hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02676
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN2A | Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| CDK4 | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) | UniProt NCBI |
| OGFRL1 | Opioid growth factor receptor-like protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3998 | 2.98215510426e-06 | 0.75 | CDKN2A CDKN2C CDK4 | Prader-Willi and Angelman Syndrome |
| REAC:R-HSA-2559585 | 6.68850838342e-06 | 0.75 | CDKN2A CDKN2C CDK4 | Oncogene Induced Senescence |
| WP:WP45 | 8.93316220103e-06 | 0.75 | CDKN2A CDKN2C CDK4 | G1 to S cell cycle control |
| REAC:R-HSA-9632697 | 1.00555407742e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| REAC:R-HSA-9630791 | 1.00555407742e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| CORUM:1642 | 1.50819606993e-05 | 0.5 | CDKN2A CDK4 | p16-cyclin D2-CDK4 complex |
| REAC:R-HSA-69236 | 1.54728521392e-05 | 0.75 | CDKN2A CDKN2C CDK4 | G1 Phase |
| REAC:R-HSA-69231 | 1.54728521392e-05 | 0.75 | CDKN2A CDKN2C CDK4 | Cyclin D associated events in G1 |
| WP:WP2261 | 1.99028350738e-05 | 0.75 | CDKN2A CDKN2C CDK4 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-9632700 | 3.01639213985e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| REAC:R-HSA-9630747 | 3.01639213985e-05 | 0.5 | CDKN2A CDK4 | Diseases of Cellular Senescence |
| REAC:R-HSA-9632693 | 3.01639213985e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects |
| REAC:R-HSA-9630794 | 3.01639213985e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| REAC:R-HSA-9630750 | 3.01639213985e-05 | 0.5 | CDKN2A CDK4 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects |
| KEGG:01522 | 3.14744143419e-05 | 0.75 | CDKN2A CDKN2C CDK4 | Endocrine resistance |
| WP:WP179 | 5.68642674079e-05 | 0.75 | CDKN2A CDKN2C CDK4 | Cell Cycle |
| KEGG:04110 | 7.51264877201e-05 | 0.75 | CDKN2A CDKN2C CDK4 | Cell cycle |
| KEGG:04934 | 0.000122203178829 | 0.75 | CDKN2A CDKN2C CDK4 | Cushing syndrome |
| HP:0002894 | 0.000181431813171 | 0.75 | CDKN2A CDKN2C CDK4 | Neoplasm of the pancreas |
| REAC:R-HSA-2559582 | 0.00025917959103 | 0.75 | CDKN2A CDKN2C CDK4 | Senescence-Associated Secretory Phenotype (SASP) |
| KEGG:05166 | 0.000334381475127 | 0.75 | CDKN2A CDKN2C CDK4 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-2559580 | 0.000396320737366 | 0.75 | CDKN2A CDKN2C CDK4 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-453279 | 0.000695357358954 | 0.75 | CDKN2A CDKN2C CDK4 | Mitotic G1-G1/S phases |
| WP:WP4204 | 0.000729007032317 | 0.5 | CDKN2A CDK4 | Tumor suppressor activity of SMARCB1 |
| WP:WP2828 | 0.00105523555839 | 0.5 | CDKN2A CDK4 | Bladder Cancer |
| KEGG:05219 | 0.00133025918726 | 0.5 | CDKN2A CDK4 | Bladder cancer |
| REAC:R-HSA-2559583 | 0.00145806857207 | 0.75 | CDKN2A CDKN2C CDK4 | Cellular Senescence |
| HP:0012056 | 0.00149887618857 | 0.5 | CDKN2A CDK4 | Cutaneous melanoma |
| HP:0008069 | 0.00173850840205 | 0.75 | CDKN2A CDKN2C CDK4 | Neoplasm of the skin |
| HP:0012334 | 0.00177124047018 | 0.5 | CDKN2A CDKN2C | Extrahepatic cholestasis |
| GO:0016538 | 0.00281780772825 | 0.75 | CDKN2A CDKN2C CDK4 | cyclin-dependent protein serine/threonine kinase regulator activity |
| HP:0007378 | 0.0032959701335 | 0.75 | CDKN2A CDKN2C CDK4 | Neoplasm of the gastrointestinal tract |
| HP:0100641 | 0.00347280043641 | 0.5 | CDKN2A CDKN2C | Neoplasm of the adrenal cortex |
| KEGG:05218 | 0.00376859643257 | 0.5 | CDKN2A CDK4 | Melanoma |
| KEGG:04115 | 0.00401698930658 | 0.5 | CDKN2A CDK4 | p53 signaling pathway |
| KEGG:05223 | 0.00401698930658 | 0.5 | CDKN2A CDK4 | Non-small cell lung cancer |
| WP:WP4255 | 0.00403274972955 | 0.5 | CDKN2A CDK4 | Non-small cell lung cancer |
| KEGG:05214 | 0.00453740909542 | 0.5 | CDKN2A CDK4 | Glioma |
| KEGG:05212 | 0.00494838688052 | 0.5 | CDKN2A CDK4 | Pancreatic cancer |
| HP:0001732 | 0.00521370204815 | 0.75 | CDKN2A CDKN2C CDK4 | Abnormality of the pancreas |
| KEGG:05220 | 0.00537705972469 | 0.5 | CDKN2A CDK4 | Chronic myeloid leukemia |
| WP:WP4263 | 0.00567595707464 | 0.5 | CDKN2A CDK4 | Pancreatic adenocarcinoma pathway |
| HP:0011792 | 0.00652537513546 | 0.75 | CDKN2A CDKN2C CDK4 | Neoplasm by histology |
| HP:0100631 | 0.00920632571228 | 0.5 | CDKN2A CDKN2C | Neoplasm of the adrenal gland |
| WP:WP2877 | 0.0132924049077 | 0.5 | CDKN2A CDKN2C | Vitamin D Receptor Pathway |
| REAC:R-HSA-2262752 | 0.0147563350021 | 0.75 | CDKN2A CDKN2C CDK4 | Cellular responses to stress |
| HP:0001480 | 0.01857406376 | 0.5 | CDKN2A CDK4 | Freckling |
| KEGG:04218 | 0.0206513420529 | 0.5 | CDKN2A CDK4 | Cellular senescence |
| KEGG:05225 | 0.0248155779574 | 0.5 | CDKN2A CDK4 | Hepatocellular carcinoma |
| REAC:R-HSA-8953897 | 0.0253615474256 | 0.75 | CDKN2A CDKN2C CDK4 | Cellular responses to external stimuli |
| HP:0030895 | 0.0277254502169 | 0.5 | CDKN2A CDK4 | Abnormal gastrointestinal motility |
| HP:0002579 | 0.0277254502169 | 0.5 | CDKN2A CDK4 | Gastrointestinal dysmotility |
| REAC:R-HSA-69278 | 0.0299490115235 | 0.75 | CDKN2A CDKN2C CDK4 | Cell Cycle, Mitotic |
| KEGG:05203 | 0.03463652866 | 0.5 | CDKN2A CDK4 | Viral carcinogenesis |
| HP:0006753 | 0.0360996225593 | 0.5 | CDKN2A CDK4 | Neoplasm of the stomach |
| HP:0002861 | 0.0373855400094 | 0.5 | CDKN2A CDK4 | Melanoma |
| GO:2000134 | 0.0383423539882 | 0.75 | CDKN2A CDKN2C CDK4 | negative regulation of G1/S transition of mitotic cell cycle |
| GO:1902807 | 0.0396936057372 | 0.75 | CDKN2A CDKN2C CDK4 | negative regulation of cell cycle G1/S phase transition |
| KEGG:05163 | 0.0399515654372 | 0.5 | CDKN2A CDK4 | Human cytomegalovirus infection |
| CORUM:5287 | 0.0499140284799 | 0.25 | CDK4 | CCND1-CDK4 complex |
| CORUM:3084 | 0.0499140284799 | 0.25 | CDK4 | CCND1-CDK4 complex |
| CORUM:5107 | 0.0499140284799 | 0.25 | CDK4 | p34(SEI-1)-CDK4-CyclinD2 complex |
| CORUM:3086 | 0.0499140284799 | 0.25 | CDK4 | CCND3-CDK4 complex |
| CORUM:3085 | 0.0499140284799 | 0.25 | CDK4 | CCND2-CDK4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN2A | CDK4 | 0.974 | 0.886 | hein_WMM bioplex (CDK4) bioplex_WMM youn_WMM hein (CDK4) gupta_WMM |
| CDKN2C | CDK4 | 0.654 | 0.692 | bioplex (CDK4,CDKN2C) bioplex_WMM |
| CDK4 | OGFRL1 | 0.65 | 0.689 | bioplex (CDK4) bioplex_WMM |
| CDKN2C | CDKN2A | 0.011 | 0.139 | bioplex_WMM WMM_only |
| CDKN2A | OGFRL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CDKN2C | OGFRL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02676 has an average edge precision of 0.429 which is ranked 3031 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN2A | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |
| CDKN2C | HuMAP2_01131 HuMAP2_01816 HuMAP2_02228 HuMAP2_02676 HuMAP2_03854 HuMAP2_05212 HuMAP2_06056 HuMAP2_06643 |
| CDK4 | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |
| OGFRL1 | HuMAP2_01131 HuMAP2_02676 HuMAP2_06643 |