hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02735
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDCL | Phosducin-like protein (PHLP) | UniProt NCBI |
| GNB5 | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | UniProt NCBI |
| RGS6 | Regulator of G-protein signaling 6 (RGS6) (S914) | UniProt NCBI |
| GNB2 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6814122 | 7.4593283151e-09 | 1.0 | GNB5 GNB2 PDCL RGS6 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-390466 | 2.31729719e-07 | 1.0 | GNB5 GNB2 PDCL RGS6 | Chaperonin-mediated protein folding |
| REAC:R-HSA-391251 | 3.01267951631e-07 | 1.0 | GNB5 GNB2 PDCL RGS6 | Protein folding |
| WP:WP536 | 6.29942598895e-05 | 0.75 | GNB5 RGS6 GNB2 | Calcium Regulation in the Cardiac Cell |
| WP:WP289 | 8.20829615168e-05 | 0.75 | GNB5 RGS6 GNB2 | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-8964315 | 0.00120515287053 | 0.5 | GNB5 GNB2 | G beta:gamma signalling through BTK |
| REAC:R-HSA-392851 | 0.00136571756437 | 0.5 | GNB5 GNB2 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-8964616 | 0.00153629461685 | 0.5 | GNB5 GNB2 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-418217 | 0.00153629461685 | 0.5 | GNB5 GNB2 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-500657 | 0.00171688133139 | 0.5 | GNB5 GNB2 | Presynaptic function of Kainate receptors |
| REAC:R-HSA-392170 | 0.0019074750117 | 0.5 | GNB5 GNB2 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-392451 | 0.00210807296175 | 0.5 | GNB5 GNB2 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-420092 | 0.00210807296175 | 0.5 | GNB5 GNB2 | Glucagon-type ligand receptors |
| REAC:R-HSA-428930 | 0.00210807296175 | 0.5 | GNB5 GNB2 | Thromboxane signalling through TP receptor |
| REAC:R-HSA-418592 | 0.00231867248578 | 0.5 | GNB5 GNB2 | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-202040 | 0.00326103241616 | 0.5 | GNB5 GNB2 | G-protein activation |
| REAC:R-HSA-400042 | 0.00326103241616 | 0.5 | GNB5 GNB2 | Adrenaline,noradrenaline inhibits insulin secretion |
| REAC:R-HSA-451326 | 0.00352159938331 | 0.5 | GNB5 GNB2 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-397795 | 0.00379215175563 | 0.5 | GNB5 GNB2 | G-protein beta:gamma signalling |
| REAC:R-HSA-456926 | 0.00379215175563 | 0.5 | GNB5 GNB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-418594 | 0.00390449052912 | 0.75 | GNB5 RGS6 GNB2 | G alpha (i) signalling events |
| REAC:R-HSA-392518 | 0.00407268683926 | 0.5 | GNB5 GNB2 | Signal amplification |
| WP:WP2355 | 0.00581387281279 | 0.5 | GNB5 GNB2 | Corticotropin-releasing hormone signaling pathway |
| REAC:R-HSA-381676 | 0.00596538345738 | 0.5 | GNB5 GNB2 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| KEGG:04727 | 0.00613079763587 | 0.5 | GNB5 GNB2 | GABAergic synapse |
| WP:WP35 | 0.00623747495525 | 0.5 | GNB5 GNB2 | G Protein Signaling Pathways |
| KEGG:05032 | 0.00644602944709 | 0.5 | GNB5 GNB2 | Morphine addiction |
| REAC:R-HSA-432040 | 0.00667602194349 | 0.5 | GNB5 GNB2 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.00742649434549 | 0.5 | GNB5 GNB2 | Aquaporin-mediated transport |
| KEGG:04713 | 0.00761107721317 | 0.5 | GNB5 GNB2 | Circadian entrainment |
| KEGG:04726 | 0.00887201996914 | 0.5 | GNB5 GNB2 | Serotonergic synapse |
| KEGG:04725 | 0.00905997214328 | 0.5 | GNB5 GNB2 | Cholinergic synapse |
| REAC:R-HSA-418597 | 0.00947680746611 | 0.5 | GNB5 GNB2 | G alpha (z) signalling events |
| KEGG:04724 | 0.00983130325145 | 0.5 | GNB5 GNB2 | Glutamatergic synapse |
| WP:WP3929 | 0.012672821387 | 0.5 | GNB5 GNB2 | Chemokine signaling pathway |
| REAC:R-HSA-4086398 | 0.0137933430055 | 0.5 | GNB5 GNB2 | Ca2+ pathway |
| KEGG:04926 | 0.0141554312811 | 0.5 | GNB5 GNB2 | Relaxin signaling pathway |
| KEGG:04728 | 0.014392043024 | 0.5 | GNB5 GNB2 | Dopaminergic synapse |
| KEGG:04371 | 0.0151135129134 | 0.5 | GNB5 GNB2 | Apelin signaling pathway |
| KEGG:04062 | 0.016608760826 | 0.5 | GNB5 GNB2 | Chemokine signaling pathway |
| KEGG:04723 | 0.0171226599156 | 0.5 | GNB5 GNB2 | Retrograde endocannabinoid signaling |
| REAC:R-HSA-373080 | 0.0189130304237 | 0.5 | GNB5 GNB2 | Class B/2 (Secretin family receptors) |
| WP:WP4223 | 0.0197782099748 | 0.5 | GNB5 GNB2 | Ras Signaling |
| REAC:R-HSA-9009391 | 0.0214457367555 | 0.5 | GNB5 GNB2 | Extra-nuclear estrogen signaling |
| REAC:R-HSA-422356 | 0.0234490216385 | 0.5 | GNB5 GNB2 | Regulation of insulin secretion |
| REAC:R-HSA-416482 | 0.0262582706021 | 0.5 | GNB5 GNB2 | G alpha (12/13) signalling events |
| KEGG:05167 | 0.0267154932054 | 0.5 | GNB5 GNB2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05034 | 0.027038855262 | 0.5 | GNB5 GNB2 | Alcoholism |
| REAC:R-HSA-418346 | 0.0292253078855 | 0.5 | GNB5 GNB2 | Platelet homeostasis |
| KEGG:04014 | 0.0331864260111 | 0.5 | GNB5 GNB2 | Ras signaling pathway |
| REAC:R-HSA-388396 | 0.0339148209768 | 0.75 | GNB5 RGS6 GNB2 | GPCR downstream signalling |
| REAC:R-HSA-111885 | 0.0364771667023 | 0.5 | GNB5 GNB2 | Opioid Signalling |
| KEGG:05170 | 0.0387812861874 | 0.5 | GNB5 GNB2 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0399515654372 | 0.5 | GNB5 GNB2 | Human cytomegalovirus infection |
| REAC:R-HSA-392499 | 0.0403329683602 | 1.0 | GNB5 GNB2 PDCL RGS6 | Metabolism of proteins |
| REAC:R-HSA-372790 | 0.0432949536543 | 0.75 | GNB5 RGS6 GNB2 | Signaling by GPCR |
| REAC:R-HSA-163685 | 0.0464213162589 | 0.5 | GNB5 GNB2 | Integration of energy metabolism |
| CORUM:7018 | 0.0499140284799 | 0.25 | GNB5 | GNAI1-GNB5-GNGT1 complex |
| CORUM:7143 | 0.0499140284799 | 0.25 | GNB2 | GNAS-L-GNB2-GNG1 complex |
| CORUM:7146 | 0.0499140284799 | 0.25 | GNB5 | GNAS-L-GNB1-GNG1 complex |
| CORUM:3828 | 0.0499140284799 | 0.25 | PDCL | DRIP78-PHLP complex |
| CORUM:7015 | 0.0499140284799 | 0.25 | GNB2 | GNAI1-GNB2-GNGT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNB5 | RGS6 | 0.383 | 0.551 | bioplex (RGS6) bioplex_WMM |
| PDCL | GNB5 | 0.374 | 0.546 | bioplex (GNB5) bioplex_WMM |
| PDCL | GNB2 | 0.047 | 0.293 | hein_WMM bioplex (GNB2) bioplex_WMM |
Images
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Complex HuMAP2_02735 has an average edge precision of 0.463 which is ranked 2782 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDCL | HuMAP2_02735 HuMAP2_03750 HuMAP2_04444 HuMAP2_05976 |
| GNB5 | HuMAP2_02735 HuMAP2_03750 HuMAP2_04463 HuMAP2_05976 |
| RGS6 | HuMAP2_02735 HuMAP2_03750 HuMAP2_04463 |
| GNB2 | HuMAP2_02735 HuMAP2_02804 HuMAP2_03216 HuMAP2_03750 HuMAP2_05976 |