hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02717
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DPP8 | Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) | UniProt NCBI |
| HELLS | Lymphoid-specific helicase (EC 3.6.4.-) (Proliferation-associated SNF2-like protein) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin subfamily A member 6) | UniProt NCBI |
| METTL1 | tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) | UniProt NCBI |
| ZFR | Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog) | UniProt NCBI |
| WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008176 | 0.00450823411379 | 0.4 | METTL1 WDR4 | tRNA (guanine-N7-)-methyltransferase activity |
| REAC:R-HSA-6782315 | 0.0110102589414 | 0.4 | METTL1 WDR4 | tRNA modification in the nucleus and cytosol |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| METTL1 | ZFR | 0.125 | 0.398 | fraction |
| ZFR | HELLS | 0.116 | 0.387 | youn_WMM fraction treiber_WMM |
| METTL1 | WDR4 | 0.09 | 0.354 | bioplex (METTL1,WDR4) bioplex_WMM fraction |
| DPP8 | WDR4 | 0.071 | 0.352 | bioplex () bioplex_WMM |
Images
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Complex HuMAP2_02717 has an average edge precision of 0.373 which is ranked 3610 out of all 6965 complexes.
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