hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02678
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KAT5 | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (cPLA(2)-interacting protein) | UniProt NCBI |
| ING3 | Inhibitor of growth protein 3 (p47ING3) | UniProt NCBI |
| YEATS4 | YEATS domain-containing protein 4 (Glioma-amplified sequence 41) (Gas41) (NuMA-binding protein 1) (NuBI-1) (NuBI1) | UniProt NCBI |
| EPC1 | Enhancer of polycomb homolog 1 | UniProt NCBI |
| EPC2 | Enhancer of polycomb homolog 2 (EPC-like) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2857 | 2.44051186012e-14 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | NuA4/Tip60 HAT complex |
| CORUM:798 | 3.66076779018e-14 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | NuA4/Tip60-HAT complex A |
| GO:0043189 | 9.52557378781e-11 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | H4/H2A histone acetyltransferase complex |
| GO:0035267 | 9.52557378781e-11 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | NuA4 histone acetyltransferase complex |
| GO:0032777 | 1.2197780676e-10 | 0.8 | KAT5 EPC2 ING3 EPC1 | Piccolo NuA4 histone acetyltransferase complex |
| CORUM:528 | 2.4762098927e-10 | 0.8 | KAT5 YEATS4 ING3 EPC1 | NuA4/Tip60-HAT complex |
| CORUM:529 | 3.30143569849e-10 | 0.8 | KAT5 YEATS4 ING3 EPC1 | NuA4/Tip60-HAT complex |
| GO:1902562 | 6.13901440096e-09 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | H4 histone acetyltransferase complex |
| CORUM:2856 | 1.62061692851e-07 | 0.6 | KAT5 ING3 EPC1 | NuA4/Tip60 HAT complex |
| GO:0000123 | 1.72940527637e-07 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | histone acetyltransferase complex |
| GO:0031248 | 3.20924936678e-07 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | protein acetyltransferase complex |
| GO:1902493 | 3.20924936678e-07 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | acetyltransferase complex |
| REAC:R-HSA-3214847 | 5.88493116331e-06 | 0.8 | KAT5 YEATS4 ING3 EPC1 | HATs acetylate histones |
| GO:0004402 | 4.46760620155e-05 | 0.8 | KAT5 EPC2 ING3 EPC1 | histone acetyltransferase activity |
| GO:0061733 | 5.1601378618e-05 | 0.8 | KAT5 EPC2 ING3 EPC1 | peptide-lysine-N-acetyltransferase activity |
| REAC:R-HSA-3247509 | 7.68024844941e-05 | 0.8 | KAT5 YEATS4 ING3 EPC1 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 7.68024844941e-05 | 0.8 | KAT5 YEATS4 ING3 EPC1 | Chromatin organization |
| GO:0034212 | 9.31770903001e-05 | 0.8 | KAT5 EPC2 ING3 EPC1 | peptide N-acetyltransferase activity |
| GO:0008080 | 0.000164422098058 | 0.8 | KAT5 EPC2 ING3 EPC1 | N-acetyltransferase activity |
| CORUM:787 | 0.000187691761896 | 0.4 | EPC1 KAT5 | NuA4/Tip60-HAT complex B |
| GO:0016410 | 0.000310236355112 | 0.8 | KAT5 EPC2 ING3 EPC1 | N-acyltransferase activity |
| GO:0016407 | 0.000403202499238 | 0.8 | KAT5 EPC2 ING3 EPC1 | acetyltransferase activity |
| GO:0043968 | 0.000507918241599 | 0.6 | YEATS4 ING3 EPC1 | histone H2A acetylation |
| GO:0016573 | 0.000625996400903 | 0.8 | KAT5 YEATS4 ING3 EPC1 | histone acetylation |
| GO:0018393 | 0.000674764960334 | 0.8 | KAT5 YEATS4 ING3 EPC1 | internal peptidyl-lysine acetylation |
| GO:0006475 | 0.000809132371969 | 0.8 | KAT5 YEATS4 ING3 EPC1 | internal protein amino acid acetylation |
| GO:0018394 | 0.000838244988417 | 0.8 | KAT5 YEATS4 ING3 EPC1 | peptidyl-lysine acetylation |
| GO:0006473 | 0.0022600637582 | 0.8 | KAT5 YEATS4 ING3 EPC1 | protein acetylation |
| GO:0043543 | 0.00534283459488 | 0.8 | KAT5 YEATS4 ING3 EPC1 | protein acylation |
| GO:0016747 | 0.00558300460276 | 0.8 | KAT5 EPC2 ING3 EPC1 | transferase activity, transferring acyl groups other than amino-acyl groups |
| GO:0016746 | 0.00896454920435 | 0.8 | KAT5 EPC2 ING3 EPC1 | transferase activity, transferring acyl groups |
| GO:1990234 | 0.0112296002627 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | transferase complex |
| GO:0043967 | 0.0211681462149 | 0.6 | YEATS4 ING3 EPC1 | histone H4 acetylation |
| GO:0018205 | 0.0327910140884 | 0.8 | KAT5 YEATS4 ING3 EPC1 | peptidyl-lysine modification |
| GO:0044451 | 0.0442638282809 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | nucleoplasm part |
| CORUM:0000000 | 0.0474603483533 | 1.0 | KAT5 YEATS4 EPC2 ING3 EPC1 | CORUM root |
| CORUM:7324 | 0.0499494897235 | 0.2 | KAT5 | HINT1-TIP60 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KAT5 | ING3 | 1.0 | 0.949 | hein_WMM bioplex (KAT5) bioplex_WMM hein (ING3) |
| YEATS4 | EPC1 | 1.0 | 0.949 | hein_WMM bioplex (YEATS4) bioplex_WMM youn_WMM hein (YEATS4) |
| YEATS4 | KAT5 | 0.999 | 0.948 | hein_WMM bioplex (KAT5,YEATS4) bioplex_WMM hein (YEATS4) |
| YEATS4 | EPC2 | 0.998 | 0.939 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (YEATS4) |
| YEATS4 | ING3 | 0.993 | 0.918 | hein_WMM bioplex (YEATS4) bioplex_WMM hein (ING3,YEATS4) |
| KAT5 | EPC2 | 0.984 | 0.899 | hein_WMM bioplex (KAT5) bioplex_WMM |
| ING3 | EPC2 | 0.935 | 0.85 | hein_WMM bioplex_WMM hein (ING3) |
| ING3 | EPC1 | 0.92 | 0.844 | hein_WMM bioplex_WMM hein (ING3) |
| KAT5 | EPC1 | 0.901 | 0.825 | hein_WMM bioplex (KAT5) bioplex_WMM youn_WMM |
| EPC1 | EPC2 | 0.113 | 0.38 | hein_WMM bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02678 has an average edge precision of 0.85 which is ranked 760 out of all 6965 complexes.
Related Complexes