425e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 7.01630067925e-05 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Intracellular signaling by second messengers |
| GO:0060333 | 0.000125031076937 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | interferon-gamma-mediated signaling pathway |
| GO:1900034 | 0.000155889098397 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | regulation of cellular response to heat |
| REAC:R-HSA-5663202 | 0.000189340345518 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Diseases of signal transduction |
| REAC:R-HSA-112316 | 0.000198489420183 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Neuronal System |
| KEGG:05200 | 0.000217862252065 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Pathways in cancer |
| GO:0005516 | 0.000234344694802 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | calmodulin binding |
| REAC:R-HSA-442729 | 0.000283261545489 | 0.4 | CAMK2B CAMK2G | CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde |
| REAC:R-HSA-2262752 | 0.000402506828977 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cellular responses to stress |
| GO:0034605 | 0.000536428901306 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | cellular response to heat |
| GO:0071346 | 0.0005799178998 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | cellular response to interferon-gamma |
| GO:0030666 | 0.000780783958982 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | endocytic vesicle membrane |
| REAC:R-HSA-8953897 | 0.00083024651806 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cellular responses to external stimuli |
| GO:0034341 | 0.000868135384463 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | response to interferon-gamma |
| GO:0009408 | 0.000898817254521 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | response to heat |
| REAC:R-HSA-449147 | 0.000989720440926 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Signaling by Interleukins |
| REAC:R-HSA-388396 | 0.00122449193088 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | GPCR downstream signalling |
| GO:0051924 | 0.00155534683144 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | regulation of calcium ion transport |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Signaling by GPCR |
| GO:0009266 | 0.00185620980997 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | response to temperature stimulus |
| REAC:R-HSA-382551 | 0.00191509203292 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Transport of small molecules |
| REAC:R-HSA-1280215 | 0.00329327042719 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Cytokine Signaling in Immune system |
| GO:0043502 | 0.00703245670927 | 0.6 | CAMK2B CAMK2G CAMK2D | regulation of muscle adaptation |
| GO:0030139 | 0.0102459772477 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | endocytic vesicle |
| GO:0010959 | 0.0104396464573 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | regulation of metal ion transport |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Disease |
| GO:0010666 | 0.0135228859698 | 0.4 | CAMK2D CAMK2A | positive regulation of cardiac muscle cell apoptotic process |
| GO:0010663 | 0.0135228859698 | 0.4 | CAMK2D CAMK2A | positive regulation of striated muscle cell apoptotic process |
| GO:0043500 | 0.0146610377831 | 0.6 | CAMK2B CAMK2G CAMK2D | muscle adaptation |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Generic Transcription Pathway |
| GO:0006816 | 0.0200611173853 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | calcium ion transport |
| WP:WP4549 | 0.0215596505176 | 0.4 | CAMK2B CAMK2A | Fragile X Syndrome |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | RNA Polymerase II Transcription |
| GO:0070838 | 0.0296922319758 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | divalent metal ion transport |
| GO:0072511 | 0.0296922319758 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | divalent inorganic cation transport |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | CAMK2A CAMK2G CAMK2B CAMK2D | Gene expression (Transcription) |
| GO:0014733 | 0.0450641792523 | 0.4 | CAMK2B CAMK2G | regulation of skeletal muscle adaptation |
| CORUM:5655 | 0.0499494897235 | 0.2 | CAMK2A | Ternary complex (LRRC7, CAMK2a, ACTN4) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAMK2G | CAMK2D | 1.0 | 0.949 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2D | CAMK2A | 0.996 | 0.928 | bioplex (CAMK2D) bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2B | CAMK2D | 0.988 | 0.901 | bioplex (CAMK2D) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| UNG | CAMK2D | 0.269 | 0.483 | bioplex (CAMK2D) bioplex_WMM |
| CAMK2B | CAMK2A | 0.022 | 0.207 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
| CAMK2G | CAMK2B | 0.01 | 0.14 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CAMK2G | CAMK2A | 0.009 | 0.098 | bioplex_WMM boldt (CAMK2A) boldt_WMM |
| UNG | CAMK2A | 0.008 | 0.066 | bioplex_WMM WMM_only |
| UNG | CAMK2B | 0.008 | 0.059 | bioplex_WMM WMM_only |
| UNG | CAMK2G | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_02476 has an average edge precision of 0.384 which is ranked 3485 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAMK2G | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05617 |
| CAMK2B | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| UNG | HuMAP2_00728 HuMAP2_02007 HuMAP2_02476 HuMAP2_03797 |
| CAMK2A | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645 |
| CAMK2D | HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 |