hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02547
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP1R8 | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)] | UniProt NCBI |
| PPP1R2 | Protein phosphatase inhibitor 2 (IPP-2) | UniProt NCBI |
| PPP1CA | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PP-1A) (EC 3.1.3.16) | UniProt NCBI |
| PPP1CB | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53) | UniProt NCBI |
| PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2173788 | 3.60987410111e-06 | 0.6 | PPP1CA PPP1CB PPP1CC | Downregulation of TGF-beta receptor signaling |
| REAC:R-HSA-163560 | 4.17943282079e-06 | 0.6 | PPP1CA PPP1CB PPP1CC | Triglyceride catabolism |
| WP:WP2636 | 5.65516175491e-06 | 0.6 | PPP1CA PPP1CB PPP1CC | Common Pathways Underlying Drug Addiction |
| REAC:R-HSA-2173789 | 7.93420714119e-06 | 0.6 | PPP1CA PPP1CB PPP1CC | TGF-beta receptor signaling activates SMADs |
| GO:0006470 | 8.60332857394e-06 | 1.0 | PPP1CC PPP1R8 PPP1CA PPP1CB PPP1R2 | protein dephosphorylation |
| REAC:R-HSA-8979227 | 1.62204393343e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | Triglyceride metabolism |
| GO:0072357 | 3.17736949706e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | PTW/PP1 phosphatase complex |
| KEGG:04720 | 3.25178756029e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | Long-term potentiation |
| KEGG:05031 | 3.25178756029e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | Amphetamine addiction |
| KEGG:04750 | 7.32179527008e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | Inflammatory mediator regulation of TRP channels |
| GO:0016311 | 7.95557043395e-05 | 1.0 | PPP1CC PPP1R8 PPP1CA PPP1CB PPP1R2 | dephosphorylation |
| KEGG:03015 | 9.41040777628e-05 | 0.6 | PPP1CA PPP1CB PPP1CC | mRNA surveillance pathway |
| WP:WP4541 | 0.00011435890921 | 0.6 | PPP1CA PPP1CB PPP1CC | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-400253 | 0.000118030564163 | 0.6 | PPP1CA PPP1CB PPP1CC | Circadian Clock |
| KEGG:04270 | 0.000134356221711 | 0.6 | PPP1CA PPP1CB PPP1CC | Vascular smooth muscle contraction |
| REAC:R-HSA-170834 | 0.000135380656388 | 0.6 | PPP1CA PPP1CB PPP1CC | Signaling by TGF-beta Receptor Complex |
| KEGG:04931 | 0.00014703288327 | 0.6 | PPP1CA PPP1CB PPP1CC | Insulin resistance |
| KEGG:04114 | 0.000169883843985 | 0.6 | PPP1CA PPP1CB PPP1CC | Oocyte meiosis |
| KEGG:04611 | 0.000189775187446 | 0.6 | PPP1CA PPP1CB PPP1CC | Platelet activation |
| KEGG:04728 | 0.000246133668344 | 0.6 | PPP1CA PPP1CB PPP1CC | Dopaminergic synapse |
| KEGG:04910 | 0.000271467766564 | 0.6 | PPP1CA PPP1CB PPP1CC | Insulin signaling pathway |
| KEGG:04261 | 0.000298475605268 | 0.6 | PPP1CA PPP1CB PPP1CC | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-9006936 | 0.000306125075711 | 0.6 | PPP1CA PPP1CB PPP1CC | Signaling by TGF-beta family members |
| KEGG:04921 | 0.000342240622109 | 0.6 | PPP1CA PPP1CB PPP1CC | Oxytocin signaling pathway |
| KEGG:04022 | 0.000390066928635 | 0.6 | PPP1CA PPP1CB PPP1CC | cGMP-PKG signaling pathway |
| KEGG:04390 | 0.000398445237125 | 0.6 | PPP1CA PPP1CB PPP1CC | Hippo signaling pathway |
| KEGG:04218 | 0.000424294655338 | 0.6 | PPP1CA PPP1CB PPP1CC | Cellular senescence |
| WP:WP3594 | 0.00046043508805 | 0.6 | PPP1CA PPP1CB PPP1CC | Circadian rhythm related genes |
| KEGG:05034 | 0.000636959120994 | 0.6 | PPP1CA PPP1CB PPP1CC | Alcoholism |
| KEGG:04024 | 0.000684138808884 | 0.6 | PPP1CA PPP1CB PPP1CC | cAMP signaling pathway |
| WP:WP306 | 0.000719570270021 | 0.6 | PPP1CA PPP1CB PPP1CC | Focal Adhesion |
| GO:0043153 | 0.000739960245213 | 0.6 | PPP1CA PPP1CB PPP1CC | entrainment of circadian clock by photoperiod |
| GO:0009648 | 0.000878614215261 | 0.6 | PPP1CA PPP1CB PPP1CC | photoperiodism |
| KEGG:04810 | 0.000910491071115 | 0.6 | PPP1CA PPP1CB PPP1CC | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.000925161775741 | 0.6 | PPP1CA PPP1CB PPP1CC | Proteoglycans in cancer |
| KEGG:04510 | 0.000939988213226 | 0.6 | PPP1CA PPP1CB PPP1CC | Focal adhesion |
| GO:0009649 | 0.00120569794977 | 0.6 | PPP1CA PPP1CB PPP1CC | entrainment of circadian clock |
| KEGG:05168 | 0.00749393790538 | 0.6 | PPP1CA PPP1CB PPP1CC | Herpes simplex virus 1 infection |
| GO:1903293 | 0.00826983957236 | 0.6 | PPP1CA PPP1CB PPP1CC | phosphatase complex |
| GO:0008287 | 0.00826983957236 | 0.6 | PPP1CA PPP1CB PPP1CC | protein serine/threonine phosphatase complex |
| GO:0032922 | 0.0250406933376 | 0.6 | PPP1CA PPP1CB PPP1CC | circadian regulation of gene expression |
| GO:0004722 | 0.0412952841175 | 0.6 | PPP1CA PPP1CB PPP1CC | protein serine/threonine phosphatase activity |
| CORUM:180 | 0.0499494897235 | 0.2 | PPP1CA | PNUTS-PP1 complex |
| CORUM:7423 | 0.0499494897235 | 0.2 | PPP1CA | PPP1CA-PPP1R13L complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PPP1R2 | PPP1CC | 1.0 | 0.949 | hein_WMM bioplex (PPP1CC) bioplex_WMM Guru boldt youn_WMM hein (PPP1CC) gupta_WMM fraction boldt_WMM |
| PPP1R8 | PPP1CC | 1.0 | 0.949 | hein_WMM bioplex (PPP1CC) bioplex_WMM boldt youn_WMM hein (PPP1CC) fraction boldt_WMM |
| PPP1CA | PPP1CC | 1.0 | 0.949 | hein_WMM bioplex (PPP1CA,PPP1CC) bioplex_WMM boldt (PPP1CA) youn_WMM hein (PPP1CC) Malo gupta_WMM fraction boldt_WMM |
| PPP1CB | PPP1CA | 1.0 | 0.949 | hein_WMM bioplex (PPP1CA) bioplex_WMM boldt youn_WMM hein (PPP1CB) Malo gupta_WMM fraction boldt_WMM |
| PPP1R8 | PPP1CA | 1.0 | 0.949 | hein_WMM bioplex (PPP1CA) bioplex_WMM boldt (PPP1CA) youn_WMM fraction boldt_WMM |
| PPP1CB | PPP1CC | 1.0 | 0.949 | hein_WMM bioplex (PPP1CC) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| PPP1R2 | PPP1CA | 0.999 | 0.949 | hein_WMM bioplex (PPP1CA) bioplex_WMM boldt (PPP1CA) youn_WMM gupta_WMM boldt_WMM |
| PPP1CB | PPP1R2 | 0.354 | 0.539 | hein_WMM bioplex_WMM Guru boldt (PPP1CB) youn_WMM hein (PPP1CB) gupta_WMM fraction boldt_WMM |
| PPP1R8 | PPP1R2 | 0.021 | 0.191 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| PPP1R8 | PPP1CB | 0.019 | 0.186 | hein_WMM bioplex_WMM boldt (PPP1CB) youn_WMM hein (PPP1CB) boldt_WMM |
Images
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Complex HuMAP2_02547 has an average edge precision of 0.756 which is ranked 1117 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PPP1R8 | HuMAP2_00684 HuMAP2_02547 HuMAP2_03280 HuMAP2_03724 HuMAP2_06520 |
| PPP1R2 | HuMAP2_02547 HuMAP2_06945 |
| PPP1CA | HuMAP2_02547 HuMAP2_06738 |
| PPP1CB | HuMAP2_02074 HuMAP2_02547 HuMAP2_05298 HuMAP2_05638 |
| PPP1CC | HuMAP2_02547 HuMAP2_06738 |