hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02610
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AIMP1 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (Multisynthase complex auxiliary component p43) [Cleaved into: Endothelial monocyte-activating polypeptide 2 (EMAP-2) (Endothelial monocyte-activating polypeptide II) (EMAP-II) (Small inducible cytokine subfamily E member 1)] | UniProt NCBI |
| DARS | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) | UniProt NCBI |
| MARS | Methionine--tRNA ligase, cytoplasmic (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3040 | 3.71837842278e-08 | 1.0 | DARS AIMP1 MARS | Multisynthetase complex |
| REAC:R-HSA-379716 | 9.09984147875e-07 | 1.0 | DARS AIMP1 MARS | Cytosolic tRNA aminoacylation |
| REAC:R-HSA-379724 | 5.16137253834e-06 | 1.0 | DARS AIMP1 MARS | tRNA Aminoacylation |
| GO:0017101 | 1.49850650438e-05 | 1.0 | DARS AIMP1 MARS | aminoacyl-tRNA synthetase multienzyme complex |
| REAC:R-HSA-2408522 | 0.000108111871608 | 1.0 | DARS AIMP1 MARS | Selenoamino acid metabolism |
| KEGG:00970 | 0.000422858026176 | 0.666666666667 | DARS MARS | Aminoacyl-tRNA biosynthesis |
| GO:0006418 | 0.0011207920467 | 1.0 | DARS AIMP1 MARS | tRNA aminoacylation for protein translation |
| HP:0001256 | 0.00112686264524 | 1.0 | DARS AIMP1 MARS | Intellectual disability, mild |
| GO:0043039 | 0.00137862598403 | 1.0 | DARS AIMP1 MARS | tRNA aminoacylation |
| GO:0043038 | 0.00137862598403 | 1.0 | DARS AIMP1 MARS | amino acid activation |
| HP:0003676 | 0.00143712383153 | 1.0 | DARS AIMP1 MARS | Progressive |
| REAC:R-HSA-72766 | 0.00180867442135 | 1.0 | DARS AIMP1 MARS | Translation |
| REAC:R-HSA-71291 | 0.00315795701338 | 1.0 | DARS AIMP1 MARS | Metabolism of amino acids and derivatives |
| HP:0012447 | 0.00509281251216 | 1.0 | DARS AIMP1 MARS | Abnormal myelination |
| HP:0003679 | 0.00619014428056 | 1.0 | DARS AIMP1 MARS | Pace of progression |
| HP:0001257 | 0.0255710895815 | 1.0 | DARS AIMP1 MARS | Spasticity |
| HP:0001276 | 0.0448141259844 | 1.0 | DARS AIMP1 MARS | Hypertonia |
| KEGG:00450 | 0.0499753562667 | 0.333333333333 | MARS | Selenocompound metabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AIMP1 | MARS | 1.0 | 0.949 | hein_WMM bioplex (AIMP1) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DARS | MARS | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| DARS | AIMP1 | 1.0 | 0.949 | hein_WMM bioplex (AIMP1) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02610 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AIMP1 | HuMAP2_01246 HuMAP2_02610 HuMAP2_03598 HuMAP2_05659 |
| DARS | HuMAP2_01246 HuMAP2_02610 HuMAP2_03598 HuMAP2_05659 |
| MARS | HuMAP2_01246 HuMAP2_02610 HuMAP2_03598 HuMAP2_05659 |