hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_02730
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | UniProt NCBI |
| RNF2 | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | UniProt NCBI |
| PCGF1 | Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68) | UniProt NCBI |
| PCGF3 | Polycomb group RING finger protein 3 (RING finger protein 3A) | UniProt NCBI |
| RYBP | RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1) | UniProt NCBI |
| FBRS | Probable fibrosin-1 | UniProt NCBI |
| BMI1 | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51) | UniProt NCBI |
| MORC4 | MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4) | UniProt NCBI |
| RING1 | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | UniProt NCBI |
| BCOR | BCL-6 corepressor (BCoR) | UniProt NCBI |
| PCGF5 | Polycomb group RING finger protein 5 (RING finger protein 159) | UniProt NCBI |
| AUTS2 | Autism susceptibility gene 2 protein | UniProt NCBI |
| YAF2 | YY1-associated factor 2 | UniProt NCBI |
| BCORL1 | BCL-6 corepressor-like protein 1 (BCoR-L1) (BCoR-like protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035518 | 2.44838165311e-20 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | histone H2A monoubiquitination |
| GO:0033522 | 2.05260787131e-18 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | histone H2A ubiquitination |
| GO:0010390 | 1.00500521473e-17 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | histone monoubiquitination |
| CORUM:1178 | 2.9502389644e-16 | 0.428571428571 | RNF2 RYBP BCOR PCGF1 KDM2B RING1 | BCOR complex |
| GO:0016574 | 5.63501323629e-16 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | histone ubiquitination |
| GO:0006513 | 1.24955533279e-14 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | protein monoubiquitination |
| REAC:R-HSA-8939243 | 2.23045585904e-13 | 0.5 | RNF2 AUTS2 RYBP YAF2 PCGF5 BMI1 RING1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| GO:0031519 | 6.4473377657e-13 | 0.571428571429 | PCGF3 RNF2 RYBP PCGF1 PCGF5 BMI1 KDM2B RING1 | PcG protein complex |
| GO:0035102 | 4.94117498871e-11 | 0.428571428571 | RNF2 PCGF3 PCGF1 PCGF5 BMI1 RING1 | PRC1 complex |
| GO:0000152 | 1.41656001728e-10 | 0.5 | RNF2 PCGF3 BCOR PCGF1 PCGF5 BMI1 RING1 | nuclear ubiquitin ligase complex |
| GO:0036353 | 9.17026171826e-10 | 0.357142857143 | PCGF5 BMI1 RNF2 PCGF1 PCGF3 | histone H2A-K119 monoubiquitination |
| GO:0016570 | 9.8847501147e-10 | 0.714285714286 | PCGF3 AUTS2 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | histone modification |
| GO:0016569 | 1.55597634667e-09 | 0.714285714286 | PCGF3 AUTS2 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | covalent chromatin modification |
| REAC:R-HSA-8953750 | 2.28285777263e-08 | 0.357142857143 | RYBP BMI1 RNF2 RING1 YAF2 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-8878171 | 1.07777342633e-07 | 0.5 | RNF2 AUTS2 RYBP YAF2 PCGF5 BMI1 RING1 | Transcriptional regulation by RUNX1 |
| CORUM:1462 | 1.40594241297e-07 | 0.214285714286 | RNF2 RING1 BMI1 | hPRC1L complex |
| GO:0006325 | 3.34437447918e-07 | 0.714285714286 | PCGF3 AUTS2 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | chromatin organization |
| WP:WP4553 | 1.61037401297e-06 | 0.285714285714 | KDM2B RNF2 PCGF1 BCOR | FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma |
| CORUM:115 | 5.77705673861e-06 | 0.214285714286 | RNF2 RING1 BMI1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0070317 | 7.03440079024e-06 | 0.357142857143 | RYBP BMI1 RNF2 RING1 YAF2 | negative regulation of G0 to G1 transition |
| CORUM:1194 | 7.698474228e-06 | 0.214285714286 | RNF2 RING1 YAF2 | E2F-6 complex |
| CORUM:116 | 7.698474228e-06 | 0.214285714286 | RNF2 RING1 BMI1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0070316 | 8.09613314971e-06 | 0.357142857143 | RYBP BMI1 RNF2 RING1 YAF2 | regulation of G0 to G1 transition |
| GO:0045023 | 1.06027129364e-05 | 0.357142857143 | RYBP BMI1 RNF2 RING1 YAF2 | G0 to G1 transition |
| GO:0016567 | 1.3741154574e-05 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | protein ubiquitination |
| GO:0051276 | 3.34794101741e-05 | 0.714285714286 | PCGF3 AUTS2 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | chromosome organization |
| GO:0032446 | 4.00916035919e-05 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | protein modification by small protein conjugation |
| GO:0000151 | 6.49851437361e-05 | 0.5 | RNF2 PCGF3 BCOR PCGF1 PCGF5 BMI1 RING1 | ubiquitin ligase complex |
| REAC:R-HSA-4655427 | 7.5846029651e-05 | 0.214285714286 | RNF2 RING1 BMI1 | SUMOylation of DNA methylation proteins |
| KEGG:04550 | 0.000220976673906 | 0.285714285714 | PCGF5 BMI1 PCGF1 PCGF3 | Signaling pathways regulating pluripotency of stem cells |
| CORUM:5513 | 0.00026157999168 | 0.142857142857 | RING1 BMI1 | RING1-Polycomb repressive complex |
| CORUM:929 | 0.000268153805613 | 0.214285714286 | RNF2 RING1 BMI1 | CEN complex |
| GO:0070647 | 0.000318486165502 | 0.642857142857 | PCGF3 RNF2 RYBP BCOR PCGF1 PCGF5 BMI1 KDM2B RING1 | protein modification by small protein conjugation or removal |
| REAC:R-HSA-3899300 | 0.00162427315552 | 0.214285714286 | RNF2 RING1 BMI1 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 0.00188522137934 | 0.214285714286 | RNF2 RING1 BMI1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-212436 | 0.00430212968401 | 0.5 | RNF2 AUTS2 RYBP YAF2 PCGF5 BMI1 RING1 | Generic Transcription Pathway |
| REAC:R-HSA-8943724 | 0.00476520821243 | 0.214285714286 | RNF2 RING1 BMI1 | Regulation of PTEN gene transcription |
| REAC:R-HSA-4551638 | 0.00708211449109 | 0.214285714286 | RNF2 RING1 BMI1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-73857 | 0.00877410882909 | 0.5 | RNF2 AUTS2 RYBP YAF2 PCGF5 BMI1 RING1 | RNA Polymerase II Transcription |
| REAC:R-HSA-3108214 | 0.00923610675298 | 0.214285714286 | RNF2 RING1 BMI1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-74160 | 0.0178041110562 | 0.5 | RNF2 AUTS2 RYBP YAF2 PCGF5 BMI1 RING1 | Gene expression (Transcription) |
| REAC:R-HSA-2559580 | 0.046378500571 | 0.214285714286 | RNF2 RING1 BMI1 | Oxidative Stress Induced Senescence |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RYBP | RNF2 | 1.0 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (RNF2) |
| RING1 | RYBP | 1.0 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (RING1) |
| PCGF1 | RYBP | 0.999 | 0.949 | hein_WMM bioplex (RYBP) bioplex_WMM hein (PCGF1) |
| FBRS | PCGF5 | 0.992 | 0.912 | bioplex (PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM |
| FBRS | RYBP | 0.932 | 0.846 | hein_WMM bioplex (RYBP) bioplex_WMM |
| RYBP | PCGF3 | 0.923 | 0.844 | bioplex (RYBP) bioplex_WMM |
| RYBP | BMI1 | 0.918 | 0.841 | hein_WMM bioplex (RYBP) bioplex_WMM |
| RING1 | YAF2 | 0.892 | 0.819 | hein_WMM bioplex (YAF2) bioplex_WMM hein (RING1) |
| YAF2 | RNF2 | 0.888 | 0.818 | hein_WMM bioplex (YAF2) bioplex_WMM hein (RNF2) |
| BCOR | RYBP | 0.863 | 0.799 | hein_WMM bioplex (RYBP) bioplex_WMM |
| AUTS2 | PCGF5 | 0.825 | 0.774 | bioplex (PCGF5) bioplex_WMM boldt youn_WMM boldt_WMM |
| KDM2B | RYBP | 0.772 | 0.751 | hein_WMM bioplex (RYBP) bioplex_WMM |
| PCGF1 | YAF2 | 0.726 | 0.736 | hein_WMM bioplex (YAF2) bioplex_WMM hein (PCGF1) |
| PCGF5 | RYBP | 0.585 | 0.663 | bioplex (PCGF5,RYBP) bioplex_WMM |
| RING1 | RNF2 | 0.551 | 0.644 | hein_WMM bioplex_WMM hein (RING1,RNF2) boldt_WMM |
| PCGF5 | RNF2 | 0.365 | 0.544 | hein_WMM bioplex (PCGF5) bioplex_WMM boldt boldt_WMM |
| PCGF5 | RING1 | 0.361 | 0.544 | hein_WMM bioplex (PCGF5) bioplex_WMM youn_WMM boldt_WMM |
| AUTS2 | RYBP | 0.331 | 0.521 | bioplex (RYBP) bioplex_WMM |
| FBRS | RNF2 | 0.301 | 0.496 | hein_WMM bioplex_WMM boldt hein (RNF2) gupta_WMM boldt_WMM |
| PCGF1 | KDM2B | 0.264 | 0.482 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1) gupta_WMM |
| FBRS | YAF2 | 0.226 | 0.468 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | BCOR | 0.196 | 0.45 | hein_WMM bioplex (YAF2) bioplex_WMM hein (BCOR) |
| RYBP | MORC4 | 0.191 | 0.444 | bioplex (RYBP) bioplex_WMM |
| PCGF1 | BCOR | 0.144 | 0.407 | hein_WMM bioplex_WMM youn_WMM hein (BCOR,PCGF1) gupta_WMM |
| YAF2 | KDM2B | 0.141 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | RYBP | 0.133 | 0.405 | hein_WMM bioplex (YAF2) bioplex_WMM |
| PCGF5 | YAF2 | 0.122 | 0.394 | bioplex (PCGF5,YAF2) bioplex_WMM |
| YAF2 | PCGF3 | 0.119 | 0.392 | bioplex (YAF2) bioplex_WMM |
| RYBP | BCORL1 | 0.118 | 0.392 | hein_WMM bioplex (RYBP) bioplex_WMM |
| YAF2 | BMI1 | 0.088 | 0.353 | hein_WMM bioplex (YAF2) bioplex_WMM |
| FBRS | RING1 | 0.085 | 0.35 | hein_WMM bioplex_WMM youn_WMM hein (RING1) boldt_WMM |
| RNF2 | BMI1 | 0.068 | 0.35 | hein_WMM bioplex_WMM hein (RNF2) |
| RING1 | PCGF1 | 0.064 | 0.348 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1,RING1) gupta_WMM |
| RING1 | BMI1 | 0.042 | 0.27 | hein_WMM bioplex_WMM hein (RING1) |
| BCOR | KDM2B | 0.04 | 0.267 | hein_WMM bioplex_WMM youn_WMM hein (BCOR) gupta_WMM |
| AUTS2 | FBRS | 0.031 | 0.24 | bioplex_WMM boldt youn_WMM boldt_WMM |
| PCGF1 | BCORL1 | 0.027 | 0.228 | hein_WMM bioplex_WMM youn_WMM hein (PCGF1) |
| YAF2 | BCORL1 | 0.025 | 0.218 | hein_WMM bioplex (YAF2) bioplex_WMM |
| YAF2 | MORC4 | 0.024 | 0.211 | bioplex (YAF2) bioplex_WMM |
| AUTS2 | RNF2 | 0.019 | 0.185 | bioplex_WMM boldt boldt_WMM |
| AUTS2 | RING1 | 0.019 | 0.185 | bioplex_WMM youn_WMM WMM_only boldt_WMM |
| RING1 | BCOR | 0.018 | 0.182 | hein_WMM bioplex_WMM youn_WMM hein (BCOR,RING1) gupta_WMM |
| PCGF5 | PCGF3 | 0.017 | 0.172 | bioplex_WMM boldt boldt_WMM |
| PCGF1 | RNF2 | 0.017 | 0.166 | hein_WMM bioplex_WMM hein (PCGF1,RNF2) gupta_WMM |
| RNF2 | PCGF3 | 0.017 | 0.165 | bioplex_WMM boldt boldt_WMM |
| AUTS2 | PCGF3 | 0.015 | 0.152 | bioplex_WMM boldt boldt_WMM |
| AUTS2 | YAF2 | 0.015 | 0.151 | bioplex (YAF2) bioplex_WMM |
| FBRS | PCGF3 | 0.015 | 0.14 | bioplex_WMM boldt boldt_WMM |
| BCOR | RNF2 | 0.014 | 0.137 | hein_WMM bioplex_WMM hein (BCOR,RNF2) gupta_WMM |
| PCGF1 | BMI1 | 0.013 | 0.155 | hein_WMM bioplex_WMM WMM_only |
| PCGF1 | PCGF3 | 0.012 | 0.145 | bioplex_WMM WMM_only |
| RING1 | PCGF3 | 0.012 | 0.146 | bioplex_WMM WMM_only boldt_WMM |
| RING1 | KDM2B | 0.012 | 0.145 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KDM2B | MORC4 | 0.011 | 0.148 | bioplex_WMM youn_WMM WMM_only |
| FBRS | KDM2B | 0.011 | 0.144 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| FBRS | PCGF1 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BMI1 | PCGF3 | 0.011 | 0.132 | bioplex_WMM WMM_only |
| RING1 | BCORL1 | 0.011 | 0.138 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KDM2B | BCORL1 | 0.011 | 0.145 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PCGF5 | KDM2B | 0.011 | 0.141 | bioplex_WMM youn_WMM WMM_only |
| PCGF1 | MORC4 | 0.01 | 0.139 | bioplex_WMM youn_WMM WMM_only |
| KDM2B | PCGF3 | 0.01 | 0.133 | bioplex_WMM WMM_only |
| AUTS2 | BCORL1 | 0.01 | 0.134 | bioplex_WMM youn_WMM WMM_only |
| FBRS | BMI1 | 0.01 | 0.132 | hein_WMM bioplex_WMM WMM_only |
| AUTS2 | KDM2B | 0.01 | 0.133 | bioplex_WMM youn_WMM WMM_only |
| BCORL1 | MORC4 | 0.01 | 0.129 | bioplex_WMM youn_WMM WMM_only |
| RNF2 | BCORL1 | 0.01 | 0.129 | hein_WMM bioplex_WMM WMM_only |
| KDM2B | BMI1 | 0.01 | 0.122 | hein_WMM bioplex_WMM WMM_only |
| PCGF5 | MORC4 | 0.01 | 0.12 | bioplex_WMM youn_WMM WMM_only |
| PCGF3 | MORC4 | 0.01 | 0.101 | bioplex_WMM WMM_only |
| FBRS | BCORL1 | 0.01 | 0.1 | bioplex_WMM youn_WMM WMM_only |
| BMI1 | BCORL1 | 0.01 | 0.099 | bioplex_WMM WMM_only |
| PCGF5 | PCGF1 | 0.01 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| AUTS2 | MORC4 | 0.01 | 0.097 | bioplex_WMM youn_WMM WMM_only |
| FBRS | MORC4 | 0.009 | 0.108 | bioplex_WMM youn_WMM WMM_only |
| BMI1 | MORC4 | 0.009 | 0.113 | bioplex_WMM WMM_only |
| AUTS2 | PCGF1 | 0.009 | 0.116 | bioplex_WMM youn_WMM WMM_only |
| RING1 | MORC4 | 0.009 | 0.108 | bioplex_WMM youn_WMM WMM_only |
| PCGF5 | BCORL1 | 0.009 | 0.106 | bioplex_WMM youn_WMM WMM_only |
| BCORL1 | PCGF3 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| BCOR | PCGF3 | 0.009 | 0.09 | bioplex_WMM WMM_only |
| BCOR | BCORL1 | 0.009 | 0.09 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BCOR | MORC4 | 0.009 | 0.098 | bioplex_WMM youn_WMM WMM_only |
| RNF2 | MORC4 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| AUTS2 | BMI1 | 0.008 | 0.096 | bioplex_WMM WMM_only |
| PCGF5 | BMI1 | 0.008 | 0.084 | hein_WMM bioplex_WMM WMM_only |
| FBRS | BCOR | 0.008 | 0.083 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| BCOR | BMI1 | 0.008 | 0.08 | hein_WMM bioplex_WMM WMM_only |
| AUTS2 | BCOR | 0.008 | 0.01 | bioplex_WMM youn_WMM WMM_only |
| PCGF5 | BCOR | 0.007 | 0.004 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KDM2B | RNF2 | 0.007 | 0.004 | hein_WMM bioplex_WMM hein (RNF2) gupta_WMM |
Images
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Complex HuMAP2_02730 has an average edge precision of 0.305 which is ranked 4503 out of all 6965 complexes.
Related Complexes