hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_02755
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ZBTB24 | Zinc finger and BTB domain-containing protein 24 (Zinc finger protein 450) | UniProt NCBI |
| HADHA | Trifunctional enzyme subunit alpha, mitochondrial (78 kDa gastrin-binding protein) (Monolysocardiolipin acyltransferase) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | UniProt NCBI |
| RBMX2 | RNA-binding motif protein, X-linked 2 | UniProt NCBI |
| RPS8 | 40S ribosomal protein S8 (Small ribosomal subunit protein eS8) | UniProt NCBI |
| HADHB | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7262 | 6.70868171695e-06 | 0.4 | HADHA HADHB | 3-Hydroxyacyl CoA dehydrogenase |
| REAC:R-HSA-77285 | 4.04876825444e-05 | 0.4 | HADHA HADHB | Beta oxidation of myristoyl-CoA to lauroyl-CoA |
| REAC:R-HSA-77305 | 4.04876825444e-05 | 0.4 | HADHA HADHB | Beta oxidation of palmitoyl-CoA to myristoyl-CoA |
| HP:0025145 | 4.64766403483e-05 | 0.4 | HADHA HADHB | Rigors |
| REAC:R-HSA-77310 | 0.000134922692372 | 0.4 | HADHA HADHB | Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA |
| REAC:R-HSA-77348 | 0.000134922692372 | 0.4 | HADHA HADHB | Beta oxidation of octanoyl-CoA to hexanoyl-CoA |
| REAC:R-HSA-77350 | 0.000134922692372 | 0.4 | HADHA HADHB | Beta oxidation of hexanoyl-CoA to butanoyl-CoA |
| HP:0008138 | 0.000139411195565 | 0.4 | HADHA HADHB | Equinus calcaneus |
| HP:0025144 | 0.000139411195565 | 0.4 | HADHA HADHB | Shivering |
| REAC:R-HSA-1482798 | 0.000202356855584 | 0.4 | HADHA HADHB | Acyl chain remodeling of CL |
| REAC:R-HSA-77346 | 0.000202356855584 | 0.4 | HADHA HADHB | Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
| REAC:R-HSA-77288 | 0.000202356855584 | 0.4 | HADHA HADHB | mitochondrial fatty acid beta-oxidation of unsaturated fatty acids |
| WP:WP3871 | 0.000220106689546 | 0.4 | HADHA HADHB | Valproic acid pathway |
| HP:0006555 | 0.000278784943944 | 0.4 | HADHA HADHB | Diffuse hepatic steatosis |
| REAC:R-HSA-77286 | 0.000485460775426 | 0.4 | HADHA HADHB | mitochondrial fatty acid beta-oxidation of saturated fatty acids |
| HP:0008110 | 0.000696775152219 | 0.4 | HADHA HADHB | Equinovarus deformity |
| HP:0007067 | 0.000696775152219 | 0.4 | HADHA HADHB | Distal peripheral sensory neuropathy |
| HP:0003756 | 0.000696775152219 | 0.4 | HADHA HADHB | Skeletal myopathy |
| HP:0011808 | 0.000696775152219 | 0.4 | HADHA HADHB | Decreased patellar reflex |
| KEGG:00062 | 0.0010832092153 | 0.4 | HADHA HADHB | Fatty acid elongation |
| HP:0025143 | 0.00167158658755 | 0.4 | HADHA HADHB | Chills |
| HP:0009063 | 0.00167158658755 | 0.4 | HADHA HADHB | Progressive distal muscle weakness |
| WP:WP143 | 0.00186538306079 | 0.4 | HADHA HADHB | Fatty Acid Beta Oxidation |
| HP:0100626 | 0.00361982515692 | 0.4 | HADHA HADHB | Chronic hepatic failure |
| KEGG:00071 | 0.00367693195997 | 0.4 | HADHA HADHB | Fatty acid degradation |
| HP:0001985 | 0.00422256197273 | 0.4 | HADHA HADHB | Hypoketotic hypoglycemia |
| GO:0016509 | 0.00450823411379 | 0.4 | HADHA HADHB | long-chain-3-hydroxyacyl-CoA dehydrogenase activity |
| KEGG:00280 | 0.00461334650691 | 0.4 | HADHA HADHB | Valine, leucine and isoleucine degradation |
| HP:0002476 | 0.00556671743772 | 0.4 | HADHA HADHB | Primitive reflex |
| KEGG:01212 | 0.00587609842855 | 0.4 | HADHA HADHB | Fatty acid metabolism |
| HP:0008364 | 0.00709565752293 | 0.4 | HADHA HADHB | Abnormality of the calcaneus |
| REAC:R-HSA-77289 | 0.00709716303977 | 0.4 | HADHA HADHB | Mitochondrial Fatty Acid Beta-Oxidation |
| HP:0002913 | 0.0107072942689 | 0.4 | HADHA HADHB | Myoglobinuria |
| HP:0002600 | 0.0127896924378 | 0.4 | HADHA HADHB | Hyporeflexia of lower limbs |
| TF:M06646 | 0.0135228859698 | 0.4 | HADHA HADHB | Factor: znf607; motif: NGGATCAAGAAA |
| TF:M06646_0 | 0.0135228859698 | 0.4 | HADHA HADHB | Factor: znf607; motif: NGGATCAAGAAA; match class: 0 |
| HP:0005180 | 0.0138999712057 | 0.4 | HADHA HADHB | Tricuspid regurgitation |
| HP:0031651 | 0.0150562782431 | 0.4 | HADHA HADHB | Abnormal tricuspid valve physiology |
| HP:0003201 | 0.0162585949147 | 0.4 | HADHA HADHB | Rhabdomyolysis |
| HP:0000829 | 0.0229596708254 | 0.4 | HADHA HADHB | Hypoparathyroidism |
| WP:WP706 | 0.0266864861787 | 0.4 | HADHA HADHB | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| HP:0003551 | 0.0398018408038 | 0.4 | HADHA HADHB | Difficulty climbing stairs |
| HP:0040083 | 0.0437194132729 | 0.4 | HADHA HADHB | Toe walking |
| GO:0035965 | 0.0450641792523 | 0.4 | HADHA HADHB | cardiolipin acyl-chain remodeling |
| HP:0001987 | 0.0478196851342 | 0.4 | HADHA HADHB | Hyperammonemia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HADHA | HADHB | 1.0 | 0.949 | hein_WMM bioplex (HADHB) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
| HADHA | RPS8 | 0.07 | 0.348 | hein_WMM bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| ZBTB24 | RPS8 | 0.052 | 0.301 | bioplex (RPS8) bioplex_WMM |
| RBMX2 | RPS8 | 0.041 | 0.27 | bioplex (RPS8) bioplex_WMM treiber_WMM |
| ZBTB24 | RBMX2 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| HADHB | RBMX2 | 0.007 | 0.003 | WMM_only treiber_WMM |
| HADHA | RBMX2 | 0.007 | 0.003 | WMM_only treiber_WMM |
| HADHB | RPS8 | 0.0 | 0.011 | bioplex (HADHB) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_02755 has an average edge precision of 0.239 which is ranked 5543 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ZBTB24 | HuMAP2_01223 HuMAP2_02755 HuMAP2_06544 |
| HADHA | HuMAP2_01254 HuMAP2_02755 HuMAP2_06681 HuMAP2_06710 |
| RBMX2 | HuMAP2_02181 HuMAP2_02755 HuMAP2_04341 HuMAP2_04877 |
| RPS8 | HuMAP2_02207 HuMAP2_02755 HuMAP2_05622 HuMAP2_06544 |
| HADHB | HuMAP2_01254 HuMAP2_02755 HuMAP2_03276 HuMAP2_06329 HuMAP2_06798 |