hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02611
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha) | UniProt NCBI |
| PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4582 | 1.67661599273e-05 | 1.0 | PIK3R1 PIK3R2 | Cancer immunotherapy by CTLA4 blockade |
| WP:WP22 | 4.47097598062e-05 | 1.0 | PIK3R1 PIK3R2 | IL-9 Signaling Pathway |
| REAC:R-HSA-198203 | 4.69258569465e-05 | 1.0 | PIK3R1 PIK3R2 | PI3K/AKT activation |
| KEGG:04960 | 6.7842358023e-05 | 1.0 | PIK3R1 PIK3R2 | Aldosterone-regulated sodium reabsorption |
| REAC:R-HSA-2730905 | 7.54165558069e-05 | 1.0 | PIK3R1 PIK3R2 | Role of LAT2/NTAL/LAB on calcium mobilization |
| WP:WP205 | 8.60662876269e-05 | 1.0 | PIK3R1 PIK3R2 | IL-7 Signaling Pathway |
| KEGG:04973 | 0.000113800084426 | 1.0 | PIK3R1 PIK3R2 | Carbohydrate digestion and absorption |
| KEGG:04923 | 0.000138019076752 | 1.0 | PIK3R1 PIK3R2 | Regulation of lipolysis in adipocytes |
| KEGG:04930 | 0.000138019076752 | 1.0 | PIK3R1 PIK3R2 | Type II diabetes mellitus |
| WP:WP3844 | 0.000162072879297 | 1.0 | PIK3R1 PIK3R2 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| WP:WP3937 | 0.000162072879297 | 1.0 | PIK3R1 PIK3R2 | Microglia Pathogen Phagocytosis Pathway |
| REAC:R-HSA-210993 | 0.000175971963549 | 1.0 | PIK3R1 PIK3R2 | Tie2 Signaling |
| WP:WP244 | 0.000196722943147 | 1.0 | PIK3R1 PIK3R2 | Alpha 6 Beta 4 signaling pathway |
| KEGG:04929 | 0.000208779385658 | 1.0 | PIK3R1 PIK3R2 | GnRH secretion |
| KEGG:04370 | 0.000216657853041 | 1.0 | PIK3R1 PIK3R2 | VEGF signaling pathway |
| KEGG:04664 | 0.000216657853041 | 1.0 | PIK3R1 PIK3R2 | Fc epsilon RI signaling pathway |
| KEGG:04213 | 0.000224682217969 | 1.0 | PIK3R1 PIK3R2 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-912526 | 0.000227925590883 | 1.0 | PIK3R1 PIK3R2 | Interleukin receptor SHC signaling |
| KEGG:05213 | 0.00023285248044 | 1.0 | PIK3R1 PIK3R2 | Endometrial cancer |
| WP:WP2828 | 0.000234726238982 | 1.0 | PIK3R1 PIK3R2 | Bladder Cancer |
| KEGG:05221 | 0.00025823865312 | 1.0 | PIK3R1 PIK3R2 | Acute myeloid leukemia |
| WP:WP127 | 0.000261924676198 | 1.0 | PIK3R1 PIK3R2 | IL-5 Signaling Pathway |
| KEGG:04917 | 0.00027589225596 | 1.0 | PIK3R1 PIK3R2 | Prolactin signaling pathway |
| KEGG:05218 | 0.00027589225596 | 1.0 | PIK3R1 PIK3R2 | Melanoma |
| WP:WP2332 | 0.000276082766803 | 1.0 | PIK3R1 PIK3R2 | Interleukin-11 Signaling Pathway |
| KEGG:05211 | 0.000284937903697 | 1.0 | PIK3R1 PIK3R2 | Renal cell carcinoma |
| REAC:R-HSA-389357 | 0.000286582912066 | 1.0 | PIK3R1 PIK3R2 | CD28 dependent PI3K/Akt signaling |
| KEGG:05223 | 0.000294129448977 | 1.0 | PIK3R1 PIK3R2 | Non-small cell lung cancer |
| REAC:R-HSA-912631 | 0.000318425457851 | 1.0 | PIK3R1 PIK3R2 | Regulation of signaling by CBL |
| WP:WP364 | 0.000320792526609 | 1.0 | PIK3R1 PIK3R2 | IL-6 signaling pathway |
| WP:WP286 | 0.000320792526609 | 1.0 | PIK3R1 PIK3R2 | IL-3 Signaling Pathway |
| KEGG:04662 | 0.000322579470084 | 1.0 | PIK3R1 PIK3R2 | B cell receptor signaling pathway |
| KEGG:05230 | 0.000322579470084 | 1.0 | PIK3R1 PIK3R2 | Central carbon metabolism in cancer |
| KEGG:05214 | 0.000332354605541 | 1.0 | PIK3R1 PIK3R2 | Glioma |
| REAC:R-HSA-2424491 | 0.000351943927099 | 1.0 | PIK3R1 PIK3R2 | DAP12 signaling |
| REAC:R-HSA-2029485 | 0.000351943927099 | 1.0 | PIK3R1 PIK3R2 | Role of phospholipids in phagocytosis |
| KEGG:05212 | 0.000362555397177 | 1.0 | PIK3R1 PIK3R2 | Pancreatic cancer |
| KEGG:01524 | 0.00037291412281 | 1.0 | PIK3R1 PIK3R2 | Platinum drug resistance |
| KEGG:05100 | 0.000383418745988 | 1.0 | PIK3R1 PIK3R2 | Bacterial invasion of epithelial cells |
| WP:WP4566 | 0.000385621678328 | 1.0 | PIK3R1 PIK3R2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-373753 | 0.000387138319809 | 1.0 | PIK3R1 PIK3R2 | Nephrin family interactions |
| KEGG:05220 | 0.00039406926671 | 1.0 | PIK3R1 PIK3R2 | Chronic myeloid leukemia |
| KEGG:01521 | 0.00039406926671 | 1.0 | PIK3R1 PIK3R2 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP4539 | 0.000402760419587 | 1.0 | PIK3R1 PIK3R2 | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04012 | 0.000449510333482 | 1.0 | PIK3R1 PIK3R2 | ErbB signaling pathway |
| KEGG:05235 | 0.000461036239468 | 1.0 | PIK3R1 PIK3R2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| REAC:R-HSA-2172127 | 0.000462554875615 | 1.0 | PIK3R1 PIK3R2 | DAP12 interactions |
| KEGG:04750 | 0.000472708042999 | 1.0 | PIK3R1 PIK3R2 | Inflammatory mediator regulation of TRP channels |
| KEGG:04914 | 0.000472708042999 | 1.0 | PIK3R1 PIK3R2 | Progesterone-mediated oocyte maturation |
| WP:WP195 | 0.00047504119794 | 1.0 | PIK3R1 PIK3R2 | IL-1 signaling pathway |
| KEGG:05210 | 0.000484525744074 | 1.0 | PIK3R1 PIK3R2 | Colorectal cancer |
| KEGG:04211 | 0.000484525744074 | 1.0 | PIK3R1 PIK3R2 | Longevity regulating pathway |
| WP:WP395 | 0.000494042845858 | 1.0 | PIK3R1 PIK3R2 | IL-4 Signaling Pathway |
| WP:WP2018 | 0.000494042845858 | 1.0 | PIK3R1 PIK3R2 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| KEGG:05146 | 0.000520854232564 | 1.0 | PIK3R1 PIK3R2 | Amoebiasis |
| WP:WP585 | 0.000533163885688 | 1.0 | PIK3R1 PIK3R2 | Interferon type I signaling pathways |
| KEGG:04620 | 0.000533255523815 | 1.0 | PIK3R1 PIK3R2 | Toll-like receptor signaling pathway |
| KEGG:04666 | 0.000558495798951 | 1.0 | PIK3R1 PIK3R2 | Fc gamma R-mediated phagocytosis |
| KEGG:05142 | 0.000558495798951 | 1.0 | PIK3R1 PIK3R2 | Chagas disease (American trypanosomiasis) |
| KEGG:04670 | 0.000558495798951 | 1.0 | PIK3R1 PIK3R2 | Leukocyte transendothelial migration |
| KEGG:04625 | 0.000558495798951 | 1.0 | PIK3R1 PIK3R2 | C-type lectin receptor signaling pathway |
| KEGG:05231 | 0.000571334782835 | 1.0 | PIK3R1 PIK3R2 | Choline metabolism in cancer |
| WP:WP304 | 0.000573775250846 | 1.0 | PIK3R1 PIK3R2 | Kit receptor signaling pathway |
| WP:WP61 | 0.000573775250846 | 1.0 | PIK3R1 PIK3R2 | Notch Signaling Pathway |
| KEGG:05215 | 0.000584319664263 | 1.0 | PIK3R1 PIK3R2 | Prostate cancer |
| KEGG:01522 | 0.000584319664263 | 1.0 | PIK3R1 PIK3R2 | Endocrine resistance |
| KEGG:04660 | 0.000584319664263 | 1.0 | PIK3R1 PIK3R2 | T cell receptor signaling pathway |
| REAC:R-HSA-109704 | 0.000588249135293 | 1.0 | PIK3R1 PIK3R2 | PI3K Cascade |
| REAC:R-HSA-186763 | 0.000588249135293 | 1.0 | PIK3R1 PIK3R2 | Downstream signal transduction |
| WP:WP4205 | 0.000594639805422 | 1.0 | PIK3R1 PIK3R2 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04933 | 0.000597450443235 | 1.0 | PIK3R1 PIK3R2 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 0.000610727119751 | 1.0 | PIK3R1 PIK3R2 | Small cell lung cancer |
| KEGG:04070 | 0.000610727119751 | 1.0 | PIK3R1 PIK3R2 | Phosphatidylinositol signaling system |
| KEGG:04668 | 0.000624149693812 | 1.0 | PIK3R1 PIK3R2 | TNF signaling pathway |
| REAC:R-HSA-114604 | 0.000633499068778 | 1.0 | PIK3R1 PIK3R2 | GPVI-mediated activation cascade |
| REAC:R-HSA-389356 | 0.000633499068778 | 1.0 | PIK3R1 PIK3R2 | CD28 co-stimulation |
| KEGG:04725 | 0.000665292801258 | 1.0 | PIK3R1 PIK3R2 | Cholinergic synapse |
| WP:WP4155 | 0.000704551298279 | 1.0 | PIK3R1 PIK3R2 | Endometrial cancer |
| KEGG:04650 | 0.000707748986601 | 1.0 | PIK3R1 PIK3R2 | Natural killer cell mediated cytotoxicity |
| KEGG:04066 | 0.000722192843471 | 1.0 | PIK3R1 PIK3R2 | HIF-1 signaling pathway |
| WP:WP1403 | 0.000751123964743 | 1.0 | PIK3R1 PIK3R2 | AMP-activated Protein Kinase (AMPK) Signaling |
| KEGG:04931 | 0.000751518249842 | 1.0 | PIK3R1 PIK3R2 | Insulin resistance |
| KEGG:04380 | 0.000766399799344 | 1.0 | PIK3R1 PIK3R2 | Osteoclast differentiation |
| WP:WP2032 | 0.000774969169973 | 1.0 | PIK3R1 PIK3R2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-8853659 | 0.000779304410004 | 1.0 | PIK3R1 PIK3R2 | RET signaling |
| REAC:R-HSA-112399 | 0.000779304410004 | 1.0 | PIK3R1 PIK3R2 | IRS-mediated signalling |
| KEGG:04722 | 0.000827384972793 | 1.0 | PIK3R1 PIK3R2 | Neurotrophin signaling pathway |
| REAC:R-HSA-451927 | 0.000831258037338 | 1.0 | PIK3R1 PIK3R2 | Interleukin-2 family signaling |
| KEGG:04071 | 0.000858752944782 | 1.0 | PIK3R1 PIK3R2 | Sphingolipid signaling pathway |
| REAC:R-HSA-1266695 | 0.000884887588134 | 1.0 | PIK3R1 PIK3R2 | Interleukin-7 signaling |
| KEGG:04611 | 0.000890704506947 | 1.0 | PIK3R1 PIK3R2 | Platelet activation |
| WP:WP4255 | 0.000899783916099 | 1.0 | PIK3R1 PIK3R2 | Non-small cell lung cancer |
| KEGG:05135 | 0.000906899134346 | 1.0 | PIK3R1 PIK3R2 | Yersinia infection |
| KEGG:04152 | 0.000906899134346 | 1.0 | PIK3R1 PIK3R2 | AMPK signaling pathway |
| KEGG:04919 | 0.00092323965929 | 1.0 | PIK3R1 PIK3R2 | Thyroid hormone signaling pathway |
| KEGG:04068 | 0.000939726081777 | 1.0 | PIK3R1 PIK3R2 | FoxO signaling pathway |
| REAC:R-HSA-2428928 | 0.000940193062392 | 1.0 | PIK3R1 PIK3R2 | IRS-related events triggered by IGF1R |
| REAC:R-HSA-2428924 | 0.000940193062392 | 1.0 | PIK3R1 PIK3R2 | IGF1R signaling cascade |
| REAC:R-HSA-1433557 | 0.000997174460113 | 1.0 | PIK3R1 PIK3R2 | Signaling by SCF-KIT |
| REAC:R-HSA-2404192 | 0.000997174460113 | 1.0 | PIK3R1 PIK3R2 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| WP:WP2034 | 0.00100634217697 | 1.0 | PIK3R1 PIK3R2 | Leptin signaling pathway |
| WP:WP2037 | 0.00100634217697 | 1.0 | PIK3R1 PIK3R2 | Prolactin Signaling Pathway |
| KEGG:04926 | 0.00104170846513 | 1.0 | PIK3R1 PIK3R2 | Relaxin signaling pathway |
| REAC:R-HSA-74751 | 0.0010558317813 | 1.0 | PIK3R1 PIK3R2 | Insulin receptor signalling cascade |
| KEGG:04630 | 0.00105921617042 | 1.0 | PIK3R1 PIK3R2 | JAK-STAT signaling pathway |
| WP:WP1544 | 0.0010618567954 | 1.0 | PIK3R1 PIK3R2 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04915 | 0.00107686977326 | 1.0 | PIK3R1 PIK3R2 | Estrogen signaling pathway |
| WP:WP69 | 0.00109017297661 | 1.0 | PIK3R1 PIK3R2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04550 | 0.00109466927365 | 1.0 | PIK3R1 PIK3R2 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-512988 | 0.00111616502594 | 1.0 | PIK3R1 PIK3R2 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:05418 | 0.00113070596705 | 1.0 | PIK3R1 PIK3R2 | Fluid shear stress and atherosclerosis |
| KEGG:04910 | 0.00113070596705 | 1.0 | PIK3R1 PIK3R2 | Insulin signaling pathway |
| KEGG:04210 | 0.00113070596705 | 1.0 | PIK3R1 PIK3R2 | Apoptosis |
| KEGG:04072 | 0.00114894316007 | 1.0 | PIK3R1 PIK3R2 | Phospholipase D signaling pathway |
| KEGG:05162 | 0.00118585523873 | 1.0 | PIK3R1 PIK3R2 | Measles |
| KEGG:05224 | 0.00122335090758 | 1.0 | PIK3R1 PIK3R2 | Breast cancer |
| KEGG:04062 | 0.00122335090758 | 1.0 | PIK3R1 PIK3R2 | Chemokine signaling pathway |
| WP:WP2261 | 0.00123734260264 | 1.0 | PIK3R1 PIK3R2 | Signaling Pathways in Glioblastoma |
| KEGG:05226 | 0.00124231758831 | 1.0 | PIK3R1 PIK3R2 | Gastric cancer |
| WP:WP4263 | 0.00126789427184 | 1.0 | PIK3R1 PIK3R2 | Pancreatic adenocarcinoma pathway |
| KEGG:04932 | 0.00128068864242 | 1.0 | PIK3R1 PIK3R2 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04140 | 0.00128068864242 | 1.0 | PIK3R1 PIK3R2 | Autophagy - animal |
| WP:WP673 | 0.00133011535423 | 1.0 | PIK3R1 PIK3R2 | ErbB Signaling Pathway |
| KEGG:05160 | 0.00133933945516 | 1.0 | PIK3R1 PIK3R2 | Hepatitis C |
| WP:WP23 | 0.00142624133782 | 1.0 | PIK3R1 PIK3R2 | B Cell Receptor Signaling Pathway |
| WP:WP75 | 0.00142624133782 | 1.0 | PIK3R1 PIK3R2 | Toll-like Receptor Signaling Pathway |
| WP:WP138 | 0.00142624133782 | 1.0 | PIK3R1 PIK3R2 | Androgen receptor signaling pathway |
| KEGG:04150 | 0.00150216111442 | 1.0 | PIK3R1 PIK3R2 | mTOR signaling pathway |
| KEGG:04218 | 0.00152317036077 | 1.0 | PIK3R1 PIK3R2 | Cellular senescence |
| KEGG:05164 | 0.00158707348511 | 1.0 | PIK3R1 PIK3R2 | Influenza A |
| REAC:R-HSA-2219530 | 0.00165916422775 | 1.0 | PIK3R1 PIK3R2 | Constitutive Signaling by Aberrant PI3K in Cancer |
| WP:WP4658 | 0.00166357564612 | 1.0 | PIK3R1 PIK3R2 | Small cell lung cancer |
| KEGG:05161 | 0.00174128718926 | 1.0 | PIK3R1 PIK3R2 | Hepatitis B |
| KEGG:05206 | 0.00178666132548 | 1.0 | PIK3R1 PIK3R2 | MicroRNAs in cancer |
| KEGG:05225 | 0.00183261905189 | 1.0 | PIK3R1 PIK3R2 | Hepatocellular carcinoma |
| REAC:R-HSA-1660499 | 0.00189044166556 | 1.0 | PIK3R1 PIK3R2 | Synthesis of PIPs at the plasma membrane |
| KEGG:05167 | 0.00197399377215 | 1.0 | PIK3R1 PIK3R2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:04360 | 0.00197399377215 | 1.0 | PIK3R1 PIK3R2 | Axon guidance |
| WP:WP710 | 0.00199554561268 | 1.0 | PIK3R1 PIK3R2 | DNA Damage Response (only ATM dependent) |
| KEGG:04024 | 0.00209581822151 | 1.0 | PIK3R1 PIK3R2 | cAMP signaling pathway |
| KEGG:04015 | 0.00217066366165 | 1.0 | PIK3R1 PIK3R2 | Rap1 signaling pathway |
| REAC:R-HSA-186797 | 0.00239824647466 | 1.0 | PIK3R1 PIK3R2 | Signaling by PDGF |
| REAC:R-HSA-388841 | 0.00239824647466 | 1.0 | PIK3R1 PIK3R2 | Costimulation by the CD28 family |
| KEGG:05169 | 0.00242963180249 | 1.0 | PIK3R1 PIK3R2 | Epstein-Barr virus infection |
| KEGG:04014 | 0.00245633105307 | 1.0 | PIK3R1 PIK3R2 | Ras signaling pathway |
| KEGG:04810 | 0.00253730419006 | 1.0 | PIK3R1 PIK3R2 | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.00256458703081 | 1.0 | PIK3R1 PIK3R2 | Proteoglycans in cancer |
| KEGG:05203 | 0.00256458703081 | 1.0 | PIK3R1 PIK3R2 | Viral carcinogenesis |
| WP:WP4217 | 0.00257192893285 | 1.0 | PIK3R1 PIK3R2 | Ebola Virus Pathway on Host |
| WP:WP1449 | 0.00257192893285 | 1.0 | PIK3R1 PIK3R2 | Regulation of toll-like receptor signaling pathway |
| KEGG:04510 | 0.00259201576911 | 1.0 | PIK3R1 PIK3R2 | Focal adhesion |
| KEGG:05166 | 0.00281669798708 | 1.0 | PIK3R1 PIK3R2 | Human T-cell leukemia virus 1 infection |
| WP:WP3915 | 0.00284130523568 | 1.0 | PIK3R1 PIK3R2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP366 | 0.00284130523568 | 1.0 | PIK3R1 PIK3R2 | TGF-beta Signaling Pathway |
| WP:WP3929 | 0.00284130523568 | 1.0 | PIK3R1 PIK3R2 | Chemokine signaling pathway |
| REAC:R-HSA-74752 | 0.00286750504412 | 1.0 | PIK3R1 PIK3R2 | Signaling by Insulin receptor |
| KEGG:05170 | 0.00287432751701 | 1.0 | PIK3R1 PIK3R2 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | PIK3R1 PIK3R2 | Human cytomegalovirus infection |
| WP:WP51 | 0.00322133819403 | 1.0 | PIK3R1 PIK3R2 | Regulation of Actin Cytoskeleton |
| WP:WP4239 | 0.00336999814539 | 1.0 | PIK3R1 PIK3R2 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP2380 | 0.00342029662517 | 1.0 | PIK3R1 PIK3R2 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP4396 | 0.00347096768628 | 1.0 | PIK3R1 PIK3R2 | Nonalcoholic fatty liver disease |
| WP:WP4262 | 0.00357342755251 | 1.0 | PIK3R1 PIK3R2 | Breast cancer pathway |
| REAC:R-HSA-9009391 | 0.00359485582679 | 1.0 | PIK3R1 PIK3R2 | Extra-nuclear estrogen signaling |
| MIRNA:hsa-miR-126-3p | 0.00374237747518 | 1.0 | PIK3R1 PIK3R2 | hsa-miR-126-3p |
| WP:WP4666 | 0.00388974910314 | 1.0 | PIK3R1 PIK3R2 | Hepatitis B infection |
| REAC:R-HSA-6811558 | 0.00393171644273 | 1.0 | PIK3R1 PIK3R2 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-2219528 | 0.004164669804 | 1.0 | PIK3R1 PIK3R2 | PI3K/AKT Signaling in Cancer |
| WP:WP481 | 0.00438938066897 | 1.0 | PIK3R1 PIK3R2 | Insulin Signaling |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | PIK3R1 PIK3R2 | Signaling by NTRK1 (TRKA) |
| WP:WP4223 | 0.00444675819405 | 1.0 | PIK3R1 PIK3R2 | Ras Signaling |
| WP:WP437 | 0.00473923453945 | 1.0 | PIK3R1 PIK3R2 | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | PIK3R1 PIK3R2 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-1483255 | 0.00503279815751 | 1.0 | PIK3R1 PIK3R2 | PI Metabolism |
| REAC:R-HSA-2029480 | 0.0052959181411 | 1.0 | PIK3R1 PIK3R2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:04151 | 0.00654350485448 | 1.0 | PIK3R1 PIK3R2 | PI3K-Akt signaling pathway |
| WP:WP306 | 0.00654923464894 | 1.0 | PIK3R1 PIK3R2 | Focal Adhesion |
| REAC:R-HSA-202424 | 0.00656291627866 | 1.0 | PIK3R1 PIK3R2 | Downstream TCR signaling |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | PIK3R1 PIK3R2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | PIK3R1 PIK3R2 | Signaling by NTRKs |
| KEGG:05165 | 0.00707836525128 | 1.0 | PIK3R1 PIK3R2 | Human papillomavirus infection |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | PIK3R1 PIK3R2 | Signaling by VEGF |
| REAC:R-HSA-202733 | 0.00863268175469 | 1.0 | PIK3R1 PIK3R2 | Cell surface interactions at the vascular wall |
| REAC:R-HSA-1500931 | 0.00880362594785 | 1.0 | PIK3R1 PIK3R2 | Cell-Cell communication |
| WP:WP3888 | 0.00889388896944 | 1.0 | PIK3R1 PIK3R2 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-202403 | 0.00950416195513 | 1.0 | PIK3R1 PIK3R2 | TCR signaling |
| KEGG:05168 | 0.010450786984 | 1.0 | PIK3R1 PIK3R2 | Herpes simplex virus 1 infection |
| REAC:R-HSA-2454202 | 0.0119660935214 | 1.0 | PIK3R1 PIK3R2 | Fc epsilon receptor (FCERI) signaling |
| WP:WP3932 | 0.0121610546673 | 1.0 | PIK3R1 PIK3R2 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| REAC:R-HSA-416476 | 0.0147112561527 | 1.0 | PIK3R1 PIK3R2 | G alpha (q) signalling events |
| WP:WP4172 | 0.015291110435 | 1.0 | PIK3R1 PIK3R2 | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0157394270613 | 1.0 | PIK3R1 PIK3R2 | Pathways in cancer |
| HP:0000506 | 0.0211319299793 | 1.0 | PIK3R1 PIK3R2 | Telecanthus |
| REAC:R-HSA-1483257 | 0.0282158474125 | 1.0 | PIK3R1 PIK3R2 | Phospholipid metabolism |
| GO:0046935 | 0.029754345151 | 1.0 | PIK3R1 PIK3R2 | 1-phosphatidylinositol-3-kinase regulator activity |
| WP:WP2249 | 0.0332875339197 | 0.5 | PIK3R1 | Metastatic brain tumor |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | PIK3R1 PIK3R2 | ESR-mediated signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | PIK3R1 PIK3R2 | FLT3 Signaling |
| GO:0035014 | 0.0410249304355 | 1.0 | PIK3R1 PIK3R2 | phosphatidylinositol 3-kinase regulator activity |
| REAC:R-HSA-76002 | 0.0414841334642 | 1.0 | PIK3R1 PIK3R2 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | PIK3R1 PIK3R2 | PIP3 activates AKT signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | PIK3R1 PIK3R2 | Other interleukin signaling |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | PIK3R1 PIK3R2 | Signaling by Nuclear Receptors |
| CORUM:3133 | 0.0499173803268 | 0.5 | PIK3R1 | Phosphatidylinositol 3-kinase (PIK3CA, PIK3R1) |
| CORUM:7361 | 0.0499173803268 | 0.5 | PIK3R1 | ARAF-PIK3R1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PIK3R2 | PIK3R1 | 1.0 | 0.949 | bioplex (PIK3R2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_02611 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PIK3R1 | HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 |
| PIK3R2 | HuMAP2_00324 HuMAP2_00730 HuMAP2_02534 HuMAP2_02611 HuMAP2_05290 HuMAP2_06494 |