hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02691
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GRK2 | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein coupled receptor kinase 2) | UniProt NCBI |
| GRK3 | Beta-adrenergic receptor kinase 2 (Beta-ARK-2) (EC 2.7.11.15) (G-protein-coupled receptor kinase 3) | UniProt NCBI |
| PAPOLA | Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha) | UniProt NCBI |
| PPWD1 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC 5.2.1.8) (Spliceosome-associated cyclophilin) | UniProt NCBI |
| HPF1 | Histone PARylation factor 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4249 | 0.00233629086428 | 0.4 | GRK3 GRK2 | Hedgehog Signaling Pathway |
| KEGG:04340 | 0.00403884103568 | 0.4 | GRK3 GRK2 | Hedgehog signaling pathway |
| KEGG:05032 | 0.0137641082753 | 0.4 | GRK3 GRK2 | Morphine addiction |
| KEGG:04724 | 0.020974746694 | 0.4 | GRK3 GRK2 | Glutamatergic synapse |
| GO:0047696 | 0.0270421395626 | 0.4 | GRK3 GRK2 | beta-adrenergic receptor kinase activity |
| KEGG:04740 | 0.0322094461771 | 0.4 | GRK3 GRK2 | Olfactory transduction |
| KEGG:04062 | 0.0353865382697 | 0.4 | GRK3 GRK2 | Chemokine signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GRK3 | GRK2 | 1.0 | 0.949 | bioplex (GRK2) bioplex_WMM |
| GRK2 | PAPOLA | 0.203 | 0.454 | youn_WMM fraction |
| PPWD1 | PAPOLA | 0.066 | 0.35 | youn_WMM fraction |
| HPF1 | PAPOLA | 0.047 | 0.29 | fraction |
| PPWD1 | GRK2 | 0.025 | 0.215 | fraction |
| HPF1 | PPWD1 | 0.003 | 0.012 | fraction |
| HPF1 | GRK2 | 0.0 | 0.0 | fraction |
| PPWD1 | GRK3 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_02691 has an average edge precision of 0.284 which is ranked 4828 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GRK2 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| GRK3 | HuMAP2_01849 HuMAP2_02054 HuMAP2_02691 HuMAP2_06904 |
| PAPOLA | HuMAP2_02691 HuMAP2_04635 |
| PPWD1 | HuMAP2_01345 HuMAP2_02691 |
| HPF1 | HuMAP2_02691 HuMAP2_05822 |