hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02503
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RHOJ | Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein) | UniProt NCBI |
| LLGL1 | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | UniProt NCBI |
| TP53BP2 | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) | UniProt NCBI |
| PARD3 | Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) | UniProt NCBI |
| RGL1 | Ral guanine nucleotide dissociation stimulator-like 1 (RalGDS-like 1) | UniProt NCBI |
| PRKCZ | Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta) | UniProt NCBI |
| PRKCI | Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota) | UniProt NCBI |
| FRMD6 | FERM domain-containing protein 6 (Willin) | UniProt NCBI |
| PARD6A | Partitioning defective 6 homolog alpha (PAR-6) (PAR-6 alpha) (PAR-6A) (PAR6C) (Tax interaction protein 40) (TIP-40) | UniProt NCBI |
| PARD6B | Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B) | UniProt NCBI |
| PARD6G | Partitioning defective 6 homolog gamma (PAR-6 gamma) (PAR6D) | UniProt NCBI |
| RASSF8 | Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1) | UniProt NCBI |
| UTY | Histone demethylase UTY (EC 1.14.11.-) (Ubiquitously-transcribed TPR protein on the Y chromosome) (Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein) | UniProt NCBI |
| WWC1 | Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) | UniProt NCBI |
| BRWD3 | Bromodomain and WD repeat-containing protein 3 | UniProt NCBI |
| LLGL2 | Lethal(2) giant larvae protein homolog 2 (HGL) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04390 | 8.78416047119e-18 | 0.6875 | PARD6A FRMD6 TP53BP2 LLGL1 PARD6G PRKCZ LLGL2 PRKCI WWC1 PARD3 PARD6B | Hippo signaling pathway |
| GO:0007163 | 4.80972354203e-12 | 0.625 | PARD6A RHOJ PARD6B LLGL2 LLGL1 PARD6G PRKCZ PRKCI WWC1 PARD3 | establishment or maintenance of cell polarity |
| KEGG:04530 | 4.19993085121e-11 | 0.5 | PARD6A PARD6B LLGL2 LLGL1 PARD6G PRKCZ PRKCI PARD3 | Tight junction |
| REAC:R-HSA-420029 | 5.8040500491e-10 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | Tight junction interactions |
| KEGG:05165 | 1.97932460822e-08 | 0.5 | PARD6A PARD6B LLGL2 LLGL1 PARD6G PRKCZ PRKCI PARD3 | Human papillomavirus infection |
| CORUM:956 | 4.70911134935e-08 | 0.1875 | PRKCI PARD6B PARD3 | PAR-3-PAR-6B-PRKCI complex |
| CORUM:959 | 4.70911134935e-08 | 0.1875 | PRKCI PARD6B LLGL1 | LLGL1-PAR-6B-PRKCI complex |
| CORUM:955 | 4.70911134935e-08 | 0.1875 | PRKCI PARD6B LLGL2 | LLGL2-PAR-6B-PRKCI complex |
| CORUM:7444 | 1.88241120858e-07 | 0.1875 | PRKCI PARD3 PARD6A | HOOK2-PAR3-Par6alpha-PKCiota complex |
| REAC:R-HSA-421270 | 2.06179256799e-07 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | Cell-cell junction organization |
| CORUM:905 | 4.70294668147e-07 | 0.1875 | PRKCI PARD3 PARD6A | KIF3A/B-PAR-3-aPKC-PAR-6 complex |
| KEGG:04015 | 8.59123543796e-07 | 0.375 | PARD6A PARD6B PRKCI PARD6G PRKCZ PARD3 | Rap1 signaling pathway |
| REAC:R-HSA-446728 | 2.43099118889e-06 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | Cell junction organization |
| KEGG:04144 | 4.81332368142e-06 | 0.375 | PARD6A PARD6B PRKCI PARD6G PRKCZ PARD3 | Endocytosis |
| REAC:R-HSA-1500931 | 1.60251266552e-05 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | Cell-Cell communication |
| GO:0070830 | 2.62268343933e-05 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | bicellular tight junction assembly |
| GO:0120192 | 2.97526458171e-05 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | tight junction assembly |
| KEGG:04360 | 3.2607757052e-05 | 0.3125 | PRKCZ PARD6G PARD3 PARD6B PARD6A | Axon guidance |
| GO:0005938 | 3.41118564336e-05 | 0.4375 | PARD6A PARD6B LLGL1 PARD6G LLGL2 RHOJ PARD3 | cell cortex |
| GO:0120193 | 3.7936983251e-05 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | tight junction organization |
| GO:0043297 | 5.96676667503e-05 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | apical junction assembly |
| REAC:R-HSA-2173791 | 0.000124779341828 | 0.1875 | PRKCZ PARD3 PARD6A | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| CORUM:831 | 0.000150180288233 | 0.125 | PARD6A PARD3 | PAR-6-PAR-3-VE-cadherin complex, endothelial |
| CORUM:918 | 0.000150180288233 | 0.125 | PARD6A PARD3 | PAR3-PAR6-PALS1 complex |
| CORUM:847 | 0.000150180288233 | 0.125 | PRKCI PARD3 | RICH1-PAR3-aPKC polarity complex |
| CORUM:7300 | 0.000150180288233 | 0.125 | PRKCI PARD6A | PARD3B-PARD6A-PRKCI complex |
| CORUM:6294 | 0.000150180288233 | 0.125 | PRKCZ WWC1 | DDR1-PRKCZ-WWC1 complex |
| CORUM:5535 | 0.000150180288233 | 0.125 | PARD6A PARD3 | PLCB3-PARD3-PARD6A complex |
| CORUM:5534 | 0.000150180288233 | 0.125 | PARD6A PARD3 | PLCB1-PARD3-PARD6A complex |
| GO:0099568 | 0.00058646416716 | 0.4375 | PARD6A PARD6B LLGL1 PARD6G LLGL2 RHOJ PARD3 | cytoplasmic region |
| GO:0007010 | 0.000660231229325 | 0.625 | PARD6A PARD6B BRWD3 PRKCI PARD6G LLGL2 LLGL1 RHOJ PARD3 FRMD6 | cytoskeleton organization |
| GO:0007043 | 0.00157805614048 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | cell-cell junction assembly |
| GO:0030010 | 0.00196126668693 | 0.3125 | PRKCZ WWC1 LLGL2 PARD3 LLGL1 | establishment of cell polarity |
| GO:0045216 | 0.00410466876303 | 0.3125 | PRKCI PARD6G PARD3 PARD6B PARD6A | cell-cell junction organization |
| REAC:R-HSA-170834 | 0.0132747452849 | 0.1875 | PRKCZ PARD3 PARD6A | Signaling by TGF-beta Receptor Complex |
| GO:0017016 | 0.017944722408 | 0.375 | PARD6A PARD6B LLGL1 PARD6G LLGL2 RGL1 | Ras GTPase binding |
| KEGG:04392 | 0.0181737998974 | 0.125 | WWC1 FRMD6 | Hippo signaling pathway - multiple species |
| GO:0031267 | 0.0250509164442 | 0.375 | PARD6A PARD6B LLGL1 PARD6G LLGL2 RGL1 | small GTPase binding |
| WP:WP2012 | 0.0271467575269 | 0.125 | PRKCZ PRKCI | miRs in Muscle Cell Differentiation |
| REAC:R-HSA-9006936 | 0.0296696699019 | 0.1875 | PRKCZ PARD3 PARD6A | Signaling by TGF-beta family members |
| WP:WP481 | 0.0430986895041 | 0.1875 | PRKCZ RHOJ PRKCI | Insulin Signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RASSF8 | PARD3 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| PARD6B | PARD3 | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B) |
| PRKCZ | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B,PRKCZ) bioplex_WMM hein (PARD6B) |
| PRKCI | PARD6B | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B,PRKCI) |
| PARD6B | LLGL2 | 1.0 | 0.949 | hein_WMM bioplex (LLGL2,PARD6B) bioplex_WMM hein (LLGL2,PARD6B) |
| TP53BP2 | RASSF8 | 1.0 | 0.949 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM hein (RASSF8) gupta_WMM boldt_WMM |
| PARD6B | LLGL1 | 1.0 | 0.949 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (LLGL1,PARD6B) |
| PRKCI | LLGL2 | 0.988 | 0.901 | hein_WMM bioplex (LLGL2) bioplex_WMM hein (LLGL2,PRKCI) fraction |
| PRKCI | LLGL1 | 0.844 | 0.788 | hein_WMM bioplex_WMM hein (LLGL1,PRKCI) Malo gupta_WMM fraction treiber_WMM |
| PRKCZ | PARD6G | 0.836 | 0.779 | bioplex (PRKCZ) bioplex_WMM |
| PARD6B | RASSF8 | 0.76 | 0.75 | hein_WMM bioplex (PARD6B) bioplex_WMM hein (PARD6B) |
| BRWD3 | LLGL2 | 0.396 | 0.556 | bioplex (LLGL2) bioplex_WMM |
| PARD6B | WWC1 | 0.287 | 0.489 | bioplex (PARD6B) bioplex_WMM |
| PRKCZ | PARD6A | 0.215 | 0.464 | bioplex (PRKCZ) bioplex_WMM |
| PARD6G | LLGL2 | 0.194 | 0.447 | bioplex (LLGL2) bioplex_WMM |
| FRMD6 | RASSF8 | 0.181 | 0.436 | bioplex (FRMD6,RASSF8) bioplex_WMM boldt_WMM |
| PRKCI | PARD3 | 0.157 | 0.415 | hein_WMM bioplex_WMM boldt youn_WMM hein (PRKCI) gupta_WMM boldt_WMM |
| RGL1 | LLGL2 | 0.154 | 0.414 | bioplex (LLGL2) bioplex_WMM |
| PRKCZ | PRKCI | 0.068 | 0.35 | hein_WMM bioplex (PRKCZ) bioplex_WMM |
| PRKCZ | LLGL1 | 0.051 | 0.296 | hein_WMM bioplex (PRKCZ) bioplex_WMM |
| FRMD6 | TP53BP2 | 0.047 | 0.29 | bioplex (FRMD6) bioplex_WMM boldt_WMM |
| PRKCZ | LLGL2 | 0.043 | 0.273 | hein_WMM bioplex (LLGL2,PRKCZ) bioplex_WMM |
| PARD6A | LLGL2 | 0.043 | 0.271 | hein_WMM bioplex (LLGL2) bioplex_WMM Guru hein (LLGL2) fraction |
| PRKCI | PARD6A | 0.043 | 0.27 | hein_WMM bioplex_WMM hein (PRKCI) |
| PARD6G | RHOJ | 0.036 | 0.266 | bioplex (RHOJ) bioplex_WMM |
| PARD6B | TP53BP2 | 0.027 | 0.228 | hein_WMM hein (PARD6B) |
| PRKCZ | WWC1 | 0.023 | 0.209 | bioplex (PRKCZ) bioplex_WMM |
| TP53BP2 | UTY | 0.023 | 0.207 | fraction |
| PARD6G | PARD6B | 0.012 | 0.15 | bioplex_WMM WMM_only |
| PARD6B | PARD6A | 0.012 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| PARD6G | PRKCI | 0.012 | 0.147 | bioplex_WMM WMM_only boldt_WMM |
| TP53BP2 | PARD3 | 0.011 | 0.133 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PARD6G | PARD6A | 0.01 | 0.128 | bioplex_WMM WMM_only |
| LLGL2 | WWC1 | 0.01 | 0.103 | bioplex_WMM WMM_only |
| PRKCI | WWC1 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| PARD3 | LLGL2 | 0.009 | 0.091 | hein_WMM bioplex_WMM WMM_only |
| BRWD3 | RGL1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| PRKCZ | PARD3 | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only |
| PARD6A | BRWD3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PARD6A | RGL1 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| PRKCZ | RGL1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PARD6G | RGL1 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKCZ | BRWD3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PARD6G | BRWD3 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKCZ | RASSF8 | 0.008 | 0.085 | hein_WMM bioplex_WMM WMM_only |
| FRMD6 | PARD3 | 0.008 | 0.085 | bioplex_WMM WMM_only boldt_WMM |
| PARD3 | LLGL1 | 0.008 | 0.085 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| LLGL1 | WWC1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| PARD3 | WWC1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PARD6A | LLGL1 | 0.008 | 0.079 | hein_WMM bioplex_WMM WMM_only |
| PARD6B | BRWD3 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PARD6B | RGL1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PRKCI | BRWD3 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| PRKCI | RGL1 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| PARD6A | WWC1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| RASSF8 | LLGL2 | 0.008 | 0.055 | hein_WMM bioplex_WMM WMM_only |
| RASSF8 | WWC1 | 0.008 | 0.044 | bioplex_WMM WMM_only |
| PARD6G | WWC1 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| LLGL1 | LLGL2 | 0.008 | 0.025 | hein_WMM bioplex (LLGL2) bioplex_WMM |
| PRKCI | TP53BP2 | 0.007 | 0.009 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| FRMD6 | PRKCI | 0.007 | 0.005 | bioplex_WMM WMM_only boldt_WMM |
| RASSF8 | LLGL1 | 0.007 | 0.011 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PARD6G | LLGL1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| PRKCZ | TP53BP2 | 0.007 | 0.01 | hein_WMM WMM_only |
| PARD6B | RHOJ | 0.007 | 0.007 | bioplex (RHOJ) bioplex_WMM |
| TP53BP2 | LLGL1 | 0.007 | 0.005 | hein_WMM youn_WMM gupta_WMM WMM_only |
| TP53BP2 | LLGL2 | 0.007 | 0.001 | hein_WMM WMM_only |
| PARD6G | PARD3 | 0.007 | 0.005 | WMM_only boldt_WMM |
| PARD3 | PARD6A | 0.007 | 0.004 | hein_WMM WMM_only |
| RASSF8 | RGL1 | 0.007 | 0.001 | youn_WMM WMM_only |
| TP53BP2 | RGL1 | 0.007 | 0.002 | youn_WMM WMM_only |
| PRKCI | RASSF8 | 0.003 | 0.013 | hein_WMM bioplex (RASSF8) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PRKCI | RHOJ | 0.0 | 0.007 | bioplex (RHOJ) bioplex_WMM |
Images
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Complex HuMAP2_02503 has an average edge precision of 0.254 which is ranked 5312 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RHOJ | HuMAP2_01239 HuMAP2_02503 |
| LLGL1 | HuMAP2_01528 HuMAP2_02503 |
| TP53BP2 | HuMAP2_00604 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04686 |
| PARD3 | HuMAP2_01053 HuMAP2_01276 HuMAP2_01528 HuMAP2_02149 HuMAP2_02503 HuMAP2_05511 |
| RGL1 | HuMAP2_01528 HuMAP2_02503 |
| PRKCZ | HuMAP2_00362 HuMAP2_00450 HuMAP2_01528 HuMAP2_02503 |
| PRKCI | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02503 |
| FRMD6 | HuMAP2_00008 HuMAP2_01276 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 HuMAP2_04491 |
| PARD6A | HuMAP2_01528 HuMAP2_02503 |
| PARD6B | HuMAP2_00450 HuMAP2_01276 HuMAP2_01528 HuMAP2_02149 HuMAP2_02503 HuMAP2_05511 |
| PARD6G | HuMAP2_00362 HuMAP2_01239 HuMAP2_01528 HuMAP2_02503 |
| RASSF8 | HuMAP2_00604 HuMAP2_01053 HuMAP2_01276 HuMAP2_02149 HuMAP2_02376 HuMAP2_02503 HuMAP2_04109 |
| UTY | HuMAP2_02503 |
| WWC1 | HuMAP2_02503 |
| BRWD3 | HuMAP2_01528 HuMAP2_02503 |
| LLGL2 | HuMAP2_01528 HuMAP2_02503 |