hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02545
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CCN2 | CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) | UniProt NCBI |
| CREBBP | CREB-binding protein (EC 2.3.1.48) | UniProt NCBI |
| EP300 | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | UniProt NCBI |
| CITED2 | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) | UniProt NCBI |
| C3orf62 | Uncharacterized protein C3orf62 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866907 | 2.28267971382e-07 | 0.6 | CITED2 CREBBP EP300 | Activation of the TFAP2 (AP-2) family of transcription factors |
| REAC:R-HSA-1234158 | 3.26064244298e-07 | 0.6 | CITED2 CREBBP EP300 | Regulation of gene expression by Hypoxia-inducible Factor |
| REAC:R-HSA-9614657 | 1.23570409997e-06 | 0.6 | CITED2 CREBBP EP300 | FOXO-mediated transcription of cell death genes |
| REAC:R-HSA-8864260 | 9.90965664735e-06 | 0.6 | CITED2 CREBBP EP300 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| CORUM:571 | 2.0123342217e-05 | 0.4 | CREBBP EP300 | p300-CBP-p270 complex |
| CORUM:4 | 4.0241279111e-05 | 0.4 | CREBBP EP300 | Multisubunit ACTR coactivator complex |
| HP:0001042 | 4.64766403483e-05 | 0.4 | CREBBP EP300 | High axial triradius |
| HP:0008107 | 4.64766403483e-05 | 0.4 | CREBBP EP300 | Plantar crease between first and second toes |
| HP:0005895 | 4.64766403483e-05 | 0.4 | CREBBP EP300 | Radial deviation of thumb terminal phalanx |
| REAC:R-HSA-9614085 | 8.34369774361e-05 | 0.6 | CITED2 CREBBP EP300 | FOXO-mediated transcription |
| CORUM:2638 | 0.000100576175246 | 0.4 | CREBBP EP300 | HES1 promoter corepressor complex |
| REAC:R-HSA-3134973 | 0.000134922692372 | 0.4 | CREBBP EP300 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production |
| HP:0010775 | 0.000139411195565 | 0.4 | CREBBP EP300 | Vascular ring |
| HP:0000756 | 0.000139411195565 | 0.4 | CREBBP EP300 | Agoraphobia |
| CORUM:570 | 0.000140787732431 | 0.4 | CREBBP EP300 | p300-CBP-p270-SWI/SNF complex |
| REAC:R-HSA-1234174 | 0.000175005907139 | 0.6 | CITED2 CREBBP EP300 | Cellular response to hypoxia |
| HP:0011087 | 0.000278784943944 | 0.4 | CREBBP EP300 | Talon cusp |
| HP:0010562 | 0.000278784943944 | 0.4 | CREBBP EP300 | Keloids |
| REAC:R-HSA-8878159 | 0.000338412904811 | 0.6 | EP300 CCN2 CREBBP | Transcriptional regulation by RUNX3 |
| HP:0009715 | 0.00046457916755 | 0.4 | CREBBP EP300 | Papillary cystadenoma of the epididymis |
| HP:0030421 | 0.00046457916755 | 0.4 | CREBBP EP300 | Epididymal neoplasm |
| HP:0004411 | 0.00046457916755 | 0.4 | CREBBP EP300 | Deviated nasal septum |
| HP:0001135 | 0.00046457916755 | 0.4 | CREBBP EP300 | Chorioretinal dystrophy |
| WP:WP3657 | 0.000509836133129 | 0.4 | CREBBP EP300 | Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex |
| REAC:R-HSA-9617629 | 0.000606744453221 | 0.4 | CREBBP EP300 | Regulation of FOXO transcriptional activity by acetylation |
| HP:0000273 | 0.000696775152219 | 0.4 | CREBBP EP300 | Facial grimacing |
| HP:0002700 | 0.000696775152219 | 0.4 | CREBBP EP300 | Large foramen magnum |
| HP:0000136 | 0.000696775152219 | 0.4 | CREBBP EP300 | Bifid uterus |
| HP:0010314 | 0.000696775152219 | 0.4 | CREBBP EP300 | Premature thelarche |
| GO:1903846 | 0.00103355958129 | 0.6 | CITED2 CREBBP EP300 | positive regulation of cellular response to transforming growth factor beta stimulus |
| GO:0030511 | 0.00103355958129 | 0.6 | CITED2 CREBBP EP300 | positive regulation of transforming growth factor beta receptor signaling pathway |
| REAC:R-HSA-3371568 | 0.00105126658749 | 0.4 | CREBBP EP300 | Attenuation phase |
| REAC:R-HSA-8941856 | 0.00105126658749 | 0.4 | CREBBP EP300 | RUNX3 regulates NOTCH signaling |
| REAC:R-HSA-918233 | 0.00122631290825 | 0.4 | CREBBP EP300 | TRAF3-dependent IRF activation pathway |
| REAC:R-HSA-210744 | 0.00122631290825 | 0.4 | CREBBP EP300 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| HP:0002699 | 0.00130029756695 | 0.4 | CREBBP EP300 | Abnormality of the foramen magnum |
| WP:WP4241 | 0.00144719807027 | 0.4 | CREBBP EP300 | Type 2 papillary renal cell carcinoma |
| WP:WP3414 | 0.00144719807027 | 0.4 | CREBBP EP300 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| HP:0002236 | 0.00167158658755 | 0.4 | CREBBP EP300 | Frontal upsweep of hair |
| HP:0002697 | 0.00167158658755 | 0.4 | CREBBP EP300 | Parietal foramina |
| HP:0011298 | 0.00167158658755 | 0.4 | CREBBP EP300 | Prominent digit pad |
| HP:0009714 | 0.00167158658755 | 0.4 | CREBBP EP300 | Abnormality of the epididymis |
| HP:0001212 | 0.00167158658755 | 0.4 | CREBBP EP300 | Prominent fingertip pads |
| REAC:R-HSA-1368082 | 0.00206071490935 | 0.4 | CREBBP EP300 | RORA activates gene expression |
| HP:0010181 | 0.00208920255027 | 0.4 | CREBBP EP300 | Duplication of phalanx of toe |
| HP:0010066 | 0.00208920255027 | 0.4 | CREBBP EP300 | Duplication of phalanx of hallux |
| REAC:R-HSA-9013695 | 0.00230284247734 | 0.4 | CREBBP EP300 | NOTCH4 Intracellular Domain Regulates Transcription |
| HP:0005324 | 0.0025531267598 | 0.4 | CREBBP EP300 | Disturbance of facial expression |
| HP:0011587 | 0.0025531267598 | 0.4 | CREBBP EP300 | Abnormal branching pattern of the aortic arch |
| REAC:R-HSA-5621575 | 0.00282729215335 | 0.4 | CREBBP EP300 | CD209 (DC-SIGN) signaling |
| HP:0025068 | 0.0030633405246 | 0.4 | CREBBP EP300 | Incomitant strabismus |
| HP:0009921 | 0.0030633405246 | 0.4 | CREBBP EP300 | Duane anomaly |
| WP:WP560 | 0.00314132080553 | 0.4 | CREBBP EP300 | TGF-beta Receptor Signaling |
| REAC:R-HSA-9013508 | 0.00340529843133 | 0.4 | CREBBP EP300 | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-3371571 | 0.00340529843133 | 0.4 | CREBBP EP300 | HSF1-dependent transactivation |
| HP:0010721 | 0.00422256197273 | 0.4 | CREBBP EP300 | Abnormal hair whorl |
| HP:0031938 | 0.00422256197273 | 0.4 | CREBBP EP300 | Abnormal conus terminalis morphology |
| HP:0002144 | 0.00422256197273 | 0.4 | CREBBP EP300 | Tethered cord |
| HP:0000419 | 0.00422256197273 | 0.4 | CREBBP EP300 | Abnormality of the nasal septum |
| HP:0002183 | 0.00422256197273 | 0.4 | CREBBP EP300 | Phonophobia |
| KEGG:04330 | 0.00461334650691 | 0.4 | CREBBP EP300 | Notch signaling pathway |
| HP:0009765 | 0.00487153229182 | 0.4 | CREBBP EP300 | Low hanging columella |
| REAC:R-HSA-186712 | 0.00546022370076 | 0.4 | CREBBP EP300 | Regulation of beta-cell development |
| REAC:R-HSA-933541 | 0.00546022370076 | 0.4 | CREBBP EP300 | TRAF6 mediated IRF7 activation |
| HP:0001869 | 0.00556671743772 | 0.4 | CREBBP EP300 | Deep plantar creases |
| HP:0000049 | 0.00556671743772 | 0.4 | CREBBP EP300 | Shawl scrotum |
| HP:0005743 | 0.00630809873773 | 0.4 | CREBBP EP300 | Avascular necrosis of the capital femoral epiphysis |
| WP:WP3651 | 0.00667641105618 | 0.4 | CREBBP EP300 | Pathways Affected in Adenoid Cystic Carcinoma |
| HP:0002869 | 0.00709565752293 | 0.4 | CREBBP EP300 | Flared iliac wings |
| HP:0002696 | 0.00709565752293 | 0.4 | CREBBP EP300 | Abnormal parietal bone morphology |
| HP:0002370 | 0.00709565752293 | 0.4 | CREBBP EP300 | Poor coordination |
| HP:0000579 | 0.00792937512816 | 0.4 | CREBBP EP300 | Nasolacrimal duct obstruction |
| HP:0025112 | 0.00792937512816 | 0.4 | CREBBP EP300 | Sound sensitivity |
| HP:0002866 | 0.00792937512816 | 0.4 | CREBBP EP300 | Hypoplastic iliac wing |
| KEGG:04720 | 0.00805388520034 | 0.4 | CREBBP EP300 | Long-term potentiation |
| KEGG:05211 | 0.00831682765542 | 0.4 | CREBBP EP300 | Renal cell carcinoma |
| HP:0011355 | 0.00846318146995 | 0.8 | EP300 CITED2 CCN2 CREBBP | Localized skin lesion |
| HP:0000520 | 0.00879065778809 | 0.6 | CITED2 CREBBP EP300 | Proptosis |
| KEGG:04520 | 0.00998234880291 | 0.4 | CREBBP EP300 | Adherens junction |
| WP:WP4018 | 0.0104424923561 | 0.4 | CREBBP EP300 | Pathways in clear cell renal cell carcinoma |
| REAC:R-HSA-3899300 | 0.0104745816743 | 0.4 | CREBBP EP300 | SUMOylation of transcription cofactors |
| HP:0009617 | 0.0107072942689 | 0.4 | CREBBP EP300 | Abnormality of the distal phalanx of the thumb |
| HP:0000742 | 0.0107072942689 | 0.4 | CREBBP EP300 | Self-mutilation |
| REAC:R-HSA-2122947 | 0.012121451174 | 0.4 | CREBBP EP300 | NOTCH1 Intracellular Domain Regulates Transcription |
| WP:WP138 | 0.0126363339816 | 0.4 | CREBBP EP300 | Androgen receptor signaling pathway |
| REAC:R-HSA-9012852 | 0.0126969553517 | 0.4 | CREBBP EP300 | Signaling by NOTCH3 |
| KEGG:04350 | 0.0127624438559 | 0.4 | CREBBP EP300 | TGF-beta signaling pathway |
| HP:0002870 | 0.0127896924378 | 0.4 | CREBBP EP300 | Obstructive sleep apnea |
| HP:0100323 | 0.0127896924378 | 0.4 | CREBBP EP300 | Juvenile aseptic necrosis |
| HP:0001335 | 0.0127896924378 | 0.4 | CREBBP EP300 | Bimanual synkinesia |
| HP:0002088 | 0.0138760898251 | 0.8 | EP300 CITED2 CCN2 CREBBP | Abnormal lung morphology |
| HP:0003083 | 0.0138999712057 | 0.4 | CREBBP EP300 | Dislocated radial head |
| HP:0011481 | 0.0150562782431 | 0.4 | CREBBP EP300 | Abnormal lacrimal duct morphology |
| HP:0003995 | 0.0150562782431 | 0.4 | CREBBP EP300 | Abnormality of the radial head |
| WP:WP399 | 0.0153509614858 | 0.4 | CREBBP EP300 | Wnt Signaling Pathway and Pluripotency |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | EP300 CITED2 CCN2 CREBBP | Generic Transcription Pathway |
| KEGG:04916 | 0.016617964273 | 0.4 | CREBBP EP300 | Melanogenesis |
| KEGG:05215 | 0.0169933560846 | 0.4 | CREBBP EP300 | Prostate cancer |
| HP:0004209 | 0.0178412399264 | 0.6 | CITED2 CREBBP EP300 | Clinodactyly of the 5th finger |
| HP:0009179 | 0.0183132582526 | 0.6 | CITED2 CREBBP EP300 | Deviation of the 5th finger |
| REAC:R-HSA-2894858 | 0.0184727645209 | 0.4 | CREBBP EP300 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894862 | 0.0184727645209 | 0.4 | CREBBP EP300 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644606 | 0.0184727645209 | 0.4 | CREBBP EP300 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2644603 | 0.0184727645209 | 0.4 | CREBBP EP300 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644602 | 0.0184727645209 | 0.4 | CREBBP EP300 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| HP:0011063 | 0.0188011826397 | 0.4 | CREBBP EP300 | Abnormality of incisor morphology |
| KEGG:04922 | 0.0193326076279 | 0.4 | CREBBP EP300 | Glucagon signaling pathway |
| HP:0005306 | 0.0201414164419 | 0.4 | CREBBP EP300 | Capillary hemangioma |
| KEGG:04066 | 0.020974746694 | 0.4 | CREBBP EP300 | HIF-1 signaling pathway |
| HP:0011061 | 0.0215839586173 | 0.6 | EP300 CCN2 CREBBP | Abnormality of dental structure |
| WP:WP4217 | 0.0226950547009 | 0.4 | CREBBP EP300 | Ebola Virus Pathway on Host |
| HP:0100744 | 0.0229596708254 | 0.4 | CREBBP EP300 | Abnormality of the humeroradial joint |
| HP:0040019 | 0.023494903838 | 0.6 | CITED2 CREBBP EP300 | Finger clinodactyly |
| HP:0012303 | 0.0244376541782 | 0.4 | CREBBP EP300 | Abnormal aortic arch morphology |
| HP:0010057 | 0.0244376541782 | 0.4 | CREBBP EP300 | Abnormality of the phalanges of the hallux |
| WP:WP366 | 0.0250517914711 | 0.4 | CREBBP EP300 | TGF-beta Signaling Pathway |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | EP300 CITED2 CCN2 CREBBP | RNA Polymerase II Transcription |
| HP:0012252 | 0.0256832651071 | 0.8 | EP300 CITED2 CCN2 CREBBP | Abnormal respiratory system morphology |
| REAC:R-HSA-1834949 | 0.0261457156832 | 0.4 | CREBBP EP300 | Cytosolic sensors of pathogen-associated DNA |
| WP:WP706 | 0.0266864861787 | 0.4 | CREBBP EP300 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| KEGG:04919 | 0.0267668372004 | 0.4 | CREBBP EP300 | Thyroid hormone signaling pathway |
| REAC:R-HSA-1980143 | 0.0269854937899 | 0.4 | CREBBP EP300 | Signaling by NOTCH1 |
| GO:0018076 | 0.0270421395626 | 0.4 | CREBBP EP300 | N-terminal peptidyl-lysine acetylation |
| KEGG:04068 | 0.0272411437938 | 0.4 | CREBBP EP300 | FoxO signaling pathway |
| REAC:R-HSA-400253 | 0.0278384291304 | 0.4 | CREBBP EP300 | Circadian Clock |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | CITED2 CREBBP EP300 | Cellular responses to stress |
| HP:0001956 | 0.0291468055875 | 0.4 | CREBBP EP300 | Truncal obesity |
| HP:0001631 | 0.0292374582023 | 0.6 | CITED2 CREBBP EP300 | Atrial septal defect |
| HP:0011603 | 0.0295629530581 | 0.6 | CITED2 CREBBP EP300 | Congenital malformation of the great arteries |
| HP:0011994 | 0.0295629530581 | 0.6 | CITED2 CREBBP EP300 | Abnormal atrial septum morphology |
| KEGG:04110 | 0.0301730300338 | 0.4 | CREBBP EP300 | Cell cycle |
| KEGG:04630 | 0.030676003082 | 0.4 | CREBBP EP300 | JAK-STAT signaling pathway |
| HP:0010055 | 0.0325153883173 | 0.4 | CREBBP EP300 | Broad hallux |
| HP:0000946 | 0.0325153883173 | 0.4 | CREBBP EP300 | Hypoplastic ilia |
| HP:0005120 | 0.0326006997834 | 0.6 | CITED2 CREBBP EP300 | Abnormal cardiac atrium morphology |
| REAC:R-HSA-168928 | 0.0341769281663 | 0.4 | CREBBP EP300 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| WP:WP4666 | 0.0341988987854 | 0.4 | CREBBP EP300 | Hepatitis B infection |
| HP:0001629 | 0.035837654624 | 0.6 | CITED2 CREBBP EP300 | Ventricular septal defect |
| HP:0009929 | 0.0360671162807 | 0.4 | CREBBP EP300 | Abnormality of the columella |
| HP:0002999 | 0.0360671162807 | 0.4 | CREBBP EP300 | Patellar dislocation |
| HP:0010438 | 0.0384968933304 | 0.6 | CITED2 CREBBP EP300 | Abnormal ventricular septum morphology |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | EP300 CITED2 CCN2 CREBBP | Gene expression (Transcription) |
| HP:0010574 | 0.0398018408038 | 0.4 | CREBBP EP300 | Abnormality of the epiphysis of the femoral head |
| REAC:R-HSA-381340 | 0.0401214552357 | 0.4 | CREBBP EP300 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-9013694 | 0.0411580285567 | 0.4 | CREBBP EP300 | Signaling by NOTCH4 |
| HP:0006499 | 0.0437194132729 | 0.4 | CREBBP EP300 | Abnormality of femoral epiphysis |
| KEGG:04310 | 0.0451834163131 | 0.4 | CREBBP EP300 | Wnt signaling pathway |
| HP:0006500 | 0.0457467210618 | 0.4 | CREBBP EP300 | Abnormality of lower limb epiphysis morphology |
| KEGG:05164 | 0.0457961859483 | 0.4 | CREBBP EP300 | Influenza A |
| KEGG:05152 | 0.0470338525035 | 0.4 | CREBBP EP300 | Tuberculosis |
| HP:0004097 | 0.0472480670031 | 0.6 | CITED2 CREBBP EP300 | Deviation of finger |
| REAC:R-HSA-3371556 | 0.0476518941102 | 0.4 | CREBBP EP300 | Cellular response to heat stress |
| HP:0002094 | 0.0476946051304 | 0.6 | EP300 CCN2 CREBBP | Dyspnea |
| HP:0000614 | 0.0478196851342 | 0.4 | CREBBP EP300 | Abnormal nasolacrimal system morphology |
| HP:0000022 | 0.0478196851342 | 0.4 | CREBBP EP300 | Abnormality of male internal genitalia |
| HP:0004207 | 0.0485960101036 | 0.6 | CITED2 CREBBP EP300 | Abnormal 5th finger morphology |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | CITED2 CREBBP EP300 | Cellular responses to external stimuli |
| HP:0001837 | 0.0499382869304 | 0.4 | CREBBP EP300 | Broad toe |
| CORUM:2958 | 0.0499494897235 | 0.2 | CREBBP | SMAD1-CBP complex |
| CORUM:6590 | 0.0499494897235 | 0.2 | CREBBP | FOXO3-CBP complex |
| CORUM:5573 | 0.0499494897235 | 0.2 | CREBBP | Stat1-alpha-dimer-CBP DNA-protein complex |
| CORUM:3749 | 0.0499494897235 | 0.2 | CREBBP | CREBBP-SMAD2 hexameric complex |
| CORUM:5375 | 0.0499494897235 | 0.2 | EP300 | EGR-EP300 complex |
| CORUM:1158 | 0.0499494897235 | 0.2 | EP300 | p33ING1b-p300 complex |
| CORUM:2641 | 0.0499494897235 | 0.2 | CREBBP | CREBBP-KAT2B-MYOD1 complex |
| CORUM:3750 | 0.0499494897235 | 0.2 | CREBBP | CREBBP-SMAD3 hexameric complex |
| CORUM:2642 | 0.0499494897235 | 0.2 | EP300 | SMAD1-P300 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EP300 | C3orf62 | 0.275 | 0.487 | bioplex (C3orf62) bioplex_WMM |
| CCN2 | EP300 | 0.267 | 0.483 | bioplex (CCN2) bioplex_WMM |
| EP300 | CITED2 | 0.059 | 0.332 | hein_WMM hein (EP300) |
| CREBBP | EP300 | 0.041 | 0.269 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| CREBBP | C3orf62 | 0.02 | 0.186 | bioplex (C3orf62) bioplex_WMM |
| CREBBP | CCN2 | 0.013 | 0.15 | bioplex (CCN2) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_02545 has an average edge precision of 0.318 which is ranked 4375 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CCN2 | HuMAP2_02545 HuMAP2_06609 |
| CREBBP | HuMAP2_02530 HuMAP2_02545 |
| EP300 | HuMAP2_02545 HuMAP2_06609 |
| CITED2 | HuMAP2_02545 HuMAP2_06609 |
| C3orf62 | HuMAP2_02545 HuMAP2_06609 |