hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02617
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SH3GLB2 | Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) | UniProt NCBI |
| NAAA | N-acylethanolamine-hydrolyzing acid amidase (EC 3.5.1.-) (Acid ceramidase-like protein) (N-acylsphingosine amidohydrolase-like) (ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta] | UniProt NCBI |
| GLDC | Glycine dehydrogenase (decarboxylating), mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) | UniProt NCBI |
| BAG1 | BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1) | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | UniProt NCBI |
| SEC24A | Protein transport protein Sec24A (SEC24-related protein A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04141 | 2.12688843743e-05 | 0.571428571429 | SEC24D BAG1 SEC24A SEC23B | Protein processing in endoplasmic reticulum |
| WP:WP1982 | 0.000152785198067 | 0.428571428571 | SEC23B SEC24A SEC24D | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| GO:0090110 | 0.00115446662879 | 0.428571428571 | SEC23B SEC24A SEC24D | COPII-coated vesicle cargo loading |
| GO:0030127 | 0.00144279242783 | 0.428571428571 | SEC23B SEC24A SEC24D | COPII vesicle coat |
| GO:0035459 | 0.00560674176034 | 0.428571428571 | SEC23B SEC24A SEC24D | vesicle cargo loading |
| REAC:R-HSA-983170 | 0.00945016076191 | 0.285714285714 | SEC24D SEC24A | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| REAC:R-HSA-5694530 | 0.0110517363252 | 0.285714285714 | SEC24D SEC24A | Cargo concentration in the ER |
| CORUM:6115 | 0.0249993571594 | 0.142857142857 | BAG1 | BAG1-HSP70 complex |
| REAC:R-HSA-1655829 | 0.038372634236 | 0.285714285714 | SEC24D SEC24A | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0012507 | 0.0447246492298 | 0.428571428571 | SEC23B SEC24A SEC24D | ER to Golgi transport vesicle membrane |
| CORUM:6114 | 0.0499886427319 | 0.142857142857 | BAG1 | BAG1-HSC70 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SEC24A | SEC24D | 0.803 | 0.766 | bioplex_WMM Malo fraction |
| SEC23B | SEC24D | 0.679 | 0.708 | bioplex_WMM Malo fraction |
| SEC23B | SEC24A | 0.072 | 0.354 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| SEC24D | NAAA | 0.048 | 0.296 | bioplex (NAAA) bioplex_WMM |
| SEC24D | GLDC | 0.043 | 0.273 | fraction |
| SEC23B | GLDC | 0.035 | 0.265 | bioplex_WMM fraction |
| SEC24D | BAG1 | 0.023 | 0.207 | fraction |
| SEC24D | SH3GLB2 | 0.023 | 0.211 | fraction |
| SEC24A | SH3GLB2 | 0.007 | 0.0 | youn_WMM WMM_only |
| SEC23B | BAG1 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| SEC24A | BAG1 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| SEC23B | SH3GLB2 | 0.0 | 0.01 | youn_WMM gupta_WMM fraction |
| SEC24A | NAAA | 0.0 | 0.0 | bioplex (NAAA) bioplex_WMM |
Images
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Complex HuMAP2_02617 has an average edge precision of 0.239 which is ranked 5548 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SH3GLB2 | HuMAP2_02617 |
| NAAA | HuMAP2_02617 HuMAP2_02981 HuMAP2_05176 HuMAP2_06365 |
| GLDC | HuMAP2_02576 HuMAP2_02617 HuMAP2_04961 HuMAP2_05176 HuMAP2_06365 |
| BAG1 | HuMAP2_00761 HuMAP2_02527 HuMAP2_02617 HuMAP2_06941 |
| SEC24D | HuMAP2_00758 HuMAP2_01495 HuMAP2_02617 HuMAP2_05176 HuMAP2_06365 |
| SEC23B | HuMAP2_00758 HuMAP2_02617 HuMAP2_05176 HuMAP2_06134 HuMAP2_06365 |
| SEC24A | HuMAP2_00758 HuMAP2_01495 HuMAP2_02072 HuMAP2_02617 HuMAP2_03296 HuMAP2_05176 HuMAP2_06365 |