hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02732
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | UniProt NCBI |
| TUBA1C | Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain] | UniProt NCBI |
| TUBB6 | Tubulin beta-6 chain (Tubulin beta class V) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371497 | 9.93609173322e-06 | 1.0 | DNAJA1 TUBB6 TUBA1C | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| REAC:R-HSA-190840 | 0.000909962567223 | 0.666666666667 | TUBB6 TUBA1C | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.00102366202924 | 0.666666666667 | TUBB6 TUBA1C | Transport of connexons to the plasma membrane |
| WP:WP2272 | 0.00126905060241 | 0.666666666667 | TUBB6 TUBA1C | Pathogenic Escherichia coli infection |
| REAC:R-HSA-389977 | 0.00140483748394 | 0.666666666667 | TUBB6 TUBA1C | Post-chaperonin tubulin folding pathway |
| KEGG:04540 | 0.00155543182841 | 0.666666666667 | TUBB6 TUBA1C | Gap junction |
| REAC:R-HSA-190861 | 0.00169234301901 | 0.666666666667 | TUBB6 TUBA1C | Gap junction assembly |
| REAC:R-HSA-9619483 | 0.00184610965854 | 0.666666666667 | TUBB6 TUBA1C | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 0.00184610965854 | 0.666666666667 | TUBB6 TUBA1C | Formation of tubulin folding intermediates by CCT/TriC |
| WP:WP2359 | 0.00205158647954 | 0.666666666667 | TUBB6 TUBA1C | Parkin-Ubiquitin Proteasomal System pathway |
| REAC:R-HSA-389957 | 0.00234745427481 | 0.666666666667 | TUBB6 TUBA1C | Prefoldin mediated transfer of substrate to CCT/TriC |
| REAC:R-HSA-5626467 | 0.00252791438215 | 0.666666666667 | TUBB6 TUBA1C | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.00310931782116 | 0.666666666667 | TUBB6 TUBA1C | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| REAC:R-HSA-190828 | 0.00375073705264 | 0.666666666667 | TUBB6 TUBA1C | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.00397787610966 | 0.666666666667 | TUBB6 TUBA1C | Gap junction trafficking and regulation |
| KEGG:04145 | 0.00402657539006 | 0.666666666667 | TUBB6 TUBA1C | Phagosome |
| REAC:R-HSA-8955332 | 0.00445214779833 | 0.666666666667 | TUBB6 TUBA1C | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-9609736 | 0.0046992786316 | 0.666666666667 | TUBB6 TUBA1C | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | DNAJA1 TUBB6 TUBA1C | Cellular responses to stress |
| REAC:R-HSA-437239 | 0.00661568366637 | 0.666666666667 | TUBB6 TUBA1C | Recycling pathway of L1 |
| KEGG:05130 | 0.00692087445383 | 0.666666666667 | TUBB6 TUBA1C | Pathogenic Escherichia coli infection |
| REAC:R-HSA-6811436 | 0.00818423736949 | 0.666666666667 | TUBB6 TUBA1C | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-5620924 | 0.00851790571699 | 0.666666666667 | TUBB6 TUBA1C | Intraflagellar transport |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | DNAJA1 TUBB6 TUBA1C | Cellular responses to external stimuli |
| REAC:R-HSA-983189 | 0.0106595435179 | 0.666666666667 | TUBB6 TUBA1C | Kinesins |
| REAC:R-HSA-1445148 | 0.015207050821 | 0.666666666667 | TUBB6 TUBA1C | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-438064 | 0.0175395775792 | 0.666666666667 | TUBB6 TUBA1C | Post NMDA receptor activation events |
| REAC:R-HSA-8852276 | 0.0190186686906 | 0.666666666667 | TUBB6 TUBA1C | The role of GTSE1 in G2/M progression after G2 checkpoint |
| REAC:R-HSA-442755 | 0.0232544758505 | 0.666666666667 | TUBB6 TUBA1C | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-380320 | 0.0267094284906 | 0.666666666667 | TUBB6 TUBA1C | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-390466 | 0.0267094284906 | 0.666666666667 | TUBB6 TUBA1C | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 0.0304025344128 | 0.666666666667 | TUBB6 TUBA1C | Protein folding |
| REAC:R-HSA-6811434 | 0.0304025344128 | 0.666666666667 | TUBB6 TUBA1C | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 0.03104119222 | 0.666666666667 | TUBB6 TUBA1C | COPI-mediated anterograde transport |
| REAC:R-HSA-5610787 | 0.0406759452204 | 0.666666666667 | TUBB6 TUBA1C | Hedgehog 'off' state |
| REAC:R-HSA-373760 | 0.0406759452204 | 0.666666666667 | TUBB6 TUBA1C | L1CAM interactions |
| REAC:R-HSA-2132295 | 0.0444303896492 | 0.666666666667 | TUBB6 TUBA1C | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.0475526064057 | 0.666666666667 | TUBB6 TUBA1C | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TUBA1C | TUBB6 | 0.729 | 0.735 | hein_WMM bioplex (TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM boldt_WMM treiber_WMM |
| TUBA1C | DNAJA1 | 0.555 | 0.647 | hein_WMM bioplex (DNAJA1,TUBA1C) bioplex_WMM boldt youn_WMM hein (TUBA1C) gupta_WMM fraction boldt_WMM treiber_WMM |
| DNAJA1 | TUBB6 | 0.009 | 0.099 | hein_WMM bioplex (DNAJA1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02732 has an average edge precision of 0.494 which is ranked 2533 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DNAJA1 | HuMAP2_00105 HuMAP2_01876 HuMAP2_02513 HuMAP2_02619 HuMAP2_02732 HuMAP2_05358 HuMAP2_06642 |
| TUBA1C | HuMAP2_00105 HuMAP2_00284 HuMAP2_01876 HuMAP2_02619 HuMAP2_02732 HuMAP2_05358 |
| TUBB6 | HuMAP2_00284 HuMAP2_00602 HuMAP2_01876 HuMAP2_02732 HuMAP2_05358 HuMAP2_06702 |