hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02671
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NAXE | NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) (YjeF N-terminal domain-containing protein 1) (YjeF_N1) | UniProt NCBI |
| MTHFD1 | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | UniProt NCBI |
| GMPR | GMP reductase 1 (GMPR 1) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 1) (Guanosine monophosphate reductase 1) | UniProt NCBI |
| ADHFE1 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial (HOT) (EC 1.1.99.24) (Alcohol dehydrogenase iron-containing protein 1) (ADHFe1) (Fe-containing alcohol dehydrogenase) | UniProt NCBI |
| NPEPL1 | Probable aminopeptidase NPEPL1 (EC 3.4.11.-) (Aminopeptidase-like 1) | UniProt NCBI |
| GMPR2 | GMP reductase 2 (GMPR 2) (EC 1.7.1.7) (Guanosine 5'-monophosphate oxidoreductase 2) (Guanosine monophosphate reductase 2) | UniProt NCBI |
| YJEFN3 | YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-74217 | 0.00208509668734 | 0.285714285714 | GMPR2 GMPR | Purine salvage |
| REAC:R-HSA-8956321 | 0.00728151453382 | 0.285714285714 | GMPR2 GMPR | Nucleotide salvage |
| GO:0003920 | 0.00946729163895 | 0.285714285714 | GMPR2 GMPR | GMP reductase activity |
| GO:0016657 | 0.00946729163895 | 0.285714285714 | GMPR2 GMPR | oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor |
| GO:0015950 | 0.00946729163895 | 0.285714285714 | GMPR2 GMPR | purine nucleotide interconversion |
| GO:0015951 | 0.00946729163895 | 0.285714285714 | GMPR2 GMPR | purine ribonucleotide interconversion |
| GO:0052856 | 0.0283955176165 | 0.285714285714 | NAXE YJEFN3 | NADHX epimerase activity |
| GO:0052857 | 0.0283955176165 | 0.285714285714 | NAXE YJEFN3 | NADPHX epimerase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GMPR2 | GMPR | 0.991 | 0.911 | bioplex (GMPR2) bioplex_WMM |
| MTHFD1 | GMPR | 0.873 | 0.805 | fraction |
| NAXE | GMPR2 | 0.352 | 0.538 | bioplex (GMPR2) fraction |
| ADHFE1 | GMPR | 0.315 | 0.51 | fraction |
| ADHFE1 | GMPR2 | 0.159 | 0.416 | fraction |
| NPEPL1 | NAXE | 0.134 | 0.405 | fraction |
| YJEFN3 | GMPR2 | 0.102 | 0.365 | fraction |
| NAXE | GMPR | 0.096 | 0.358 | fraction |
| NPEPL1 | MTHFD1 | 0.064 | 0.349 | fraction |
| GMPR2 | MTHFD1 | 0.064 | 0.347 | bioplex (GMPR2) fraction |
| ADHFE1 | NPEPL1 | 0.053 | 0.301 | fraction |
| NAXE | MTHFD1 | 0.017 | 0.168 | bioplex_WMM fraction |
Images
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Complex HuMAP2_02671 has an average edge precision of 0.456 which is ranked 2828 out of all 6965 complexes.
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