hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02595
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AP2A2 | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | UniProt NCBI |
| CLINT1 | Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR) | UniProt NCBI |
| SLC22A12 | Solute carrier family 22 member 12 (Organic anion transporter 4-like protein) (Renal-specific transporter) (RST) (Urate anion exchanger 1) | UniProt NCBI |
| AP2S1 | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin) | UniProt NCBI |
| BMP2K | BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1) | UniProt NCBI |
| CYSTM1 | Cysteine-rich and transmembrane domain-containing protein 1 | UniProt NCBI |
| STON2 | Stonin-2 (Stoned B) | UniProt NCBI |
| MFSD4A | Major facilitator superfamily domain-containing protein 4A (Major facilitator superfamily domain-containing protein 4) | UniProt NCBI |
| AP2A1 | AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) | UniProt NCBI |
| AAK1 | AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1) | UniProt NCBI |
| CCDC32 | Coiled-coil domain-containing protein 32 | UniProt NCBI |
| SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4 (Glucose transporter type 4, insulin-responsive) (GLUT-4) | UniProt NCBI |
| SMAP2 | Stromal membrane-associated protein 2 (Stromal membrane-associated protein 1-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0072583 | 1.77062370253e-06 | 0.384615384615 | AP2A1 BMP2K AP2S1 AP2A2 AAK1 | clathrin-dependent endocytosis |
| REAC:R-HSA-8856825 | 2.01640542634e-06 | 0.384615384615 | AP2A1 STON2 AP2S1 AP2A2 AAK1 | Cargo recognition for clathrin-mediated endocytosis |
| REAC:R-HSA-182218 | 2.48180721128e-06 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Nef Mediated CD8 Down-regulation |
| REAC:R-HSA-167590 | 1.04078471185e-05 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Nef Mediated CD4 Down-regulation |
| REAC:R-HSA-8856828 | 1.3132163639e-05 | 0.384615384615 | AP2A1 STON2 AP2S1 AP2A2 AAK1 | Clathrin-mediated endocytosis |
| REAC:R-HSA-8866427 | 2.72174749009e-05 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | VLDLR internalisation and degradation |
| REAC:R-HSA-5140745 | 3.5364893291e-05 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | WNT5A-dependent internalization of FZD2, FZD5 and ROR2 |
| REAC:R-HSA-177504 | 3.5364893291e-05 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Retrograde neurotrophin signalling |
| REAC:R-HSA-199991 | 4.43644428305e-05 | 0.538461538462 | STON2 AAK1 SLC2A4 AP2S1 CLINT1 AP2A1 AP2A2 | Membrane Trafficking |
| REAC:R-HSA-5099900 | 4.49871899684e-05 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | WNT5A-dependent internalization of FZD4 |
| REAC:R-HSA-5653656 | 6.39422909366e-05 | 0.538461538462 | STON2 AAK1 SLC2A4 AP2S1 CLINT1 AP2A1 AP2A2 | Vesicle-mediated transport |
| REAC:R-HSA-164938 | 0.000100647329171 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| WP:WP4159 | 0.0001052749019 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | GABA receptor Signaling |
| REAC:R-HSA-8964038 | 0.000119458488481 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | LDL clearance |
| REAC:R-HSA-164952 | 0.000248891114269 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | The role of Nef in HIV-1 replication and disease pathogenesis |
| REAC:R-HSA-8964043 | 0.000448201146504 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Plasma lipoprotein clearance |
| KEGG:04961 | 0.000506803765009 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Endocrine and other factor-regulated calcium reabsorption |
| WP:WP2267 | 0.000541141642827 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Synaptic Vesicle Pathway |
| KEGG:04721 | 0.00122812073775 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Synaptic vesicle cycle |
| GO:0030128 | 0.00145089086092 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | clathrin coat of endocytic vesicle |
| GO:0030122 | 0.00145089086092 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | AP-2 adaptor complex |
| REAC:R-HSA-437239 | 0.00172656844301 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Recycling pathway of L1 |
| GO:0030276 | 0.00173508490005 | 0.307692307692 | CLINT1 AP2S1 AP2A2 AP2A1 | clathrin binding |
| KEGG:04144 | 0.0018406557575 | 0.307692307692 | AP2A1 AP2S1 AP2A2 SMAP2 | Endocytosis |
| REAC:R-HSA-3928665 | 0.00184609565232 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | EPH-ephrin mediated repulsion of cells |
| GO:0035615 | 0.00217524004777 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | clathrin adaptor activity |
| GO:0030132 | 0.00217524004777 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | clathrin coat of coated pit |
| GO:0030136 | 0.00263942984361 | 0.384615384615 | AP2A1 SLC2A4 AP2S1 AP2A2 AAK1 | clathrin-coated vesicle |
| GO:0140312 | 0.00310592047764 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | cargo adaptor activity |
| REAC:R-HSA-174824 | 0.00335417455625 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Plasma lipoprotein assembly, remodeling, and clearance |
| GO:0036020 | 0.0042684894035 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | endolysosome membrane |
| GO:0030131 | 0.00739126269782 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | clathrin adaptor complex |
| REAC:R-HSA-187037 | 0.00746158185843 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Signaling by NTRK1 (TRKA) |
| GO:0006897 | 0.0103283965529 | 0.461538461538 | STON2 AAK1 BMP2K AP2S1 AP2A1 AP2A2 | endocytosis |
| GO:0032802 | 0.0117469826046 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | low-density lipoprotein particle receptor catabolic process |
| REAC:R-HSA-2682334 | 0.0121973441103 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | EPH-Ephrin signaling |
| REAC:R-HSA-4086400 | 0.0144426443732 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | PCP/CE pathway |
| REAC:R-HSA-166520 | 0.0144426443732 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Signaling by NTRKs |
| GO:0036019 | 0.014450541162 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | endolysosome |
| GO:0006898 | 0.0161852653228 | 0.384615384615 | AP2A1 BMP2K AP2S1 AP2A2 AAK1 | receptor-mediated endocytosis |
| GO:0030125 | 0.0210352917967 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | clathrin vesicle coat |
| KEGG:05016 | 0.0216723097972 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Huntington disease |
| REAC:R-HSA-382551 | 0.0249292215347 | 0.384615384615 | AP2A1 SLC2A4 AP2S1 AP2A2 SLC22A12 | Transport of small molecules |
| REAC:R-HSA-373760 | 0.0261054202275 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.0297545147109 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | MHC class II antigen presentation |
| GO:0030135 | 0.0304596699724 | 0.384615384615 | AP2A1 SLC2A4 AP2S1 AP2A2 AAK1 | coated vesicle |
| REAC:R-HSA-162909 | 0.0345543632488 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Host Interactions of HIV factors |
| GO:0032799 | 0.039619012417 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | low-density lipoprotein receptor particle metabolic process |
| REAC:R-HSA-3858494 | 0.0486944728845 | 0.230769230769 | AP2S1 AP2A2 AP2A1 | Beta-catenin independent WNT signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CCDC32 | AP2S1 | 0.987 | 0.901 | bioplex (AP2S1) bioplex_WMM |
| AP2S1 | AP2A1 | 0.98 | 0.896 | hein_WMM bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AP2A2 | AP2S1 | 0.971 | 0.883 | bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| AAK1 | AP2S1 | 0.776 | 0.752 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM |
| AP2S1 | STON2 | 0.657 | 0.696 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM |
| BMP2K | CLINT1 | 0.27 | 0.483 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| SMAP2 | CLINT1 | 0.268 | 0.482 | hein_WMM youn (SMAP2) bioplex (CLINT1) bioplex_WMM boldt youn_WMM boldt_WMM |
| AP2S1 | BMP2K | 0.256 | 0.479 | hein_WMM bioplex (AP2S1) bioplex_WMM youn_WMM |
| AP2A2 | AP2A1 | 0.066 | 0.349 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STON2 | CLINT1 | 0.054 | 0.302 | hein_WMM bioplex (CLINT1) bioplex_WMM youn_WMM gupta_WMM |
| CLINT1 | AP2A1 | 0.052 | 0.299 | hein_WMM bioplex (CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SLC2A4 | SMAP2 | 0.039 | 0.263 | bioplex (SLC2A4) bioplex_WMM |
| BMP2K | AP2A1 | 0.036 | 0.263 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SMAP2 | MFSD4A | 0.029 | 0.23 | bioplex (MFSD4A) bioplex_WMM |
| AP2A2 | CLINT1 | 0.029 | 0.23 | bioplex (CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SLC22A12 | SMAP2 | 0.029 | 0.23 | bioplex (SLC22A12) bioplex_WMM |
| CYSTM1 | MFSD4A | 0.022 | 0.198 | bioplex (MFSD4A) bioplex_WMM |
| STON2 | BMP2K | 0.018 | 0.176 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AAK1 | BMP2K | 0.015 | 0.148 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| AAK1 | CLINT1 | 0.013 | 0.155 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| AAK1 | AP2A1 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AAK1 | AP2A2 | 0.011 | 0.143 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| AP2A2 | STON2 | 0.01 | 0.12 | bioplex_WMM youn_WMM WMM_only |
| AAK1 | STON2 | 0.01 | 0.097 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| AP2A2 | BMP2K | 0.01 | 0.098 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CCDC32 | AP2A2 | 0.009 | 0.097 | bioplex_WMM WMM_only |
| CCDC32 | AP2A1 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| STON2 | AP2A1 | 0.008 | 0.077 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SMAP2 | STON2 | 0.008 | 0.067 | hein_WMM youn (SMAP2) bioplex_WMM |
| CCDC32 | AAK1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| CCDC32 | STON2 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| CCDC32 | BMP2K | 0.008 | 0.025 | bioplex_WMM WMM_only |
| CYSTM1 | SMAP2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| AP2S1 | CLINT1 | 0.007 | 0.008 | hein_WMM bioplex (AP2S1,CLINT1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| AAK1 | SMAP2 | 0.007 | 0.01 | hein_WMM youn_WMM WMM_only |
| AP2A2 | SMAP2 | 0.007 | 0.003 | youn (SMAP2) bioplex_WMM youn_WMM |
| SMAP2 | AP2A1 | 0.007 | 0.002 | hein_WMM youn (SMAP2) bioplex_WMM youn_WMM |
| SMAP2 | BMP2K | 0.006 | 0.006 | hein_WMM youn (SMAP2) bioplex_WMM youn_WMM |
| SMAP2 | AP2S1 | 0.005 | 0.012 | youn (SMAP2) bioplex_WMM youn_WMM |
| SLC2A4 | CLINT1 | 0.005 | 0.006 | bioplex (SLC2A4) |
Images
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Complex HuMAP2_02595 has an average edge precision of 0.238 which is ranked 5577 out of all 6965 complexes.
Related Complexes