hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02664
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | UniProt NCBI |
| OSGEP | Probable tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7555 | 1.00555407742e-05 | 1.0 | OSGEP LAGE3 | KEOPS complex |
| CORUM:7556 | 3.51943927099e-05 | 1.0 | OSGEP LAGE3 | PRAME complex |
| HP:0100720 | 0.000260475748797 | 1.0 | OSGEP LAGE3 | Hypoplasia of the ear cartilage |
| HP:0002410 | 0.000454162844056 | 1.0 | OSGEP LAGE3 | Aqueductal stenosis |
| HP:0002036 | 0.00100182980306 | 1.0 | OSGEP LAGE3 | Hiatus hernia |
| REAC:R-HSA-6782315 | 0.00137425723915 | 1.0 | OSGEP LAGE3 | tRNA modification in the nucleus and cytosol |
| HP:0005108 | 0.00176322045339 | 1.0 | OSGEP LAGE3 | Abnormality of the intervertebral disk |
| HP:0000096 | 0.00425777666302 | 1.0 | OSGEP LAGE3 | Glomerulosclerosis |
| GO:0000408 | 0.00676235117068 | 1.0 | OSGEP LAGE3 | EKC/KEOPS complex |
| HP:0003774 | 0.00694601996791 | 1.0 | OSGEP LAGE3 | Stage 5 chronic kidney disease |
| HP:0001181 | 0.00716308309191 | 1.0 | OSGEP LAGE3 | Adducted thumb |
| REAC:R-HSA-72306 | 0.00863268175469 | 1.0 | OSGEP LAGE3 | tRNA processing |
| HP:0000341 | 0.00977118001255 | 1.0 | OSGEP LAGE3 | Narrow forehead |
| HP:0000601 | 0.00977118001255 | 1.0 | OSGEP LAGE3 | Hypotelorism |
| HP:0012622 | 0.0105526072589 | 1.0 | OSGEP LAGE3 | Chronic kidney disease |
| HP:0001166 | 0.0119217746565 | 1.0 | OSGEP LAGE3 | Arachnodactyly |
| HP:0000112 | 0.0124928176442 | 1.0 | OSGEP LAGE3 | Nephropathy |
| HP:0001238 | 0.0155483985436 | 1.0 | OSGEP LAGE3 | Slender finger |
| HP:0001622 | 0.019295242007 | 1.0 | OSGEP LAGE3 | Premature birth |
| HP:0000100 | 0.019295242007 | 1.0 | OSGEP LAGE3 | Nephrotic syndrome |
| HP:0001302 | 0.0203872364924 | 1.0 | OSGEP LAGE3 | Pachygyria |
| HP:0000095 | 0.0258806032458 | 1.0 | OSGEP LAGE3 | Abnormality of renal glomerulus morphology |
| HP:0031263 | 0.0258806032458 | 1.0 | OSGEP LAGE3 | Abnormal renal corpuscle morphology |
| HP:0001339 | 0.0275703561803 | 1.0 | OSGEP LAGE3 | Lissencephaly |
| HP:0000093 | 0.0306559919738 | 1.0 | OSGEP LAGE3 | Proteinuria |
| HP:0020129 | 0.0343827988412 | 1.0 | OSGEP LAGE3 | Abnormal urine protein level |
| GO:0070525 | 0.0351642260875 | 1.0 | OSGEP LAGE3 | tRNA threonylcarbamoyladenosine metabolic process |
| HP:0011035 | 0.0358354520556 | 1.0 | OSGEP LAGE3 | Abnormal renal cortex morphology |
| HP:0100490 | 0.0408946925611 | 1.0 | OSGEP LAGE3 | Camptodactyly of finger |
| HP:0001220 | 0.0419466138543 | 1.0 | OSGEP LAGE3 | Interphalangeal joint contracture of finger |
| HP:0000400 | 0.0440905296328 | 1.0 | OSGEP LAGE3 | Macrotia |
| HP:0006261 | 0.0457335305099 | 1.0 | OSGEP LAGE3 | Abnormal phalangeal joint morphology of the hand |
| HP:0012575 | 0.047406586281 | 1.0 | OSGEP LAGE3 | Abnormal nephron morphology |
| HP:0004374 | 0.0485386539584 | 1.0 | OSGEP LAGE3 | Hemiplegia/hemiparesis |
| HP:0012785 | 0.0491096969462 | 1.0 | OSGEP LAGE3 | Flexion contracture of finger |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LAGE3 | OSGEP | 1.0 | 0.949 | hein_WMM bioplex (OSGEP) bioplex_WMM boldt hein (OSGEP) fraction boldt_WMM |
Images
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Complex HuMAP2_02664 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LAGE3 | HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134 HuMAP2_04445 HuMAP2_05672 |
| OSGEP | HuMAP2_01144 HuMAP2_01706 HuMAP2_02664 HuMAP2_03463 HuMAP2_04134 |