hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02487

Confidence: Medium

Genename	Protein Name	Links
AASS	Alpha-aminoadipic semialdehyde synthase, mitochondrial (LKR/SDH) [Includes: Lysine ketoglutarate reductase (LKR) (LOR) (EC 1.5.1.8); Saccharopine dehydrogenase (SDH) (EC 1.5.1.9)]	UniProt NCBI
NUDT13	Nucleoside diphosphate-linked moiety X motif 13 (Nudix motif 13) (EC 3.-.-.-) (Protein KiSS-16)	UniProt NCBI
HK3	Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III)	UniProt NCBI
HKDC1	Putative hexokinase HKDC1 (EC 2.7.1.1) (Hexokinase domain-containing protein 1)	UniProt NCBI
HK1	Hexokinase-1 (EC 2.7.1.1) (Brain form hexokinase) (Hexokinase type I) (HK I)	UniProt NCBI
HK2	Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Muscle form hexokinase)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:00524	1.69395416216e-12	0.666666666667	HK3 HK2 HK1 HKDC1	Neomycin, kanamycin and gentamicin biosynthesis
GO:0004340	1.82947049513e-09	0.666666666667	HK3 HK2 HK1 HKDC1	glucokinase activity
GO:0004396	1.82947049513e-09	0.666666666667	HK3 HK2 HK1 HKDC1	hexokinase activity
GO:0008865	1.82947049513e-09	0.666666666667	HK3 HK2 HK1 HKDC1	fructokinase activity
GO:0019158	1.82947049513e-09	0.666666666667	HK3 HK2 HK1 HKDC1	mannokinase activity
KEGG:00052	5.93173080889e-09	0.666666666667	HK3 HK2 HK1 HKDC1	Galactose metabolism
KEGG:00500	1.06302905623e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Starch and sucrose metabolism
KEGG:00051	1.38216392363e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Fructose and mannose metabolism
WP:WP500	2.2241968272e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Glycogen Synthesis and Degradation
KEGG:04973	3.08457532346e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Carbohydrate digestion and absorption
KEGG:04930	4.57986525811e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Type II diabetes mellitus
KEGG:00520	5.50422736802e-08	0.666666666667	HK3 HK2 HK1 HKDC1	Amino sugar and nucleotide sugar metabolism
KEGG:00010	2.00550054089e-07	0.666666666667	HK3 HK2 HK1 HKDC1	Glycolysis / Gluconeogenesis
KEGG:05230	2.57949248408e-07	0.666666666667	HK3 HK2 HK1 HKDC1	Central carbon metabolism in cancer
KEGG:04066	1.314948731e-06	0.666666666667	HK3 HK2 HK1 HKDC1	HIF-1 signaling pathway
GO:0019200	2.18611257075e-06	0.666666666667	HK3 HK2 HK1 HKDC1	carbohydrate kinase activity
GO:0051156	2.18611257075e-06	0.666666666667	HK3 HK2 HK1 HKDC1	glucose 6-phosphate metabolic process
KEGG:01200	2.2343091987e-06	0.666666666667	HK3 HK2 HK1 HKDC1	Carbon metabolism
KEGG:04910	3.24115048953e-06	0.666666666667	HK3 HK2 HK1 HKDC1	Insulin signaling pathway
GO:0006734	1.90965027829e-05	0.666666666667	NUDT13 HK2 HK1 HK3	NADH metabolic process
WP:WP534	1.97581132023e-05	0.5	HK3 HK2 HK1	Glycolysis and Gluconeogenesis
WP:WP4018	0.000121904053629	0.5	HK3 HK2 HK1	Pathways in clear cell renal cell carcinoma
GO:0001678	0.000216594058417	0.666666666667	HK3 HK2 HK1 HKDC1	cellular glucose homeostasis
GO:0006002	0.000217734118711	0.5	HK3 HK2 HK1	fructose 6-phosphate metabolic process
REAC:R-HSA-70171	0.000269929792646	0.5	HK3 HK2 HK1	Glycolysis
REAC:R-HSA-70326	0.000521133699904	0.5	HK3 HK2 HK1	Glucose metabolism
GO:0006096	0.001058235898	0.666666666667	HK3 HK2 HK1 HKDC1	glycolytic process
GO:0006757	0.00110514929169	0.666666666667	HK3 HK2 HK1 HKDC1	ATP generation from ADP
GO:0046031	0.00120362941431	0.666666666667	HK3 HK2 HK1 HKDC1	ADP metabolic process
KEGG:01100	0.0012193073463	0.833333333333	HK3 HK2 AASS HK1 HKDC1	Metabolic pathways
GO:0009179	0.00130853702278	0.666666666667	HK3 HK2 HK1 HKDC1	purine ribonucleoside diphosphate metabolic process
GO:0009135	0.00130853702278	0.666666666667	HK3 HK2 HK1 HKDC1	purine nucleoside diphosphate metabolic process
GO:0009185	0.00142014462948	0.666666666667	HK3 HK2 HK1 HKDC1	ribonucleoside diphosphate metabolic process
GO:0006165	0.00147854761151	0.666666666667	HK3 HK2 HK1 HKDC1	nucleoside diphosphate phosphorylation
GO:0046939	0.00153873030218	0.666666666667	HK3 HK2 HK1 HKDC1	nucleotide phosphorylation
GO:0009132	0.00186759839818	0.666666666667	HK3 HK2 HK1 HKDC1	nucleoside diphosphate metabolic process
GO:0042593	0.00186759839818	0.666666666667	HK3 HK2 HK1 HKDC1	glucose homeostasis
GO:0033500	0.00193921959428	0.666666666667	HK3 HK2 HK1 HKDC1	carbohydrate homeostasis
GO:0009117	0.00347904996734	0.833333333333	NUDT13 HK1 HK2 HKDC1 HK3	nucleotide metabolic process
GO:0006090	0.00350044252869	0.666666666667	HK3 HK2 HK1 HKDC1	pyruvate metabolic process
GO:0006753	0.00370861986137	0.833333333333	NUDT13 HK1 HK2 HKDC1 HK3	nucleoside phosphate metabolic process
GO:0061620	0.00529364410104	0.5	HK3 HK2 HK1	glycolytic process through glucose-6-phosphate
GO:0061718	0.00529364410104	0.5	HK3 HK2 HK1	glucose catabolic process to pyruvate
GO:0061621	0.00529364410104	0.5	HK3 HK2 HK1	canonical glycolysis
GO:0061615	0.00529364410104	0.5	HK3 HK2 HK1	glycolytic process through fructose-6-phosphate
GO:0006735	0.00529364410104	0.5	HK3 HK2 HK1	NADH regeneration
GO:0006007	0.00734442516369	0.5	HK3 HK2 HK1	glucose catabolic process
GO:0016052	0.00811327342942	0.666666666667	HK3 HK2 HK1 HKDC1	carbohydrate catabolic process
GO:0055086	0.00830945606578	0.833333333333	NUDT13 HK1 HK2 HKDC1 HK3	nucleobase-containing small molecule metabolic process
REAC:R-HSA-71387	0.0169658388819	0.5	HK3 HK2 HK1	Metabolism of carbohydrates
GO:0019674	0.0178456165824	0.5	HK3 HK2 HK1	NAD metabolic process
GO:0072656	0.020283420769	0.333333333333	HK1 HK2	maintenance of protein location in mitochondrion
REAC:R-HSA-1430728	0.0278608311428	0.833333333333	NUDT13 HK2 AASS HK1 HK3	Metabolism
GO:0019320	0.0312028564126	0.5	HK3 HK2 HK1	hexose catabolic process
GO:0046034	0.0457293961323	0.666666666667	HK3 HK2 HK1 HKDC1	ATP metabolic process
GO:0044281	0.0463583278121	1.0	HKDC1 AASS HK2 NUDT13 HK1 HK3	small molecule metabolic process
GO:0046365	0.0499477329172	0.5	HK3 HK2 HK1	monosaccharide catabolic process
CORUM:7418	0.0499726005494	0.166666666667	HK1	HK1-VDAC1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
HK1	HKDC1	1.0	0.949	bioplex (HK1) bioplex_WMM
HK3	HKDC1	0.798	0.764	bioplex (HK3) bioplex_WMM
HK1	HK2	0.711	0.728	bioplex (HK1) bioplex_WMM boldt youn_WMM boldt_WMM
HK1	NUDT13	0.042	0.269	fraction
HK1	AASS	0.03	0.236	bioplex_WMM boldt youn_WMM fraction boldt_WMM
HK2	AASS	0.025	0.215	bioplex_WMM fraction boldt_WMM
HK2	HK3	0.019	0.184	bioplex (HK3) bioplex_WMM
HK1	HK3	0.013	0.152	bioplex (HK3) bioplex_WMM
HK2	HKDC1	0.007	0.012	bioplex_WMM WMM_only
NUDT13	AASS	0.0	0.013	fraction
HK2	NUDT13	0.0	0.012	fraction

Images

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Complex HuMAP2_02487 has an average edge precision of 0.321 which is ranked 4329 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AASS	HuMAP2_01636 HuMAP2_02487 HuMAP2_02895 HuMAP2_06671
NUDT13	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487
HK3	HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487
HKDC1	HuMAP2_01222 HuMAP2_01580 HuMAP2_01636 HuMAP2_02487
HK1	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918
HK2	HuMAP2_01222 HuMAP2_01636 HuMAP2_02487 HuMAP2_03918

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_02487