hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02565
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLINT1 | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | UniProt NCBI |
| CLTCL1 | Clathrin heavy chain 2 (Clathrin heavy chain on chromosome 22) (CLH-22) | UniProt NCBI |
| STAMBPL1 | AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1) | UniProt NCBI |
| STON2 | Stonin-2 (Stoned B) | UniProt NCBI |
| BMP2K | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | UniProt NCBI |
| SMAP2 | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | UniProt NCBI |
| PICALM | Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein) | UniProt NCBI |
| CLTB | Clathrin light chain B (Lcb) | UniProt NCBI |
| GAK | Cyclin-G-associated kinase (EC 2.7.11.1) | UniProt NCBI |
| PIK3C2A | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha) | UniProt NCBI |
| GTSE1 | G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8856828 | 3.67217221731e-08 | 0.545454545455 | GAK CLTCL1 CLTB STON2 PIK3C2A PICALM | Clathrin-mediated endocytosis |
| REAC:R-HSA-199992 | 2.27075460244e-07 | 0.454545454545 | GAK PICALM CLTB CLINT1 PIK3C2A | trans-Golgi Network Vesicle Budding |
| GO:0030276 | 2.80210849534e-06 | 0.454545454545 | CLTCL1 PICALM CLTB CLINT1 GAK | clathrin binding |
| REAC:R-HSA-199991 | 8.37499384313e-06 | 0.636363636364 | GAK CLTCL1 CLTB CLINT1 STON2 PIK3C2A PICALM | Membrane Trafficking |
| REAC:R-HSA-432722 | 1.09583582513e-05 | 0.363636363636 | GAK PICALM CLINT1 PIK3C2A | Golgi Associated Vesicle Biogenesis |
| REAC:R-HSA-5653656 | 1.21177317663e-05 | 0.636363636364 | GAK CLTCL1 CLTB CLINT1 STON2 PIK3C2A PICALM | Vesicle-mediated transport |
| GO:0006897 | 4.73098980678e-05 | 0.636363636364 | GAK CLTCL1 CLTB STON2 PIK3C2A BMP2K PICALM | endocytosis |
| REAC:R-HSA-8856825 | 8.34948143766e-05 | 0.363636363636 | CLTCL1 PICALM CLTB STON2 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0072583 | 0.000250749065309 | 0.363636363636 | GAK BMP2K CLTB PICALM | clathrin-dependent endocytosis |
| GO:0098657 | 0.000316161939786 | 0.636363636364 | GAK CLTCL1 CLTB STON2 PIK3C2A BMP2K PICALM | import into cell |
| GO:0048268 | 0.00328477723547 | 0.272727272727 | PIK3C2A CLTB PICALM | clathrin coat assembly |
| GO:0006898 | 0.00592810412069 | 0.454545454545 | CLTCL1 BMP2K PICALM CLTB GAK | receptor-mediated endocytosis |
| REAC:R-HSA-196025 | 0.0059596653991 | 0.181818181818 | CLTCL1 CLTB | Formation of annular gap junctions |
| REAC:R-HSA-190873 | 0.00714871709538 | 0.181818181818 | CLTCL1 CLTB | Gap junction degradation |
| GO:1905224 | 0.0247952876258 | 0.181818181818 | GAK PICALM | clathrin-coated pit assembly |
| KEGG:04144 | 0.0249651242209 | 0.272727272727 | CLTCL1 CLTB SMAP2 | Endocytosis |
| KEGG:04961 | 0.0268399486057 | 0.181818181818 | CLTCL1 CLTB | Endocrine and other factor-regulated calcium reabsorption |
| GO:0030118 | 0.0341613355681 | 0.272727272727 | CLTCL1 CLTB PICALM | clathrin coat |
| KEGG:04721 | 0.0481126379603 | 0.181818181818 | CLTCL1 CLTB | Synaptic vesicle cycle |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3C2A | PICALM | 0.807 | 0.767 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| CLTCL1 | PICALM | 0.758 | 0.748 | hein_WMM bioplex (PICALM) bioplex_WMM hein (PICALM) gupta_WMM |
| PICALM | BMP2K | 0.751 | 0.743 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| CLTCL1 | STAMBPL1 | 0.662 | 0.698 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| CLTB | CLINT1 | 0.47 | 0.605 | hein_WMM bioplex (CLINT1) bioplex_WMM boldt hein (CLTB) boldt_WMM |
| CLTCL1 | CLTB | 0.459 | 0.598 | hein_WMM bioplex_WMM Guru hein (CLTB) fraction |
| CLTB | PICALM | 0.338 | 0.527 | hein_WMM bioplex (PICALM) bioplex_WMM hein (CLTB,PICALM) |
| PIK3C2A | STAMBPL1 | 0.33 | 0.52 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| STAMBPL1 | GTSE1 | 0.294 | 0.495 | hein_WMM bioplex (STAMBPL1) bioplex_WMM hein (GTSE1) |
| GAK | STAMBPL1 | 0.274 | 0.486 | hein_WMM bioplex (STAMBPL1) bioplex_WMM hein (GAK) |
| BMP2K | CLINT1 | 0.27 | 0.483 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| SMAP2 | CLINT1 | 0.268 | 0.482 | hein_WMM youn (SMAP2) bioplex (CLINT1) bioplex_WMM boldt youn_WMM boldt_WMM |
| GTSE1 | PICALM | 0.216 | 0.464 | hein_WMM bioplex (PICALM) bioplex_WMM youn_WMM hein (GTSE1,PICALM) gupta_WMM |
| CLTCL1 | CLINT1 | 0.201 | 0.45 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| CLTB | STON2 | 0.117 | 0.389 | hein_WMM bioplex_WMM hein (CLTB) |
| CLTB | BMP2K | 0.115 | 0.385 | hein_WMM bioplex_WMM hein (CLTB) |
| STAMBPL1 | PICALM | 0.109 | 0.378 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| CLTB | GTSE1 | 0.085 | 0.35 | hein_WMM bioplex (GTSE1) bioplex_WMM hein (CLTB,GTSE1) |
| STON2 | PICALM | 0.077 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (PICALM) gupta_WMM |
| PIK3C2A | CLINT1 | 0.075 | 0.357 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| PICALM | CLINT1 | 0.055 | 0.311 | hein_WMM bioplex (PICALM) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STON2 | CLINT1 | 0.054 | 0.302 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| STAMBPL1 | CLINT1 | 0.051 | 0.297 | hein_WMM bioplex (STAMBPL1) bioplex_WMM gupta_WMM |
| GTSE1 | CLINT1 | 0.044 | 0.276 | hein_WMM bioplex (GTSE1) bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM fraction |
| PIK3C2A | CLTB | 0.039 | 0.265 | hein_WMM bioplex_WMM hein (CLTB) |
| SMAP2 | PIK3C2A | 0.026 | 0.215 | hein_WMM youn (SMAP2) bioplex_WMM youn_WMM |
| PIK3C2A | GTSE1 | 0.025 | 0.212 | hein_WMM bioplex_WMM youn_WMM hein (GTSE1) gupta_WMM |
| STON2 | GTSE1 | 0.024 | 0.214 | hein_WMM bioplex_WMM hein (GTSE1) gupta_WMM |
| GTSE1 | BMP2K | 0.021 | 0.185 | hein_WMM bioplex_WMM hein (GTSE1) gupta_WMM |
| STAMBPL1 | BMP2K | 0.02 | 0.188 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| CLTCL1 | GTSE1 | 0.019 | 0.182 | hein_WMM bioplex_WMM hein (GTSE1) gupta_WMM |
| GAK | CLTCL1 | 0.018 | 0.178 | hein_WMM bioplex_WMM hein (GAK) gupta_WMM |
| CLTB | STAMBPL1 | 0.018 | 0.178 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| STON2 | BMP2K | 0.018 | 0.176 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GAK | STON2 | 0.016 | 0.161 | hein_WMM bioplex_WMM youn_WMM hein (GAK) |
| GAK | BMP2K | 0.015 | 0.146 | hein_WMM bioplex_WMM youn_WMM hein (GAK) |
| STAMBPL1 | STON2 | 0.015 | 0.139 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| SMAP2 | PICALM | 0.013 | 0.155 | hein_WMM youn (SMAP2) bioplex_WMM boldt youn_WMM boldt_WMM |
| PIK3C2A | BMP2K | 0.013 | 0.152 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CLTCL1 | PIK3C2A | 0.011 | 0.133 | hein_WMM bioplex_WMM WMM_only |
| GAK | PIK3C2A | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM hein (GAK) gupta_WMM |
| CLTCL1 | BMP2K | 0.01 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| SMAP2 | STAMBPL1 | 0.009 | 0.109 | hein_WMM bioplex (STAMBPL1) bioplex_WMM |
| CLTCL1 | STON2 | 0.009 | 0.098 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| PIK3C2A | STON2 | 0.008 | 0.095 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SMAP2 | STON2 | 0.008 | 0.067 | hein_WMM youn (SMAP2) bioplex_WMM |
| CLTCL1 | SMAP2 | 0.007 | 0.003 | hein_WMM bioplex_WMM WMM_only |
| SMAP2 | CLTB | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| SMAP2 | BMP2K | 0.006 | 0.006 | hein_WMM youn (SMAP2) bioplex_WMM youn_WMM |
| GAK | SMAP2 | 0.006 | 0.01 | hein_WMM youn (SMAP2) bioplex_WMM youn_WMM |
| GAK | GTSE1 | 0.005 | 0.007 | hein_WMM bioplex_WMM youn_WMM hein (GAK,GTSE1) gupta_WMM |
| SMAP2 | GTSE1 | 0.004 | 0.01 | hein_WMM bioplex_WMM youn_WMM hein (GTSE1) |
| GAK | CLTB | 0.004 | 0.018 | hein_WMM bioplex_WMM hein (CLTB,GAK) |
| GAK | PICALM | 0.0 | 0.009 | hein_WMM bioplex_WMM youn_WMM hein (GAK,PICALM) gupta_WMM |
| GAK | CLINT1 | 0.0 | 0.001 | hein_WMM bioplex_WMM youn_WMM hein (GAK) gupta_WMM fraction |
Images
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Complex HuMAP2_02565 has an average edge precision of 0.273 which is ranked 4981 out of all 6965 complexes.
Related Complexes