hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02483

Confidence: High

Genename	Protein Name	Links
STOML2	Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)	UniProt NCBI
NDUFA2	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit)	UniProt NCBI
NDUFV2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (NADH-ubiquinone oxidoreductase 24 kDa subunit)	UniProt NCBI
NDUFS1	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 1.6.99.3) (EC 7.1.1.2) (Complex I-75kD) (CI-75kD)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2920	3.77881803953e-07	0.75	NDUFA2 NDUFS1 NDUFV2	Respiratory chain complex I (lambda subunit) mitochondrial
WP:WP4324	5.27244283038e-06	0.75	NDUFA2 NDUFS1 NDUFV2	Mitochondrial complex I assembly model OXPHOS system
WP:WP623	5.90406253623e-06	0.75	NDUFA2 NDUFS1 NDUFV2	Oxidative phosphorylation
CORUM:178	6.65885054531e-06	0.75	NDUFA2 NDUFS1 NDUFV2	Respiratory chain complex I (holoenzyme), mitochondrial
HP:0002928	1.51194013037e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Decreased activity of the pyruvate dehydrogenase complex
HP:0007183	2.17602308369e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Focal T2 hyperintense basal ganglia lesion
WP:WP111	2.91471848583e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Electron Transport Chain (OXPHOS system in mitochondria)
REAC:R-HSA-6799198	2.97715563398e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Complex I biogenesis
HP:0012751	3.01047192721e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal basal ganglia MRI signal intensity
KEGG:00190	7.14089641582e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Oxidative phosphorylation
KEGG:05012	8.70468528245e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Parkinson disease
HP:0007020	8.90798039133e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Progressive spastic paraplegia
WP:WP4396	9.39528133447e-05	0.75	NDUFA2 NDUFS1 NDUFV2	Nonalcoholic fatty liver disease
KEGG:04723	0.000100163001336	0.75	NDUFA2 NDUFS1 NDUFV2	Retrograde endocannabinoid signaling
KEGG:04932	0.000102469260232	0.75	NDUFA2 NDUFS1 NDUFV2	Non-alcoholic fatty liver disease (NAFLD)
HP:0008972	0.000109546633338	0.75	NDUFA2 NDUFS1 NDUFV2	Decreased activity of mitochondrial respiratory chain
HP:0011922	0.000115110986177	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal activity of mitochondrial respiratory chain
KEGG:05010	0.000159400563286	0.75	NDUFA2 NDUFS1 NDUFV2	Alzheimer disease
REAC:R-HSA-611105	0.000180191665247	0.75	NDUFA2 NDUFS1 NDUFV2	Respiratory electron transport
HP:0030085	0.000189197899452	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal CSF lactate level
HP:0002490	0.000189197899452	0.75	NDUFA2 NDUFS1 NDUFV2	Increased CSF lactate
GO:0006119	0.000193719078201	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	oxidative phosphorylation
HP:0002073	0.000205387753182	0.75	NDUFA2 NDUFS1 NDUFV2	Progressive cerebellar ataxia
CORUM:2904	0.000226087640536	0.5	NDUFA2 NDUFV2	Respiratory chain complex I (intermediate VII/650kD), mitochondrial
KEGG:05016	0.000238258771068	0.75	NDUFA2 NDUFS1 NDUFV2	Huntington disease
CORUM:2905	0.000276304589937	0.5	NDUFA2 NDUFV2	Respiratory chain complex I (intermediate), mitochondrial
CORUM:2948	0.000276304589937	0.5	NDUFV2 NDUFS1	Respiratory chain complex I (incomplete intermediate), mitochondrial
HP:0025454	0.000322204655363	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal CSF metabolite level
REAC:R-HSA-163200	0.000340340039133	0.75	NDUFA2 NDUFS1 NDUFV2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
KEGG:04714	0.000399392690129	0.75	NDUFA2 NDUFS1 NDUFV2	Thermogenesis
HP:0002415	0.0004073240164	0.75	NDUFA2 NDUFS1 NDUFV2	Leukodystrophy
HP:0000712	0.000537158365517	0.75	NDUFA2 NDUFS1 NDUFV2	Emotional lability
HP:0001258	0.000789545884353	0.75	NDUFA2 NDUFS1 NDUFV2	Spastic paraplegia
HP:0003287	0.000831010499476	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of mitochondrial metabolism
REAC:R-HSA-1428517	0.000984664941346	0.75	NDUFA2 NDUFS1 NDUFV2	The citric acid (TCA) cycle and respiratory electron transport
HP:0010550	0.00135691083476	0.75	NDUFA2 NDUFS1 NDUFV2	Paraplegia
HP:0000580	0.00138633858335	0.75	NDUFA2 NDUFS1 NDUFV2	Pigmentary retinopathy
HP:0012103	0.00141618772939	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of the mitochondrion
HP:0002151	0.00160429803987	0.75	NDUFA2 NDUFS1 NDUFV2	Increased serum lactate
HP:0002061	0.00202891029227	0.75	NDUFA2 NDUFS1 NDUFV2	Lower limb spasticity
HP:0000998	0.0020673289471	0.75	NDUFA2 NDUFS1 NDUFV2	Hypertrichosis
HP:0002134	0.00210622821499	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of the basal ganglia
HP:0010551	0.0029405563548	0.75	NDUFA2 NDUFS1 NDUFV2	Paraplegia/paraparesis
HP:0011400	0.00298968747372	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal CNS myelination
GO:0003954	0.00305917975424	0.75	NDUFA2 NDUFS1 NDUFV2	NADH dehydrogenase activity
GO:0050136	0.00305917975424	0.75	NDUFA2 NDUFS1 NDUFV2	NADH dehydrogenase (quinone) activity
GO:0008137	0.00305917975424	0.75	NDUFA2 NDUFS1 NDUFV2	NADH dehydrogenase (ubiquinone) activity
GO:0046034	0.00312639352664	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	ATP metabolic process
HP:0002104	0.00409014842826	0.75	NDUFA2 NDUFS1 NDUFV2	Apnea
HP:0000602	0.00433834919234	0.75	NDUFA2 NDUFS1 NDUFV2	Ophthalmoplegia
GO:0005747	0.00480126971785	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial respiratory chain complex I
GO:0030964	0.00480126971785	0.75	NDUFA2 NDUFS1 NDUFV2	NADH dehydrogenase complex
GO:0045271	0.00480126971785	0.75	NDUFA2 NDUFS1 NDUFV2	respiratory chain complex I
HP:0001639	0.00514254331689	0.75	NDUFA2 NDUFS1 NDUFV2	Hypertrophic cardiomyopathy
GO:0006120	0.00514395792508	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial electron transport, NADH to ubiquinone
HP:0000597	0.00604005240459	0.75	NDUFA2 NDUFS1 NDUFV2	Ophthalmoparesis
GO:0016655	0.0080085486554	0.75	NDUFA2 NDUFS1 NDUFV2	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
HP:0012748	0.00986303631958	0.5	NDUFV2 NDUFS1	Focal T2 hyperintense brainstem lesion
HP:0007703	0.00998881995999	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of retinal pigmentation
HP:0008316	0.0105423007107	0.5	NDUFV2 NDUFS1	Abnormal mitochondria in muscle tissue
HP:0010864	0.0105492816297	0.75	NDUFA2 NDUFS1 NDUFV2	Intellectual disability, severe
HP:0001941	0.0114887691482	0.75	NDUFA2 NDUFS1 NDUFV2	Acidosis
HP:0001629	0.0118548950455	0.75	NDUFA2 NDUFS1 NDUFV2	Ventricular septal defect
HP:0012747	0.0127153557137	0.5	NDUFV2 NDUFS1	Abnormal brainstem MRI signal intensity
HP:0010438	0.0127391041765	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal ventricular septum morphology
HP:0002793	0.0127391041765	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal pattern of respiration
GO:0010257	0.0130360493673	0.75	NDUFA2 NDUFS1 NDUFV2	NADH dehydrogenase complex assembly
GO:0032981	0.0130360493673	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial respiratory chain complex I assembly
HP:0007704	0.0134847743701	0.5	NDUFV2 NDUFS1	Paroxysmal involuntary eye movements
HP:0025116	0.0134847743701	0.5	NDUFV2 NDUFS1	Fetal distress
HP:0011923	0.0134847743701	0.5	NDUFV2 NDUFS1	Decreased activity of mitochondrial complex I
HP:0004360	0.014922003471	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of acid-base homeostasis
HP:0000114	0.0150911756538	0.5	NDUFV2 NDUFS1	Proximal tubulopathy
GO:0005743	0.0166033324327	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	mitochondrial inner membrane
HP:0003542	0.0176695962482	0.5	NDUFV2 NDUFS1	Increased serum pyruvate
HP:0004366	0.0176695962482	0.5	NDUFV2 NDUFS1	Abnormality of glycolysis
GO:0098803	0.0181462528862	0.75	NDUFA2 NDUFS1 NDUFV2	respiratory chain complex
GO:0005746	0.0189701239271	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial respirasome
GO:0006091	0.0197812720484	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	generation of precursor metabolites and energy
HPA:022020_03	0.021450045509	0.75	NDUFA2 STOML2 NDUFV2	hippocampus; neuronal cells[Uncertain,High]
HPA:021010_03	0.0218446946143	0.75	NDUFA2 STOML2 NDUFV2	heart muscle; myocytes[Uncertain,High]
HP:0001332	0.0219842049556	0.75	NDUFA2 NDUFS1 NDUFV2	Dystonia
GO:0070469	0.0225145500348	0.75	NDUFA2 NDUFS1 NDUFV2	respirasome
GO:0019866	0.0226824675867	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	organelle inner membrane
HP:0010549	0.0233097913112	0.75	NDUFA2 NDUFS1 NDUFV2	Weakness due to upper motor neuron dysfunction
HP:0011013	0.023433582519	0.5	NDUFV2 NDUFS1	Abnormal circulating carbohydrate concentration
HP:0012447	0.0257035156736	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal myelination
GO:0042775	0.0275320606423	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial ATP synthesis coupled electron transport
GO:0042773	0.0286174056273	0.75	NDUFA2 NDUFS1 NDUFV2	ATP synthesis coupled electron transport
HP:0002921	0.0295907808511	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormality of the cerebrospinal fluid
HP:0003737	0.0300060012618	0.5	NDUFV2 NDUFS1	Mitochondrial myopathy
HP:0001138	0.0300060012618	0.5	NDUFV2 NDUFS1	Optic neuropathy
HPA:040010_03	0.031444391961	0.75	NDUFA2 STOML2 NDUFV2	seminal vesicle; glandular cells[Uncertain,High]
HP:0001638	0.0319094681526	0.75	NDUFA2 NDUFS1 NDUFV2	Cardiomyopathy
HP:0011017	0.0321477366073	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal cellular physiology
GO:0007005	0.0330068688285	1.0	NDUFA2 NDUFS1 STOML2 NDUFV2	mitochondrion organization
HP:0025354	0.034595498986	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal cellular phenotype
HP:0001260	0.034595498986	0.75	NDUFA2 NDUFS1 NDUFV2	Dysarthria
HP:0001713	0.034595498986	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal cardiac ventricle morphology
HP:0001637	0.0369012487759	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal myocardium morphology
GO:0016651	0.037022076332	0.75	NDUFA2 NDUFS1 NDUFV2	oxidoreductase activity, acting on NAD(P)H
GO:1990204	0.0396936057372	0.75	NDUFA2 NDUFS1 NDUFV2	oxidoreductase complex
HP:0001903	0.041529593035	0.75	NDUFA2 NDUFS1 NDUFV2	Anemia
GO:0033108	0.0424904593616	0.75	NDUFA2 NDUFS1 NDUFV2	mitochondrial respiratory chain complex assembly
HP:0031466	0.0435417391965	0.75	NDUFA2 NDUFS1 NDUFV2	Impairment in personality functioning
GO:0022904	0.0439367749778	0.75	NDUFA2 NDUFS1 NDUFV2	respiratory electron transport chain
HP:0000817	0.0441507593067	0.5	NDUFV2 NDUFS1	Poor eye contact
HP:0001671	0.0450177785718	0.75	NDUFA2 NDUFS1 NDUFV2	Abnormal cardiac septum morphology
GO:0022900	0.0454154921687	0.75	NDUFA2 NDUFS1 NDUFV2	electron transport chain
HP:0003800	0.0470133620262	0.5	NDUFV2 NDUFS1	Muscle abnormality related to mitochondrial dysfunction

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NDUFA2	NDUFS1	0.988	0.901	hein_WMM bioplex_WMM youn_WMM fraction
NDUFS1	NDUFV2	0.896	0.821	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM
NDUFA2	NDUFV2	0.774	0.752	hein_WMM bioplex_WMM youn_WMM fraction
NDUFS1	STOML2	0.617	0.674	hein_WMM bioplex (NDUFS1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
NDUFA2	STOML2	0.008	0.066	hein_WMM bioplex_WMM youn_WMM WMM_only
NDUFV2	STOML2	0.0	0.017	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM

Images

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Complex HuMAP2_02483 has an average edge precision of 0.538 which is ranked 2285 out of all 6965 complexes.

Related Complexes

Genename	Complexes
STOML2	HuMAP2_01373 HuMAP2_01573 HuMAP2_01787 HuMAP2_02483 HuMAP2_05031
NDUFA2	HuMAP2_01359 HuMAP2_01373 HuMAP2_01573 HuMAP2_02483 HuMAP2_03501
NDUFV2	HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_02483 HuMAP2_03501 HuMAP2_05031
NDUFS1	HuMAP2_01373 HuMAP2_01573 HuMAP2_01600 HuMAP2_02247 HuMAP2_02483 HuMAP2_03501 HuMAP2_05031 HuMAP2_05043

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02483