hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02747
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DYNC1I2 | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | UniProt NCBI |
| DYNC1LI1 | Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) (Dynein light chain A) (DLC-A) (Dynein light intermediate chain 1, cytosolic) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 1.88400237495e-07 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 2.97115076526e-07 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Vasopressin-regulated water reabsorption |
| KEGG:05132 | 1.44061718026e-06 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Salmonella infection |
| REAC:R-HSA-6811436 | 8.81209945571e-06 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 9.93609173322e-06 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| KEGG:04145 | 1.20588724809e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Phagosome |
| GO:0045504 | 2.59741127426e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | dynein heavy chain binding |
| REAC:R-HSA-141444 | 5.64603800841e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 5.64603800841e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Amplification of signal from the kinetochores |
| REAC:R-HSA-6807878 | 6.62885685587e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | COPI-mediated anterograde transport |
| REAC:R-HSA-69618 | 8.92382428809e-05 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Mitotic Spindle Checkpoint |
| GO:0005868 | 0.000103533176666 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | cytoplasmic dynein complex |
| REAC:R-HSA-2132295 | 0.000113954833063 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | MHC class II antigen presentation |
| REAC:R-HSA-2500257 | 0.000126264796487 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-8856688 | 0.000160847790881 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-5663220 | 0.00017233319357 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | RHO GTPases Activate Formins |
| REAC:R-HSA-199977 | 0.000219108356997 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.000355291261341 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-2467813 | 0.000451723953992 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.000513949964862 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.000513949964862 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000522107900813 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-6811442 | 0.000564194667652 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0030286 | 0.000968126020406 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | dynein complex |
| REAC:R-HSA-446203 | 0.00171641263924 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Asparagine N-linked glycosylation |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.00218937240413 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 0.00398320383305 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | M Phase |
| REAC:R-HSA-2262752 | 0.00501472976187 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Cellular responses to stress |
| REAC:R-HSA-194315 | 0.00591618280835 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Signaling by Rho GTPases |
| REAC:R-HSA-8953897 | 0.00865480168204 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Cellular responses to external stimuli |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Cell Cycle, Mitotic |
| GO:0019886 | 0.0103137207675 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| GO:0002495 | 0.0106693663112 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | antigen processing and presentation of peptide antigen via MHC class II |
| GO:0002504 | 0.0110330947082 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Vesicle-mediated transport |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Cell Cycle |
| REAC:R-HSA-1280218 | 0.0202947578047 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | Adaptive Immune System |
| WP:WP4352 | 0.0212517549636 | 0.666666666667 | DYNC1LI1 DYNC1I2 | Ciliary landscape |
| GO:0005875 | 0.0356085105614 | 1.0 | DYNC1LI2 DYNC1I2 DYNC1LI1 | microtubule associated complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DYNC1LI1 | DYNC1I2 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1I2,DYNC1LI1) bioplex_WMM boldt youn_WMM hein (DYNC1LI1) Malo gupta_WMM fraction boldt_WMM |
| DYNC1I2 | DYNC1LI2 | 1.0 | 0.949 | hein_WMM bioplex (DYNC1I2) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| DYNC1LI1 | DYNC1LI2 | 0.999 | 0.949 | hein_WMM bioplex (DYNC1LI1) bioplex_WMM boldt youn_WMM hein (DYNC1LI1) gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02747 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DYNC1I2 | HuMAP2_02747 HuMAP2_02795 |
| DYNC1LI2 | HuMAP2_02747 HuMAP2_02795 HuMAP2_04880 |
| DYNC1LI1 | HuMAP2_00118 HuMAP2_02747 HuMAP2_02795 |