hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02652
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TBCD | Tubulin-specific chaperone D (Beta-tubulin cofactor D) (tfcD) (SSD-1) (Tubulin-folding cofactor D) | UniProt NCBI |
| KDM5C | Lysine-specific demethylase 5C (EC 1.14.11.-) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) | UniProt NCBI |
| TPM2 | Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2) | UniProt NCBI |
| MYH6 | Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha) | UniProt NCBI |
| ACTN4 | Alpha-actinin-4 (Non-muscle alpha-actinin 4) | UniProt NCBI |
| TNNI1 | Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform) | UniProt NCBI |
| ACTN1 | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 5.9673145044e-08 | 0.571428571429 | TPM2 TNNI1 ACTN4 MYH6 | Striated Muscle Contraction Pathway |
| REAC:R-HSA-390522 | 6.91320337457e-05 | 0.428571428571 | TPM2 TNNI1 MYH6 | Striated Muscle Contraction |
| GO:0030048 | 0.00401549948599 | 0.571428571429 | TPM2 TNNI1 ACTN4 MYH6 | actin filament-based movement |
| REAC:R-HSA-373753 | 0.00728151453382 | 0.285714285714 | ACTN4 ACTN1 | Nephrin family interactions |
| HP:0010876 | 0.00803286615942 | 0.571428571429 | TPM2 ACTN4 TBCD MYH6 | Abnormal circulating protein level |
| REAC:R-HSA-397014 | 0.00856161121757 | 0.428571428571 | TPM2 TNNI1 MYH6 | Muscle contraction |
| GO:0015629 | 0.0116130510065 | 0.714285714286 | TPM2 TNNI1 ACTN4 ACTN1 MYH6 | actin cytoskeleton |
| KEGG:04520 | 0.0229343695188 | 0.285714285714 | ACTN4 ACTN1 | Adherens junction |
| WP:WP2118 | 0.0232759452351 | 0.285714285714 | ACTN4 ACTN1 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| HP:0000297 | 0.0265508883611 | 0.285714285714 | TBCD KDM5C | Facial hypotonia |
| GO:0033275 | 0.026626530587 | 0.428571428571 | TPM2 TNNI1 MYH6 | actin-myosin filament sliding |
| GO:0030049 | 0.026626530587 | 0.428571428571 | TPM2 TNNI1 MYH6 | muscle filament sliding |
| KEGG:04260 | 0.0278177533068 | 0.285714285714 | TPM2 MYH6 | Cardiac muscle contraction |
| KEGG:05410 | 0.0315889561635 | 0.285714285714 | TPM2 MYH6 | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05146 | 0.0347751411246 | 0.285714285714 | ACTN4 ACTN1 | Amoebiasis |
| KEGG:05414 | 0.0347751411246 | 0.285714285714 | TPM2 MYH6 | Dilated cardiomyopathy (DCM) |
| KEGG:04670 | 0.0372632222286 | 0.285714285714 | ACTN4 ACTN1 | Leukocyte transendothelial migration |
| CORUM:4025 | 0.0499886427319 | 0.142857142857 | ACTN1 | ACTN1-PARVB complex |
| CORUM:5655 | 0.0499886427319 | 0.142857142857 | ACTN4 | Ternary complex (LRRC7, CAMK2a, ACTN4) |
| CORUM:6455 | 0.0499886427319 | 0.142857142857 | TBCD | ARL2-TBCD complex |
| CORUM:6697 | 0.0499886427319 | 0.142857142857 | TBCD | ARL2-TBCD complex |
| CORUM:6788 | 0.0499886427319 | 0.142857142857 | ACTN4 | SLC9A3R1-ACTN4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYH6 | TPM2 | 0.985 | 0.899 | Guru fraction |
| ACTN4 | ACTN1 | 0.859 | 0.796 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| TPM2 | ACTN4 | 0.801 | 0.766 | hein_WMM bioplex_WMM Guru fraction |
| TPM2 | ACTN1 | 0.548 | 0.642 | hein_WMM bioplex_WMM Guru fraction |
| TPM2 | TNNI1 | 0.078 | 0.352 | Guru fraction |
| TBCD | ACTN4 | 0.037 | 0.265 | fraction |
| KDM5C | ACTN1 | 0.03 | 0.231 | fraction |
| KDM5C | ACTN4 | 0.03 | 0.231 | fraction |
| TBCD | ACTN1 | 0.022 | 0.211 | fraction |
| TBCD | KDM5C | 0.007 | 0.003 | bioplex_WMM WMM_only |
| TBCD | TPM2 | 0.003 | 0.017 | fraction |
| MYH6 | TNNI1 | 0.0 | 0.001 | Guru fraction |
Images
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Complex HuMAP2_02652 has an average edge precision of 0.368 which is ranked 3664 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TBCD | HuMAP2_01301 HuMAP2_02498 HuMAP2_02652 |
| KDM5C | HuMAP2_02652 HuMAP2_04405 |
| TPM2 | HuMAP2_02652 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 HuMAP2_06391 |
| MYH6 | HuMAP2_00710 HuMAP2_01870 HuMAP2_02652 HuMAP2_03104 HuMAP2_04204 HuMAP2_06061 HuMAP2_06387 |
| ACTN4 | HuMAP2_02652 HuMAP2_04204 HuMAP2_06387 |
| TNNI1 | HuMAP2_02652 HuMAP2_06061 HuMAP2_06387 |
| ACTN1 | HuMAP2_02652 HuMAP2_04204 HuMAP2_06387 |