hu.MAP 2.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Links
FBXO44	F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)	UniProt NCBI
CDK13	Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)	UniProt NCBI
CDK12	Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)	UniProt NCBI
SCAF4	SR-related and CTD-associated factor 4 (CTD-binding SR-like protein RA4) (Splicing factor, arginine/serine-rich 15)	UniProt NCBI
YBX3	Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)	UniProt NCBI
CCNK	Cyclin-K	UniProt NCBI
SDAD1	Protein SDA1 homolog (Nucleolar protein 130) (SDA1 domain-containing protein 1) (hSDA)	UniProt NCBI
MYH8	Myosin-8 (Myosin heavy chain 8) (Myosin heavy chain, skeletal muscle, perinatal) (MyHC-perinatal)	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6796648	0.000672008352303	0.375	CDK12 CDK13 CCNK	TP53 Regulates Transcription of DNA Repair Genes
GO:0070816	0.000837474301274	0.375	CDK12 CDK13 CCNK	phosphorylation of RNA polymerase II C-terminal domain
GO:0019908	0.00111635111712	0.375	CDK12 CDK13 CCNK	nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0008353	0.00413439262839	0.375	CDK12 CDK13 CCNK	RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0004693	0.00896175085475	0.375	CDK12 CDK13 CCNK	cyclin-dependent protein serine/threonine kinase activity
GO:0097472	0.0102394198288	0.375	CDK12 CDK13 CCNK	cyclin-dependent protein kinase activity
GO:0002944	0.0126230555186	0.25	CDK12 CCNK	cyclin K-CDK12 complex
GO:0002945	0.0126230555186	0.25	CDK13 CCNK	cyclin K-CDK13 complex
GO:0032786	0.0184623087477	0.375	CDK12 CDK13 CCNK	positive regulation of DNA-templated transcription, elongation
GO:0000307	0.0330194726961	0.375	CDK12 CDK13 CCNK	cyclin-dependent protein kinase holoenzyme complex
CORUM:1083	0.0497224828424	0.125	CCNK	P-TEFb.4 complex

Protein 1	Protein 2	Score	Precision	Evidence
CDK12	CDK13	0.997	0.934	bioplex (CDK13) bioplex_WMM youn_WMM
CCNK	CDK12	0.424	0.575	hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction
CDK12	SCAF4	0.164	0.42	bioplex_WMM youn_WMM gupta_WMM fraction
CDK13	FBXO44	0.08	0.351	bioplex (CDK13) bioplex_WMM
MYH8	YBX3	0.057	0.32	fraction
SCAF4	YBX3	0.055	0.305	bioplex_WMM youn_WMM gupta_WMM fraction
CDK12	SDAD1	0.034	0.261	bioplex_WMM youn_WMM gupta_WMM fraction
CCNK	CDK13	0.024	0.214	bioplex (CDK13) bioplex_WMM youn_WMM
CDK12	FBXO44	0.008	0.086	bioplex_WMM WMM_only
CCNK	FBXO44	0.008	0.028	bioplex_WMM WMM_only
SCAF4	SDAD1	0.008	0.012	youn_WMM gupta_WMM WMM_only
CDK13	SDAD1	0.007	0.01	youn_WMM WMM_only
CCNK	MYH8	0.007	0.002	bioplex_WMM WMM_only
CCNK	SDAD1	0.007	0.001	bioplex_WMM youn_WMM gupta_WMM WMM_only
SCAF4	CDK13	0.006	0.004	youn_WMM WMM_only
CCNK	SCAF4	0.006	0.002	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDK13	YBX3	0.006	0.005	bioplex (CDK13) bioplex_WMM youn_WMM
CCNK	YBX3	0.005	0.009	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDK12	YBX3	0.004	0.01	bioplex_WMM youn_WMM gupta_WMM fraction
SDAD1	YBX3	0.004	0.009	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM

Click to enlarge

Complex HuMAP2_02631 has an average edge precision of 0.178 which is ranked 6447 out of all 6965 complexes.

Genename	Complexes
FBXO44	HuMAP2_01243 HuMAP2_02631 HuMAP2_03315 HuMAP2_05800
CDK13	HuMAP2_01243 HuMAP2_01539 HuMAP2_02631 HuMAP2_03159 HuMAP2_03315 HuMAP2_05800
CDK12	HuMAP2_00587 HuMAP2_01243 HuMAP2_01539 HuMAP2_02631 HuMAP2_03315 HuMAP2_03637 HuMAP2_05800
SCAF4	HuMAP2_00587 HuMAP2_01243 HuMAP2_02300 HuMAP2_02631 HuMAP2_03637 HuMAP2_05800
YBX3	HuMAP2_01695 HuMAP2_02631 HuMAP2_03425 HuMAP2_03637 HuMAP2_05476 HuMAP2_06751
CCNK	HuMAP2_00587 HuMAP2_01243 HuMAP2_02631 HuMAP2_03315 HuMAP2_03637 HuMAP2_05800
SDAD1	HuMAP2_01243 HuMAP2_02181 HuMAP2_02631 HuMAP2_03315
MYH8	HuMAP2_01077 HuMAP2_02631 HuMAP2_05532