hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_02685

Confidence: Medium

Genename	Protein Name	Links
LAMTOR2	Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)	UniProt NCBI
TRIM37	E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)	UniProt NCBI
LAMTOR3	Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)	UniProt NCBI
LAMTOR1	Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)	UniProt NCBI
LAMTOR5	Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)	UniProt NCBI
ODF2L	Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like)	UniProt NCBI
BORCS7	BLOC-1-related complex subunit 7 (Diaskedin)	UniProt NCBI
BORCS8	BLOC-1-related complex subunit 8 (MEF2B neighbor)	UniProt NCBI
BORCS5	BLOC-1-related complex subunit 5 (Loss of heterozygosity 12 chromosomal region 1) (Myristoylated lysosomal protein) (Myrlysin)	UniProt NCBI
LAMTOR4	Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]	UniProt NCBI
CCDC172	Coiled-coil domain-containing protein 172	UniProt NCBI
TEX35	Testis-expressed protein 35	UniProt NCBI
BORCS6	BLOC-1-related complex subunit 6 (Lysosome-dispersing protein) (Lyspersin)	UniProt NCBI
ZNF610	Zinc finger protein 610	UniProt NCBI
CCDC57	Coiled-coil domain-containing protein 57	UniProt NCBI
CCDC122	Coiled-coil domain-containing protein 122	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6888	6.59631697235e-11	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	v-ATPase-Ragulator-AXIN/LKB1-AMPK complex
GO:0071986	2.14561866932e-10	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Ragulator complex
CORUM:7545	2.87035802876e-09	0.25	BORCS7 BORCS6 BORCS5 BORCS8	BORC complex
REAC:R-HSA-166208	5.06779959994e-09	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	mTORC1-mediated signalling
REAC:R-HSA-380972	1.88435064143e-08	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Energy dependent regulation of mTOR by LKB1-AMPK
REAC:R-HSA-165159	1.09645398884e-07	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	mTOR signalling
REAC:R-HSA-8943724	7.88574315513e-07	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Regulation of PTEN gene transcription
GO:0099078	3.09998667106e-06	0.25	BORCS7 BORCS6 BORCS5 BORCS8	BORC complex
REAC:R-HSA-5628897	4.46371325701e-06	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	TP53 Regulates Metabolic Genes
REAC:R-HSA-1632852	6.83118775799e-06	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Macroautophagy
GO:0071230	8.34717198287e-06	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	cellular response to amino acid stimulus
GO:0032008	9.7803076989e-06	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	positive regulation of TOR signaling
REAC:R-HSA-9612973	1.60251266552e-05	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Autophagy
KEGG:04150	1.65748189508e-05	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	mTOR signaling pathway
GO:0043200	2.01747533946e-05	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	response to amino acid
REAC:R-HSA-6807070	6.22221952328e-05	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	PTEN Regulation
GO:0031902	0.000120699950898	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	late endosome membrane
CORUM:5226	0.000150180288233	0.125	LAMTOR2 LAMTOR3	p14-Mp1-ERK2 complex
CORUM:5222	0.000150180288233	0.125	LAMTOR2 LAMTOR3	p14-Mp1-MEK1 complex
REAC:R-HSA-1257604	0.000779922138149	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	PIP3 activates AKT signaling
GO:0032006	0.000821323239289	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	regulation of TOR signaling
REAC:R-HSA-9006925	0.00167294247316	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Intracellular signaling by second messengers
GO:0031929	0.00176138594312	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	TOR signaling
GO:0071229	0.00229450083779	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	cellular response to acid chemical
REAC:R-HSA-3700989	0.00649630818657	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Transcriptional Regulation by TP53
GO:0001101	0.00843702274718	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	response to acid chemical
GO:0005765	0.0101092994803	0.375	LAMTOR2 LAMTOR4 LAMTOR1 BORCS5 LAMTOR5 LAMTOR3	lysosomal membrane
GO:0098852	0.0101092994803	0.375	LAMTOR2 LAMTOR4 LAMTOR1 BORCS5 LAMTOR5 LAMTOR3	lytic vacuole membrane
GO:0016241	0.0157958024601	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	regulation of macroautophagy
GO:0005774	0.0214637106261	0.375	LAMTOR2 LAMTOR4 LAMTOR1 BORCS5 LAMTOR5 LAMTOR3	vacuolar membrane
GO:0005085	0.0220618366607	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	guanyl-nucleotide exchange factor activity
HPA:014010_22	0.026471307782	0.375	LAMTOR2 BORCS7 LAMTOR1 LAMTOR5 BORCS8 CCDC57	endometrium 2; cells in endometrial stroma[Approved,Medium]
GO:0045121	0.0266748312334	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	membrane raft
GO:0098857	0.0275127397605	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	membrane microdomain
GO:0005770	0.0275127397605	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	late endosome
GO:0098589	0.0310751924705	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	membrane region
REAC:R-HSA-8953897	0.0325399792756	0.3125	LAMTOR2 LAMTOR4 LAMTOR1 LAMTOR3 LAMTOR5	Cellular responses to external stimuli

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BORCS5	BORCS6	0.998	0.937	bioplex (BORCS6) bioplex_WMM youn_WMM
BORCS7	BORCS6	0.988	0.902	bioplex (BORCS6) bioplex_WMM
BORCS6	BORCS8	0.95	0.858	bioplex (BORCS6) bioplex_WMM
ODF2L	BORCS6	0.949	0.858	bioplex (BORCS6) bioplex_WMM
BORCS6	LAMTOR2	0.922	0.843	bioplex (BORCS6) bioplex_WMM
LAMTOR4	BORCS6	0.915	0.839	bioplex (BORCS6) bioplex_WMM
LAMTOR3	BORCS6	0.761	0.749	bioplex (BORCS6) bioplex_WMM
LAMTOR1	BORCS6	0.753	0.747	bioplex (BORCS6) bioplex_WMM
BORCS6	TRIM37	0.197	0.45	bioplex (BORCS6) bioplex_WMM
LAMTOR1	LAMTOR3	0.193	0.446	bioplex_WMM fraction
BORCS6	CCDC122	0.174	0.433	bioplex (BORCS6) bioplex_WMM
LAMTOR5	BORCS6	0.113	0.38	bioplex (BORCS6) bioplex_WMM
CCDC172	CCDC122	0.084	0.348	bioplex (CCDC172) bioplex_WMM
CCDC57	BORCS6	0.049	0.293	bioplex (BORCS6) bioplex_WMM
LAMTOR5	LAMTOR1	0.048	0.294	hein_WMM bioplex_WMM fraction
BORCS7	TEX35	0.044	0.28	bioplex (TEX35) bioplex_WMM
ZNF610	TRIM37	0.027	0.225	bioplex (ZNF610) bioplex_WMM
BORCS5	TEX35	0.024	0.216	bioplex (TEX35) bioplex_WMM
BORCS5	BORCS7	0.013	0.143	bioplex_WMM WMM_only boldt_WMM
CCDC57	BORCS8	0.009	0.108	bioplex_WMM WMM_only
ODF2L	CCDC57	0.009	0.102	bioplex_WMM WMM_only
CCDC57	CCDC122	0.009	0.108	bioplex_WMM WMM_only
BORCS7	CCDC57	0.009	0.108	bioplex_WMM WMM_only
ODF2L	BORCS8	0.009	0.095	bioplex_WMM WMM_only
CCDC57	TRIM37	0.009	0.096	bioplex_WMM gupta_WMM WMM_only
BORCS8	CCDC122	0.009	0.099	bioplex_WMM WMM_only
ODF2L	CCDC122	0.009	0.097	bioplex_WMM WMM_only
BORCS7	BORCS8	0.009	0.098	bioplex_WMM WMM_only
BORCS5	CCDC57	0.009	0.098	bioplex_WMM WMM_only
BORCS7	ODF2L	0.009	0.096	bioplex_WMM WMM_only
LAMTOR5	CCDC57	0.008	0.094	bioplex_WMM WMM_only
LAMTOR4	BORCS8	0.008	0.09	hein_WMM bioplex_WMM WMM_only
BORCS7	CCDC122	0.008	0.089	bioplex_WMM WMM_only
ODF2L	TRIM37	0.008	0.084	bioplex_WMM gupta_WMM WMM_only
TRIM37	BORCS8	0.008	0.085	bioplex_WMM WMM_only
BORCS5	BORCS8	0.008	0.08	bioplex_WMM WMM_only
BORCS5	ODF2L	0.008	0.082	bioplex_WMM WMM_only
LAMTOR5	BORCS8	0.008	0.078	bioplex_WMM WMM_only
LAMTOR5	ODF2L	0.008	0.072	bioplex_WMM WMM_only
TRIM37	CCDC122	0.008	0.071	bioplex_WMM WMM_only
BORCS7	TRIM37	0.008	0.067	bioplex_WMM WMM_only
BORCS5	CCDC122	0.008	0.067	bioplex_WMM WMM_only
LAMTOR5	CCDC122	0.008	0.061	bioplex_WMM WMM_only
LAMTOR4	CCDC57	0.008	0.06	bioplex_WMM WMM_only
LAMTOR5	BORCS7	0.008	0.06	bioplex_WMM WMM_only
LAMTOR3	CCDC57	0.008	0.06	bioplex_WMM WMM_only
LAMTOR1	BORCS8	0.008	0.033	hein_WMM bioplex_WMM WMM_only
LAMTOR1	CCDC57	0.008	0.022	bioplex_WMM WMM_only
BORCS5	TRIM37	0.008	0.019	bioplex_WMM WMM_only
LAMTOR5	TRIM37	0.008	0.024	bioplex_WMM WMM_only
LAMTOR4	ODF2L	0.008	0.015	bioplex_WMM WMM_only
LAMTOR5	BORCS5	0.008	0.016	bioplex_WMM WMM_only
LAMTOR3	BORCS8	0.008	0.013	bioplex_WMM WMM_only
LAMTOR3	ODF2L	0.008	0.012	bioplex_WMM WMM_only
LAMTOR4	LAMTOR3	0.007	0.011	bioplex_WMM WMM_only
LAMTOR4	CCDC122	0.007	0.008	bioplex_WMM WMM_only
LAMTOR5	LAMTOR4	0.007	0.008	bioplex_WMM WMM_only
BORCS7	LAMTOR4	0.007	0.008	bioplex_WMM WMM_only
LAMTOR3	CCDC122	0.007	0.007	bioplex_WMM WMM_only
BORCS7	LAMTOR3	0.007	0.008	bioplex_WMM WMM_only
LAMTOR1	LAMTOR4	0.007	0.012	hein_WMM bioplex_WMM WMM_only
LAMTOR1	ODF2L	0.007	0.008	bioplex_WMM WMM_only
CCDC57	LAMTOR2	0.007	0.005	bioplex_WMM WMM_only
LAMTOR1	CCDC122	0.007	0.012	bioplex_WMM WMM_only
LAMTOR1	BORCS7	0.007	0.009	bioplex_WMM WMM_only
LAMTOR4	TRIM37	0.007	0.0	bioplex_WMM WMM_only
LAMTOR3	TRIM37	0.007	0.005	bioplex_WMM WMM_only
BORCS5	CCDC172	0.007	0.005	gupta_WMM WMM_only
BORCS5	LAMTOR4	0.007	0.002	bioplex_WMM WMM_only
BORCS5	LAMTOR3	0.007	0.005	bioplex_WMM WMM_only
LAMTOR2	BORCS8	0.007	0.003	bioplex_WMM WMM_only
ODF2L	LAMTOR2	0.007	0.002	bioplex_WMM WMM_only
LAMTOR1	TRIM37	0.007	0.008	bioplex_WMM WMM_only
LAMTOR1	BORCS5	0.007	0.008	bioplex_WMM WMM_only
LAMTOR2	CCDC122	0.007	0.004	bioplex_WMM WMM_only
BORCS7	LAMTOR2	0.007	0.004	bioplex_WMM WMM_only
LAMTOR5	LAMTOR3	0.007	0.007	bioplex_WMM WMM_only
LAMTOR2	TRIM37	0.007	0.008	bioplex_WMM WMM_only
LAMTOR5	LAMTOR2	0.007	0.005	hein_WMM bioplex_WMM WMM_only
BORCS5	LAMTOR2	0.007	0.007	bioplex_WMM WMM_only
LAMTOR4	LAMTOR2	0.006	0.005	bioplex_WMM WMM_only
LAMTOR1	LAMTOR2	0.0	0.017	hein_WMM bioplex_WMM WMM_only
LAMTOR3	LAMTOR2	0.0	0.004	bioplex_WMM WMM_only

Images

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Complex HuMAP2_02685 has an average edge precision of 0.155 which is ranked 6668 out of all 6965 complexes.

Related Complexes

Genename	Complexes
LAMTOR2	HuMAP2_02266 HuMAP2_02685 HuMAP2_03784
TRIM37	HuMAP2_02568 HuMAP2_02685 HuMAP2_06197
LAMTOR3	HuMAP2_01885 HuMAP2_02685 HuMAP2_03784
LAMTOR1	HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784
LAMTOR5	HuMAP2_01018 HuMAP2_01885 HuMAP2_02685 HuMAP2_03784
ODF2L	HuMAP2_02266 HuMAP2_02685 HuMAP2_03784
BORCS7	HuMAP2_01218 HuMAP2_02685 HuMAP2_03181
BORCS8	HuMAP2_02685 HuMAP2_03784
BORCS5	HuMAP2_01218 HuMAP2_02266 HuMAP2_02685
LAMTOR4	HuMAP2_01297 HuMAP2_01678 HuMAP2_02685
CCDC172	HuMAP2_02685 HuMAP2_06215
TEX35	HuMAP2_01218 HuMAP2_02444 HuMAP2_02685 HuMAP2_03181
BORCS6	HuMAP2_02266 HuMAP2_02685 HuMAP2_03784
ZNF610	HuMAP2_02568 HuMAP2_02685
CCDC57	HuMAP2_02266 HuMAP2_02685 HuMAP2_03784
CCDC122	HuMAP2_02685 HuMAP2_06215

hu.MAP 2.0: Complex View

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Complex: HuMAP2_02685