hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02725
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD244 | Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244) | UniProt NCBI |
| PDXDC1 | Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-) | UniProt NCBI |
| POMT1 | Protein O-mannosyl-transferase 1 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 1) | UniProt NCBI |
| POMT2 | Protein O-mannosyl-transferase 2 (EC 2.4.1.109) (Dolichyl-phosphate-mannose--protein mannosyltransferase 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5083633 | 3.01639213985e-05 | 0.5 | POMT1 POMT2 | Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 |
| REAC:R-HSA-5083629 | 3.01639213985e-05 | 0.5 | POMT1 POMT2 | Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 |
| HP:0040173 | 0.000227244870274 | 0.5 | POMT1 POMT2 | Abnormality of the tongue muscle |
| HP:0006888 | 0.000227244870274 | 0.5 | POMT1 POMT2 | Meningoencephalocele |
| HP:0012693 | 0.000340836782771 | 0.5 | POMT1 POMT2 | Abnormal thalamic size |
| HP:0012695 | 0.000340836782771 | 0.5 | POMT1 POMT2 | Decreased thalamic volume |
| HP:0006899 | 0.000340836782771 | 0.5 | POMT1 POMT2 | Fusion of the cerebellar hemispheres |
| KEGG:00514 | 0.000420053056823 | 0.5 | POMT1 POMT2 | Other types of O-glycan biosynthesis |
| KEGG:00515 | 0.000420053056823 | 0.5 | POMT1 POMT2 | Mannose type O-glycan biosynthesis |
| HP:0030099 | 0.000817788537784 | 0.5 | POMT1 POMT2 | Reduced muscle fiber alpha dystroglycan |
| HP:0004637 | 0.00102214412276 | 0.5 | POMT1 POMT2 | Decreased cervical spine mobility |
| HP:0030112 | 0.00102214412276 | 0.5 | POMT1 POMT2 | Abnormal muscle fiber alpha dystroglycan |
| HP:0030046 | 0.00102214412276 | 0.5 | POMT1 POMT2 | Hypoglycosylation of alpha-dystroglycan |
| HP:0006955 | 0.00102214412276 | 0.5 | POMT1 POMT2 | Olivopontocerebellar hypoplasia |
| HP:0007291 | 0.00124917537299 | 0.5 | POMT1 POMT2 | Posterior fossa cyst |
| HP:0002189 | 0.00177124047018 | 0.5 | POMT1 POMT2 | Excessive daytime sleepiness |
| HP:0007015 | 0.00177124047018 | 0.5 | POMT1 POMT2 | Poor gross motor coordination |
| HP:0007033 | 0.00206626211915 | 0.5 | POMT1 POMT2 | Cerebellar dysplasia |
| HP:0031882 | 0.00206626211915 | 0.5 | POMT1 POMT2 | Agyria |
| HP:0003707 | 0.00238393503741 | 0.5 | POMT1 POMT2 | Calf muscle pseudohypertrophy |
| HP:0007260 | 0.00238393503741 | 0.5 | POMT1 POMT2 | Type II lissencephaly |
| HP:0000659 | 0.00238393503741 | 0.5 | POMT1 POMT2 | Peters anomaly |
| HP:0008443 | 0.00238393503741 | 0.5 | POMT1 POMT2 | Spinal deformities |
| HP:0012400 | 0.00347280043641 | 0.5 | POMT1 POMT2 | Abnormal aldolase level |
| HP:0000557 | 0.0038810174634 | 0.5 | POMT1 POMT2 | Buphthalmos |
| HP:0003741 | 0.00431185527855 | 0.5 | POMT1 POMT2 | Congenital muscular dystrophy |
| HP:0007731 | 0.00476530778748 | 0.5 | POMT1 POMT2 | Chorioretinal dysplasia |
| HP:0007227 | 0.00524136889643 | 0.5 | POMT1 POMT2 | Macrogyria |
| HP:0007973 | 0.00524136889643 | 0.5 | POMT1 POMT2 | Retinal dysplasia |
| HP:0010508 | 0.00524136889643 | 0.5 | POMT1 POMT2 | Metatarsus valgus |
| HP:0003327 | 0.00574003251223 | 0.5 | POMT1 POMT2 | Axial muscle weakness |
| HP:0010663 | 0.00626129254237 | 0.5 | POMT1 POMT2 | Abnormality of thalamus morphology |
| HP:0030089 | 0.00626129254237 | 0.5 | POMT1 POMT2 | Abnormal muscle fiber protein expression |
| HP:0002085 | 0.00737157747856 | 0.5 | POMT1 POMT2 | Occipital encephalocele |
| HP:0012110 | 0.00857217497701 | 0.5 | POMT1 POMT2 | Hypoplasia of the pons |
| HP:0006957 | 0.00920632571228 | 0.5 | POMT1 POMT2 | Loss of ability to walk |
| HP:0007204 | 0.00920632571228 | 0.5 | POMT1 POMT2 | Diffuse white matter abnormalities |
| HP:0030197 | 0.00986303631958 | 0.5 | POMT1 POMT2 | Fatigable weakness of skeletal muscles |
| HP:0001090 | 0.00986303631958 | 0.5 | POMT1 POMT2 | Abnormally large globe |
| HP:0000485 | 0.011244112798 | 0.5 | POMT1 POMT2 | Megalocornea |
| REAC:R-HSA-3906995 | 0.013274030298 | 0.5 | POMT1 POMT2 | Diseases associated with O-glycosylation of proteins |
| HP:0001460 | 0.0142767163782 | 0.5 | POMT1 POMT2 | Aplasia/Hypoplasia involving the skeletal musculature |
| HP:0001087 | 0.0150911756538 | 0.5 | POMT1 POMT2 | Developmental glaucoma |
| HP:0007361 | 0.0159281461127 | 0.5 | POMT1 POMT2 | Abnormality of the pons |
| HP:0045040 | 0.0159281461127 | 0.5 | POMT1 POMT2 | Abnormal lactate dehydrogenase activity |
| HP:0002275 | 0.0176695962482 | 0.5 | POMT1 POMT2 | Poor motor coordination |
| HP:0000413 | 0.0176695962482 | 0.5 | POMT1 POMT2 | Atresia of the external auditory canal |
| HP:0002505 | 0.01857406376 | 0.5 | POMT1 POMT2 | Progressive inability to walk |
| HP:0002435 | 0.0204504532642 | 0.5 | POMT1 POMT2 | Meningocele |
| HP:0008981 | 0.0214223630957 | 0.5 | POMT1 POMT2 | Calf muscle hypertrophy |
| HP:0008968 | 0.0224167415402 | 0.5 | POMT1 POMT2 | Muscle hypertrophy of the lower extremities |
| HP:0005162 | 0.025534627766 | 0.5 | POMT1 POMT2 | Left ventricular dysfunction |
| HP:0007362 | 0.0266188198793 | 0.5 | POMT1 POMT2 | Aplasia/Hypoplasia of the brainstem |
| HP:0002828 | 0.0266188198793 | 0.5 | POMT1 POMT2 | Multiple joint contractures |
| HP:0002365 | 0.0266188198793 | 0.5 | POMT1 POMT2 | Hypoplasia of the brainstem |
| GO:0004169 | 0.0270421395626 | 0.5 | POMT1 POMT2 | dolichyl-phosphate-mannose-protein mannosyltransferase activity |
| HP:0003306 | 0.0277254502169 | 0.5 | POMT1 POMT2 | Spinal rigidity |
| HP:0410031 | 0.0300060012618 | 0.5 | POMT1 POMT2 | Submucous cleft of soft and hard palate |
| HP:0000176 | 0.0300060012618 | 0.5 | POMT1 POMT2 | Submucous cleft hard palate |
| HP:0000609 | 0.0311799098191 | 0.5 | POMT1 POMT2 | Optic nerve hypoplasia |
| HP:0001360 | 0.0323762323007 | 0.5 | POMT1 POMT2 | Holoprosencephaly |
| HP:0002938 | 0.0335949626331 | 0.5 | POMT1 POMT2 | Lumbar hyperlordosis |
| HP:0000528 | 0.0335949626331 | 0.5 | POMT1 POMT2 | Anophthalmia |
| REAC:R-HSA-5173105 | 0.0356320611636 | 0.5 | POMT1 POMT2 | O-linked glycosylation |
| HP:0000110 | 0.0373855400094 | 0.5 | POMT1 POMT2 | Renal dysplasia |
| HP:0001105 | 0.0373855400094 | 0.5 | POMT1 POMT2 | Retinal atrophy |
| HP:0001430 | 0.0386938410225 | 0.5 | POMT1 POMT2 | Abnormality of the calf musculature |
| HP:0000372 | 0.0386938410225 | 0.5 | POMT1 POMT2 | Abnormality of the auditory canal |
| HP:0030872 | 0.0400245195282 | 0.5 | POMT1 POMT2 | Abnormal cardiac ventricular function |
| HP:0006829 | 0.0400245195282 | 0.5 | POMT1 POMT2 | Severe muscular hypotonia |
| HP:0002518 | 0.0413775694569 | 0.5 | POMT1 POMT2 | Abnormality of the periventricular white matter |
| HP:0010662 | 0.0441507593067 | 0.5 | POMT1 POMT2 | Abnormality of the diencephalon |
| HP:0001712 | 0.0455708870915 | 0.5 | POMT1 POMT2 | Left ventricular hypertrophy |
| HP:0003325 | 0.049965329079 | 0.5 | POMT1 POMT2 | Limb-girdle muscle weakness |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CD244 | POMT2 | 0.835 | 0.779 | bioplex (CD244) bioplex_WMM |
| POMT1 | CD244 | 0.395 | 0.555 | bioplex (CD244) bioplex_WMM |
| PDXDC1 | CD244 | 0.042 | 0.27 | bioplex (CD244) bioplex_WMM |
| POMT1 | POMT2 | 0.01 | 0.117 | bioplex_WMM WMM_only |
| PDXDC1 | POMT2 | 0.006 | 0.005 | bioplex_WMM WMM_only |
| PDXDC1 | POMT1 | 0.006 | 0.001 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02725 has an average edge precision of 0.288 which is ranked 4778 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CD244 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 HuMAP2_02850 HuMAP2_04962 |
| PDXDC1 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 |
| POMT1 | HuMAP2_01309 HuMAP2_01760 HuMAP2_02725 |
| POMT2 | HuMAP2_01760 HuMAP2_02377 HuMAP2_02725 HuMAP2_02850 |