hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02498
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBCD | Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) | UniProt NCBI |
| EML2 | Echinoderm microtubule-associated protein-like 2 (EMAP-2) (HuEMAP-2) | UniProt NCBI |
| TUBB2A | Tubulin beta-2A chain (Tubulin beta class IIa) | UniProt NCBI |
| TUBA4A | Tubulin alpha-4A chain (Alpha-tubulin 1) (Testis-specific alpha-tubulin) (Tubulin H2-alpha) (Tubulin alpha-1 chain) | UniProt NCBI |
| TUBB2B | Tubulin beta-2B chain | UniProt NCBI |
| TCP11L1 | T-complex protein 11-like protein 1 | UniProt NCBI |
| ARL2 | ADP-ribosylation factor-like protein 2 | UniProt NCBI |
| CAPS | Calcyphosin (Calcyphosine) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-389977 | 3.30142017002e-11 | 0.625 | TUBB2A TUBB2B ARL2 TBCD TUBA4A | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-391251 | 9.79230638132e-08 | 0.625 | TUBB2A TUBB2B ARL2 TBCD TUBA4A | Protein folding |
| CORUM:6697 | 1.16880143691e-05 | 0.25 | TBCD ARL2 | ARL2-TBCD complex |
| CORUM:6455 | 1.16880143691e-05 | 0.25 | TBCD ARL2 | ARL2-TBCD complex |
| REAC:R-HSA-190840 | 1.22205513984e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 1.46609667673e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Transport of connexons to the plasma membrane |
| REAC:R-HSA-190861 | 3.17792583502e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Gap junction assembly |
| CORUM:6713 | 3.50546248845e-05 | 0.25 | TBCD ARL2 | TBCD-ARL2-tubulin(beta) complex |
| REAC:R-HSA-9619483 | 3.6309999393e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 3.6309999393e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-389957 | 5.2434024277e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 5.87113050867e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | RHO GTPases activate IQGAPs |
| CORUM:6715 | 7.00904180673e-05 | 0.25 | TBCD ARL2 | TBCD-ARL2-tubulin(beta)-TBCE complex |
| REAC:R-HSA-389958 | 8.04968851895e-05 | 0.375 | TUBB2A TUBB2B TUBA4A | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 0.000107081011906 | 0.375 | TUBB2A TUBB2B TUBA4A | Gap junction trafficking |
| WP:WP2272 | 0.000112365649743 | 0.375 | TUBB2A TUBB2B TUBA4A | Pathogenic Escherichia coli infection |
| REAC:R-HSA-157858 | 0.00011709032871 | 0.375 | TUBB2A TUBB2B TUBA4A | Gap junction trafficking and regulation |
| REAC:R-HSA-8955332 | 0.000138935544096 | 0.375 | TUBB2A TUBB2B TUBA4A | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.000150806270193 | 0.375 | TUBB2A TUBB2B TUBA4A | Assembly and cell surface presentation of NMDA receptors |
| WP:WP2359 | 0.000231842376148 | 0.375 | TUBB2A TUBB2B TUBA4A | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-437239 | 0.000253220273433 | 0.375 | TUBB2A TUBB2B TUBA4A | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.000349320722342 | 0.375 | TUBB2A TUBB2B TUBA4A | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 0.000371059637687 | 0.375 | TUBB2A TUBB2B TUBA4A | Intraflagellar transport |
| REAC:R-HSA-3371497 | 0.00039367823385 | 0.375 | TUBB2A TUBB2B TUBA4A | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:04540 | 0.000456537344649 | 0.375 | TUBB2A TUBB2B TUBA4A | Gap junction |
| REAC:R-HSA-983189 | 0.000520565653718 | 0.375 | TUBB2A TUBB2B TUBA4A | Kinesins |
| REAC:R-HSA-1445148 | 0.000889143304928 | 0.375 | TUBB2A TUBB2B TUBA4A | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| GO:0000226 | 0.00110198532296 | 0.75 | ARL2 TUBB2A TBCD TUBB2B EML2 TUBA4A | microtubule cytoskeleton organization |
| REAC:R-HSA-438064 | 0.00110207094363 | 0.375 | TUBB2A TUBB2B TUBA4A | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 0.0012447250077 | 0.375 | TUBB2A TUBB2B TUBA4A | The role of GTSE1 in G2/M progression after G2 checkpoint |
| GO:0015630 | 0.00140172168705 | 0.875 | ARL2 TUBB2A TBCD TCP11L1 TUBB2B TUBA4A EML2 | microtubule cytoskeleton |
| REAC:R-HSA-442755 | 0.00168368382424 | 0.375 | TUBB2A TUBB2B TUBA4A | Activation of NMDA receptors and postsynaptic events |
| KEGG:04145 | 0.00189668381974 | 0.375 | TUBB2A TUBB2B TUBA4A | Phagosome |
| REAC:R-HSA-390466 | 0.00207274644436 | 0.375 | TUBB2A TUBB2B TUBA4A | Chaperonin-mediated protein folding |
| REAC:R-HSA-380320 | 0.00207274644436 | 0.375 | TUBB2A TUBB2B TUBA4A | Recruitment of NuMA to mitotic centrosomes |
| GO:0005874 | 0.00236775566102 | 0.625 | TUBB2A TUBB2B TBCD TCP11L1 TUBA4A | microtubule |
| REAC:R-HSA-6811434 | 0.00251706956712 | 0.375 | TUBB2A TUBB2B TUBA4A | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.00259674522301 | 0.375 | TUBB2A TUBB2B TUBA4A | COPI-mediated anterograde transport |
| REAC:R-HSA-5610787 | 0.00389285199534 | 0.375 | TUBB2A TUBB2B TUBA4A | Hedgehog 'off' state |
| REAC:R-HSA-373760 | 0.00389285199534 | 0.375 | TUBB2A TUBB2B TUBA4A | L1CAM interactions |
| KEGG:05130 | 0.00425215180026 | 0.375 | TUBB2A TUBB2B TUBA4A | Pathogenic Escherichia coli infection |
| REAC:R-HSA-2132295 | 0.00444260066134 | 0.375 | TUBB2A TUBB2B TUBA4A | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.00491753466842 | 0.375 | TUBB2A TUBB2B TUBA4A | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.00624858257827 | 0.375 | TUBB2A TUBB2B TUBA4A | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.00668968471604 | 0.375 | TUBB2A TUBB2B TUBA4A | RHO GTPases Activate Formins |
| GO:0007017 | 0.0070136898898 | 0.75 | ARL2 TUBB2A TBCD TUBB2B EML2 TUBA4A | microtubule-based process |
| GO:0044430 | 0.0075667656243 | 0.875 | ARL2 TUBB2A TBCD TCP11L1 TUBB2B TUBA4A EML2 | cytoskeletal part |
| REAC:R-HSA-5358351 | 0.00813495132609 | 0.375 | TUBB2A TUBB2B TUBA4A | Signaling by Hedgehog |
| REAC:R-HSA-199977 | 0.0084817691389 | 0.375 | TUBB2A TUBB2B TUBA4A | ER to Golgi Anterograde Transport |
| REAC:R-HSA-983231 | 0.0113973458459 | 0.375 | TUBB2A TUBB2B TUBA4A | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-948021 | 0.0136666479669 | 0.375 | TUBB2A TUBB2B TUBA4A | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-112314 | 0.0151608156971 | 0.375 | TUBB2A TUBB2B TUBA4A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-2467813 | 0.0173144812533 | 0.375 | TUBB2A TUBB2B TUBA4A | Separation of Sister Chromatids |
| REAC:R-HSA-69275 | 0.019355786785 | 0.375 | TUBB2A TUBB2B TUBA4A | G2/M Transition |
| REAC:R-HSA-68882 | 0.0196596693296 | 0.375 | TUBB2A TUBB2B TUBA4A | Mitotic Anaphase |
| REAC:R-HSA-5617833 | 0.0196596693296 | 0.375 | TUBB2A TUBB2B TUBA4A | Cilium Assembly |
| REAC:R-HSA-68877 | 0.0196596693296 | 0.375 | TUBB2A TUBB2B TUBA4A | Mitotic Prometaphase |
| REAC:R-HSA-2555396 | 0.0199666631287 | 0.375 | TUBB2A TUBB2B TUBA4A | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-453274 | 0.0199666631287 | 0.375 | TUBB2A TUBB2B TUBA4A | Mitotic G2-G2/M phases |
| REAC:R-HSA-6811442 | 0.021548816785 | 0.375 | TUBB2A TUBB2B TUBA4A | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0099513 | 0.0291592221593 | 0.625 | TUBB2A TUBB2B TBCD TCP11L1 TUBA4A | polymeric cytoskeletal fiber |
| REAC:R-HSA-112315 | 0.0327851038219 | 0.375 | TUBB2A TUBB2B TUBA4A | Transmission across Chemical Synapses |
| GO:0005856 | 0.0335519954693 | 0.875 | ARL2 TUBB2A TBCD TCP11L1 TUBB2B TUBA4A EML2 | cytoskeleton |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBB2B | TBCD | 0.217 | 0.464 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM |
| TUBB2B | ARL2 | 0.206 | 0.454 | bioplex (TUBB2B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| EML2 | TUBB2A | 0.149 | 0.41 | bioplex (TUBB2A) bioplex_WMM |
| TUBB2B | CAPS | 0.075 | 0.357 | bioplex (TUBB2B) bioplex_WMM |
| TUBB2A | TUBA4A | 0.073 | 0.354 | bioplex (TUBA4A) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| TUBB2A | ARL2 | 0.066 | 0.349 | bioplex (TUBB2A) bioplex_WMM youn_WMM gupta_WMM treiber_WMM |
| TUBB2A | TUBB2B | 0.062 | 0.345 | boldt youn_WMM gupta_WMM boldt_WMM bioplex_WMM |
| TUBB2B | TCP11L1 | 0.052 | 0.299 | bioplex (TUBB2B) bioplex_WMM boldt boldt_WMM |
| EML2 | TUBB2B | 0.037 | 0.268 | bioplex (TUBB2B) bioplex_WMM |
| TUBB2A | TBCD | 0.037 | 0.266 | bioplex (TUBB2A) bioplex_WMM boldt boldt_WMM |
| TUBA4A | TUBB2B | 0.024 | 0.213 | bioplex (TUBA4A,TUBB2B) bioplex_WMM boldt fraction boldt_WMM |
| EML2 | ARL2 | 0.01 | 0.126 | bioplex_WMM WMM_only |
| EML2 | CAPS | 0.009 | 0.108 | bioplex_WMM WMM_only |
| EML2 | TCP11L1 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| EML2 | TBCD | 0.009 | 0.099 | bioplex_WMM WMM_only |
| ARL2 | CAPS | 0.008 | 0.094 | bioplex_WMM WMM_only |
| CAPS | TBCD | 0.008 | 0.055 | bioplex_WMM WMM_only |
| TCP11L1 | CAPS | 0.008 | 0.013 | bioplex_WMM WMM_only |
| TCP11L1 | ARL2 | 0.007 | 0.003 | bioplex_WMM boldt boldt_WMM |
| EML2 | TUBA4A | 0.007 | 0.007 | bioplex_WMM WMM_only |
| TUBA4A | ARL2 | 0.006 | 0.003 | bioplex_WMM WMM_only |
| TCP11L1 | TBCD | 0.006 | 0.006 | bioplex_WMM boldt boldt_WMM |
| TUBA4A | TCP11L1 | 0.005 | 0.006 | bioplex (TUBA4A) bioplex_WMM boldt boldt_WMM |
| TUBA4A | TBCD | 0.004 | 0.015 | bioplex_WMM boldt boldt_WMM |
| ARL2 | TBCD | 0.0 | 0.006 | bioplex_WMM Guru boldt fraction boldt_WMM |
| TUBB2A | TCP11L1 | 0.0 | 0.002 | bioplex (TUBB2A) bioplex_WMM boldt boldt_WMM |
Images
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Complex HuMAP2_02498 has an average edge precision of 0.17 which is ranked 6527 out of all 6965 complexes.
Related Complexes