hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02549
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPHB4 | Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11) | UniProt NCBI |
| EFNB2 | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | UniProt NCBI |
| EFNB1 | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | UniProt NCBI |
| SDC3 | Syndecan-3 (SYND3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928664 | 9.1766670065e-07 | 0.75 | EFNB1 EPHB4 EFNB2 | Ephrin signaling |
| REAC:R-HSA-3928662 | 1.23194951195e-05 | 0.75 | EFNB1 EPHB4 EFNB2 | EPHB-mediated forward signaling |
| REAC:R-HSA-3928665 | 2.0455616978e-05 | 0.75 | EFNB1 EPHB4 EFNB2 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-2682334 | 0.00013762853655 | 0.75 | EFNB1 EPHB4 EFNB2 | EPH-Ephrin signaling |
| KEGG:04360 | 0.000196203606831 | 0.75 | EFNB1 EPHB4 EFNB2 | Axon guidance |
| WP:WP4561 | 0.000502988822667 | 0.5 | EFNB2 EFNB1 | Cell migration and invasion through p75NTR |
| MIRNA:hsa-miR-3689f | 0.017952543721 | 0.5 | EFNB2 SDC3 | hsa-miR-3689f |
| MIRNA:hsa-miR-3689a-5p | 0.0187858608682 | 0.5 | EFNB2 SDC3 | hsa-miR-3689a-5p |
| MIRNA:hsa-miR-3689b-5p | 0.0187858608682 | 0.5 | EFNB2 SDC3 | hsa-miR-3689b-5p |
| MIRNA:hsa-miR-3689e | 0.0187858608682 | 0.5 | EFNB2 SDC3 | hsa-miR-3689e |
| GO:0048013 | 0.0264744736345 | 0.75 | EFNB1 EPHB4 EFNB2 | ephrin receptor signaling pathway |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | EFNB1 EPHB4 EFNB2 | Axon guidance |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EFNB2 | EFNB1 | 1.0 | 0.949 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EFNB2 | SDC3 | 0.903 | 0.827 | bioplex (EFNB2) bioplex_WMM |
| EPHB4 | EFNB2 | 0.679 | 0.708 | bioplex (EFNB2) bioplex_WMM gupta_WMM |
| EPHB4 | SDC3 | 0.008 | 0.029 | bioplex_WMM WMM_only |
| EFNB1 | SDC3 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| EPHB4 | EFNB1 | 0.007 | 0.0 | bioplex_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_02549 has an average edge precision of 0.423 which is ranked 3083 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPHB4 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 |
| EFNB2 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| EFNB1 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |
| SDC3 | HuMAP2_00251 HuMAP2_02549 HuMAP2_03654 HuMAP2_05092 |