hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02542
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | UniProt NCBI |
| PNP | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) | UniProt NCBI |
| UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1) | UniProt NCBI |
| EIF5A | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 6.03224412208e-05 | 0.5 | DOHH EIF5A | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 0.00596538345738 | 0.5 | DOHH EIF5A | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| HP:0002273 | 0.00920632571228 | 0.5 | UCHL1 PNP | Tetraparesis |
| CORUM:6208 | 0.0249595281251 | 0.25 | PNP | PNP homotrimer complex |
| CORUM:7105 | 0.0249595281251 | 0.25 | UCHL1 | PRRX1-UCHL1 complex |
| CORUM:7106 | 0.0249595281251 | 0.25 | UCHL1 | PRRX2-UCHL1 complex |
| WP:WP3302 | 0.0333519728792 | 0.25 | EIF5A | eIF5A regulation in response to inhibition of the nuclear export system |
| HP:0030182 | 0.0335949626331 | 0.5 | UCHL1 PNP | Tetraplegia/tetraparesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DOHH | EIF5A | 0.385 | 0.551 | bioplex (DOHH) bioplex_WMM |
| PNP | UCHL1 | 0.109 | 0.377 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| DOHH | UCHL1 | 0.108 | 0.373 | bioplex (DOHH) bioplex_WMM fraction |
| EIF5A | PNP | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| EIF5A | UCHL1 | 0.006 | 0.003 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM treiber_WMM |
| DOHH | PNP | 0.006 | 0.002 | bioplex (DOHH) bioplex_WMM |
Images
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Complex HuMAP2_02542 has an average edge precision of 0.218 which is ranked 5885 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DOHH | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 HuMAP2_05181 |
| PNP | HuMAP2_01944 HuMAP2_02509 HuMAP2_02542 HuMAP2_03554 HuMAP2_05985 |
| UCHL1 | HuMAP2_02542 |
| EIF5A | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 |