hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02710
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLIRP | SRA stem-loop-interacting RNA-binding protein, mitochondrial | UniProt NCBI |
| CDH1 | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] | UniProt NCBI |
| CTNND1 | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | UniProt NCBI |
| LRPPRC | Leucine-rich PPR motif-containing protein, mitochondrial (130 kDa leucine-rich protein) (LRP 130) (GP130) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0007651 | 0.000136359131835 | 0.5 | CTNND1 CDH1 | Ectropion of lower eyelids |
| HP:0002744 | 0.000340836782771 | 0.5 | CTNND1 CDH1 | Bilateral cleft lip and palate |
| REAC:R-HSA-8876493 | 0.000361772624521 | 0.5 | CTNND1 CDH1 | InlA-mediated entry of Listeria monocytogenes into host cells |
| HP:0009743 | 0.000477128766336 | 0.5 | CTNND1 CDH1 | Distichiasis |
| HP:0008496 | 0.000477128766336 | 0.5 | CTNND1 CDH1 | Multiple rows of eyelashes |
| HP:0100336 | 0.000636114718594 | 0.5 | CTNND1 CDH1 | Bilateral cleft lip |
| HP:0200040 | 0.000817788537784 | 0.5 | CTNND1 CDH1 | Epidermoid cyst |
| HP:0012905 | 0.000817788537784 | 0.5 | CTNND1 CDH1 | Euryblepharon |
| HP:0100337 | 0.00149887618857 | 0.5 | CTNND1 CDH1 | Bilateral cleft palate |
| REAC:R-HSA-8876384 | 0.00171688133139 | 0.5 | CTNND1 CDH1 | Listeria monocytogenes entry into host cells |
| HP:0025245 | 0.00206626211915 | 0.5 | CTNND1 CDH1 | Cutaneous cyst |
| HP:0100338 | 0.00206626211915 | 0.5 | CTNND1 CDH1 | Non-midline cleft palate |
| REAC:R-HSA-418990 | 0.00352159938331 | 0.5 | CTNND1 CDH1 | Adherens junctions interactions |
| KEGG:04520 | 0.00467243468204 | 0.5 | CTNND1 CDH1 | Adherens junction |
| HP:0100335 | 0.00796059020261 | 0.5 | CTNND1 CDH1 | Non-midline cleft lip |
| HP:0000698 | 0.00920632571228 | 0.5 | CTNND1 CDH1 | Conical tooth |
| REAC:R-HSA-421270 | 0.00947680746611 | 0.5 | CTNND1 CDH1 | Cell-cell junction organization |
| HP:0012725 | 0.0195010181256 | 0.5 | CTNND1 CDH1 | Cutaneous syndactyly |
| REAC:R-HSA-446728 | 0.0248339118539 | 0.5 | CTNND1 CDH1 | Cell junction organization |
| CORUM:6599 | 0.0249595281251 | 0.25 | CTNND1 | CTNND1-GLIS2 complex |
| HP:0000656 | 0.0288545127028 | 0.5 | CTNND1 CDH1 | Ectropion |
| KEGG:04015 | 0.0293559966201 | 0.5 | CTNND1 CDH1 | Rap1 signaling pathway |
| CORUM:5320 | 0.0499140284799 | 0.25 | CDH1 | CDH1-SKP2 complex |
| CORUM:5319 | 0.0499140284799 | 0.25 | CDH1 | CDH1-CKS1B complex |
| CORUM:5281 | 0.0499140284799 | 0.25 | CDH1 | Cell-cell junction complex (CDH1-CTNNB1) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LRPPRC | SLIRP | 0.853 | 0.791 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (LRPPRC) fraction boldt_WMM |
| SLIRP | CDH1 | 0.148 | 0.409 | hein_WMM bioplex_WMM hein (CDH1) |
| LRPPRC | CDH1 | 0.092 | 0.355 | hein_WMM bioplex_WMM hein (CDH1) treiber_WMM |
| CDH1 | CTNND1 | 0.026 | 0.215 | hein_WMM bioplex_WMM hein (CDH1) treiber_WMM |
| SLIRP | CTNND1 | 0.007 | 0.002 | hein_WMM bioplex_WMM WMM_only |
| LRPPRC | CTNND1 | 0.006 | 0.004 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_02710 has an average edge precision of 0.296 which is ranked 4654 out of all 6965 complexes.
Related Complexes