hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02639

Confidence: Medium

Genename	Protein Name	Links
PER1	Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)	UniProt NCBI
FBXL3	F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)	UniProt NCBI
CRY2	Cryptochrome-2	UniProt NCBI
CRY1	Cryptochrome-1	UniProt NCBI
TEKT4	Tektin-4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04710	2.75543196072e-09	0.8	CRY2 FBXL3 CRY1 PER1	Circadian rhythm
REAC:R-HSA-400253	2.46446696587e-07	0.8	CRY2 FBXL3 CRY1 PER1	Circadian Clock
GO:0043153	3.72971334932e-07	0.8	CRY2 FBXL3 CRY1 PER1	entrainment of circadian clock by photoperiod
GO:0009648	4.7240495605e-07	0.8	CRY2 FBXL3 CRY1 PER1	photoperiodism
GO:0009649	7.29370383293e-07	0.8	CRY2 FBXL3 CRY1 PER1	entrainment of circadian clock
WP:WP3594	2.47680251413e-06	0.8	CRY2 FBXL3 CRY1 PER1	Circadian rhythm related genes
WP:WP3298	3.01539944338e-06	0.6	CRY2 CRY1 PER1	Melatonin metabolism and effects
WP:WP410	7.69263363807e-06	0.6	CRY2 CRY1 PER1	Exercise-induced Circadian Regulation
GO:2000323	1.81582264982e-05	0.6	CRY2 CRY1 PER1	negative regulation of glucocorticoid receptor signaling pathway
GO:2000322	1.81582264982e-05	0.6	CRY2 CRY1 PER1	regulation of glucocorticoid receptor signaling pathway
CORUM:2773	4.0241279111e-05	0.4	CRY2 FBXL3	Ubiquitin E3 ligase (CRY2, SKP1A, CUL1, FBXL3)
CORUM:2772	4.0241279111e-05	0.4	CRY1 FBXL3	Ubiquitin E3 ligase (CRY1, SKP1A, CUL1, FBXL3)
GO:0031958	0.000108905457596	0.6	CRY2 CRY1 PER1	corticosteroid receptor signaling pathway
GO:0042921	0.000108905457596	0.6	CRY2 CRY1 PER1	glucocorticoid receptor signaling pathway
GO:0042752	0.000192129923302	0.8	CRY2 FBXL3 CRY1 PER1	regulation of circadian rhythm
GO:0007623	0.00141941829177	0.8	CRY2 FBXL3 CRY1 PER1	circadian rhythm
GO:0048511	0.0022600637582	0.8	CRY2 FBXL3 CRY1 PER1	rhythmic process
GO:0033144	0.00265002518516	0.6	CRY2 CRY1 PER1	negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0071483	0.00450823411379	0.4	CRY2 CRY1	cellular response to blue light
GO:0009785	0.00450823411379	0.4	CRY2 CRY1	blue light signaling pathway
GO:0009637	0.00450823411379	0.4	CRY2 CRY1	response to blue light
GO:0009882	0.00450823411379	0.4	CRY2 CRY1	blue light photoreceptor activity
GO:0009416	0.00595830214782	0.8	CRY2 FBXL3 CRY1 PER1	response to light stimulus
GO:0032922	0.0250406933376	0.6	CRY2 CRY1 PER1	circadian regulation of gene expression
GO:0009314	0.0260363554847	0.8	CRY2 FBXL3 CRY1 PER1	response to radiation
GO:0033143	0.0293579111372	0.6	CRY2 CRY1 PER1	regulation of intracellular steroid hormone receptor signaling pathway

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CRY1	PER1	0.998	0.944	hein_WMM bioplex (CRY1,PER1) bioplex_WMM hein (CRY1)
CRY2	CRY1	0.996	0.929	hein_WMM bioplex (CRY1) bioplex_WMM
CRY1	FBXL3	0.149	0.411	bioplex (CRY1,FBXL3) bioplex_WMM
CRY2	TEKT4	0.076	0.357	bioplex (TEKT4) bioplex_WMM
CRY1	TEKT4	0.074	0.356	bioplex (TEKT4) bioplex_WMM
CRY2	PER1	0.011	0.148	hein_WMM bioplex_WMM WMM_only
CRY2	FBXL3	0.007	0.005	bioplex_WMM WMM_only
PER1	FBXL3	0.007	0.007	bioplex_WMM WMM_only
FBXL3	TEKT4	0.0	0.006	bioplex (TEKT4) bioplex_WMM

Images

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Complex HuMAP2_02639 has an average edge precision of 0.351 which is ranked 3927 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PER1	HuMAP2_02639 HuMAP2_02822 HuMAP2_03989 HuMAP2_05794 HuMAP2_06686
FBXL3	HuMAP2_02639 HuMAP2_03436 HuMAP2_06178
CRY2	HuMAP2_02639 HuMAP2_02822 HuMAP2_06178 HuMAP2_06686
CRY1	HuMAP2_02639 HuMAP2_02822 HuMAP2_05794 HuMAP2_06178 HuMAP2_06686
TEKT4	HuMAP2_02639 HuMAP2_06049 HuMAP2_06178 HuMAP2_06217 HuMAP2_06686

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02639