hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02711
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TIMELESS | Protein timeless homolog (hTIM) | UniProt NCBI |
| GINS4 | DNA replication complex GINS protein SLD5 (GINS complex subunit 4) [Cleaved into: DNA replication complex GINS protein SLD5, N-terminally processed] | UniProt NCBI |
| GINS3 | DNA replication complex GINS protein PSF3 (GINS complex subunit 3) | UniProt NCBI |
| TIPIN | TIMELESS-interacting protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031298 | 2.03382379613e-05 | 0.75 | GINS4 TIMELESS TIPIN | replication fork protection complex |
| CORUM:678 | 3.01612206104e-05 | 0.5 | GINS4 GINS3 | GINS complex |
| GO:0006261 | 0.000252118978237 | 1.0 | GINS4 GINS3 TIMELESS TIPIN | DNA-dependent DNA replication |
| REAC:R-HSA-176974 | 0.000663071622452 | 0.5 | GINS4 GINS3 | Unwinding of DNA |
| GO:0006260 | 0.00184822285327 | 1.0 | GINS4 GINS3 TIMELESS TIPIN | DNA replication |
| GO:0043596 | 0.00386509246613 | 0.75 | GINS4 TIMELESS TIPIN | nuclear replication fork |
| REAC:R-HSA-69190 | 0.00497416142364 | 0.5 | GINS4 GINS3 | DNA strand elongation |
| GO:0005657 | 0.0150889595431 | 0.75 | GINS4 TIMELESS TIPIN | replication fork |
| GO:0043111 | 0.0162267366884 | 0.5 | TIPIN TIMELESS | replication fork arrest |
| REAC:R-HSA-5693607 | 0.0464213162589 | 0.5 | TIPIN TIMELESS | Processing of DNA double-strand break ends |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TIPIN | TIMELESS | 1.0 | 0.949 | hein_WMM bioplex (TIPIN) bioplex_WMM hein (TIMELESS,TIPIN) |
| GINS3 | TIPIN | 0.929 | 0.845 | hein_WMM bioplex (GINS3,TIPIN) bioplex_WMM youn_WMM hein (TIPIN) |
| GINS3 | GINS4 | 0.434 | 0.578 | hein_WMM bioplex (GINS3) bioplex_WMM Guru Malo fraction |
| TIPIN | GINS4 | 0.285 | 0.489 | hein_WMM bioplex (TIPIN) bioplex_WMM hein (TIPIN) |
| GINS4 | TIMELESS | 0.021 | 0.189 | hein_WMM bioplex_WMM hein (TIMELESS) |
| GINS3 | TIMELESS | 0.019 | 0.185 | hein_WMM bioplex (GINS3) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_02711 has an average edge precision of 0.539 which is ranked 2277 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TIMELESS | HuMAP2_02127 HuMAP2_02711 HuMAP2_06094 |
| GINS4 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 HuMAP2_05280 |
| GINS3 | HuMAP2_01803 HuMAP2_02711 HuMAP2_03617 HuMAP2_03710 |
| TIPIN | HuMAP2_01803 HuMAP2_02711 HuMAP2_06094 |