hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02509
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PNP | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | UniProt NCBI |
| SSBP1 | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | UniProt NCBI |
| XDH | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)] | UniProt NCBI |
| SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (EC 6.2.1.4) (GTP-specific succinyl-CoA synthetase subunit beta) (G-SCS) (GTPSCS) (Succinyl-CoA synthetase beta-G chain) (SCS-betaG) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4224 | 0.000352218401684 | 0.5 | PNP XDH | Purine metabolism |
| REAC:R-HSA-74259 | 0.000783559910601 | 0.5 | PNP XDH | Purine catabolism |
| REAC:R-HSA-8956319 | 0.00326103241616 | 0.5 | PNP XDH | Nucleobase catabolism |
| HP:0004352 | 0.00920632571228 | 0.5 | PNP XDH | Abnormal circulating purine concentration |
| HP:0010932 | 0.00920632571228 | 0.5 | PNP XDH | Abnormal circulating nucleobase concentration |
| KEGG:00230 | 0.0121132892553 | 0.5 | PNP XDH | Purine metabolism |
| CORUM:6066 | 0.0249595281251 | 0.25 | XDH | Xanthine oxidase |
| CORUM:6208 | 0.0249595281251 | 0.25 | PNP | PNP homotrimer complex |
| WP:WP3633 | 0.0333519728792 | 0.25 | XDH | Caffeine and Theobromine metabolism |
| REAC:R-HSA-15869 | 0.0364771667023 | 0.5 | PNP XDH | Metabolism of nucleotides |
| KEGG:00232 | 0.0497141369515 | 0.25 | XDH | Caffeine metabolism |
| CORUM:393 | 0.0499140284799 | 0.25 | SUCLG2 | Succinyl-CoA synthetase, GDP-forming |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PNP | SUCLG2 | 0.031 | 0.238 | bioplex_WMM fraction |
| SSBP1 | SUCLG2 | 0.027 | 0.228 | bioplex (SUCLG2) bioplex_WMM fraction |
| XDH | PNP | 0.026 | 0.221 | fraction |
| SSBP1 | XDH | 0.007 | 0.001 | WMM_only boldt_WMM |
| SSBP1 | PNP | 0.0 | 0.005 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02509 has an average edge precision of 0.139 which is ranked 6788 out of all 6965 complexes.
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