hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02724
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NEDD4 | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4) | UniProt NCBI |
| NEDD4L | E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2) | UniProt NCBI |
| HECW2 | E3 ubiquitin-protein ligase HECW2 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 2) (HECT-type E3 ubiquitin transferase HECW2) (NEDD4-like E3 ubiquitin-protein ligase 2) | UniProt NCBI |
| FAM189A2 | Protein FAM189A2 (Protein X123) | UniProt NCBI |
| WBP1 | WW domain-binding protein 1 (WBP-1) | UniProt NCBI |
| WWP1 | NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:2000650 | 0.000152436922042 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of sodium ion transmembrane transporter activity |
| GO:1902306 | 0.000217734118711 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of sodium ion transmembrane transport |
| REAC:R-HSA-983168 | 0.00034508144622 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | Antigen processing: Ubiquitination & Proteasome degradation |
| KEGG:04120 | 0.000590221771159 | 0.5 | WWP1 NEDD4L NEDD4 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-1253288 | 0.000620139265586 | 0.333333333333 | NEDD4 WWP1 | Downregulation of ERBB4 signaling |
| GO:0010766 | 0.000660060925697 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of sodium ion transport |
| REAC:R-HSA-983169 | 0.000702192273232 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | Class I MHC mediated antigen processing & presentation |
| KEGG:04144 | 0.00329433483006 | 0.5 | WWP1 NEDD4L NEDD4 | Endocytosis |
| REAC:R-HSA-1280218 | 0.00813952609875 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | Adaptive Immune System |
| GO:0061630 | 0.00946139207598 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | ubiquitin protein ligase activity |
| GO:2000649 | 0.0118307664632 | 0.5 | HECW2 NEDD4L NEDD4 | regulation of sodium ion transmembrane transporter activity |
| GO:0061659 | 0.0120717988454 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | ubiquitin-like protein ligase activity |
| GO:0045732 | 0.0126525088214 | 0.666666666667 | HECW2 WWP1 NEDD4L NEDD4 | positive regulation of protein catabolic process |
| GO:0032413 | 0.0222806450818 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of ion transmembrane transporter activity |
| REAC:R-HSA-1236394 | 0.0227674337622 | 0.333333333333 | NEDD4 WWP1 | Signaling by ERBB4 |
| GO:1902305 | 0.0239073169747 | 0.5 | HECW2 NEDD4L NEDD4 | regulation of sodium ion transmembrane transport |
| HPA:047020 | 0.0279167002763 | 1.0 | NEDD4L WBP1 HECW2 FAM189A2 WWP1 NEDD4 | soft tissue 1; chondrocytes |
| GO:1904063 | 0.0292571070793 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of cation transmembrane transport |
| GO:0032410 | 0.0353486827187 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of transporter activity |
| WP:WP366 | 0.0416969783243 | 0.333333333333 | NEDD4L WWP1 | TGF-beta Signaling Pathway |
| GO:0048814 | 0.0447070305646 | 0.5 | HECW2 NEDD4L NEDD4 | regulation of dendrite morphogenesis |
| GO:0034766 | 0.0472791215337 | 0.5 | HECW2 NEDD4L NEDD4 | negative regulation of ion transmembrane transport |
| GO:0002028 | 0.0499477329172 | 0.5 | HECW2 NEDD4L NEDD4 | regulation of sodium ion transport |
| CORUM:6690 | 0.0499726005494 | 0.166666666667 | NEDD4 | NEDD4-PI4K2A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HECW2 | FAM189A2 | 0.156 | 0.415 | bioplex (FAM189A2) bioplex_WMM |
| NEDD4L | FAM189A2 | 0.155 | 0.415 | bioplex (FAM189A2) bioplex_WMM |
| NEDD4L | WBP1 | 0.068 | 0.347 | bioplex (WBP1) bioplex_WMM |
| NEDD4 | FAM189A2 | 0.062 | 0.341 | bioplex (FAM189A2) bioplex_WMM |
| FAM189A2 | WWP1 | 0.058 | 0.325 | bioplex (FAM189A2) bioplex_WMM |
| NEDD4L | NEDD4 | 0.05 | 0.298 | bioplex_WMM WMM_only |
| WBP1 | WWP1 | 0.024 | 0.213 | bioplex (WBP1) bioplex_WMM |
| NEDD4 | WWP1 | 0.02 | 0.186 | bioplex_WMM WMM_only |
| NEDD4L | WWP1 | 0.019 | 0.183 | bioplex_WMM WMM_only |
| HECW2 | WWP1 | 0.017 | 0.175 | bioplex_WMM WMM_only |
| NEDD4L | HECW2 | 0.016 | 0.165 | bioplex_WMM WMM_only |
| NEDD4 | HECW2 | 0.016 | 0.159 | bioplex_WMM WMM_only |
| WBP1 | NEDD4 | 0.006 | 0.003 | bioplex (WBP1) bioplex_WMM |
| WBP1 | HECW2 | 0.006 | 0.006 | bioplex (WBP1) bioplex_WMM |
Images
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Complex HuMAP2_02724 has an average edge precision of 0.231 which is ranked 5687 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NEDD4 | HuMAP2_02724 HuMAP2_04200 |
| NEDD4L | HuMAP2_01315 HuMAP2_02724 HuMAP2_04200 |
| HECW2 | HuMAP2_02724 HuMAP2_04200 |
| FAM189A2 | HuMAP2_02724 HuMAP2_04200 |
| WBP1 | HuMAP2_01315 HuMAP2_01416 HuMAP2_02724 HuMAP2_04200 |
| WWP1 | HuMAP2_02724 HuMAP2_04200 HuMAP2_06558 |