hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02534
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NISCH | Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein) | UniProt NCBI |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | UniProt NCBI |
| PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta) | UniProt NCBI |
| NYAP2 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2 | UniProt NCBI |
| PIK3R3 | Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK) | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | UniProt NCBI |
| PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta) | UniProt NCBI |
| PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1) | UniProt NCBI |
| IRS2 | Insulin receptor substrate 2 (IRS-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 6.96921488012e-17 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Cancer immunotherapy by CTLA4 blockade |
| REAC:R-HSA-8853659 | 5.83743048168e-16 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | RET signaling |
| KEGG:04930 | 2.18213885499e-15 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Type II diabetes mellitus |
| KEGG:04923 | 2.18213885499e-15 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Regulation of lipolysis in adipocytes |
| REAC:R-HSA-2219530 | 1.005729009e-14 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Constitutive Signaling by Aberrant PI3K in Cancer |
| KEGG:04213 | 1.31877165761e-14 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Longevity regulating pathway - multiple species |
| REAC:R-HSA-912526 | 1.36468460719e-14 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Interleukin receptor SHC signaling |
| REAC:R-HSA-912631 | 4.27179654803e-14 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Regulation of signaling by CBL |
| WP:WP3937 | 1.9637446257e-13 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Microglia Pathogen Phagocytosis Pathway |
| KEGG:04960 | 2.08076718387e-13 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Aldosterone-regulated sodium reabsorption |
| KEGG:04211 | 2.1552042163e-13 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Longevity regulating pathway |
| REAC:R-HSA-198203 | 2.30133179326e-13 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | PI3K/AKT activation |
| REAC:R-HSA-6811558 | 2.38435744402e-13 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 2.93835826033e-13 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | PI3K/AKT Signaling in Cancer |
| REAC:R-HSA-199418 | 4.82747824279e-13 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-451927 | 9.96657276479e-13 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Interleukin-2 family signaling |
| KEGG:04931 | 1.04441528814e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Insulin resistance |
| KEGG:04973 | 1.08305778594e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Carbohydrate digestion and absorption |
| REAC:R-HSA-9027276 | 1.89732358523e-12 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | Erythropoietin activates Phosphoinositide-3-kinase (PI3K) |
| KEGG:04152 | 2.04648003484e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | AMPK signaling pathway |
| KEGG:04068 | 2.32379828295e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | FoxO signaling pathway |
| REAC:R-HSA-512988 | 2.55465677902e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| WP:WP4539 | 3.54072082476e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04910 | 4.49755144452e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Insulin signaling pathway |
| WP:WP3915 | 4.96829786575e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Angiopoietin Like Protein 8 Regulatory Pathway |
| KEGG:04140 | 7.00968028031e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Autophagy - animal |
| KEGG:04932 | 7.00968028031e-12 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04929 | 7.26988946367e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | GnRH secretion |
| KEGG:04664 | 8.15866687403e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Fc epsilon RI signaling pathway |
| KEGG:04370 | 8.15866687403e-12 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | VEGF signaling pathway |
| WP:WP4396 | 1.01356556839e-11 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Nonalcoholic fatty liver disease |
| KEGG:05213 | 1.02091940374e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Endometrial cancer |
| WP:WP4205 | 1.19453683528e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | MET in type 1 papillary renal cell carcinoma |
| REAC:R-HSA-1660499 | 1.34592605095e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Synthesis of PIPs at the plasma membrane |
| KEGG:05221 | 1.40774515749e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Acute myeloid leukemia |
| KEGG:04917 | 1.72800248839e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Prolactin signaling pathway |
| KEGG:05218 | 1.72800248839e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Melanoma |
| KEGG:05211 | 1.90956659092e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Renal cell carcinoma |
| WP:WP4155 | 2.02186638462e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Endometrial cancer |
| KEGG:05223 | 2.10674287855e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Non-small cell lung cancer |
| KEGG:05206 | 2.28880121133e-11 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | MicroRNAs in cancer |
| WP:WP481 | 2.33428535362e-11 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Insulin Signaling |
| WP:WP1403 | 2.46501532017e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | AMP-activated Protein Kinase (AMPK) Signaling |
| KEGG:05230 | 2.80275248538e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Central carbon metabolism in cancer |
| KEGG:04662 | 2.80275248538e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | B cell receptor signaling pathway |
| KEGG:05214 | 3.07345387084e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Glioma |
| GO:0005942 | 3.72076586335e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phosphatidylinositol 3-kinase complex |
| KEGG:05212 | 4.01950397596e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Pancreatic cancer |
| WP:WP4255 | 4.3063650446e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Non-small cell lung cancer |
| KEGG:01524 | 4.38415334866e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Platinum drug resistance |
| KEGG:05100 | 4.77593604752e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Bacterial invasion of epithelial cells |
| KEGG:01521 | 5.19644116378e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 5.19644116378e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Chronic myeloid leukemia |
| WP:WP1544 | 7.17284133681e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04012 | 7.7903310595e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | ErbB signaling pathway |
| KEGG:05235 | 8.42051901351e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04750 | 9.09258336969e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Inflammatory mediator regulation of TRP channels |
| KEGG:04914 | 9.09258336969e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Progesterone-mediated oocyte maturation |
| KEGG:05210 | 9.80871742187e-11 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Colorectal cancer |
| KEGG:05146 | 1.22447549178e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Amoebiasis |
| WP:WP4263 | 1.23689360957e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Pancreatic adenocarcinoma pathway |
| KEGG:04620 | 1.31608280772e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Toll-like receptor signaling pathway |
| REAC:R-HSA-9006335 | 1.37817390218e-10 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | Signaling by Erythropoietin |
| WP:WP673 | 1.43270964727e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | ErbB Signaling Pathway |
| KEGG:04670 | 1.51647608583e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Leukocyte transendothelial migration |
| KEGG:04625 | 1.51647608583e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | C-type lectin receptor signaling pathway |
| KEGG:04666 | 1.51647608583e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Fc gamma R-mediated phagocytosis |
| KEGG:05142 | 1.51647608583e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Chagas disease (American trypanosomiasis) |
| KEGG:05231 | 1.62581872979e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Choline metabolism in cancer |
| KEGG:05215 | 1.74164638906e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Prostate cancer |
| KEGG:04660 | 1.74164638906e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | T cell receptor signaling pathway |
| KEGG:01522 | 1.74164638906e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Endocrine resistance |
| WP:WP3844 | 1.75174481801e-10 | 0.555555555556 | PIK3CA PIK3R1 PIK3CB PIK3R3 PIK3R2 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| WP:WP75 | 1.77436782738e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Toll-like Receptor Signaling Pathway |
| KEGG:04933 | 1.86426258708e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 1.99398133949e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Small cell lung cancer |
| KEGG:04070 | 1.99398133949e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Phosphatidylinositol signaling system |
| KEGG:04668 | 2.13112739086e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | TNF signaling pathway |
| KEGG:04725 | 2.59054276313e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Cholinergic synapse |
| REAC:R-HSA-1483255 | 2.8025143252e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | PI Metabolism |
| WP:WP4658 | 2.84214033157e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Small cell lung cancer |
| GO:0046854 | 3.05699419639e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phosphatidylinositol phosphorylation |
| KEGG:04650 | 3.12957537261e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Natural killer cell mediated cytotoxicity |
| REAC:R-HSA-109704 | 3.30352397046e-10 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | PI3K Cascade |
| KEGG:04066 | 3.32875750097e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | HIF-1 signaling pathway |
| KEGG:04380 | 3.99069116044e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Osteoclast differentiation |
| REAC:R-HSA-114604 | 4.02077997106e-10 | 0.555555555556 | PIK3CA PIK3R1 PIK3CB PIK3R3 PIK3R2 | GPVI-mediated activation cascade |
| WP:WP710 | 4.95436558563e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | DNA Damage Response (only ATM dependent) |
| KEGG:04722 | 5.04052820001e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Neurotrophin signaling pathway |
| KEGG:04071 | 5.64596298968e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Sphingolipid signaling pathway |
| KEGG:04611 | 6.31073809885e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Platelet activation |
| KEGG:05135 | 6.66679130442e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Yersinia infection |
| REAC:R-HSA-112399 | 6.946636541e-10 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | IRS-mediated signalling |
| KEGG:04919 | 7.03940687275e-10 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Thyroid hormone signaling pathway |
| KEGG:04926 | 1.0164763194e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Relaxin signaling pathway |
| KEGG:04630 | 1.06932397385e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | JAK-STAT signaling pathway |
| WP:WP1449 | 1.07327598507e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Regulation of toll-like receptor signaling pathway |
| WP:WP4217 | 1.07327598507e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Ebola Virus Pathway on Host |
| KEGG:04915 | 1.12443834992e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Estrogen signaling pathway |
| REAC:R-HSA-2428928 | 1.1368560936e-09 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2428924 | 1.1368560936e-09 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | IGF1R signaling cascade |
| REAC:R-HSA-1257604 | 1.14361204261e-09 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | PIP3 activates AKT signaling |
| GO:0014065 | 1.17352596499e-09 | 0.777777777778 | NYAP2 IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | phosphatidylinositol 3-kinase signaling |
| KEGG:04550 | 1.18189636987e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04210 | 1.3041607195e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Apoptosis |
| KEGG:05418 | 1.3041607195e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-2404192 | 1.32603473019e-09 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| KEGG:04072 | 1.36913067799e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Phospholipase D signaling pathway |
| GO:0046834 | 1.44563440081e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | lipid phosphorylation |
| WP:WP3929 | 1.4529533162e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Chemokine signaling pathway |
| KEGG:05162 | 1.50717039023e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Measles |
| REAC:R-HSA-74751 | 1.53956601595e-09 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Insulin receptor signalling cascade |
| KEGG:05224 | 1.65659964777e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Breast cancer |
| KEGG:04062 | 1.65659964777e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Chemokine signaling pathway |
| WP:WP4566 | 1.67895392262e-09 | 0.555555555556 | PIK3CA PIK3R1 PIK3CB PIK3R3 PIK3R2 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:05226 | 1.73581450711e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Gastric cancer |
| WP:WP51 | 2.12735148189e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Regulation of Actin Cytoskeleton |
| KEGG:05160 | 2.1807773686e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Hepatitis C |
| WP:WP4239 | 2.43949211296e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Epithelial to mesenchymal transition in colorectal cancer |
| REAC:R-HSA-2730905 | 2.56759639518e-09 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Role of LAT2/NTAL/LAB on calcium mobilization |
| KEGG:04150 | 3.08802795263e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | mTOR signaling pathway |
| WP:WP395 | 3.17902620667e-09 | 0.555555555556 | PIK3CA IRS2 PIK3CD PIK3R2 PIK3R1 | IL-4 Signaling Pathway |
| KEGG:04218 | 3.22076347495e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Cellular senescence |
| REAC:R-HSA-9006925 | 3.44102446206e-09 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Intracellular signaling by second messengers |
| KEGG:05164 | 3.64777836532e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Influenza A |
| WP:WP4666 | 3.76848612578e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Hepatitis B infection |
| KEGG:05161 | 4.83010194235e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Hepatitis B |
| KEGG:05225 | 5.63805040328e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Hepatocellular carcinoma |
| WP:WP4223 | 5.65150850021e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Ras Signaling |
| GO:0048015 | 6.1454064317e-09 | 0.777777777778 | NYAP2 IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | phosphatidylinositol-mediated signaling |
| GO:0048017 | 6.48878082044e-09 | 0.777777777778 | NYAP2 IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | inositol lipid-mediated signaling |
| KEGG:04360 | 7.05862885417e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Axon guidance |
| KEGG:05167 | 7.05862885417e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04024 | 8.45900034614e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | cAMP signaling pathway |
| KEGG:04015 | 9.40489782818e-09 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Rap1 signaling pathway |
| KEGG:05169 | 1.32168442201e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Epstein-Barr virus infection |
| KEGG:04014 | 1.3659972826e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Ras signaling pathway |
| KEGG:04810 | 1.50641526786e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Regulation of actin cytoskeleton |
| KEGG:05205 | 1.5558058372e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Proteoglycans in cancer |
| KEGG:05203 | 1.5558058372e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Viral carcinogenesis |
| KEGG:04510 | 1.60653552477e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Focal adhesion |
| REAC:R-HSA-210993 | 1.66669636949e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Tie2 Signaling |
| WP:WP306 | 1.82038599155e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Focal Adhesion |
| WP:WP2037 | 1.96069993469e-08 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Prolactin Signaling Pathway |
| REAC:R-HSA-5663202 | 1.96920954037e-08 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Diseases of signal transduction |
| REAC:R-HSA-74752 | 2.03399167253e-08 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Signaling by Insulin receptor |
| KEGG:05166 | 2.06413159453e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Human T-cell leukemia virus 1 infection |
| KEGG:05170 | 2.19404471798e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Human immunodeficiency virus 1 infection |
| GO:0043491 | 2.23615878347e-08 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | protein kinase B signaling |
| KEGG:05163 | 2.40161285727e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Human cytomegalovirus infection |
| WP:WP2261 | 3.31510588082e-08 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | Signaling Pathways in Glioblastoma |
| GO:0030258 | 4.45883752586e-08 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | lipid modification |
| REAC:R-HSA-389357 | 4.72759878881e-08 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| REAC:R-HSA-1483257 | 5.31704918368e-08 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Phospholipid metabolism |
| REAC:R-HSA-187037 | 6.08329446281e-08 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2029485 | 7.2960444442e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-2424491 | 7.2960444442e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | DAP12 signaling |
| REAC:R-HSA-373753 | 8.91499029266e-08 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Nephrin family interactions |
| WP:WP3932 | 1.17180831946e-07 | 0.666666666667 | IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-2172127 | 1.29432338004e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | DAP12 interactions |
| WP:WP4564 | 1.69350079967e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R3 PIK3CD | Neural Crest Cell Migration during Development |
| REAC:R-HSA-166520 | 1.87584364163e-07 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Signaling by NTRKs |
| REAC:R-HSA-186763 | 2.13599251618e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Downstream signal transduction |
| WP:WP4172 | 2.32881288076e-07 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | PI3K-Akt Signaling Pathway |
| WP:WP4565 | 2.40980292737e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R3 PIK3CD | Neural Crest Cell Migration in Cancer |
| REAC:R-HSA-389356 | 2.49132113888e-07 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | CD28 co-stimulation |
| KEGG:04151 | 2.59637737306e-07 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | PI3K-Akt signaling pathway |
| WP:WP524 | 2.6925845626e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3CD | G13 Signaling Pathway |
| KEGG:05165 | 3.28471627939e-07 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Human papillomavirus infection |
| REAC:R-HSA-449147 | 3.58181286498e-07 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Signaling by Interleukins |
| GO:0006661 | 3.67242223947e-07 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phosphatidylinositol biosynthetic process |
| REAC:R-HSA-422475 | 3.73147832929e-07 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Axon guidance |
| WP:WP4262 | 4.82282341568e-07 | 0.555555555556 | PIK3CA PIK3R1 PIK3CD PIK3R3 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-1266695 | 4.9723001016e-07 | 0.444444444444 | PIK3R1 IRS2 PIK3R3 PIK3R2 | Interleukin-7 signaling |
| GO:0051897 | 5.83332926163e-07 | 0.666666666667 | IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | positive regulation of protein kinase B signaling |
| REAC:R-HSA-1433557 | 6.35898309752e-07 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by SCF-KIT |
| GO:0016303 | 6.4446669519e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R3 PIK3CD | 1-phosphatidylinositol-3-kinase activity |
| GO:0035004 | 6.4446669519e-07 | 0.444444444444 | PIK3CA PIK3CB PIK3R3 PIK3CD | phosphatidylinositol 3-kinase activity |
| KEGG:05168 | 1.05199779973e-06 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Herpes simplex virus 1 infection |
| WP:WP585 | 1.14864607294e-06 | 0.444444444444 | IRS2 PIK3CD PIK3R2 PIK3R1 | Interferon type I signaling pathways |
| GO:0046488 | 2.5418180423e-06 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phosphatidylinositol metabolic process |
| REAC:R-HSA-1280215 | 2.9392675018e-06 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Cytokine Signaling in Immune system |
| GO:0052742 | 3.06865717378e-06 | 0.444444444444 | PIK3CA PIK3CB PIK3R3 PIK3CD | phosphatidylinositol kinase activity |
| GO:0051896 | 3.4199931875e-06 | 0.666666666667 | IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | regulation of protein kinase B signaling |
| KEGG:05200 | 3.56042421268e-06 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Pathways in cancer |
| REAC:R-HSA-186797 | 3.82119311117e-06 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Signaling by PDGF |
| REAC:R-HSA-388841 | 3.82119311117e-06 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Costimulation by the CD28 family |
| GO:0014068 | 6.06398665154e-06 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | positive regulation of phosphatidylinositol 3-kinase signaling |
| REAC:R-HSA-9006934 | 6.26634545565e-06 | 0.666666666667 | PIK3R3 IRS2 PIK3R2 PIK3CA PIK3R1 PIK3CB | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-9009391 | 8.68020476795e-06 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-9607240 | 1.30450636784e-05 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | FLT3 Signaling |
| CORUM:3133 | 1.34129279418e-05 | 0.222222222222 | PIK3CA PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| GO:0046474 | 1.4717677167e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | glycerophospholipid biosynthetic process |
| REAC:R-HSA-76002 | 1.71989431523e-05 | 0.555555555556 | PIK3CA PIK3R1 PIK3CB PIK3R3 PIK3R2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-449836 | 1.87958156503e-05 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R2 PIK3R1 | Other interleukin signaling |
| REAC:R-HSA-2029480 | 1.89764939991e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fcgamma receptor (FCGR) dependent phagocytosis |
| REAC:R-HSA-1266738 | 2.17311216595e-05 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Developmental Biology |
| REAC:R-HSA-1643685 | 2.67246013942e-05 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Disease |
| GO:0008654 | 2.80002256762e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phospholipid biosynthetic process |
| GO:0045017 | 2.88227833807e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | glycerolipid biosynthetic process |
| REAC:R-HSA-202424 | 2.92246982613e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Downstream TCR signaling |
| REAC:R-HSA-4420097 | 3.19728957771e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | VEGFA-VEGFR2 Pathway |
| GO:0014066 | 3.52997318041e-05 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | regulation of phosphatidylinositol 3-kinase signaling |
| WP:WP4481 | 3.67915356407e-05 | 0.333333333333 | PIK3CA PIK3CD PIK3CB | Resistin as a regulator of inflammation |
| GO:0019898 | 4.03666840352e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | extrinsic component of membrane |
| GO:0061695 | 4.26202104025e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-194138 | 4.4935789035e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Signaling by VEGF |
| WP:WP244 | 4.93971721616e-05 | 0.333333333333 | IRS2 PIK3R2 PIK3R1 | Alpha 6 Beta 4 signaling pathway |
| REAC:R-HSA-202733 | 5.06866182303e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 5.27203336366e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Cell-Cell communication |
| GO:0008286 | 5.55372064128e-05 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | insulin receptor signaling pathway |
| REAC:R-HSA-202403 | 6.14699446971e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | TCR signaling |
| REAC:R-HSA-556833 | 9.1283760825e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Metabolism of lipids |
| REAC:R-HSA-2454202 | 9.75039727383e-05 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-1280218 | 9.914735111e-05 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Adaptive Immune System |
| GO:0006650 | 0.000102534373978 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | glycerophospholipid metabolic process |
| WP:WP286 | 0.000103654201195 | 0.333333333333 | PIK3CD PIK3R2 PIK3R1 | IL-3 Signaling Pathway |
| REAC:R-HSA-416476 | 0.000147346986949 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | G alpha (q) signalling events |
| GO:0035005 | 0.000266683990267 | 0.333333333333 | PIK3CA PIK3CD PIK3CB | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| GO:0046486 | 0.000352997876339 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | glycerolipid metabolic process |
| WP:WP2032 | 0.000391654898324 | 0.333333333333 | PIK3CA PIK3R2 PIK3R1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| GO:0006644 | 0.000409843135621 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | phospholipid metabolic process |
| GO:0036092 | 0.000426565421795 | 0.333333333333 | PIK3CA PIK3CD PIK3CB | phosphatidylinositol-3-phosphate biosynthetic process |
| GO:0032869 | 0.000432779300447 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | cellular response to insulin stimulus |
| KEGG:00562 | 0.000437197629146 | 0.333333333333 | PIK3CA PIK3CD PIK3CB | Inositol phosphate metabolism |
| GO:0032868 | 0.000552435685513 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | response to insulin |
| GO:0050852 | 0.000631811092925 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | T cell receptor signaling pathway |
| REAC:R-HSA-8851907 | 0.000645991629451 | 0.222222222222 | PIK3CA PIK3R1 | MET activates PI3K/AKT signaling |
| REAC:R-HSA-9028335 | 0.000645991629451 | 0.222222222222 | PIK3CA PIK3R1 | Activated NTRK2 signals through PI3K |
| REAC:R-HSA-8939211 | 0.000812884884682 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | ESR-mediated signaling |
| REAC:R-HSA-1250342 | 0.000968683784969 | 0.222222222222 | PIK3CA PIK3R1 | PI3K events in ERBB4 signaling |
| REAC:R-HSA-9603381 | 0.000968683784969 | 0.222222222222 | PIK3CA PIK3R1 | Activated NTRK3 signals through PI3K |
| GO:0007411 | 0.00128271652 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | axon guidance |
| REAC:R-HSA-109582 | 0.00131902915988 | 0.555555555556 | PIK3CA PIK3R1 PIK3CB PIK3R3 PIK3R2 | Hemostasis |
| GO:0097485 | 0.00131992469026 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | neuron projection guidance |
| GO:0048812 | 0.00137640098394 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | neuron projection morphogenesis |
| GO:0120039 | 0.00161952254288 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | plasma membrane bounded cell projection morphogenesis |
| REAC:R-HSA-9006931 | 0.00165375222288 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | Signaling by Nuclear Receptors |
| GO:0046935 | 0.00167376753379 | 0.333333333333 | PIK3R1 PIK3R3 PIK3R2 | 1-phosphatidylinositol-3-kinase regulator activity |
| GO:0048858 | 0.00169167641371 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | cell projection morphogenesis |
| GO:0044255 | 0.0016968385817 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | cellular lipid metabolic process |
| GO:0050851 | 0.00174147966107 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | antigen receptor-mediated signaling pathway |
| WP:WP3935 | 0.00176209937796 | 0.222222222222 | PIK3R3 IRS2 | Leptin Insulin Overlap |
| REAC:R-HSA-168256 | 0.00180913033883 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Immune System |
| GO:0032990 | 0.00197945993917 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | cell part morphogenesis |
| GO:0016307 | 0.00217524004777 | 0.333333333333 | PIK3CA PIK3CD PIK3CB | phosphatidylinositol phosphate kinase activity |
| GO:0071375 | 0.00220667392396 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | cellular response to peptide hormone stimulus |
| WP:WP22 | 0.00232219124631 | 0.222222222222 | PIK3R2 PIK3R1 | IL-9 Signaling Pathway |
| REAC:R-HSA-8853334 | 0.00232265605894 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 fusions in cancer |
| REAC:R-HSA-1963642 | 0.00232265605894 | 0.222222222222 | PIK3CA PIK3R1 | PI3K events in ERBB2 signaling |
| REAC:R-HSA-5654710 | 0.00232265605894 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR3 |
| GO:0090407 | 0.00257185346749 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | organophosphate biosynthetic process |
| GO:0035014 | 0.00276765042703 | 0.333333333333 | PIK3R1 PIK3R3 PIK3R2 | phosphatidylinositol 3-kinase regulator activity |
| REAC:R-HSA-5655291 | 0.00290241019689 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR4 in disease |
| REAC:R-HSA-180292 | 0.00354627850517 | 0.222222222222 | PIK3CA PIK3R1 | GAB1 signalosome |
| WP:WP2380 | 0.00359829901051 | 0.333333333333 | IRS2 PIK3R2 PIK3R1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| GO:0002433 | 0.0036653964835 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 0.0036653964835 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fc-gamma receptor signaling pathway |
| GO:0048010 | 0.0036653964835 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | vascular endothelial growth factor receptor signaling pathway |
| GO:0038096 | 0.0036653964835 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| REAC:R-HSA-162582 | 0.00387204978319 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | Signal Transduction |
| GO:0043434 | 0.0040345056366 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | response to peptide hormone |
| GO:0002431 | 0.00407883187879 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fc receptor mediated stimulatory signaling pathway |
| REAC:R-HSA-5654720 | 0.0042542005269 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR4 |
| REAC:R-HSA-5654689 | 0.0042542005269 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR1 |
| HPA:056010_22 | 0.00429087867213 | 0.777777777778 | NISCH PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CB | tonsil; germinal center cells[Approved,Medium] |
| WP:WP205 | 0.00446181826808 | 0.222222222222 | PIK3R2 PIK3R1 | IL-7 Signaling Pathway |
| HPA:004030_22 | 0.00460249129565 | 0.777777777778 | NISCH PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CB | breast; myoepithelial cells[Approved,Medium] |
| REAC:R-HSA-5654695 | 0.00502611584178 | 0.222222222222 | PIK3CA PIK3R1 | PI-3K cascade:FGFR2 |
| REAC:R-HSA-5637810 | 0.00502611584178 | 0.222222222222 | PIK3CA PIK3R1 | Constitutive Signaling by EGFRvIII |
| REAC:R-HSA-5637812 | 0.00502611584178 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by EGFRvIII in Cancer |
| GO:1901653 | 0.00537395709228 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | cellular response to peptide |
| REAC:R-HSA-5654708 | 0.00586196406613 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR3 |
| REAC:R-HSA-9034015 | 0.00586196406613 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by NTRK3 (TRKC) |
| REAC:R-HSA-5655332 | 0.00586196406613 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 in disease |
| REAC:R-HSA-8853338 | 0.00586196406613 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 point mutants in cancer |
| GO:0007169 | 0.00616555460004 | 0.666666666667 | PIK3R3 IRS2 PIK3R2 PIK3CA PIK3R1 PIK3CB | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0008610 | 0.0064571553218 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | lipid biosynthetic process |
| GO:0050900 | 0.00763527751428 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | leukocyte migration |
| REAC:R-HSA-1839117 | 0.00772521789112 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by cytosolic FGFR1 fusion mutants |
| WP:WP3972 | 0.00782479344974 | 0.222222222222 | PIK3CA PIK3R1 | PDGFR-beta pathway |
| REAC:R-HSA-5654716 | 0.00875250290708 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR4 |
| REAC:R-HSA-5637815 | 0.00875250290708 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| REAC:R-HSA-1236382 | 0.00875250290708 | 0.222222222222 | PIK3CA PIK3R1 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| GO:0006629 | 0.0089815467535 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | lipid metabolic process |
| REAC:R-HSA-5654696 | 0.00984347966308 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR2 |
| GO:1901652 | 0.0107945845604 | 0.555555555556 | PIK3CA PIK3R1 IRS2 PIK3R3 PIK3R2 | response to peptide |
| REAC:R-HSA-1643713 | 0.010998087958 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by EGFR in Cancer |
| GO:0031175 | 0.0110598402878 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | neuron projection development |
| WP:WP2828 | 0.0121153028883 | 0.222222222222 | PIK3R2 PIK3R1 | Bladder Cancer |
| REAC:R-HSA-5654687 | 0.0122162676274 | 0.222222222222 | PIK3CA PIK3R1 | Downstream signaling of activated FGFR1 |
| REAC:R-HSA-9006115 | 0.0122162676274 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by NTRK2 (TRKB) |
| GO:0038095 | 0.0127223411758 | 0.444444444444 | PIK3CA PIK3CB PIK3R2 PIK3R1 | Fc-epsilon receptor signaling pathway |
| GO:0007409 | 0.0127226016987 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | axonogenesis |
| WP:WP127 | 0.0135106647521 | 0.222222222222 | PIK3R2 PIK3R1 | IL-5 Signaling Pathway |
| GO:0002429 | 0.0139062660017 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | immune response-activating cell surface receptor signaling pathway |
| WP:WP2332 | 0.0142365065226 | 0.222222222222 | PIK3R2 PIK3R1 | Interleukin-11 Signaling Pathway |
| WP:WP3888 | 0.0147748088741 | 0.333333333333 | PIK3CA PIK3R2 PIK3R1 | VEGFA-VEGFR2 Signaling Pathway |
| GO:0005943 | 0.0162296428096 | 0.222222222222 | PIK3CA PIK3R1 | phosphatidylinositol 3-kinase complex, class IA |
| WP:WP364 | 0.0165264608152 | 0.222222222222 | PIK3R2 PIK3R1 | IL-6 signaling pathway |
| GO:0061564 | 0.0168190747347 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | axon development |
| REAC:R-HSA-1839124 | 0.0177234980319 | 0.222222222222 | PIK3CA PIK3R1 | FGFR1 mutant receptor activation |
| REAC:R-HSA-983695 | 0.0177234980319 | 0.222222222222 | PIK3R1 PIK3CD | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| GO:0048666 | 0.0188051035954 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | neuron development |
| GO:0002768 | 0.0198693728568 | 0.555555555556 | PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R1 | immune response-regulating cell surface receptor signaling pathway |
| HPA:039010_22 | 0.0229912527872 | 0.777777777778 | NISCH PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CB | salivary gland; glandular cells[Approved,Medium] |
| GO:0000902 | 0.0239920981764 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | cell morphogenesis |
| REAC:R-HSA-5654741 | 0.0242430667307 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR3 |
| WP:WP195 | 0.0244040137687 | 0.222222222222 | PIK3R2 PIK3R1 | IL-1 signaling pathway |
| WP:WP2018 | 0.0253722167076 | 0.222222222222 | PIK3R2 PIK3R1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| GO:0040011 | 0.0277084686783 | 0.777777777778 | PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | locomotion |
| REAC:R-HSA-5654743 | 0.0278812797455 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR4 |
| WP:WP61 | 0.0294300391591 | 0.222222222222 | PIK3R2 PIK3R1 | Notch Signaling Pathway |
| WP:WP304 | 0.0294300391591 | 0.222222222222 | PIK3R2 PIK3R1 | Kit receptor signaling pathway |
| REAC:R-HSA-5655302 | 0.0297947840849 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR1 in disease |
| GO:0043551 | 0.03072093226 | 0.333333333333 | PIK3R1 PIK3R3 PIK3R2 | regulation of phosphatidylinositol 3-kinase activity |
| GO:1902533 | 0.0348378389544 | 0.666666666667 | IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | positive regulation of intracellular signal transduction |
| REAC:R-HSA-5655253 | 0.0359121718017 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR2 in disease |
| REAC:R-HSA-388396 | 0.036560466341 | 0.444444444444 | PIK3CA PIK3R1 PIK3R3 PIK3R2 | GPCR downstream signalling |
| GO:0001784 | 0.0375082902074 | 0.333333333333 | PIK3R1 PIK3R3 PIK3R2 | phosphotyrosine residue binding |
| GO:0048667 | 0.0378160513769 | 0.555555555556 | PIK3CA IRS2 PIK3CB PIK3R1 PIK3CD | cell morphogenesis involved in neuron differentiation |
| GO:0035556 | 0.0384085684948 | 0.888888888889 | NYAP2 PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CD PIK3CB | intracellular signal transduction |
| GO:1990234 | 0.0389164855088 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | transferase complex |
| WP:WP3303 | 0.0396376262126 | 0.222222222222 | PIK3CA PIK3R1 | RAC1/PAK1/p38/MMP2 Pathway |
| REAC:R-HSA-5654736 | 0.0403038960626 | 0.222222222222 | PIK3CA PIK3R1 | Signaling by FGFR1 |
| HPA:011030_21 | 0.0414631686695 | 0.777777777778 | NISCH PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CB | colon; peripheral nerve/ganglion[Approved,Low] |
| HP:0200043 | 0.0425872663121 | 0.222222222222 | PIK3CA PIK3R1 | Verrucae |
| GO:0007167 | 0.0426685244909 | 0.666666666667 | PIK3R3 IRS2 PIK3R2 PIK3CA PIK3R1 PIK3CB | enzyme linked receptor protein signaling pathway |
| GO:0032989 | 0.0426685244909 | 0.666666666667 | NYAP2 IRS2 PIK3CA PIK3CB PIK3CD PIK3R1 | cellular component morphogenesis |
| MIRNA:hsa-miR-7-5p | 0.0461674538664 | 0.444444444444 | PIK3CB IRS2 PIK3R3 PIK3CD | hsa-miR-7-5p |
| GO:0002684 | 0.0463340197206 | 0.666666666667 | IRS2 PIK3R2 PIK3CA PIK3CB PIK3CD PIK3R1 | positive regulation of immune system process |
| REAC:R-HSA-1430728 | 0.0473316214616 | 0.666666666667 | PIK3R3 PIK3R2 PIK3CA PIK3R1 PIK3CD PIK3CB | Metabolism |
| GO:0097651 | 0.0486736709081 | 0.222222222222 | PIK3CA PIK3R1 | phosphatidylinositol 3-kinase complex, class I |
| GO:0033029 | 0.0486736709081 | 0.222222222222 | PIK3CD PIK3CB | regulation of neutrophil apoptotic process |
| GO:0033031 | 0.0486736709081 | 0.222222222222 | PIK3CD PIK3CB | positive regulation of neutrophil apoptotic process |
| HPA:009020_21 | 0.0490854048243 | 0.777777777778 | NISCH PIK3R3 PIK3R2 IRS2 PIK3CA PIK3R1 PIK3CB | cervix, uterine; squamous epithelial cells[Approved,Low] |
| CORUM:7361 | 0.0499262710315 | 0.111111111111 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3R2 | PIK3R1 | 1.0 | 0.949 | bioplex (PIK3R2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R1 | PIK3CB | 0.981 | 0.896 | hein_WMM bioplex_WMM hein (PIK3R1) fraction |
| PIK3R3 | PIK3CA | 0.917 | 0.84 | hein_WMM bioplex (PIK3R3) bioplex_WMM hein (PIK3CA) |
| PIK3R3 | IRS2 | 0.885 | 0.817 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R2 | PIK3R3 | 0.878 | 0.812 | hein_WMM bioplex (PIK3R2,PIK3R3) bioplex_WMM gupta_WMM |
| PIK3R3 | PIK3CB | 0.699 | 0.721 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R3 | PIK3CD | 0.473 | 0.608 | bioplex (PIK3R3) bioplex_WMM |
| PIK3R3 | PIK3R1 | 0.224 | 0.466 | bioplex (PIK3R3) bioplex_WMM gupta_WMM |
| PIK3R1 | PIK3CA | 0.174 | 0.434 | hein_WMM bioplex_WMM hein (PIK3R1) |
| PIK3R2 | PIK3CA | 0.164 | 0.42 | hein_WMM bioplex_WMM hein (PIK3CA) |
| PIK3R2 | PIK3CB | 0.127 | 0.398 | bioplex (PIK3R2) bioplex_WMM |
| PIK3R2 | NISCH | 0.029 | 0.231 | bioplex (PIK3R2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3R1 | PIK3CD | 0.022 | 0.2 | hein_WMM bioplex_WMM hein (PIK3R1) |
| PIK3R1 | NYAP2 | 0.02 | 0.185 | hein_WMM hein (PIK3R1) |
| PIK3CA | PIK3CB | 0.02 | 0.189 | hein_WMM bioplex_WMM WMM_only |
| PIK3R1 | IRS2 | 0.012 | 0.147 | hein_WMM bioplex_WMM youn_WMM hein (PIK3R1) |
| PIK3R3 | NISCH | 0.011 | 0.139 | bioplex (PIK3R3) bioplex_WMM gupta_WMM |
| PIK3CD | IRS2 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| PIK3CD | PIK3CB | 0.009 | 0.108 | hein_WMM bioplex_WMM WMM_only |
| PIK3CD | PIK3CA | 0.009 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| PIK3CB | IRS2 | 0.008 | 0.086 | hein_WMM bioplex_WMM WMM_only |
| PIK3R1 | NISCH | 0.008 | 0.07 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| PIK3CD | NYAP2 | 0.008 | 0.062 | hein_WMM WMM_only |
| PIK3CB | NYAP2 | 0.008 | 0.062 | hein_WMM WMM_only |
| PIK3CA | IRS2 | 0.008 | 0.06 | hein_WMM bioplex_WMM WMM_only |
| PIK3CA | NYAP2 | 0.007 | 0.002 | hein_WMM WMM_only |
| IRS2 | NISCH | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| IRS2 | NYAP2 | 0.007 | 0.01 | hein_WMM WMM_only |
| PIK3R2 | IRS2 | 0.007 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| PIK3R2 | PIK3CD | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PIK3CD | NISCH | 0.007 | 0.008 | bioplex_WMM WMM_only |
| PIK3CB | NISCH | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PIK3CA | NISCH | 0.007 | 0.003 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_02534 has an average edge precision of 0.277 which is ranked 4922 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NISCH | HuMAP2_02534 |
| PIK3R1 | HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 |
| PIK3CB | HuMAP2_00730 HuMAP2_02534 HuMAP2_05290 |
| NYAP2 | HuMAP2_02534 |
| PIK3R3 | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |
| PIK3R2 | HuMAP2_00324 HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 HuMAP2_06494 |
| PIK3CD | HuMAP2_00730 HuMAP2_02534 |
| PIK3CA | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |
| IRS2 | HuMAP2_00730 HuMAP2_02534 HuMAP2_06506 |