hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02514
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBL1XR1 | F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1) | UniProt NCBI |
| ANKRD11 | Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1) | UniProt NCBI |
| NCOR1 | Nuclear receptor corepressor 1 (N-CoR) (N-CoR1) | UniProt NCBI |
| HDAC3 | Histone deacetylase 3 (HD3) (EC 3.5.1.98) (RPD3-2) (SMAP45) | UniProt NCBI |
| GPS2 | G protein pathway suppressor 2 (GPS-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:741 | 9.07524205488e-13 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | NCOR-HDAC3 complex |
| CORUM:15 | 2.72242633204e-12 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | NCOR complex |
| REAC:R-HSA-9022537 | 5.47745657224e-12 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Loss of MECP2 binding ability to the NCoR/SMRT complex |
| CORUM:2183 | 3.81057767206e-11 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Kaiso-NCOR complex |
| REAC:R-HSA-9005895 | 7.66679100486e-11 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Pervasive developmental disorders |
| REAC:R-HSA-9005891 | 7.66679100486e-11 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Loss of function of MECP2 in Rett syndrome |
| REAC:R-HSA-9022692 | 8.66228610405e-09 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Regulation of MECP2 expression and activity |
| CORUM:58 | 1.35119464053e-08 | 0.6 | GPS2 HDAC3 TBL1XR1 | SMRT complex |
| REAC:R-HSA-8986944 | 1.06659036688e-07 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-3214815 | 1.06119728025e-06 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | HDACs deacetylate histones |
| REAC:R-HSA-1989781 | 1.80427312053e-06 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 1.87424072127e-06 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| CORUM:5426 | 6.70868171695e-06 | 0.4 | HDAC3 ANKRD11 | ANCO1-HDAC3 complex |
| REAC:R-HSA-350054 | 7.93420714119e-06 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Notch-HLH transcription pathway |
| WP:WP4312 | 8.87288130353e-06 | 0.6 | GPS2 TBL1XR1 NCOR1 | Rett syndrome causing genes |
| REAC:R-HSA-2122947 | 3.34215806492e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | NOTCH1 Intracellular Domain Regulates Transcription |
| CORUM:7480 | 4.0241279111e-05 | 0.4 | NCOR1 HDAC3 | HDAC3-H1.3-SMRT-N-Cor complex |
| REAC:R-HSA-1368071 | 4.04876825444e-05 | 0.4 | NCOR1 HDAC3 | NR1D1 (REV-ERBA) represses gene expression |
| REAC:R-HSA-2151201 | 5.30427262701e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Transcriptional activation of mitochondrial biogenesis |
| REAC:R-HSA-2894858 | 6.33776832781e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 6.33776832781e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644606 | 6.33776832781e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 6.33776832781e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644602 | 6.33776832781e-05 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-4839726 | 7.68024844941e-05 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Chromatin organization |
| REAC:R-HSA-3247509 | 7.68024844941e-05 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Chromatin modifying enzymes |
| GO:0017053 | 9.31770903001e-05 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | transcriptional repressor complex |
| REAC:R-HSA-1980143 | 0.000112594374126 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Signaling by NOTCH1 |
| REAC:R-HSA-400253 | 0.000118030564163 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Circadian Clock |
| CORUM:1505 | 0.000140787732431 | 0.4 | NCOR1 HDAC3 | NCOR2 complex |
| REAC:R-HSA-381340 | 0.000205300002873 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-1592230 | 0.000295836172608 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Mitochondrial biogenesis |
| CORUM:1413 | 0.000301566439547 | 0.4 | NCOR1 HDAC3 | NCOR1 complex |
| CORUM:5614 | 0.00127157081923 | 0.4 | HDAC3 TBL1XR1 | Emerin complex 32 |
| REAC:R-HSA-556833 | 0.0024275365816 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Metabolism of lipids |
| GO:0046329 | 0.00265002518516 | 0.6 | GPS2 HDAC3 NCOR1 | negative regulation of JNK cascade |
| REAC:R-HSA-157118 | 0.0046564839046 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Signaling by NOTCH |
| GO:0032873 | 0.00541762673764 | 0.6 | GPS2 HDAC3 NCOR1 | negative regulation of stress-activated MAPK cascade |
| GO:0070303 | 0.00541762673764 | 0.6 | GPS2 HDAC3 NCOR1 | negative regulation of stress-activated protein kinase signaling cascade |
| GO:0003714 | 0.00734685288577 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | transcription corepressor activity |
| REAC:R-HSA-1852241 | 0.00946786790116 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Organelle biogenesis and maintenance |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Disease |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Generic Transcription Pathway |
| REAC:R-HSA-5663202 | 0.016617401989 | 0.6 | NCOR1 HDAC3 TBL1XR1 | Diseases of signal transduction |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | RNA Polymerase II Transcription |
| KEGG:04919 | 0.0267668372004 | 0.4 | NCOR1 HDAC3 | Thyroid hormone signaling pathway |
| GO:0019216 | 0.0292681328876 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | regulation of lipid metabolic process |
| GO:0000118 | 0.0358473364726 | 0.6 | NCOR1 HDAC3 TBL1XR1 | histone deacetylase complex |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | GPS2 NCOR1 HDAC3 TBL1XR1 | Gene expression (Transcription) |
| WP:WP3594 | 0.0426212197502 | 0.4 | NCOR1 HDAC3 | Circadian rhythm related genes |
| CORUM:0000000 | 0.0474603483533 | 1.0 | GPS2 NCOR1 TBL1XR1 HDAC3 ANKRD11 | CORUM root |
| CORUM:6244 | 0.0499494897235 | 0.2 | HDAC3 | AJUBA-GFI1-HDAC3 complex |
| CORUM:7487 | 0.0499494897235 | 0.2 | HDAC3 | DTNBP1(1A)-HDAC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HDAC3 | GPS2 | 0.944 | 0.856 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| GPS2 | ANKRD11 | 0.916 | 0.84 | bioplex (GPS2) bioplex_WMM youn_WMM |
| TBL1XR1 | GPS2 | 0.915 | 0.839 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| NCOR1 | GPS2 | 0.888 | 0.818 | bioplex (GPS2) bioplex_WMM youn_WMM gupta_WMM |
| NCOR1 | HDAC3 | 0.014 | 0.137 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| NCOR1 | TBL1XR1 | 0.013 | 0.154 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TBL1XR1 | HDAC3 | 0.009 | 0.113 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| TBL1XR1 | ANKRD11 | 0.008 | 0.095 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| NCOR1 | ANKRD11 | 0.008 | 0.092 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HDAC3 | ANKRD11 | 0.008 | 0.062 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_02514 has an average edge precision of 0.401 which is ranked 3314 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBL1XR1 | HuMAP2_00929 HuMAP2_02514 HuMAP2_02763 HuMAP2_05428 HuMAP2_05452 |
| ANKRD11 | HuMAP2_02514 HuMAP2_05428 HuMAP2_05452 |
| NCOR1 | HuMAP2_00929 HuMAP2_02514 HuMAP2_02763 HuMAP2_05428 HuMAP2_05452 |
| HDAC3 | HuMAP2_02514 HuMAP2_05428 HuMAP2_05452 |
| GPS2 | HuMAP2_02514 HuMAP2_03841 HuMAP2_05428 HuMAP2_05452 |