hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02619
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | UniProt NCBI |
| DNAJA2 | DnaJ homolog subfamily A member 2 (Cell cycle progression restoration gene 3 protein) (Dnj3) (Dj3) (HIRA-interacting protein 4) (Renal carcinoma antigen NY-REN-14) | UniProt NCBI |
| TUBA1C | Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | UniProt NCBI |
| ENDOG | Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-) | UniProt NCBI |
| TCP11L2 | T-complex protein 11-like protein 2 | UniProt NCBI |
| TUBA1B | Tubulin alpha-1B chain (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371497 | 3.23137788357e-07 | 0.666666666667 | TUBA1C DNAJA2 DNAJA1 TUBA1B | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:04210 | 0.000524612840052 | 0.5 | TUBA1C ENDOG TUBA1B | Apoptosis |
| REAC:R-HSA-2262752 | 0.00129372739211 | 0.666666666667 | TUBA1C DNAJA2 DNAJA1 TUBA1B | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.00265671127538 | 0.666666666667 | TUBA1C DNAJA2 DNAJA1 TUBA1B | Cellular responses to external stimuli |
| REAC:R-HSA-190840 | 0.0030072528049 | 0.333333333333 | TUBA1C TUBA1B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.00338255333894 | 0.333333333333 | TUBA1C TUBA1B | Transport of connexons to the plasma membrane |
| REAC:R-HSA-389977 | 0.00464022545552 | 0.333333333333 | TUBA1C TUBA1B | Post-chaperonin tubulin folding pathway |
| REAC:R-HSA-190861 | 0.0055883638448 | 0.333333333333 | TUBA1C TUBA1B | Gap junction assembly |
| REAC:R-HSA-9619483 | 0.0060953046166 | 0.333333333333 | TUBA1C TUBA1B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 0.0060953046166 | 0.333333333333 | TUBA1C TUBA1B | Formation of tubulin folding intermediates by CCT/TriC |
| WP:WP2272 | 0.00734453778716 | 0.333333333333 | TUBA1C TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-5626467 | 0.00834193552282 | 0.333333333333 | TUBA1C TUBA1B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.0102563889288 | 0.333333333333 | TUBA1C TUBA1B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| WP:WP2359 | 0.0118510730501 | 0.333333333333 | TUBA1C TUBA1B | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-190828 | 0.012367185342 | 0.333333333333 | TUBA1C TUBA1B | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0131143608537 | 0.333333333333 | TUBA1C TUBA1B | Gap junction trafficking and regulation |
| REAC:R-HSA-8955332 | 0.0146740061797 | 0.333333333333 | TUBA1C TUBA1B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.0154864524203 | 0.333333333333 | TUBA1C TUBA1B | Assembly and cell surface presentation of NMDA receptors |
| KEGG:04540 | 0.0215088204045 | 0.333333333333 | TUBA1C TUBA1B | Gap junction |
| REAC:R-HSA-437239 | 0.0217814503669 | 0.333333333333 | TUBA1C TUBA1B | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.0269276420577 | 0.333333333333 | TUBA1C TUBA1B | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 0.0280217040903 | 0.333333333333 | TUBA1C TUBA1B | Intraflagellar transport |
| REAC:R-HSA-983189 | 0.0350388564803 | 0.333333333333 | TUBA1C TUBA1B | Kinesins |
| REAC:R-HSA-1445148 | 0.0499130144295 | 0.333333333333 | TUBA1C TUBA1B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA1C | DNAJA1 | 0.555 | 0.647 | hein_WMM bioplex (DNAJA1,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM fraction boldt_WMM treiber_WMM |
| ENDOG | DNAJA1 | 0.453 | 0.594 | bioplex (DNAJA1) bioplex_WMM boldt boldt_WMM |
| TUBA1C | TUBA1B | 0.321 | 0.512 | hein_WMM bioplex (TUBA1B,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM |
| DNAJA2 | DNAJA1 | 0.14 | 0.407 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TUBA1B | TCP11L2 | 0.136 | 0.406 | hein_WMM bioplex (TUBA1B) bioplex_WMM |
| TUBA1C | DNAJA2 | 0.074 | 0.356 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM treiber_WMM |
| DNAJA1 | TCP11L2 | 0.007 | 0.006 | hein_WMM bioplex (TCP11L2) bioplex_WMM |
| DNAJA2 | TCP11L2 | 0.007 | 0.006 | hein_WMM bioplex (TCP11L2) bioplex_WMM |
| ENDOG | TUBA1B | 0.007 | 0.002 | bioplex_WMM boldt boldt_WMM |
| TUBA1B | DNAJA1 | 0.007 | 0.003 | hein_WMM bioplex (DNAJA1,TUBA1B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| DNAJA2 | ENDOG | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| TUBA1C | ENDOG | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| TUBA1C | TCP11L2 | 0.006 | 0.009 | hein_WMM bioplex (TCP11L2,TUBA1C) bioplex_WMM hein (TUBA1C) |
| DNAJA2 | TUBA1B | 0.006 | 0.008 | hein_WMM bioplex (TUBA1B) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_02619 has an average edge precision of 0.212 which is ranked 5994 out of all 6965 complexes.
Related Complexes