hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02752
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD1 | Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1) | UniProt NCBI |
| SMAD5 | Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5) | UniProt NCBI |
| SSMEM1 | Serine-rich single-pass membrane protein 1 | UniProt NCBI |
| SMURF1 | E3 ubiquitin-protein ligase SMURF1 (hSMURF1) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF1) (SMAD ubiquitination regulatory factor 1) (SMAD-specific E3 ubiquitin-protein ligase 1) | UniProt NCBI |
| SMURF2 | E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2) | UniProt NCBI |
| MARS2 | Methionine--tRNA ligase, mitochondrial (EC 6.1.1.10) (Methionyl-tRNA synthetase 2) (Mitochondrial methionyl-tRNA synthetase) (MtMetRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-201451 | 1.06023874251e-08 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | Signaling by BMP |
| KEGG:04350 | 4.79476375504e-07 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | TGF-beta signaling pathway |
| REAC:R-HSA-9006936 | 2.90272483296e-06 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | Signaling by TGF-beta family members |
| WP:WP1425 | 0.000251132317359 | 0.333333333333 | SMAD1 SMURF1 | Bone Morphogenic Protein (BMP) Signalling and Regulation |
| WP:WP3876 | 0.000306884523941 | 0.333333333333 | SMAD5 SMAD1 | BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation |
| WP:WP3927 | 0.000758026533465 | 0.333333333333 | SMAD5 SMAD1 | BMP Signaling Pathway in Eyelid Development |
| GO:0030509 | 0.00101282970404 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | BMP signaling pathway |
| WP:WP4331 | 0.00105843860426 | 0.333333333333 | SMAD5 SMAD1 | Neovascularisation processes |
| WP:WP2895 | 0.00105843860426 | 0.333333333333 | SMAD5 SMAD1 | Differentiation of white and brown adipocyte |
| GO:0071772 | 0.00120362941431 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | response to BMP |
| GO:0071773 | 0.00120362941431 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | cellular response to BMP stimulus |
| GO:0007179 | 0.0038519413587 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | transforming growth factor beta receptor signaling pathway |
| WP:WP4249 | 0.00390360990759 | 0.333333333333 | SMURF2 SMURF1 | Hedgehog Signaling Pathway |
| REAC:R-HSA-2173788 | 0.00464022545552 | 0.333333333333 | SMURF2 SMURF1 | Downregulation of TGF-beta receptor signaling |
| WP:WP560 | 0.00524729006009 | 0.333333333333 | SMAD5 SMAD1 | TGF-beta Receptor Signaling |
| KEGG:04340 | 0.00587890830807 | 0.333333333333 | SMURF2 SMURF1 | Hedgehog signaling pathway |
| REAC:R-HSA-2173789 | 0.00774747127227 | 0.333333333333 | SMURF2 SMURF1 | TGF-beta receptor signaling activates SMADs |
| GO:0071560 | 0.00790339487449 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | cellular response to transforming growth factor beta stimulus |
| GO:0071559 | 0.0089947338343 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | response to transforming growth factor beta |
| CORUM:2992 | 0.0249904952816 | 0.166666666667 | SMURF2 | Ubiquitin E3 ligase (SMAD7, SMURF2) |
| CORUM:2996 | 0.0249904952816 | 0.166666666667 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) |
| WP:WP3931 | 0.0261098195507 | 0.333333333333 | SMAD5 SMAD1 | ESC Pluripotency Pathways |
| GO:0007178 | 0.0287203705471 | 0.666666666667 | SMAD5 SMURF1 SMURF2 SMAD1 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| REAC:R-HSA-8941858 | 0.0302745579484 | 0.333333333333 | SMURF2 SMURF1 | Regulation of RUNX3 expression and activity |
| WP:WP366 | 0.0416969783243 | 0.333333333333 | SMURF2 SMURF1 | TGF-beta Signaling Pathway |
| REAC:R-HSA-4608870 | 0.0428303754683 | 0.333333333333 | SMURF2 SMURF1 | Asymmetric localization of PCP proteins |
| MIRNA:hsa-miR-675-3p | 0.0442415992422 | 0.333333333333 | SMAD5 SMAD1 | hsa-miR-675-3p |
| GO:0046332 | 0.0447070305646 | 0.5 | SMAD1 SMURF2 SMURF1 | SMAD binding |
| KEGG:04550 | 0.0459708339013 | 0.333333333333 | SMAD5 SMAD1 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-170834 | 0.0499130144295 | 0.333333333333 | SMURF2 SMURF1 | Signaling by TGF-beta Receptor Complex |
| CORUM:2642 | 0.0499726005494 | 0.166666666667 | SMAD1 | SMAD1-P300 complex |
| CORUM:1783 | 0.0499726005494 | 0.166666666667 | SMURF1 | Ubiquitin E3 ligase (SMAD7, SMURF1) - TGFBR1 |
| CORUM:2958 | 0.0499726005494 | 0.166666666667 | SMAD1 | SMAD1-CBP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMURF1 | SMURF2 | 1.0 | 0.949 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | SMAD5 | 0.315 | 0.509 | bioplex (SMURF2) bioplex_WMM |
| SMAD1 | SMURF2 | 0.118 | 0.391 | bioplex (SMURF2) bioplex_WMM |
| SMURF2 | MARS2 | 0.084 | 0.347 | bioplex (SMURF2) bioplex_WMM |
| SMAD5 | SSMEM1 | 0.021 | 0.188 | bioplex (SSMEM1) bioplex_WMM |
| SMAD1 | SMURF1 | 0.008 | 0.095 | bioplex_WMM WMM_only |
| SMURF1 | SMAD5 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| SMAD1 | SMAD5 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| SMURF1 | MARS2 | 0.008 | 0.033 | bioplex_WMM WMM_only |
| SMAD1 | MARS2 | 0.008 | 0.01 | bioplex_WMM WMM_only |
| SMAD5 | MARS2 | 0.007 | 0.016 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_02752 has an average edge precision of 0.244 which is ranked 5473 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD1 | HuMAP2_00001 HuMAP2_01252 HuMAP2_02037 HuMAP2_02752 HuMAP2_02905 HuMAP2_04429 |
| SMAD5 | HuMAP2_01252 HuMAP2_01560 HuMAP2_02752 HuMAP2_04429 |
| SSMEM1 | HuMAP2_01252 HuMAP2_01560 HuMAP2_02752 |
| SMURF1 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_03627 HuMAP2_04429 |
| SMURF2 | HuMAP2_00852 HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |
| MARS2 | HuMAP2_01252 HuMAP2_02752 HuMAP2_04429 |