hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02635
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF1 | Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1) | UniProt NCBI |
| ACAD9 | Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-) | UniProt NCBI |
| ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 1.50887656874e-06 | 1.0 | NDUFAF1 ACAD9 ECSIT | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 9.93609173322e-06 | 1.0 | NDUFAF1 ACAD9 ECSIT | Complex I biogenesis |
| CORUM:2942 | 1.00675659188e-05 | 0.666666666667 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, NDUFS3, NDUFAF1) |
| CORUM:2936 | 3.35555483123e-05 | 0.666666666667 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1) |
| CORUM:2939 | 5.03310689057e-05 | 0.666666666667 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1) |
| REAC:R-HSA-611105 | 6.02657683388e-05 | 1.0 | NDUFAF1 ACAD9 ECSIT | Respiratory electron transport |
| REAC:R-HSA-163200 | 0.000113954833063 | 1.0 | NDUFAF1 ACAD9 ECSIT | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| REAC:R-HSA-1428517 | 0.000330512177188 | 1.0 | NDUFAF1 ACAD9 ECSIT | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0032981 | 0.00326856055107 | 1.0 | NDUFAF1 ACAD9 ECSIT | mitochondrial respiratory chain complex I assembly |
| GO:0010257 | 0.00326856055107 | 1.0 | NDUFAF1 ACAD9 ECSIT | NADH dehydrogenase complex assembly |
| HP:0011923 | 0.00525183643236 | 0.666666666667 | ACAD9 NDUFAF1 | Decreased activity of mitochondrial complex I |
| GO:0033108 | 0.0106693663112 | 1.0 | NDUFAF1 ACAD9 ECSIT | mitochondrial respiratory chain complex assembly |
| HP:0008972 | 0.0161338784795 | 0.666666666667 | ACAD9 NDUFAF1 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.0166709261154 | 0.666666666667 | ACAD9 NDUFAF1 | Abnormal activity of mitochondrial respiratory chain |
| HP:0001397 | 0.041834410056 | 0.666666666667 | ACAD9 NDUFAF1 | Hepatic steatosis |
| HP:0031137 | 0.0498941597886 | 0.666666666667 | ACAD9 NDUFAF1 | Storage in hepatocytes |
| HP:0006561 | 0.0498941597886 | 0.666666666667 | ACAD9 NDUFAF1 | Lipid accumulation in hepatocytes |
| CORUM:2943 | 0.0499776345577 | 0.333333333333 | NDUFAF1 | Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACAD9 | ECSIT | 1.0 | 0.949 | bioplex (ACAD9,ECSIT) bioplex_WMM boldt youn_WMM boldt_WMM |
| ECSIT | NDUFAF1 | 0.999 | 0.949 | bioplex (ECSIT) bioplex_WMM youn_WMM |
| ACAD9 | NDUFAF1 | 0.806 | 0.767 | bioplex (ACAD9) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_02635 has an average edge precision of 0.888 which is ranked 623 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFAF1 | HuMAP2_00306 HuMAP2_02635 HuMAP2_04089 HuMAP2_04892 |
| ACAD9 | HuMAP2_00106 HuMAP2_00306 HuMAP2_02635 HuMAP2_04892 HuMAP2_05964 |
| ECSIT | HuMAP2_00306 HuMAP2_02635 HuMAP2_04089 HuMAP2_04583 HuMAP2_04892 |