hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02640

Confidence: Very High

Genename	Protein Name	Links
PRKAR1A	cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1)	UniProt NCBI
AKAP3	A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein)	UniProt NCBI
PRKACG	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	UniProt NCBI
PRKAR1B	cAMP-dependent protein kinase type I-beta regulatory subunit	UniProt NCBI
PRKACB	cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)	UniProt NCBI
GPR161	G-protein coupled receptor 161 (G-protein coupled receptor RE2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-442720	3.95630202777e-10	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	CREB1 phosphorylation through the activation of Adenylate Cyclase
WP:WP35	1.49405633792e-09	0.833333333333	PRKACG PRKAR1A AKAP3 PRKAR1B PRKACB	G Protein Signaling Pathways
REAC:R-HSA-163615	2.18078791174e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	PKA activation
WP:WP3869	2.67250261542e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Cannabinoid receptor signaling
REAC:R-HSA-164378	2.85149294827e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	PKA activation in glucagon signalling
REAC:R-HSA-111931	3.66581100449e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	PKA-mediated phosphorylation of CREB
WP:WP2012	4.51056154801e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	miRs in Muscle Cell Differentiation
WP:WP3965	6.17617913466e-09	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Lipid Metabolism Pathway
REAC:R-HSA-180024	1.06023874251e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	DARPP-32 events
REAC:R-HSA-5610787	2.05315496829e-08	0.833333333333	GPR161 PRKACG PRKAR1A PRKAR1B PRKACB	Hedgehog 'off' state
REAC:R-HSA-163359	3.76416846139e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Glucagon signaling in metabolic regulation
REAC:R-HSA-111933	4.89421979513e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Calmodulin induced events
REAC:R-HSA-111997	4.89421979513e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	CaM pathway
REAC:R-HSA-111996	6.26114845342e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Ca-dependent events
REAC:R-HSA-381676	6.26114845342e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REAC:R-HSA-5358351	7.16543775046e-08	0.833333333333	GPR161 PRKACG PRKAR1A PRKAR1B PRKACB	Signaling by Hedgehog
REAC:R-HSA-432040	7.89588505076e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Vasopressin regulates renal water homeostasis via Aquaporins
REAC:R-HSA-1489509	9.83124590848e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	DAG and IP3 signaling
REAC:R-HSA-445717	9.83124590848e-08	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Aquaporin-mediated transport
REAC:R-HSA-112043	2.98313168299e-07	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	PLC beta mediated events
REAC:R-HSA-112040	3.23137788357e-07	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	G-protein mediated events
WP:WP4540	6.67174766457e-07	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Pathways Regulating Hippo Signaling
GO:0034199	8.69705349223e-07	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	activation of protein kinase A activity
GO:0071377	8.69705349223e-07	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	cellular response to glucagon stimulus
REAC:R-HSA-422356	1.02998099357e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Regulation of insulin secretion
WP:WP4541	1.27167793569e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Hippo-Merlin Signaling Dysregulation
REAC:R-HSA-438064	1.29621455882e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Post NMDA receptor activation events
GO:0033762	1.41607269498e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	response to glucagon
REAC:R-HSA-442755	2.29512356464e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Activation of NMDA receptors and postsynaptic events
REAC:R-HSA-111885	2.5254039204e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Opioid Signalling
KEGG:04910	3.24115048953e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Insulin signaling pathway
REAC:R-HSA-163685	4.11561600349e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Integration of energy metabolism
GO:0097546	5.45777947309e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	ciliary base
GO:0044441	5.55396082418e-06	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	ciliary part
GO:0003091	8.66795236882e-06	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	renal water homeostasis
WP:WP4249	1.25967140138e-05	0.5	PRKACG PRKACB GPR161	Hedgehog Signaling Pathway
GO:0005929	1.97868763679e-05	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	cilium
KEGG:04340	2.21364046062e-05	0.5	PRKACG PRKACB GPR161	Hedgehog signaling pathway
REAC:R-HSA-983231	3.02487101892e-05	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Factors involved in megakaryocyte development and platelet production
REAC:R-HSA-112314	4.44669391559e-05	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Neurotransmitter receptors and postsynaptic signal transmission
GO:0050891	8.38584297733e-05	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	multicellular organismal water homeostasis
GO:0030104	9.85570254489e-05	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	water homeostasis
REAC:R-HSA-112315	0.000126179445512	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Transmission across Chemical Synapses
REAC:R-HSA-418594	0.00022047052897	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	G alpha (i) signalling events
REAC:R-HSA-163358	0.000221597343492	0.333333333333	PRKACG PRKACB	PKA-mediated phosphorylation of key metabolic factors
REAC:R-HSA-9006925	0.000227296904657	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Intracellular signaling by second messengers
GO:0003014	0.000246130343849	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	renal system process
WP:WP536	0.00041417182098	0.5	PRKAR1A PRKAR1B PRKACB	Calcium Regulation in the Cardiac Cell
WP:WP2436	0.000435062158246	0.333333333333	PRKACG PRKACB	Dopamine metabolism
REAC:R-HSA-8963896	0.000465187760645	0.333333333333	PRKACG PRKACB	HDL assembly
WP:WP706	0.000502836491787	0.5	PRKAR1A PRKAR1B PRKACB	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
WP:WP289	0.000539074693736	0.5	PRKAR1A PRKAR1B PRKACB	Myometrial Relaxation and Contraction Pathways
REAC:R-HSA-9010642	0.000620139265586	0.333333333333	PRKACG PRKACB	ROBO receptors bind AKAP5
REAC:R-HSA-112316	0.00064028821607	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Neuronal System
GO:0044463	0.000997295456864	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	cell projection part
GO:0120038	0.000997295456864	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	plasma membrane bounded cell projection part
REAC:R-HSA-9634600	0.00146070989197	0.333333333333	PRKACG PRKACB	Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
REAC:R-HSA-392517	0.00146070989197	0.333333333333	PRKACG PRKACB	Rap1 signalling
REAC:R-HSA-8963898	0.00232260810736	0.333333333333	PRKACG PRKACB	Plasma lipoprotein assembly
KEGG:05020	0.0025298764655	0.333333333333	PRKACG PRKACB	Prion diseases
REAC:R-HSA-109582	0.00385038750362	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Hemostasis
WP:WP2636	0.00390360990759	0.333333333333	PRKACG PRKACB	Common Pathways Underlying Drug Addiction
REAC:R-HSA-388396	0.00390747823604	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	GPCR downstream signalling
KEGG:04913	0.00437348887795	0.333333333333	PRKACG PRKACB	Ovarian steroidogenesis
REAC:R-HSA-5621575	0.00464022545552	0.333333333333	PRKACG PRKACB	CD209 (DC-SIGN) signaling
KEGG:04962	0.00485078019495	0.333333333333	PRKACG PRKACB	Vasopressin-regulated water reabsorption
REAC:R-HSA-163560	0.00510333351271	0.333333333333	PRKACG PRKACB	Triglyceride catabolism
REAC:R-HSA-372790	0.00540246444736	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Signaling by GPCR
KEGG:04923	0.00587890830807	0.333333333333	PRKACG PRKACB	Regulation of lipolysis in adipocytes
REAC:R-HSA-382551	0.00608967581104	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	Transport of small molecules
KEGG:05030	0.00642969194212	0.333333333333	PRKACG PRKACB	Cocaine addiction
KEGG:05110	0.00700491988002	0.333333333333	PRKACG PRKACB	Vibrio cholerae infection
KEGG:04961	0.0076045655811	0.333333333333	PRKACG PRKACB	Endocrine and other factor-regulated calcium reabsorption
KEGG:04924	0.00854975942062	0.333333333333	PRKACG PRKACB	Renin secretion
KEGG:04213	0.00954974409847	0.333333333333	PRKACG PRKACB	Longevity regulating pathway - multiple species
KEGG:04976	0.00954974409847	0.333333333333	PRKACG PRKACB	Bile secretion
KEGG:04927	0.00989523261713	0.333333333333	PRKACG PRKACB	Cortisol synthesis and secretion
KEGG:04742	0.0102467957679	0.333333333333	PRKACG PRKACB	Taste transduction
REAC:R-HSA-8853659	0.0102563889288	0.333333333333	PRKACG PRKACB	RET signaling
GO:0120025	0.010522585488	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	plasma membrane bounded cell projection
GO:0042995	0.0110844141438	1.0	PRKACG PRKAR1B PRKAR1A GPR161 AKAP3 PRKACB	cell projection
WP:WP1403	0.0111423482415	0.333333333333	PRKACG PRKACB	AMP-activated Protein Kinase (AMPK) Signaling
KEGG:04971	0.0113378999483	0.333333333333	PRKACG PRKACB	Gastric acid secretion
KEGG:04720	0.0117137285677	0.333333333333	PRKACG PRKACB	Long-term potentiation
KEGG:05031	0.0117137285677	0.333333333333	PRKACG PRKACB	Amphetamine addiction
REAC:R-HSA-8979227	0.012367185342	0.333333333333	PRKACG PRKACB	Triglyceride metabolism
KEGG:04918	0.0140958050009	0.333333333333	PRKACG PRKACB	Thyroid hormone synthesis
KEGG:04911	0.015804666162	0.333333333333	PRKACG PRKACB	Insulin secretion
HP:0000140	0.0166795319196	0.5	GPR161 PRKACG PRKAR1A	Abnormality of the menstrual cycle
KEGG:04970	0.0166952607135	0.333333333333	PRKACG PRKACB	Salivary secretion
HP:0000858	0.0181630394779	0.5	GPR161 PRKACG PRKAR1A	Menstrual irregularities
KEGG:04727	0.0190270141569	0.333333333333	PRKACG PRKACB	GABAergic synapse
KEGG:05032	0.0200017533138	0.333333333333	PRKACG PRKACB	Morphine addiction
KEGG:04914	0.0200017533138	0.333333333333	PRKACG PRKACB	Progesterone-mediated oocyte maturation
KEGG:04750	0.0200017533138	0.333333333333	PRKACG PRKACB	Inflammatory mediator regulation of TRP channels
KEGG:04912	0.0200017533138	0.333333333333	PRKACG PRKACB	GnRH signaling pathway
KEGG:04211	0.0204981178463	0.333333333333	PRKACG PRKACB	Longevity regulating pathway
GO:0051018	0.0207293189685	0.5	PRKAR1A PRKAR1B AKAP3	protein kinase A binding
GO:0071375	0.0209376514335	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	cellular response to peptide hormone stimulus
KEGG:04540	0.0215088204045	0.333333333333	PRKACG PRKACB	Gap junction
KEGG:05146	0.0220231518675	0.333333333333	PRKACG PRKACB	Amoebiasis
KEGG:05414	0.0220231518675	0.333333333333	PRKACG PRKACB	Dilated cardiomyopathy (DCM)
KEGG:04713	0.0236020276363	0.333333333333	PRKACG PRKACB	Circadian entrainment
KEGG:04925	0.0236020276363	0.333333333333	PRKACG PRKACB	Aldosterone synthesis and secretion
KEGG:04916	0.0241402690929	0.333333333333	PRKACG PRKACB	Melanogenesis
KEGG:01522	0.0246844798555	0.333333333333	PRKACG PRKACB	Endocrine resistance
WP:WP4321	0.0271822427146	0.333333333333	PRKACG PRKACB	Thermogenesis
KEGG:04726	0.0274949586745	0.333333333333	PRKACG PRKACB	Serotonergic synapse
KEGG:04922	0.0280749165362	0.333333333333	PRKACG PRKACB	Glucagon signaling pathway
KEGG:04725	0.0280749165362	0.333333333333	PRKACG PRKACB	Cholinergic synapse
KEGG:04928	0.0286608208008	0.333333333333	PRKACG PRKACB	Parathyroid hormone synthesis, secretion and action
KEGG:04270	0.0298504554679	0.333333333333	PRKACG PRKACB	Vascular smooth muscle contraction
KEGG:04724	0.0304541793376	0.333333333333	PRKACG PRKACB	Glutamatergic synapse
REAC:R-HSA-174824	0.0338154872995	0.333333333333	PRKACG PRKACB	Plasma lipoprotein assembly, remodeling, and clearance
GO:0043434	0.0339497870457	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	response to peptide hormone
KEGG:04114	0.0348461971614	0.333333333333	PRKACG PRKACB	Oocyte meiosis
REAC:R-HSA-162582	0.0348492364063	0.833333333333	GPR161 PRKACG PRKAR1A PRKAR1B PRKACB	Signal Transduction
GO:0032147	0.0371455172523	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	activation of protein kinase activity
KEGG:04611	0.0374860246019	0.333333333333	PRKACG PRKACB	Platelet activation
REAC:R-HSA-5610780	0.0375501136505	0.333333333333	PRKACG PRKACB	Degradation of GLI1 by the proteasome
REAC:R-HSA-5610783	0.0388379782234	0.333333333333	PRKACG PRKACB	Degradation of GLI2 by the proteasome
REAC:R-HSA-5610785	0.0388379782234	0.333333333333	PRKACG PRKACB	GLI3 is processed to GLI3R by the proteasome
KEGG:04919	0.0388413362769	0.333333333333	PRKACG PRKACB	Thyroid hormone signaling pathway
WP:WP3929	0.0416969783243	0.333333333333	PRKACG PRKACB	Chemokine signaling pathway
GO:1901653	0.0427192912202	0.666666666667	PRKACG PRKAR1A PRKAR1B PRKACB	cellular response to peptide
KEGG:04926	0.0437703225478	0.333333333333	PRKACG PRKACB	Relaxin signaling pathway
KEGG:04728	0.0444979624084	0.333333333333	PRKACG PRKACB	Dopaminergic synapse
KEGG:04915	0.0452314672739	0.333333333333	PRKACG PRKACB	Estrogen signaling pathway
KEGG:04740	0.0467160590485	0.333333333333	PRKACG PRKACB	Olfactory transduction
KEGG:04371	0.0467160590485	0.333333333333	PRKACG PRKACB	Apelin signaling pathway
REAC:R-HSA-70171	0.0470157324282	0.333333333333	PRKACG PRKACB	Glycolysis
KEGG:05012	0.0482240719397	0.333333333333	PRKACG PRKACB	Parkinson disease

Edges

Protein 1	Protein 2	Score	Precision	Evidence
PRKACB	PRKAR1A	1.0	0.949	hein_WMM bioplex (PRKACB,PRKAR1A) bioplex_WMM Guru hein (PRKACB) fraction
PRKAR1A	PRKAR1B	1.0	0.949	hein_WMM bioplex (PRKAR1A) bioplex_WMM
PRKAR1A	AKAP3	0.969	0.881	bioplex (PRKAR1A) bioplex_WMM
PRKAR1A	PRKACG	0.956	0.862	bioplex (PRKACG,PRKAR1A) bioplex_WMM
PRKACB	PRKAR1B	0.943	0.856	hein_WMM bioplex (PRKACB) bioplex_WMM hein (PRKACB)
PRKAR1A	GPR161	0.74	0.739	bioplex (GPR161,PRKAR1A) bioplex_WMM
PRKAR1B	GPR161	0.076	0.355	bioplex (GPR161) bioplex_WMM
PRKACB	PRKACG	0.047	0.29	bioplex (PRKACB,PRKACG) bioplex_WMM
PRKACG	PRKAR1B	0.018	0.177	bioplex (PRKACG) bioplex_WMM
PRKACB	GPR161	0.014	0.138	bioplex (GPR161,PRKACB) bioplex_WMM
PRKACG	GPR161	0.014	0.141	bioplex (GPR161) bioplex_WMM
GPR161	AKAP3	0.009	0.102	bioplex_WMM WMM_only
PRKAR1B	AKAP3	0.008	0.06	bioplex_WMM WMM_only
PRKACG	AKAP3	0.008	0.056	bioplex_WMM WMM_only
PRKACB	AKAP3	0.008	0.041	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02640 has an average edge precision of 0.44 which is ranked 2938 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PRKAR1A	HuMAP2_00037 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706
AKAP3	HuMAP2_02640 HuMAP2_04753 HuMAP2_05706
PRKACG	HuMAP2_01784 HuMAP2_01832 HuMAP2_02640 HuMAP2_04684 HuMAP2_05056
PRKAR1B	HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706
PRKACB	HuMAP2_00037 HuMAP2_01784 HuMAP2_01832 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684
GPR161	HuMAP2_02640 HuMAP2_04753 HuMAP2_05706

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02640