hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02506
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SZT2 | KICSTOR complex protein SZT2 (Seizure threshold 2 protein homolog) | UniProt NCBI |
| ITFG2 | KICSTOR complex protein ITFG2 (Integrin-alpha FG-GAP repeat-containing protein 2) | UniProt NCBI |
| KPTN | KICSTOR complex protein kaptin (Actin-associated protein 2E4) | UniProt NCBI |
| C12orf66 | KICSTOR complex protein C12orf66 | UniProt NCBI |
| TMCO4 | Transmembrane and coiled-coil domain-containing protein 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6754 | 1.81514593393e-13 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | KICSTOR complex |
| GO:0140007 | 6.09856266088e-10 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | KICSTOR complex |
| GO:1904262 | 1.22034183608e-07 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | negative regulation of TORC1 signaling |
| GO:1903432 | 4.37972330038e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | regulation of TORC1 signaling |
| GO:0042149 | 4.983554895e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to glucose starvation |
| GO:0032007 | 5.64772495392e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | negative regulation of TOR signaling |
| GO:0034198 | 7.17274954203e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to amino acid starvation |
| GO:1990928 | 8.04174090024e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | response to amino acid starvation |
| GO:0038202 | 8.04174090024e-06 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | TORC1 signaling |
| GO:0032006 | 0.000192129923302 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | regulation of TOR signaling |
| GO:0031929 | 0.000354439891603 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | TOR signaling |
| GO:0009267 | 0.000475835425563 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to starvation |
| GO:0042594 | 0.000753186291624 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | response to starvation |
| GO:0031669 | 0.00155534683144 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to nutrient levels |
| GO:0031668 | 0.00213856230812 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to extracellular stimulus |
| GO:0071496 | 0.00488578599782 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | cellular response to external stimulus |
| GO:0061462 | 0.00541762673764 | 0.6 | KPTN C12orf66 SZT2 | protein localization to lysosome |
| GO:0031667 | 0.00608750012464 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | response to nutrient levels |
| GO:0009991 | 0.00812559735038 | 0.8 | ITFG2 C12orf66 SZT2 KPTN | response to extracellular stimulus |
| GO:0072665 | 0.022411068229 | 0.6 | KPTN C12orf66 SZT2 | protein localization to vacuole |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITFG2 | KPTN | 0.993 | 0.917 | bioplex (ITFG2,KPTN) bioplex_WMM |
| ITFG2 | C12orf66 | 0.371 | 0.546 | bioplex (ITFG2) bioplex_WMM |
| KPTN | C12orf66 | 0.362 | 0.544 | bioplex (KPTN) bioplex_WMM |
| SZT2 | ITFG2 | 0.338 | 0.527 | bioplex (ITFG2) bioplex_WMM |
| SZT2 | KPTN | 0.267 | 0.483 | bioplex (KPTN) bioplex_WMM |
| KPTN | TMCO4 | 0.169 | 0.426 | bioplex (KPTN) bioplex_WMM |
| SZT2 | C12orf66 | 0.015 | 0.143 | bioplex_WMM WMM_only |
| C12orf66 | TMCO4 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| SZT2 | TMCO4 | 0.009 | 0.089 | bioplex_WMM WMM_only |
| ITFG2 | TMCO4 | 0.008 | 0.088 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02506 has an average edge precision of 0.387 which is ranked 3455 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SZT2 | HuMAP2_01040 HuMAP2_01293 HuMAP2_02506 |
| ITFG2 | HuMAP2_02506 HuMAP2_05888 |
| KPTN | HuMAP2_02506 HuMAP2_05888 |
| C12orf66 | HuMAP2_02506 |
| TMCO4 | HuMAP2_02506 |