hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02697
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ANKS6 | Ankyrin repeat and SAM domain-containing protein 6 (Ankyrin repeat domain-containing protein 14) (SamCystin) (Sterile alpha motif domain-containing protein 6) (SAM domain-containing protein 6) | UniProt NCBI |
| NEK8 | Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a) | UniProt NCBI |
| ANKS3 | Ankyrin repeat and SAM domain-containing protein 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6257 | 2.01342304124e-05 | 0.666666666667 | ANKS6 NEK8 | ANKS6-NEK8-INVS-NPHP3 complex |
| WP:WP4352 | 0.000100842112761 | 1.0 | ANKS6 NEK8 ANKS3 | Ciliary landscape |
| HP:0000105 | 0.00120138848745 | 0.666666666667 | ANKS6 NEK8 | Enlarged kidney |
| WP:WP4656 | 0.00251276217802 | 0.666666666667 | ANKS6 NEK8 | Joubert Syndrome |
| HP:0000090 | 0.00556051868131 | 0.666666666667 | ANKS6 NEK8 | Nephronophthisis |
| HP:0100957 | 0.00834660940556 | 0.666666666667 | ANKS6 NEK8 | Abnormal renal medulla morphology |
| HP:0001650 | 0.0130957715491 | 0.666666666667 | ANKS6 NEK8 | Aortic valve stenosis |
| HP:0001642 | 0.0278358341925 | 0.666666666667 | ANKS6 NEK8 | Pulmonic stenosis |
| HP:0001696 | 0.0337079994886 | 0.666666666667 | ANKS6 NEK8 | Situs inversus totalis |
| HP:0011534 | 0.0344813463748 | 0.666666666667 | ANKS6 NEK8 | Abnormal spatial orientation of the cardiac segments |
| HP:0031654 | 0.041834410056 | 0.666666666667 | ANKS6 NEK8 | Abnormal pulmonary valve physiology |
| HP:0001395 | 0.0426950555564 | 0.666666666667 | ANKS6 NEK8 | Hepatic fibrosis |
| HP:0001651 | 0.0426950555564 | 0.666666666667 | ANKS6 NEK8 | Dextrocardia |
| HP:0004307 | 0.0435644243888 | 0.666666666667 | ANKS6 NEK8 | Abnormal anatomic location of the heart |
| HP:0031652 | 0.0462248590062 | 0.666666666667 | ANKS6 NEK8 | Abnormal aortic valve physiology |
| CORUM:6661 | 0.0499776345577 | 0.333333333333 | NEK8 | NEK8-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ANKS6 | NEK8 | 0.115 | 0.384 | gupta (NEK8) boldt (NEK8) boldt_WMM |
| ANKS6 | ANKS3 | 0.051 | 0.296 | boldt (ANKS3,ANKS6) boldt_WMM |
| NEK8 | ANKS3 | 0.008 | 0.015 | boldt (NEK8) boldt_WMM |
Images
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Complex HuMAP2_02697 has an average edge precision of 0.232 which is ranked 5664 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ANKS6 | HuMAP2_02006 HuMAP2_02697 HuMAP2_05411 |
| NEK8 | HuMAP2_02006 HuMAP2_02697 HuMAP2_05411 |
| ANKS3 | HuMAP2_02006 HuMAP2_02697 HuMAP2_05411 |