hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02722
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COLGALT2 | Procollagen galactosyltransferase 2 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 2) (ColGalT 2) (Glycosyltransferase 25 family member 2) (Hydroxylysine galactosyltransferase 2) | UniProt NCBI |
| PLOD1 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (EC 1.14.11.4) (Lysyl hydroxylase 1) (LH1) | UniProt NCBI |
| COLGALT1 | Procollagen galactosyltransferase 1 (EC 2.4.1.50) (Collagen beta(1-O)galactosyltransferase 1) (ColGalT 1) (Glycosyltransferase 25 family member 1) (Hydroxylysine galactosyltransferase 1) | UniProt NCBI |
| COLEC11 | Collectin-11 (Collectin kidney protein 1) (CL-K1) | UniProt NCBI |
| COL4A2 | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] | UniProt NCBI |
| PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (EC 1.14.11.4) (Lysyl hydroxylase 2) (LH2) | UniProt NCBI |
| DOK1 | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | UniProt NCBI |
| PLOD3 | Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (EC 1.14.11.4) (Lysyl hydroxylase 3) (LH3); Procollagen glycosyltransferase (EC 2.4.1.50) (EC 2.4.1.66) (Galactosylhydroxylysine-glucosyltransferase) (Procollagen galactosyltransferase) (Procollagen glucosyltransferase)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1650814 | 2.00203192713e-11 | 0.75 | COLGALT1 PLOD3 PLOD2 PLOD1 COL4A2 COLGALT2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 1.3204207271e-10 | 0.75 | COLGALT1 PLOD3 PLOD2 PLOD1 COL4A2 COLGALT2 | Collagen formation |
| KEGG:00310 | 2.59959441735e-09 | 0.625 | COLGALT1 PLOD3 COLGALT2 PLOD2 PLOD1 | Lysine degradation |
| REAC:R-HSA-1474244 | 1.51216378396e-07 | 0.75 | COLGALT1 PLOD3 PLOD2 PLOD1 COL4A2 COLGALT2 | Extracellular matrix organization |
| GO:0046946 | 5.08584025729e-06 | 0.375 | PLOD3 PLOD2 PLOD1 | hydroxylysine metabolic process |
| GO:0008475 | 5.08584025729e-06 | 0.375 | PLOD3 PLOD2 PLOD1 | procollagen-lysine 5-dioxygenase activity |
| GO:0046947 | 5.08584025729e-06 | 0.375 | PLOD3 PLOD2 PLOD1 | hydroxylysine biosynthetic process |
| KEGG:00514 | 6.47457878957e-06 | 0.375 | COLGALT1 COLGALT2 PLOD3 | Other types of O-glycan biosynthesis |
| GO:0050211 | 2.03382379613e-05 | 0.375 | COLGALT1 COLGALT2 PLOD3 | procollagen galactosyltransferase activity |
| GO:0070815 | 2.03382379613e-05 | 0.375 | PLOD3 PLOD2 PLOD1 | peptidyl-lysine 5-dioxygenase activity |
| CORUM:6997 | 3.50546248845e-05 | 0.25 | COLGALT1 PLOD3 | ADIPOQ-PLOD3-GLT25D1 complex |
| GO:0030199 | 7.86864430425e-05 | 0.5 | PLOD3 COLGALT1 PLOD2 PLOD1 | collagen fibril organization |
| GO:0017185 | 0.00028444859377 | 0.375 | PLOD3 PLOD2 PLOD1 | peptidyl-lysine hydroxylation |
| HP:0025019 | 0.000498144669412 | 0.25 | PLOD1 PLOD3 | Arterial rupture |
| GO:0035250 | 0.00145089086092 | 0.375 | COLGALT1 COLGALT2 PLOD3 | UDP-galactosyltransferase activity |
| GO:0030198 | 0.00365192644755 | 0.625 | PLOD3 PLOD1 COLGALT1 COL4A2 PLOD2 | extracellular matrix organization |
| GO:0008378 | 0.00490835417906 | 0.375 | COLGALT1 COLGALT2 PLOD3 | galactosyltransferase activity |
| GO:0009067 | 0.00577307926818 | 0.375 | PLOD3 PLOD2 PLOD1 | aspartate family amino acid biosynthetic process |
| REAC:R-HSA-3000480 | 0.00606323045863 | 0.25 | COLEC11 COL4A2 | Scavenging by Class A Receptors |
| GO:0043062 | 0.0075974584004 | 0.625 | PLOD3 PLOD1 COLGALT1 COL4A2 PLOD2 | extracellular structure organization |
| GO:0018126 | 0.00779479116974 | 0.375 | PLOD3 PLOD2 PLOD1 | protein hydroxylation |
| HP:0002996 | 0.00876649877585 | 0.375 | COLEC11 PLOD2 PLOD3 | Limited elbow movement |
| HP:0001892 | 0.0136996610206 | 0.5 | PLOD3 COLGALT1 COL4A2 PLOD1 | Abnormal bleeding |
| REAC:R-HSA-2173782 | 0.0263986242322 | 0.25 | COLEC11 COL4A2 | Binding and Uptake of Ligands by Scavenger Receptors |
| CORUM:7000 | 0.0497224828424 | 0.125 | PLOD2 | PLOD2-FKBP10 complex |
| GO:0042398 | 0.0497817121827 | 0.375 | PLOD3 PLOD2 PLOD1 | cellular modified amino acid biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLOD1 | COLGALT1 | 1.0 | 0.949 | hein_WMM bioplex (PLOD1) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PLOD3 | COLGALT1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PLOD2 | COLGALT1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt Malo gupta_WMM fraction boldt_WMM |
| COL4A2 | PLOD1 | 0.602 | 0.671 | bioplex (PLOD1) bioplex_WMM boldt_WMM |
| PLOD1 | PLOD3 | 0.53 | 0.634 | hein_WMM bioplex (PLOD1) bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
| PLOD2 | PLOD1 | 0.517 | 0.631 | hein_WMM bioplex (PLOD1) bioplex_WMM boldt gupta_WMM boldt_WMM |
| COLGALT2 | DOK1 | 0.109 | 0.373 | bioplex (COLGALT2) bioplex_WMM |
| COLGALT2 | COLGALT1 | 0.103 | 0.366 | bioplex (COLGALT2) bioplex_WMM |
| COLGALT2 | PLOD3 | 0.098 | 0.358 | bioplex (COLGALT2) bioplex_WMM |
| PLOD2 | COLEC11 | 0.082 | 0.351 | bioplex (COLEC11) bioplex_WMM |
| COL4A2 | COLGALT2 | 0.047 | 0.291 | bioplex (COLGALT2) bioplex_WMM |
| PLOD2 | PLOD3 | 0.045 | 0.282 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| PLOD1 | COLGALT2 | 0.017 | 0.176 | bioplex (COLGALT2,PLOD1) bioplex_WMM |
| PLOD2 | COLGALT2 | 0.015 | 0.146 | bioplex (COLGALT2) bioplex_WMM |
| COL4A2 | COLGALT1 | 0.013 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| COL4A2 | PLOD3 | 0.012 | 0.149 | bioplex_WMM WMM_only boldt_WMM |
| COL4A2 | PLOD2 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| PLOD1 | COLEC11 | 0.008 | 0.059 | bioplex (COLEC11) bioplex_WMM |
| COL4A2 | DOK1 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| COLGALT1 | COLEC11 | 0.007 | 0.006 | bioplex (COLEC11) bioplex_WMM |
| PLOD3 | COLEC11 | 0.007 | 0.012 | bioplex (COLEC11) bioplex_WMM |
| PLOD1 | DOK1 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| DOK1 | COLGALT1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| PLOD2 | DOK1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| DOK1 | PLOD3 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| COLGALT2 | COLEC11 | 0.0 | 0.0 | bioplex (COLEC11) bioplex_WMM |
| COL4A2 | COLEC11 | 0.0 | 0.001 | bioplex (COLEC11) bioplex_WMM |
Images
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Complex HuMAP2_02722 has an average edge precision of 0.283 which is ranked 4845 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COLGALT2 | HuMAP2_02722 HuMAP2_06216 HuMAP2_06790 |
| PLOD1 | HuMAP2_02722 HuMAP2_02856 HuMAP2_04238 HuMAP2_04483 HuMAP2_05080 |
| COLGALT1 | HuMAP2_02722 HuMAP2_06216 |
| COLEC11 | HuMAP2_02722 HuMAP2_06242 |
| COL4A2 | HuMAP2_02722 HuMAP2_04238 HuMAP2_05080 HuMAP2_06216 HuMAP2_06790 |
| PLOD2 | HuMAP2_02722 HuMAP2_06242 |
| DOK1 | HuMAP2_02722 HuMAP2_04106 HuMAP2_06216 HuMAP2_06790 |
| PLOD3 | HuMAP2_02722 HuMAP2_06216 |