hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02578
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CLNS1A | Methylosome subunit pICln (Chloride channel, nucleotide sensitive 1A) (Chloride conductance regulatory protein ICln) (I(Cln)) (Chloride ion current inducer protein) (ClCI) (Reticulocyte pICln) | UniProt NCBI |
| SNRPN | Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein D) (Sm-D) (Sm protein N) (Sm-N) (SmN) (Tissue-specific-splicing protein) | UniProt NCBI |
| SNRPB | Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/B') (SmB/B') | UniProt NCBI |
| CMTR2 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC 2.1.1.296) (Cap methyltransferase 2) (Cap2 2'O-ribose methyltransferase 2) (HMTr2) (MTr2) (FtsJ methyltransferase domain-containing protein 1) (Protein adrift homolog) | UniProt NCBI |
| SNRPD2 | Small nuclear ribonucleoprotein Sm D2 (Sm-D2) (snRNP core protein D2) | UniProt NCBI |
| SNRPF | Small nuclear ribonucleoprotein F (snRNP-F) (Sm protein F) (Sm-F) (SmF) | UniProt NCBI |
| CCDC84 | Coiled-coil domain-containing protein 84 | UniProt NCBI |
| SNRPG | Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG) | UniProt NCBI |
| LSM10 | U7 snRNA-associated Sm-like protein LSm10 | UniProt NCBI |
| TOE1 | Target of EGR1 protein 1 | UniProt NCBI |
| SNRPE | Small nuclear ribonucleoprotein E (snRNP-E) (Sm protein E) (Sm-E) (SmE) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:835 | 5.77533703383e-17 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | 6S methyltransferase and RG-containing Sm proteins complex |
| CORUM:1745 | 1.03026252704e-14 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | SMN complex |
| CORUM:1068 | 1.03026252704e-14 | 0.545454545455 | TOE1 SNRPF SNRPD2 SNRPE SNRPB SNRPG | 12S U11 snRNP |
| CORUM:2757 | 1.07475929606e-13 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | SMN complex, U7 snRNA specific |
| GO:0005687 | 3.19913768116e-13 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | U4 snRNP |
| CORUM:1142 | 6.44422489706e-13 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | SMN complex |
| GO:0034709 | 1.40681009827e-12 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | methylosome |
| GO:0120114 | 2.04979800456e-12 | 0.727272727273 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG LSM10 CLNS1A | Sm-like protein family complex |
| REAC:R-HSA-111367 | 4.17603739481e-12 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | SLBP independent Processing of Histone Pre-mRNAs |
| REAC:R-HSA-77588 | 7.65349689179e-12 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| CORUM:1143 | 1.53278058629e-11 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | SMN complex |
| GO:0005685 | 5.88771104444e-11 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | U1 snRNP |
| GO:0005683 | 7.94247119785e-11 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | U7 snRNP |
| REAC:R-HSA-191859 | 1.04957670358e-10 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | snRNP Assembly |
| REAC:R-HSA-194441 | 1.04957670358e-10 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | Metabolism of non-coding RNA |
| CORUM:430 | 2.16292152415e-10 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | 18S U11/U12 snRNP |
| GO:0030532 | 2.79677650552e-10 | 0.636363636364 | SNRPB SNRPF SNRPD2 SNRPE SNRPN LSM10 SNRPG | small nuclear ribonucleoprotein complex |
| GO:0046540 | 8.99358926745e-10 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 8.99358926745e-10 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | spliceosomal tri-snRNP complex |
| CORUM:2755 | 1.02199897555e-09 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | 17S U2 snRNP |
| REAC:R-HSA-75067 | 1.61883151402e-09 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | Processing of Capped Intronless Pre-mRNA |
| GO:0000387 | 4.17182064686e-09 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | spliceosomal snRNP assembly |
| WP:WP411 | 9.35350542417e-09 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | mRNA Processing |
| GO:0005682 | 1.64704622677e-08 | 0.454545454545 | SNRPN SNRPE SNRPG SNRPB SNRPD2 | U5 snRNP |
| CORUM:1743 | 2.02774899104e-08 | 0.272727272727 | SNRPG SNRPF SNRPE | (E.F.G) complex |
| GO:0034719 | 2.33253150406e-08 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | SMN-Sm protein complex |
| GO:0005686 | 3.22857380217e-08 | 0.454545454545 | SNRPN SNRPE SNRPG SNRPB SNRPD2 | U2 snRNP |
| REAC:R-HSA-72165 | 4.24648359477e-08 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | mRNA Splicing - Minor Pathway |
| GO:0097525 | 5.4537424476e-08 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | spliceosomal snRNP complex |
| CORUM:1181 | 1.05493934442e-07 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | C complex spliceosome |
| REAC:R-HSA-73856 | 1.14420905626e-07 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | RNA Polymerase II Transcription Termination |
| GO:0034715 | 1.20667211847e-07 | 0.363636363636 | SNRPD2 SNRPE CLNS1A SNRPF | pICln-Sm protein complex |
| GO:0008334 | 1.99732718129e-07 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | histone mRNA metabolic process |
| GO:0005689 | 1.99732718129e-07 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | U12-type spliceosomal complex |
| REAC:R-HSA-72163 | 2.58215394025e-07 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 3.3661752054e-07 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | mRNA Splicing |
| CORUM:834 | 4.05059760518e-07 | 0.272727272727 | SNRPD2 CLNS1A SNRPB | 20S methylosome and RG-containing Sm protein complex |
| CORUM:3118 | 4.05059760518e-07 | 0.272727272727 | SNRPD2 SNRPB SNRPE | SMN1-SIP1-SNRP complex |
| REAC:R-HSA-8953854 | 4.16326986964e-07 | 0.727272727273 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG LSM10 CLNS1A | Metabolism of RNA |
| GO:0071007 | 5.34825903109e-07 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | U2-type catalytic step 2 spliceosome |
| GO:0071013 | 5.63018766258e-07 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | catalytic step 2 spliceosome |
| KEGG:03040 | 9.35735728433e-07 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | Spliceosome |
| GO:0005684 | 9.9198238466e-07 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | U2-type spliceosomal complex |
| GO:0006369 | 1.21629892261e-06 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | termination of RNA polymerase II transcription |
| REAC:R-HSA-72203 | 1.37311615672e-06 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0006397 | 1.86553771789e-06 | 0.727272727273 | CLNS1A SNRPF SNRPD2 SNRPE CMTR2 SNRPN SNRPG SNRPB | mRNA processing |
| CORUM:351 | 2.04045989917e-06 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | Spliceosome |
| GO:0034708 | 2.67712700803e-06 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | methyltransferase complex |
| GO:0016071 | 3.17172517553e-06 | 0.818181818182 | SNRPB SNRPF SNRPD2 SNRPE CMTR2 SNRPN SNRPG LSM10 CLNS1A | mRNA metabolic process |
| GO:0006396 | 6.46388122301e-06 | 0.818181818182 | SNRPB SNRPF SNRPD2 SNRPE CLNS1A CMTR2 SNRPN SNRPG TOE1 | RNA processing |
| GO:0071005 | 7.89839487997e-06 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | U2-type precatalytic spliceosome |
| GO:0071011 | 8.75396897163e-06 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | precatalytic spliceosome |
| GO:0000377 | 2.54243097558e-05 | 0.636363636364 | CLNS1A SNRPF SNRPD2 SNRPE SNRPN SNRPG SNRPB | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 2.54243097558e-05 | 0.636363636364 | CLNS1A SNRPF SNRPD2 SNRPE SNRPN SNRPG SNRPB | mRNA splicing, via spliceosome |
| GO:0000375 | 2.71838840465e-05 | 0.636363636364 | CLNS1A SNRPF SNRPD2 SNRPE SNRPN SNRPG SNRPB | RNA splicing, via transesterification reactions |
| GO:0005681 | 3.21030274437e-05 | 0.545454545455 | SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG | spliceosomal complex |
| GO:0006353 | 5.55613333118e-05 | 0.454545454545 | SNRPF SNRPE SNRPG LSM10 SNRPB | DNA-templated transcription, termination |
| GO:0008380 | 8.35959996597e-05 | 0.636363636364 | CLNS1A SNRPF SNRPD2 SNRPE SNRPN SNRPG SNRPB | RNA splicing |
| CORUM:825 | 0.000100616904936 | 0.181818181818 | CLNS1A SNRPB | JBP1-pICln complex |
| GO:0022618 | 0.000105217916602 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | ribonucleoprotein complex assembly |
| GO:0071826 | 0.000159351775271 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | ribonucleoprotein complex subunit organization |
| CORUM:832 | 0.00050247669008 | 0.181818181818 | CLNS1A SNRPB | Anti-Sm protein complex |
| GO:0051170 | 0.000665186312673 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | import into nucleus |
| CORUM:1749 | 0.0015050021591 | 0.181818181818 | SNRPN SNRPB | SMN-PolII-RHA complex |
| CORUM:0000000 | 0.00414038065946 | 0.818181818182 | TOE1 SNRPB SNRPF SNRPD2 SNRPE SNRPN SNRPG LSM10 CLNS1A | CORUM root |
| GO:0022613 | 0.00469400371519 | 0.545454545455 | CLNS1A SNRPF SNRPD2 SNRPE SNRPB SNRPG | ribonucleoprotein complex biogenesis |
| GO:0071010 | 0.0101325037368 | 0.272727272727 | SNRPN SNRPB SNRPG | prespliceosome |
| GO:0071004 | 0.0101325037368 | 0.272727272727 | SNRPN SNRPB SNRPG | U2-type prespliceosome |
| GO:1990904 | 0.0113403099359 | 0.636363636364 | SNRPB SNRPF SNRPD2 SNRPE SNRPN LSM10 SNRPG | ribonucleoprotein complex |
| GO:0006913 | 0.0384253986639 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | nucleocytoplasmic transport |
| GO:0051169 | 0.0406002849979 | 0.454545454545 | SNRPD2 SNRPE SNRPG SNRPB SNRPF | nuclear transport |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SNRPD2 | SNRPE | 0.998 | 0.941 | bioplex (SNRPE) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SNRPF | SNRPN | 0.804 | 0.768 | bioplex (SNRPF) bioplex_WMM gupta_WMM |
| SNRPB | SNRPG | 0.738 | 0.738 | hein_WMM bioplex (SNRPG) bioplex_WMM boldt youn_WMM boldt_WMM |
| SNRPG | CMTR2 | 0.588 | 0.662 | bioplex (SNRPG) bioplex_WMM |
| SNRPE | SNRPG | 0.584 | 0.664 | bioplex (SNRPE,SNRPG) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SNRPG | SNRPN | 0.448 | 0.592 | bioplex (SNRPG,SNRPN) bioplex_WMM gupta_WMM |
| SNRPD2 | SNRPF | 0.397 | 0.557 | hein_WMM bioplex (SNRPF) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SNRPN | CMTR2 | 0.332 | 0.522 | bioplex (SNRPN) bioplex_WMM |
| SNRPE | SNRPN | 0.313 | 0.507 | bioplex (SNRPE,SNRPN) bioplex_WMM gupta_WMM |
| SNRPB | SNRPF | 0.271 | 0.484 | hein_WMM bioplex (SNRPF) bioplex_WMM boldt boldt_WMM treiber_WMM |
| SNRPG | SNRPF | 0.27 | 0.483 | hein_WMM bioplex (SNRPF,SNRPG) bioplex_WMM boldt gupta_WMM boldt_WMM |
| SNRPE | SNRPF | 0.235 | 0.469 | bioplex (SNRPE,SNRPF) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SNRPD2 | SNRPG | 0.235 | 0.47 | hein_WMM bioplex (SNRPG) bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| SNRPB | SNRPE | 0.21 | 0.457 | bioplex (SNRPE) bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM |
| SNRPE | CMTR2 | 0.164 | 0.42 | bioplex (SNRPE) bioplex_WMM |
| SNRPD2 | SNRPN | 0.138 | 0.406 | bioplex (SNRPN) bioplex_WMM gupta_WMM |
| SNRPG | TOE1 | 0.122 | 0.394 | hein_WMM bioplex (SNRPG) bioplex_WMM youn_WMM |
| SNRPG | LSM10 | 0.104 | 0.37 | bioplex (SNRPG) bioplex_WMM youn_WMM |
| CLNS1A | SNRPE | 0.089 | 0.354 | bioplex (SNRPE) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SNRPN | TOE1 | 0.087 | 0.352 | bioplex (SNRPN) bioplex_WMM |
| SNRPG | CCDC84 | 0.081 | 0.349 | bioplex (SNRPG) bioplex_WMM |
| SNRPF | CMTR2 | 0.08 | 0.352 | bioplex (SNRPF) bioplex_WMM |
| SNRPB | SNRPD2 | 0.076 | 0.358 | hein_WMM bioplex_WMM boldt boldt_WMM treiber_WMM |
| CLNS1A | SNRPN | 0.073 | 0.357 | bioplex (SNRPN) bioplex_WMM gupta_WMM |
| SNRPF | LSM10 | 0.07 | 0.35 | bioplex (SNRPF) bioplex_WMM |
| CLNS1A | SNRPG | 0.055 | 0.306 | bioplex (SNRPG) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SNRPE | TOE1 | 0.049 | 0.293 | bioplex (SNRPE) bioplex_WMM youn_WMM |
| SNRPF | TOE1 | 0.047 | 0.293 | hein_WMM bioplex (SNRPF) bioplex_WMM |
| CLNS1A | SNRPF | 0.045 | 0.283 | bioplex (SNRPF) bioplex_WMM boldt gupta_WMM boldt_WMM |
| SNRPE | CCDC84 | 0.044 | 0.279 | bioplex (SNRPE) bioplex_WMM |
| SNRPN | LSM10 | 0.037 | 0.267 | bioplex (SNRPN) bioplex_WMM |
| SNRPB | SNRPN | 0.013 | 0.14 | bioplex (SNRPN) bioplex_WMM |
| SNRPB | LSM10 | 0.012 | 0.146 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| TOE1 | CMTR2 | 0.012 | 0.146 | bioplex_WMM WMM_only |
| SNRPD2 | CMTR2 | 0.012 | 0.148 | bioplex_WMM WMM_only |
| CLNS1A | SNRPB | 0.012 | 0.15 | hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM |
| SNRPB | CMTR2 | 0.012 | 0.15 | bioplex_WMM WMM_only |
| CLNS1A | LSM10 | 0.012 | 0.151 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SNRPD2 | LSM10 | 0.012 | 0.154 | hein_WMM bioplex_WMM WMM_only |
| CLNS1A | SNRPD2 | 0.011 | 0.141 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| SNRPE | LSM10 | 0.011 | 0.144 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SNRPB | TOE1 | 0.011 | 0.14 | hein_WMM bioplex_WMM youn_WMM WMM_only treiber_WMM |
| SNRPD2 | TOE1 | 0.011 | 0.145 | hein_WMM bioplex_WMM WMM_only |
| LSM10 | CMTR2 | 0.011 | 0.145 | bioplex_WMM WMM_only |
| CLNS1A | CMTR2 | 0.01 | 0.121 | bioplex_WMM WMM_only |
| SNRPF | CCDC84 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| LSM10 | TOE1 | 0.009 | 0.109 | bioplex_WMM youn_WMM WMM_only |
| CMTR2 | CCDC84 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| CLNS1A | TOE1 | 0.009 | 0.091 | bioplex_WMM youn_WMM WMM_only |
| SNRPN | CCDC84 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| CLNS1A | CCDC84 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SNRPB | CCDC84 | 0.008 | 0.058 | hein_WMM bioplex (CCDC84) bioplex_WMM |
| LSM10 | CCDC84 | 0.008 | 0.026 | hein_WMM bioplex_WMM WMM_only |
| TOE1 | CCDC84 | 0.008 | 0.012 | hein_WMM bioplex_WMM WMM_only |
| SNRPD2 | CCDC84 | 0.006 | 0.005 | bioplex (CCDC84) bioplex_WMM |
Images
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Complex HuMAP2_02578 has an average edge precision of 0.305 which is ranked 4499 out of all 6965 complexes.
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