hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02745
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | UniProt NCBI |
| RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5229 | 5.02777038712e-06 | 1.0 | RPA1 RPA2 | RPA complex |
| CORUM:5231 | 1.67592346237e-05 | 1.0 | RPA1 RPA2 | 53BP1-containing complex |
| CORUM:2222 | 2.51388519356e-05 | 1.0 | RPA1 RPA2 | BLM complex II |
| CORUM:2738 | 2.51388519356e-05 | 1.0 | RPA1 RPA2 | BLM complex II |
| KEGG:03430 | 3.69120786663e-05 | 1.0 | RPA1 RPA2 | Mismatch repair |
| CORUM:248 | 6.03332446455e-05 | 1.0 | RPA1 RPA2 | BRAFT complex |
| REAC:R-HSA-174437 | 7.54165558069e-05 | 1.0 | RPA1 RPA2 | Removal of the Flap Intermediate from the C-strand |
| KEGG:03030 | 9.19154528054e-05 | 1.0 | RPA1 RPA2 | DNA replication |
| REAC:R-HSA-174414 | 9.21757904306e-05 | 1.0 | RPA1 RPA2 | Processive synthesis on the C-strand of the telomere |
| CORUM:244 | 9.21757904306e-05 | 1.0 | RPA1 RPA2 | BRAFT complex |
| REAC:R-HSA-3371511 | 0.000110610948517 | 1.0 | RPA1 RPA2 | HSF1 activation |
| KEGG:03440 | 0.000113800084426 | 1.0 | RPA1 RPA2 | Homologous recombination |
| CORUM:1004 | 0.000130722030065 | 1.0 | RPA1 RPA2 | RC complex during S-phase of cell cycle |
| CORUM:1005 | 0.000130722030065 | 1.0 | RPA1 RPA2 | RC complex during G2/M-phase of cell cycle |
| KEGG:03420 | 0.000138019076752 | 1.0 | RPA1 RPA2 | Nucleotide excision repair |
| REAC:R-HSA-69166 | 0.000152509035076 | 1.0 | RPA1 RPA2 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358606 | 0.000152509035076 | 1.0 | RPA1 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 0.000152509035076 | 1.0 | RPA1 RPA2 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| KEGG:03460 | 0.000171575511903 | 1.0 | RPA1 RPA2 | Fanconi anemia pathway |
| REAC:R-HSA-69183 | 0.000175971963549 | 1.0 | RPA1 RPA2 | Processive synthesis on the lagging strand |
| REAC:R-HSA-5358508 | 0.000175971963549 | 1.0 | RPA1 RPA2 | Mismatch Repair |
| REAC:R-HSA-110312 | 0.000201110815485 | 1.0 | RPA1 RPA2 | Translesion synthesis by REV1 |
| REAC:R-HSA-5656121 | 0.000227925590883 | 1.0 | RPA1 RPA2 | Translesion synthesis by POLI |
| REAC:R-HSA-5655862 | 0.000227925590883 | 1.0 | RPA1 RPA2 | Translesion synthesis by POLK |
| REAC:R-HSA-110320 | 0.000286582912066 | 1.0 | RPA1 RPA2 | Translesion Synthesis by POLH |
| REAC:R-HSA-69186 | 0.000318425457851 | 1.0 | RPA1 RPA2 | Lagging Strand Synthesis |
| WP:WP466 | 0.000320792526609 | 1.0 | RPA1 RPA2 | DNA Replication |
| REAC:R-HSA-5651801 | 0.000351943927099 | 1.0 | RPA1 RPA2 | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-174417 | 0.000462554875615 | 1.0 | RPA1 RPA2 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-110373 | 0.000502777038712 | 1.0 | RPA1 RPA2 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 0.000502777038712 | 1.0 | RPA1 RPA2 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| WP:WP45 | 0.000727651340845 | 1.0 | RPA1 RPA2 | G1 to S cell cycle control |
| REAC:R-HSA-180786 | 0.000729026706133 | 1.0 | RPA1 RPA2 | Extension of Telomeres |
| REAC:R-HSA-110314 | 0.000729026706133 | 1.0 | RPA1 RPA2 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 0.000779304410004 | 1.0 | RPA1 RPA2 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 0.000831258037338 | 1.0 | RPA1 RPA2 | DNA strand elongation |
| REAC:R-HSA-68962 | 0.000884887588134 | 1.0 | RPA1 RPA2 | Activation of the pre-replicative complex |
| REAC:R-HSA-6783310 | 0.000997174460113 | 1.0 | RPA1 RPA2 | Fanconi Anemia Pathway |
| REAC:R-HSA-73933 | 0.000997174460113 | 1.0 | RPA1 RPA2 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5685938 | 0.0010558317813 | 1.0 | RPA1 RPA2 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-176187 | 0.00111616502594 | 1.0 | RPA1 RPA2 | Activation of ATR in response to replication stress |
| WP:WP4016 | 0.00111886173915 | 1.0 | RPA1 RPA2 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-5693616 | 0.00117817419405 | 1.0 | RPA1 RPA2 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-110313 | 0.00117817419405 | 1.0 | RPA1 RPA2 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 0.00137425723915 | 1.0 | RPA1 RPA2 | Dual Incision in GG-NER |
| REAC:R-HSA-5693579 | 0.00137425723915 | 1.0 | RPA1 RPA2 | Homologous DNA Pairing and Strand Exchange |
| WP:WP2446 | 0.00139382676196 | 1.0 | RPA1 RPA2 | Retinoblastoma Gene in Cancer |
| REAC:R-HSA-5696395 | 0.00151335888652 | 1.0 | RPA1 RPA2 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-73893 | 0.00181167326283 | 1.0 | RPA1 RPA2 | DNA Damage Bypass |
| REAC:R-HSA-6782210 | 0.00337866170015 | 1.0 | RPA1 RPA2 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 0.00348592080174 | 1.0 | RPA1 RPA2 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-3371453 | 0.00348592080174 | 1.0 | RPA1 RPA2 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-6782135 | 0.00348592080174 | 1.0 | RPA1 RPA2 | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 0.00503279815751 | 1.0 | RPA1 RPA2 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 0.00542999201809 | 1.0 | RPA1 RPA2 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 0.00584226918984 | 1.0 | RPA1 RPA2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-912446 | 0.00598304676068 | 1.0 | RPA1 RPA2 | Meiotic recombination |
| REAC:R-HSA-3371556 | 0.00598304676068 | 1.0 | RPA1 RPA2 | Cellular response to heat stress |
| REAC:R-HSA-69002 | 0.00598304676068 | 1.0 | RPA1 RPA2 | DNA Replication Pre-Initiation |
| REAC:R-HSA-73884 | 0.00626962967274 | 1.0 | RPA1 RPA2 | Base Excision Repair |
| REAC:R-HSA-6804756 | 0.00686290657842 | 1.0 | RPA1 RPA2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.00732546145404 | 1.0 | RPA1 RPA2 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.00780309964082 | 1.0 | RPA1 RPA2 | Processing of DNA double-strand break ends |
| REAC:R-HSA-73886 | 0.0096834857656 | 1.0 | RPA1 RPA2 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 0.0100471611569 | 1.0 | RPA1 RPA2 | Nucleotide Excision Repair |
| REAC:R-HSA-1500620 | 0.0107946230212 | 1.0 | RPA1 RPA2 | Meiosis |
| REAC:R-HSA-69239 | 0.0115688996608 | 1.0 | RPA1 RPA2 | Synthesis of DNA |
| REAC:R-HSA-69306 | 0.0131978972662 | 1.0 | RPA1 RPA2 | DNA Replication |
| REAC:R-HSA-1474165 | 0.0134090636225 | 1.0 | RPA1 RPA2 | Reproduction |
| REAC:R-HSA-5693567 | 0.014052618232 | 1.0 | RPA1 RPA2 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | RPA1 RPA2 | G1/S Transition |
| REAC:R-HSA-5693538 | 0.0153849773846 | 1.0 | RPA1 RPA2 | Homology Directed Repair |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | RPA1 RPA2 | Mitotic G1-G1/S phases |
| HPA:022010_13 | 0.0187418520797 | 1.0 | RPA1 RPA2 | hippocampus; glial cells[Supported,High] |
| GO:0098505 | 0.020287053512 | 1.0 | RPA1 RPA2 | G-rich strand telomeric DNA binding |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | RPA1 RPA2 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | RPA1 RPA2 | S Phase |
| HPA:050020_13 | 0.0220677221908 | 1.0 | RPA1 RPA2 | spleen; cells in white pulp[Supported,High] |
| REAC:R-HSA-5693532 | 0.0224003929981 | 1.0 | RPA1 RPA2 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.023229975112 | 1.0 | RPA1 RPA2 | G2/M Checkpoints |
| HPA:041010_13 | 0.0246385887821 | 1.0 | RPA1 RPA2 | skeletal muscle; myocytes[Supported,High] |
| HPA:024010_13 | 0.0277809452741 | 1.0 | RPA1 RPA2 | kidney; cells in glomeruli[Supported,High] |
| HPA:032020_13 | 0.028650749551 | 1.0 | RPA1 RPA2 | pancreas; islets of Langerhans[Supported,High] |
| HPA:006010_13 | 0.0295339612157 | 1.0 | RPA1 RPA2 | caudate; glial cells[Supported,High] |
| GO:0043047 | 0.029754345151 | 1.0 | RPA1 RPA2 | single-stranded telomeric DNA binding |
| GO:0098847 | 0.029754345151 | 1.0 | RPA1 RPA2 | sequence-specific single stranded DNA binding |
| HPA:022010_03 | 0.0302051685624 | 1.0 | RPA1 RPA2 | hippocampus; glial cells[Uncertain,High] |
| HPA:021010_13 | 0.0324969938972 | 1.0 | RPA1 RPA2 | heart muscle; myocytes[Supported,High] |
| HPA:028020_13 | 0.0368334458561 | 1.0 | RPA1 RPA2 | lymph node; non-germinal center cells[Supported,High] |
| HPA:035010_13 | 0.0401341771152 | 1.0 | RPA1 RPA2 | placenta; decidual cells[Supported,High] |
| HPA:009020_13 | 0.0417053553612 | 1.0 | RPA1 RPA2 | cervix, uterine; squamous epithelial cells[Supported,High] |
| HPA:014020_13 | 0.042235785137 | 1.0 | RPA1 RPA2 | endometrium 2; glandular cells[Supported,High] |
| HPA:058010_13 | 0.044664198234 | 1.0 | RPA1 RPA2 | vagina; squamous epithelial cells[Supported,High] |
| HPA:056010_13 | 0.0460426452818 | 1.0 | RPA1 RPA2 | tonsil; germinal center cells[Supported,High] |
| HPA:050020_03 | 0.0474420413729 | 1.0 | RPA1 RPA2 | spleen; cells in white pulp[Uncertain,High] |
| HPA:007010_13 | 0.0480076655415 | 1.0 | RPA1 RPA2 | cerebellum; Purkinje cells[Supported,High] |
| HPA:056020_13 | 0.0480076655415 | 1.0 | RPA1 RPA2 | tonsil; non-germinal center cells[Supported,High] |
| HPA:004020_13 | 0.0485766415569 | 1.0 | RPA1 RPA2 | breast; glandular cells[Supported,High] |
| HPA:006010_03 | 0.0491489694193 | 1.0 | RPA1 RPA2 | caudate; glial cells[Uncertain,High] |
| WP:WP531 | 0.0499262710315 | 0.5 | RPA1 | DNA Mismatch Repair |
| WP:WP3875 | 0.0499262710315 | 0.5 | RPA1 | ATR Signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RPA2 | RPA1 | 1.0 | 0.949 | hein_WMM bioplex (RPA2) bioplex_WMM Guru boldt youn_WMM hein (RPA1) Malo gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_02745 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RPA2 | HuMAP2_00586 HuMAP2_02745 HuMAP2_03624 HuMAP2_03648 HuMAP2_03650 HuMAP2_05012 HuMAP2_05034 |
| RPA1 | HuMAP2_00586 HuMAP2_02745 HuMAP2_03624 HuMAP2_03648 HuMAP2_05012 HuMAP2_05034 |